Posibilidades terapéuticas para el tratamiento de la Leishmaniosis Visceral Canina en Brasil: Revisión de la literatura
DOI:
https://doi.org/10.33448/rsd-v11i11.33760Palabras clave:
Medicamentos; L. infantum; Nuevas terapias; Zoonosis.Resumen
La leishmaniosis visceral canina (LVC) es considerada una enfermedad endémica en varias regiones de Brasil, siendo el foco de varias políticas públicas debido a su potencial zoonótico. El único medicamento regulado por el Ministerio de Agricultura, Ganadería y Abastecimiento (MAPA) en el país para el tratamiento de la enfermedad en los animales es la miltefosina. Por ello, es necesaria la búsqueda de fármacos innovadores, algunos de los cuales ya se encuentran en fase de ensayos de laboratorio y otros han sido indicados para su uso en la rutina clínica en otros países. Por lo tanto, el objetivo del presente estudio fue destacar las posibilidades terapéuticas contra la CVL, tratando de enfatizar, principalmente, los nuevos fármacos frecuentemente utilizados en la rutina clínica, así como aquellos que tienen el potencial de convertirse en opciones viables para el abordaje de la CVL en Brasil. Para la revisión, se implementó una búsqueda sistemática manual en las principales bases de datos científicas, utilizando indizadores relacionados con el tema en el período comprendido entre 1994 y 2022. Los resultados de la búsqueda sistemática revelaron que las opciones terapéuticas potencialmente activas contra Leishmania infantum incluyen la marbofloxacina, los betaglucanos, los inmunomoduladores, así como los aceites esenciales de plantas medicinales y sus compuestos derivados, que se consideran candidatos prometedores para el tratamiento y el control de la CVL. Por lo tanto, a partir de los datos recogidos, se pudo comprobar que existen muchos estudios sobre la terapéutica de la enfermedad y que su comprensión puede ser decisiva para proporcionar una buena atención al animal enfermo, así como para la aplicación de un plan farmacológico adecuado.
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Derechos de autor 2022 Mariana Timm Krolow; Mariana Reis Gomes; Nielle Versteg; Stefanie Bressan Waller; Fabiano Borges Figueiredo; Marlete Brum Cleff; Tábata Pereira Dias
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