La importancia del diagnóstico de laboratorio en la identificación de la fiebre chikungunya asociada con enfermedades reumatológicas
DOI:
https://doi.org/10.33448/rsd-v11i8.31316Palabras clave:
Chikungunya; Reumatológico; Arbovirus; Diagnóstico de laboratorio.Resumen
La fiebre chikungunya es una enfermedad viral causada por el virus CHIK, esta patología se propaga a través del vector perteneciente al género Aedes spp. Este virus pertenece al grupo de los arbovirus, comúnmente encontrados en lugares de climas tropicales, fue aislado en Tanzania en 1952. Sin embargo, presenta síntomas similares a otros arbovirus causando confusión, dificultando su identificación, los síntomas frecuentemente observados en pacientes con esta viremia son cefalea, artralgia, mialgia, tenosinovitis, en algunos casos evoluciona a una forma crónica de la enfermedad provocando daño persistente en las articulaciones. El objetivo de este trabajo fue comprender el funcionamiento del diagnóstico de laboratorio de la fiebre chikungunya asociada a daño reumatológico. Este estudio es una revisión de la literatura desarrollada a partir de investigaciones publicadas en varias bases de datos, SciELO y MEDLINE, utilizando los descriptores chikungunya, CHIK, arbovirus, diagnóstico de laboratorio, fiebre chikungunya. En este estudio pudimos mostrar la importancia del diagnóstico de laboratorio en la identificación del chikungunya y su asociación con enfermedades reumatológicas. Finalmente, concluimos que el diagnóstico de laboratorio contribuye a la identificación de la enfermedad de manera temprana y eficaz y brinda un tratamiento eficiente, y a través de esto ayuda en la concientización de la población de las precauciones a tomar para evitar la infección.
Citas
Azevedo, R. do S. da S., Oliveira, C. S., & Vasconcelos, P. F. da C. (2015). Chikungunya risk for Brazil. Revista de Saude Publica, 49(0), 58. https://doi.org/10.1590/S0034-8910.2015049006219
Balmaseda, A., Stettler, K., Medialdea-Carrera, R., Collado, D., Jin, X., Zambrana, J. V., Jaconi, S., Cameroni, E., Saborio, S., Rovida, F., Percivalle, E., Ijaz, S., Dicks, S., Ushiro-Lumb, I., Barzon, L., Siqueira, P., Brown, D. W. G., Baldanti, F., Tedder, R., & Corti, D. (2017). Antibody-based assay discriminates Zika virus infection from other flaviviruses. Proceedings of the National Academy of Sciences of the United States of America, 114(31), 8384–8389. https://doi.org/10.1073/pnas.1704984114
Bennett, J. E., Dolin, R., & Blaser, M. J. (2019). Mandell, Douglas, and bennett’s principles and practice of infectious diseases (9th ed.). Retrieved from https://books.google.at/books?id=8pKqDwAAQBAJ
Brasil.(2021). Monitoramento dos casos de arboviroses urbanas causados por vírus transmitidos pelo mosquito Aedes (dengue, chikungunya e zika), semanas epidemiológicas 1 a 44, 2021, v. 52. Disponivel em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins/boletins-epidemiologicos/edicoes/2021/boletim_epidemiologico_svs_41-2.pdf
Brito, C. A. A. de, & Cordeiro, M. T. (2016). One year after the Zika virus outbreak in Brazil: from hypotheses to evidence. Revista Da Sociedade Brasileira de Medicina Tropical, 49(5), 537–543. https://doi.org/10.1590/0037-8682-0328-2016
Broeckel, R., Haese, N., Messaoudi, I., & Streblow, D. N. (2015). Nonhuman primate models of Chikungunya virus infection and disease (CHIKV NHP model). Pathogens, 4(3), 662–681. https://doi.org/10.3390/pathogens4030662
Burt, F. J., Chen, W., Miner, J. J., Lenschow, D. J., Merits, A., Schnettler, E., Kohl, A., Rudd, P. A., Taylor, A., Herrero, L. J., Zaid, A., Ng, L. F. P., & Mahalingam, S. (2017). Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen. The Lancet In-fectious Diseases, 17(4), e107–e117. https://doi.org/10.1016/S1473-3099(16)30385-1
Cabral-Castro, M. J., Cavalcanti, M. G., Peralta, R. H. S., & Peralta, J. M. (2016). Molecular and serological techniques to detect co-circulation of DENV, ZIKV and CHIKV in suspected dengue-like syndrome patients. Journal of Clinical Virology: The Official Publication of the Pan American Society for Clinical Virology, 82, 108–111. https://doi.org/10.1016/j.jcv.2016.07.017
Castro, A. P. C. R. de, Lima, R. A., & Nascimento, J. dos S. (2016). Chikungunya: vision of the pain clinician. Revista Dor, 17(4), 299–302. https://doi.org/10.5935/1806-0013.20160093
Castro, A. P. C. R. de, Lima, R. A., & Nascimento, J. dos S. (2016). Chikungunya: vision of the pain clinician. Revista Dor, 17(4), 299–302. https://doi.org/10.5935/1806-0013.20160093
Cerol, M., Cezarino, G., Ferrinho, P., & Teodósio, R. (2020). Infecção por vírus chikungunya: revisão para clínicos. Revista da Sociedade Portuguesa de Medicina Interna, 1, 55–64.
Chirathaworn, C., Poovorawan, Y., Lertmaharit, S., Nunes, M., Faria, N. R., & De Vasconcelos, J. M. (2013). Cytokine Levels in Patients With Chikungunya Virus Infection. Ásia Pac J Trop Med, 13, 631–634.
Donalisio, M. R., & Freitas, A. R. R. (2015). Chikungunya in Brazil: an emerging challenge. Revista Brasileira de Epidemiologia [Brazilian Journal of Epidemiology], 18(1), 283–285. https://doi.org/10.1590/1980-5497201500010022
Donalisio, M. R., & Freitas, A. R. R. (2015). Chikungunya in Brazil: an emerging challenge. Revista Brasileira de Epidemiologia [Brazilian Jour-nal of Epidemiology], 18(1), 283–285. https://doi.org/10.1590/1980-5497201500010022
Essackjee, K., Goorah, S., Ramchurn, S. K., Cheeneebash, J., & Walker-Bone, K. (2013). Prevalence of and risk factors for chronic arthralgia and rheumatoid-like polyarthritis more than 2 years after infection with chikungunya virus. Postgraduate Medical Journal, 89(1054), 440–447. https://doi.org/10.1136/postgradmedj-2012-131477
Faria, A. C., Santelli, S., de Brito, C. A. A., Luz, K. G., & Neto, J. C. (2017) Chikungunya: Manejo Clínico. v. Disponivel em: https://bvsms.saude.gov.br/bvs/publicacoes/chikungunya_manejo_clinico.pdf
Fauci, A. S., & Morens, D. M. (2016). Zika Virus in the Americas--Yet Another Arbovirus Threat. The New England journal of medicine, 374(7), 601–604. https://doi.org/10.1056/NEJMp1600297
Gardner, C. L., Burke, C. W., Higgs, S. T., Klimstra, W. B., & Ryman, K. D. (2012). Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infect ed with wild-type Chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate. Virology, 425(2), 103–112.
Ghildiyal, R., & Gabrani, R. (2020). Antiviral therapeutics for chikungunya virus. Expert Opinion on Therapeutic Patents, 30(6), 467–480. https://doi.org/10.1080/13543776.2020.1751817
Giry, C., Roquebert, B., Li-Pat-Yuen, G., Gasque, P., & Jaffar-Bandjee, M.C. (2017). Simultaneous detection of chikungunya virus, dengue virus and human pathogenic Leptospira genomes using a multiplex TaqMan® assay. BMC Microbiology, 17(1). https://doi.org/10.1186/s12866-017-1019-1
Halstead, S. B. (2015). Reappearance of chikungunya, formerly called dengue, in the Americas. Emerging Infectious Diseases, 21(4), 557–561. https://doi.org/10.3201/eid2104.141723
Hilgenfeld, R. (2018). Dengue and Zika: control and antiviral treatment strategies (Vol. 1062). Springer.
Hoarau, J. J., Jaffar Bandjee, M. C., Krejbich Trotot, P., Das, T., Li-Pat-Yuen, G., Dassa, B., Denizot, M., Guichard, E., Ribera, A., Henni, T., Tallet, F., Moiton, M. P., Gauzère, B. A., Bruniquet, S., Jaffar Bandjee, Z., Morbidelli, P., Martigny, G., Jolivet, M., Gay, F., Grandadam, M., & Gasque, P. (2010). Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response. Journal of immunology (Baltimore, Md. : 1950), 184(10), 5914–5927. https://doi.org/10.4049/jimmunol.0900255
Hu, S.-F., Li, M., Zhong, L.-L., Lu, S.-M., Liu, Z.-X., Pu, J.-Y., Wen, J.-S., & Huang, X. (2015). Development of reverse-transcription loop-mediated isothermal amplification assay for rapid detection and differentiation of dengue virus serotypes 1–4. BMC Microbiology, 15(1). https://doi.org/10.1186/s12866-015-0595-1
Kam, Y.-W., Lee, W. W. L., Simarmata, D., Harjanto, S., Teng, T.-S., Tolou, H., Chow, A., Lin, R. T. P., Leo, Y.-S., Rénia, L., & Ng, L. F. P. (2012). Longitudinal analysis of the human antibody response to Chikungunya virus infection: implications for serodiagnosis and vaccine development. Journal of Virology, 86(23), 13005–13015. https://doi.org/10.1128/JVI.01780-12
Kay, N. S., Peeling, R. W., & Mabey, D. C. (2014). State of the art syphilis diagnostics: rapid point-of-care tests. Expert Review of Anti-Infective Therapy, 12(1), 63–73. https://doi.org/10.1586/14787210.2014.860356
Kelvin, A. A. (2011). Inflammatory cytokine expres- sion is associated with chikungunya virus reso- lution and symptom severity. PLoS Negl Trop Dis, 5(8).
Kucharz, E. J., & Cebula-Byrska, I. (2012). Chikungunya fever. European Journal of Internal Medicine, 23(4), 325–329. https://doi.org/10.1016/j.ejim.2012.01.009
Kuhn, J. H., Charrel, R. N., & Jameson, J. L. (2018). Arthropod-borne and rodent-borne virus infection. McGraw- Hill.
Labadie, K., Larcher, T., Joubert, C., Mannioui, A., Delache, B., Brochard, P., Guigand, L., Dubreil, L., Lebon, P., Verrier, B., de Lamballerie, X., Suhrbier,
A., Cherel, Y., Le Grand, R., & Roques, P. (2010). Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. The Journal of Clinical Investigation, 120(3), 894–906. https://doi.org/10.1172/JCI40104
Lumsden, W. H. R. (1955). General description and epidemiology. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 49, n. 1. Tanganyika territory, in 1952-1953 II. General description and epidemiology. Transactions of the Royal Society of Tropical Medicine and Hygiene, 319–327.
Markoff, L. Alphaviruses. In: Bennett, J. E., Dolin, R., & Blaser, M. J. (2015). Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases Filadélfia: Elsevier Saunders, p. 1865-1874.
Marques, C. D. L., Duarte, A. L. B. P., Ranzolin, A., Dantas, A. T., Cavalcanti, N. G., Gonçalves, R. S. G., Rocha Junior, L. F. da, Valadares, L. D. de A., Melo, A. K. G. de, Freire, E. A. M., Teixeira, R., Bezerra Neto, F. A., Medeiros, M. M. das C., Carvalho, J. F. de, Santos, M. S. F., Océa, R. A. de L. C., Levy, R. A., Andrade, C. A. F. de, Pinheiro, G. da R. C., & Christopoulos, G. (2017). Recomendações da Sociedade Brasileira de Reumatologia para diagnóstico e tratamento da febre chikungunya. Parte 1 – Diagnóstico e situações especi-ais. Revista brasileira de reumatologia, 57, 421–437. https://doi.org/10.1016/j.rbr.2017.05.004
Marston, H. D., Folkers, G. K., Morens, D. M., & Fauci, A. S. (2014). Emerging viral diseases: confronting threats with new technologies. Science translational medicine, 6(253), 253ps10. https://doi.org/10.1126/scitranslmed.3009872
Miner, J. J., Yeang, A., & Fox, H. X. (2015). Breve relatório: artrite viral de chikungunya nos Estados Unidos: uma imitação de artrite reumatóide soronegativa. Artrite Reumatol, 67, 1214–1220.
Nayak, T. K., Mamidi, P., Kumar, A., Singh, L. P., Sahoo, S. S., Chattopadhyay, S., & Chattopadhyay, S. (2017). Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages. Viruses, 9(1), 3. https://doi.org/10.3390/v9010003
Ozden, S., Huerre, M., Riviere, J.-P., Coffey, L. L., Afonso, P. V., Mouly, V., de Monredon, J., Roger, J.-C., El Amrani, M., Yvin, J.-L., Jaffar, M.-C., Frenkiel, M.-P., Sourisseau, M., Schwartz, O., Butler-Browne, G., Desprès, P., Gessain, A., & Ceccaldi, P.-E. (2007). Human muscle satellite cells as targets of Chikungunya virus infection. PloS One, 2(6), e527. https://doi.org/10.1371/journal.pone.0000527
Pabbaraju, K., Wong, S., Gill, K., Fonseca, K., Tipples, G. A., & Tellier, R. (2016). Simultaneous detection of Zika, Chikungunya and Dengue viruses by a multiplex real-time RT-PCR assay. Journal of Clinical Virology: The Official Publication of the Pan American Society for Clinical Virology, 83, 66–71. https://doi.org/10.1016/j.jcv.2016.09.001
Padmamalini, ;., Kavitha, ;., Rohit, ;., & Marston, H. (2013). Emerging Viral Diseases: Confronting Threats with New Technologies. Science Translational Medicine, 35, 1–9.
Paty, M. C., Six, C., Charlet, F., Heuzé, G., Cochet, A., Wiegandt, A., Chappert, J. L., Dejour-Salamanca, D., Guinard, A., Soler, P., Servas, V., Vivier-Darrigol, M., Ledrans, M., Debruyne, M., Schaal, O., Jeannin, C., Helynck, B., Leparc-Goffart, I., & Coignard, B. (2014). Large number of imported chikungunya cases in mainland France, 2014: a challenge for surveillance and response. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles [Euro Surveillance : European Communicable Disease Bulletin], 19(28), 20856. https://doi.org/10.2807/1560-7917.es2014.19.28.20856
Paul, D., & Bartenschlager, R. (2013). Architecture and biogenesis of plus-strand RNA virus replication factories. World journal of virology, 2(2), 32–48. https://doi.org/10.5501/wjv.v2.i2.32
Pialoux, G., Gaüzère, B. A., Jauréguiberry, S., & Strobel, M. (2007). Chikungunya, an epidemic arbovirosis. The Lancet. Infectious diseases, 7(5), 319–327. https://doi.org/10.1016/S1473-3099(07)70107-X
Powers, A. M., & Logue, C. H. (2007). Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. The Journal of General Virology, 88(Pt 9), 2363–2377. https://doi.org/10.1099/vir.0.82858-0
Rampal, Sharda, M., & Meena, H. (2007). Neurological complications in Chikungunya fever. The Journal of the Association of Physicians of India, 55, 765–769.
Randrianasolo, L., Raoelina, Y., Ratsitorahina, M., Ravolomanana, L., Andriamandimby, S., Heraud, J.-M., Rakotomanana, F., Ramanjato, R., Randrianarivo-Solofoniaina, A. E., & Richard, V. (2010). Sentinel surveillance system for early outbreak detection in Madagascar. BMC Public Health, 10(1), 31. https://doi.org/10.1186/1471-2458-10-31
Reddy, V., Mani, R. S., Desai, A., & Ravi, V. (2014). Correlação das cargas virais plasmáticas e presença de anticorpos Chikungunya IgM com citocina/ Níveis de quimiocinas durante a infecção aguda pelo vírus chikungunya. J Med Virol, 86, 1393–1401.
Reddy, V., Ravi, V., Desai, A., Parida, M., Powers, A. M., & Johnson, B. W. (2012). Utility of IgM ELISA, TaqMan real-time PCR, reverse transcription PCR, and RT-LAMP assay for the diagnosis of Chikungunya fever. Journal of Medical Virology, 84(11), 1771–1778. https://doi.org/10.1002/jmv.23406
Margarido, L.C., & Rivviti, E.A. (2005). Tratado de infectologia. 3ª ed. São Paulo: Atheneu; p.939-72.
Ross, R. W. (1956). The Newala epidemic: III. The virus: isolation, pathogenic properties and relationship to the epidemic. The Journal of Hygiene, 54(2), 177–191. https://doi.org/10.1017/s0022172400044442
Santos, C. F. (2004). Reverse transcription and polymerase chain reaction: principles and applications in dentistry. Journal of Applied Oral Science, 1, 1–11.
Schilte, C., Couderc, T., Chretien, F., Sourisseau, M., Gangneux, N., Guivel-Benhassine, F., Kraxner, A., Tschopp, J., Higgs, S., Michault, A., Arenzana-Seisdedos, F., Colonna, M., Peduto, L., Schwartz, O., Lecuit, M., & Albert, M. L. (2010). Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. The Journal of Experimental Medicine, 207(2), 429–442. https://doi.org/10.1084/jem.20090851
Schilte, C., Staikowsky, F., Couderc, T., Madec, Y., Carpentier, F., Kassab, S., Albert, M. L., Lecuit, M., & Michault, A. (2013). Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study. PLoS Neglected Tropical Diseases, 7(3), e2137. https://doi.org/10.1371/journal.pntd.0002137
Seymour, R. L., Adams, A. P., Leal, G., Alcorn, M. D., & Weaver, S. C. (2015). A Rodent Model of Chikungunya Virus Infection in RAG1 -/- Mice, with Features of Persistence, for Vaccine Safety Evaluation. PLoS neglected tropical diseases, 9(6), e0003800. https://doi.org/10.1371/journal.pntd.0003800
Shukla, J., Khan, M., Tiwari, M., Sannarangaiah, S., Sharma, S., Rao, P. V., & Parida, M. (2009). Development and evaluation of antigen capture ELISA for early clinical diagnosis of chikungunya. Diagnostic microbiology and infectious disease, 65(2), 142–149. https://doi.org/10.1016/j.diagmicrobio.2009.06.017
Silva, J. S., Mariano, Z. de F., & Scopel, I. (2008). A dengue no Brasil e as políticas de combate ao Aedes aegypti: da tentativa de erradicação às políticas de controle - The dengue fever in brazil and combat dengue fever to the Aedes aegypti: of the try eradication to control policies. Hygeia - Revista Brasileira de Geografia Médica E Da Saúde, 4(6). https://seer.ufu.br/index.php/hygeia/article/view/16906
Sissoko, D., Malvy, D., Ezzedine, K., Renault, P., Moscetti, F., Ledrans, M., & Pierre, V. (2009). Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period. PLoS Neglected Tropical Diseases, 3(3), e389. https://doi.org/10.1371/journal.pntd.0000389
Staples, J. E., Breiman, R. F., & Powers, A. M. (2009). Chikungunya fever: an epidemiological review of a re-emerging infectious disease. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 49(6), 942–948. https://doi.org/10.1086/605496
Teng, T.-S., Kam, Y.-W., Lee, B., Hapuarachchi, H. C., Wimal, A., Ng, L.-C., & Ng, L. F. P. (2015). A systematic meta-analysis of immune signatures in patients with acute Chikungunya virus infection. The Journal of Infectious Diseases, 211(12), 1925–1935. https://doi.org/10.1093/infdis/jiv049
Teo, T. H., Her, Z., Tan, J. J., Lum, F. M., Lee, W. W., Chan, Y. H., Ong, R. Y., Kam, Y. W., Leparc-Goffart, I., Gallian, P., Rénia, L., de Lamballerie, X., & Ng, L. F. (2015). Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology. Journal of virology, 89(15), 7955–7969. https://doi.org/10.1128/JVI.00909-15
Teo, T.-H., Lum, F.-M., Claser, C., Lulla, V., Lulla, A., Merits, A., Rénia, L., & Ng, L. F. P. (2013). A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice. The Journal of Immunology, 190(1), 259–269. https://doi.org/10.4049/jimmunol.1202177
Thiberville, S.-D., Boisson, V., Gaudart, J., Simon, F., Flahault, A., & de Lamballerie, X. (2013). Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, South-West Indian Ocean. PLoS Neglected Tropical Diseases, 7(1), e2004. https://doi.org/10.1371/journal.pntd.0002004
Vo, T. K. D., Bigot, P., Gazin, P., Sinou, V., De Pina, J. J., Huynh, D. C., Fumoux, F., & Parzy, D. (2007). Evaluation of a real-time PCR assay for malaria diagnosis in patients from Vietnam and in returned travellers. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101(5), 422–428. https://doi.org/10.1016/j.trstmh.2006.09.004
Wahid, B., Ali, A., Rafique, S., & Idrees, M. (2017). Global expansion of chikungunya virus: mapping the 64-year history. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases, 58, 69–76. https://doi.org/10.1016/j.ijid.2017.03.006
Weaver, S. C., & Lecuit, M. (2015). Chikungunya virus and the global spread of a mosquito-borne disease. The New England Journal of Medicine, 372(13), 1231–1239. https://doi.org/10.1056/NEJMra1406035
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2022 Ana Vitoria Bezerra Silva; Moises Thiago de Souza Freitas
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Los autores que publican en esta revista concuerdan con los siguientes términos:
1) Los autores mantienen los derechos de autor y conceden a la revista el derecho de primera publicación, con el trabajo simultáneamente licenciado bajo la Licencia Creative Commons Attribution que permite el compartir el trabajo con reconocimiento de la autoría y publicación inicial en esta revista.
2) Los autores tienen autorización para asumir contratos adicionales por separado, para distribución no exclusiva de la versión del trabajo publicada en esta revista (por ejemplo, publicar en repositorio institucional o como capítulo de libro), con reconocimiento de autoría y publicación inicial en esta revista.
3) Los autores tienen permiso y son estimulados a publicar y distribuir su trabajo en línea (por ejemplo, en repositorios institucionales o en su página personal) a cualquier punto antes o durante el proceso editorial, ya que esto puede generar cambios productivos, así como aumentar el impacto y la cita del trabajo publicado.