Factores de riesgo para el desarrollo de insuficiencia renal aguda en pacientes hospitalizados con COVID-19

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i6.29381

Palabras clave:

SARS-CoV-2; Lesión renal aguda; Factores de riesgo.

Resumen

Este estudio tiene como objetivo analizar los predictores y factores de riesgo predominantes para el desarrollo de insuficiencia renal aguda (IRA) en pacientes hospitalizados con COVID-19. Se trata de una revisión integradora de estudios de cohortes retrospectivos y prospectivos y estudios observacionales, con la búsqueda realizada en las bases de datos PubMed® y Biblioteca Virtual en Salud con las palabras clave “SARS-CoV-2”, “injuria renal aguda” y “factores de riesgo”, seleccionando aquellas que respondieron a la pregunta orientadora “¿cuáles son los predictores y factores de riesgo para el desarrollo de insuficiencia renal aguda en pacientes hospitalizados con COVID-19?”. Tras esta investigación y aplicando filtros de año de publicación e idioma, se seleccionaron inicialmente 39 artículos. Después de las exclusiones, 7 artículos fueron incluidos en la presente revisión, cuya calidad fue evaluada y sus datos recolectados utilizando la metodología PRISMA. En todos los artículos seleccionados, se verificó la significación estadística de los 11 factores de riesgo más frecuentes, como dímero D elevado, creatinina sérica, proteína C reactiva, aumento del número de leucocitos, disminución de linfocitos, edad avanzada, género, índice de masa corporal alto, hipertensión, diabetes y enfermedad renal crónica. Tras analizar los artículos seleccionados, se encontró que los factores de riesgo comunes más comunes para este desenlace de IRA son, principalmente, la edad avanzada, enfermedad renal crónica y proteína C reactiva elevada al ingreso. En general, estos factores son indicadores de riesgo y requieren una mayor atención por parte de los profesionales para proporcionar un enfoque terapéutico eficaz y prevenir resultados graves.

Citas

Astuti, I. (2020). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response. Diabetes Metab Syndr, 407–412. https://pesquisa.bvsalud.org/portal/resource/pt/mdl-32335367

Caetano, E. R. P.; Praxedes, J. N. (1988). Lesão renal na hipertensão essencial. HiperAtivo, 4:234-41. http://departamentos.cardiol.br/dha/revista/5-4/lesao.pdf

‌Casas-Aparicio, G. A., León-Rodríguez, I., Alvarado-de la Barrera, C., González-Navarro, M., Peralta-Prado, A. B., Luna-Villalobos, Y., Velasco-Morales, A., Calderón-Dávila, N., Ormsby, C. E., & Ávila-Ríos, S. (2021). Acute kidney injury in patients with severe COVID-19 in Mexico. PLOS ONE, 16(2), e0246595. https://doi.org/10.1371/journal.pone.0246595

Chakraborty, C., Bhattacharya, M., Sharma, A. R., Lee, S.-S., & Agoramoorthy, G. (2021). SARS-CoV-2 Brazil variants in Latin America: More serious research urgently needed on public health and vaccine protection. Annals of Medicine and Surgery, 66, 102428. https://doi.org/10.1016/j.amsu.2021.102428

Cheng, Y., Luo, R., Wang, K., Zhang, M., Wang, Z., Dong, L., Li, J., Yao, Y., Ge, S., & Xu, G. (2020a). Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney International, 97(5), 829–838. https://doi.org/10.1016/j.kint.2020.03.005

‌Cheng, Y., Luo, R., Wang, X., Wang, K., Zhang, N., Zhang, M., Wang, Z., Dong, L., Li, J., Zeng, R., Yao, Y., Ge, S., & Xu, G. (2020b). The Incidence, Risk Factors, and Prognosis of Acute Kidney Injury in Adult Patients with Coronavirus Disease 2019. Clinical Journal of the American Society of Nephrology, 15(10), 1394–1402. https://doi.org/10.2215/cjn.04650420

Chi, J. H., & Lee, B. J. (2022). Risk factors for hypertension and diabetes comorbidity in a Korean population: A cross-sectional study. PLOS ONE, 17(1), e0262757. https://doi.org/10.1371/journal.pone.0262757

‌Duarte-Neto, Amaro N, Renata, Luiz, S., Denise, Ellen, Theodoro-Filho, J., Pinho, Gomes-Gouvêa, M. S., Ana, de, Mauad, T., Saldiva, & Dolhnikoff, M. (2020). Pulmonary and systemic involvement in COVID-19 patients assessed with ultrasound-guided minimally invasive autopsy. Histopathology, 186–197. https://pesquisa.bvsalud.org/portal/resource/pt/mdl-32443177

Diebold, M., Schaub, S., Landmann, E., Steiger, J., & Dickenmann, M. (2021). Acute kidney injury in patients with COVID-19: a retrospective cohort study from Switzerland. Swiss Medical Weekly. https://doi.org/10.4414/smw.2021.20482

Fisher, M., Neugarten, J., Bellin, E., Yunes, M., Stahl, L., Johns, T. S., Abramowitz, M. K., Levy, R., Kumar, N., Mokrzycki, M. H., Coco, M., Dominguez, M., Prudhvi, K., & Golestaneh, L. (2020). AKI in Hospitalized Patients with and without COVID-19: A Comparison Study. Journal of the American Society of Nephrology, 31(9), 2145–2157. https://doi.org/10.1681/asn.2020040509

‌Fominskiy, E. V. Scandroglio, A. M., Monti, G., Calabrò, M. G., Landoni, G., Dell’Acqua, A., Beretta, L., Moizo, E., Ravizza, A., Monaco, F., Campochiaro, C., Pieri, M., Azzolini, M. L., Borghi, G., Crivellari, M., Conte, C., Mattioli, C., Silvani, P., Mucci, M., & Turi, S. (2020). Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy. Blood Purification, 50(1), 102–109. https://doi.org/10.1159/000508657

G;Hu, X. (2021). [Acute kidney injury in patients hospitalized with COVID-19 in Wuhan, China: a single-center retrospective observational study]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 41(2). https://doi.org/10.12122/j.issn.1673-4254.2021.02.01

Gabarre, P., Dumas, G., Dupont, T., Darmon, M., Azoulay, E., & Zafrani, L. (2020). Acute kidney injury in critically ill patients with COVID-19. Intensive Care Medicine, 46(7), 1339–1348. https://doi.org/10.1007/s00134-020-06153-9

Gao, Y., Ding, M., Dong, X., Zhang, J., Kursat Azkur, A., Azkur, D., Gan, H., Sun, Y., Fu, W., Li, W., Liang, H., Cao, Y., Yan, Q., Cao, C., Gao, H., Brüggen, M., Veen, W., Sokolowska, M., Akdis, M., & Akdis, C. A. (2020). Risk factors for severe and critically ill COVID‐19 patients: A review. Allergy, 76(2), 428–455. https://doi.org/10.1111/all.14657

Ghosn, M., Attallah, N., Badr, M., Abdallah, K., De Oliveira, B., Nadeem, A., Varghese, Y., Munde, D., Salam, S., Abduljawad, B., Saleh, K., Elkambergy, H., Wahla, A., Taha, A., Dibu, J., Bayrlee, A., Hamed, F., Rahman, N., & Mallat, J. (2021). Severe Acute Kidney Injury in Critically Ill Patients with COVID-19 Admitted to ICU: Incidence, Risk Factors, and Outcomes. Journal of Clinical Medicine, 10(6), 1217. https://doi.org/10.3390/jcm10061217

Gómez‐Belda, A. B., Fernández‐Garcés, M., Mateo‐Sanchis, E., Madrazo, M., Carmona, M., Piles‐Roger, L., & Artero, A. (2020). COVID ‐19 in older adults: What are the differences with younger patients? Geriatrics & Gerontology International, 21(1), 60–65.https://doi.org/10.1111/ggi.14102

Khruleva,Y., Mubayazvamba, T.,Troitskaya, E., Efremovtseva, M., & Kobalava, Z. (2021). Hipertension is a risk factor for acute kidney injury and a predictor of mortality in hospitalized patients with Covid-19.Journal of Hypertension, 39: e406.doi: 10.1097/01.hjh.0000749296.26490.d9

Khwaja, A. (2012). KDIGO Clinical Practice Guidelines for Acute Kidney Injury. Nephron, 120(4), c179–c184. https://doi.org/10.1159/000339789

Kolhe, N. V., Fluck, R. J., Selby, N. M., & Taal, M. W. (2020). Acute kidney injury associated with COVID-19: A retrospective cohort study. PLOS Medicine, 17(10), e1003406. https://doi.org/10.1371/journal.pmed.1003406

Lanzani, C., Simonini, M., Arcidiacono, T., Messaggio, E., Bucci, R., Betti, P., Avino, M., Magni, G., Maggioni, C., Conte, C., Querini, P. R. Ciceri, F., Castagna, A., Vezzoli, G., & Manunta, P. (2021). Role of blood pressure dysregulation on kidney and mortality outcomes in COVID-19. Kidney, blood pressure and mortality in SARS-CoV-2 infection. Journal of Nephrology, 34(2), 305–314. https://doi.org/10.1007/s40620-021-00997-0

Lin, L., Wang, X., Ren, J., Sun, Y., Yu, R., Li, K., Zheng, L., & Yan, J. (2020). Risk factors and prognosis for COVID-19-induced acute kidney injury: a meta-analysis. Journal BMJ, 10: e042573. doi: 10.1136/bmjopen-2020-042573

‌Nimkar, A., Naaraayan, A., Hasan, A., Pant, S., Durdevic, M., Suarez, C. N., Elenius, H., Hambardzumyan, A., Lakshmi, K., Mandel, M., & Jesmajian, S. (2020). Incidence and Risk Factors for Acute Kidney Injury and Its Effect on Mortality in Patients Hospitalized From COVID-19. Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 4(6), 687–695. https://doi.org/10.1016/j.mayocpiqo.2020.07.003

Pecly, I. M. D., Azevedo, R. B., Muxfeldt, E. S., Botelho, B. G., Albuquerque, G. G., Diniz, P. H. P., Silva, R., & Rodrigues, C. I. S. (2021). A review of Covid-19 and acute kidney injury: from pathophysiology to clinical results. Brazilian Journal of Nephrology, 43(4), 551–571. https://doi.org/10.1590/2175-8239-jbn-2020-0204

Peng, S., Wang, H.-Y., Sun, X., Li, P., Ye, Z., Li, Q., Wang, J., Shi, X., Liu, L., Yao, Y., Zeng, R., He, F., Li, J., Ge, S., Ke, X., Zhou, Z., Dong, E., Wang, H., Xu, G., & Zhang, L. (2020). Early versus late acute kidney injury among patients with COVID-19—a multicenter study from Wuhan, China. Nephrology Dialysis Transplantation, 35(12), 2095–2102. https://doi.org/10.1093/ndt/gfaa288

Pimentel, R. M. M., Daboin, B. E. G., Oliveira, A. G. de, & Macedo Jr, H. (2020). The dissemination of COVID-19: an expectant and preventive role in global health. Journal of Human Growth and Development, 30(1), 135–140. https://doi.org/10.7322/jhgd.v30.9976

Pontelli, M. C. Castro, I. A., Martins, R. B., Veras, F. P. Serra, L. Nascimento, D. C. Cardoso, R. S., Rosales, R., Lima, T. M., Souza, J. P., Caetité, D. B. de Lima, M. H. F., Kawahisa, J. T., Giannini, M. C. Bonjorno, L. P., Lopes, M. I. F., Batah, S. S., Siyuan, L.Assad, R. , L., & Almeida, S. C. L. (2020). Infection of human lymphomononuclear cells by SARS-CoV-2. https://doi.org/10.1101/2020.07.28.225912

Poorolajal, J., Farbakhsh, F., Mahjub, H., Bidarafsh, A., & Babaee, E. (2016). How much excess body weight, blood sugar, or age can double the risk of hypertension? Public Health, 133, 14–18. https://doi.org/10.1016/j.puhe.2015.10.014

Russo, E., Esposito, P., Taramasso, L., Magnasco, L., Saio, M., Briano, F., Russo, C., Dettori, S., Vena, A., Di Biagio, A., Garibotto, G., Bassetti, M., Viazzi, F., Alessandrini, A., Camera, M., Delfino, E., De Maria, A., Dentone, C., Di Biagio, A., & Dodi, F. (2020). Kidney disease and all-cause mortality in patients with COVID-19 hospitalized in Genoa, Northern Italy. Journal of Nephrology, 34(1), 173–183. https://doi.org/10.1007/s40620-020-00875-1

Tavares De Souza, M., Dias Da Silva, M., & De Carvalho, R. (2010). Revisão integrativa: o que é e como fazer Integrative review: what is it? How to do it? 8(1), 102–108. https://www.scielo.br/j/eins/a/ZQTBkVJZqcWrTT34cXLjtBx/?format=pdf&lang=pt

Wang, L.-L., Yang, J.-W., & Xu, J.-F. (2021). Coronavirus (SARS-CoV-2) causes lung inflammation and injury. Clin. Microbiol. Infect, -. https://pesquisa.bvsalud.org/portal/resource/pt/mdl-34861410

Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of Advanced Nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x

WHO Coronavirus (COVID-19) Dashboard. (2022). Who.int. https://covid19.who.int/

Xavier, A. R. Silva, J. S., Almeida, J. P. C. L. Conceição, J. F. F., Lacerda, G. S., & Kanaan, S. (2020). COVID-19: clinical and laboratory manifestations in novel coronavirus infection. Jornal Brasileiro de Patologia E Medicina Laboratorial. https://doi.org/10.5935/1676-2444.20200049

Xiao, G., Hu, H., Wu, F., Sha, T.,Zeng, Z., Huang, Q., Li, H., Han, J., Wenhong, C., Chen, Z., & Cai, S. (2021). Acute kidney injury in patients hospitalized with COVID-19 in Wuhan, China: a single-center retrospective observational study. Journal of Southern Medical University, 41(2), 157–163. https://doi.org/10.12122/j.issn.1673-4254.2021.02.01

Yu, S. M., & Bonventre, J. V. (2018). Acute Kidney Injury and Progression of Diabetic Kidney Disease. Advances in chronic kidney disease, 25(2), 166–180. https://doi.org/10.1053/j.ackd.2017.12.005

Publicado

08/05/2022

Cómo citar

VALENTE, E. de O.; MORAIS, C. C. de; REIS, D. B.; FALONI, J. V. A.; SENA, L. P.; VESPÚCIO, O. de P.; SILVEIRA, P. H.; SOARES, T. A. Y.; CANDIDO, P.; REIS , S. T. dos . Factores de riesgo para el desarrollo de insuficiencia renal aguda en pacientes hospitalizados con COVID-19. Research, Society and Development, [S. l.], v. 11, n. 6, p. e52511629381, 2022. DOI: 10.33448/rsd-v11i6.29381. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/29381. Acesso em: 22 nov. 2024.

Número

Sección

Ciencias de la salud