Tasa de interrupción de la terapia antirretroviral dual con dolutegravir más lamivudina en personas que viven con el VIH: una revisión sistemática
DOI:
https://doi.org/10.33448/rsd-v11i12.34758Palabras clave:
Dolutegravir; Lamivudina; Terapia antirretroviral; VIH.Resumen
Las terapias antirretrovirales se utilizan como una forma de mejorar la esperanza de vida de las personas que viven con el VIH. Con la reducción de efectos adversos, la terapia dual con dolutegravir (DTG) más lamivudina (3TC) ha demostrado ser una opción viable. Sin embargo, incluso con una eficacia similar a la terapia triple, todavía hay una falta de enfoque en las tasas de interrupción del tratamiento. Por ello, el objetivo de este trabajo fue evaluar la tasa de abandono de la terapia antirretroviral dual con DTG más 3TC en personas que viven con el VIH. Se realizó una revisión sistemática en las bases de datos PubMed, SciElo y Scopus, a partir de la selección de estudios de cohortes que reportaron la tasa de discontinuación con el uso de la terapia dual con DTG más 3TC. Se seleccionaron catorce artículos, ocho estudios retrospectivos y seis estudios prospectivos. La población estuvo constituida por 2.666 individuos, con una edad media de 50,4 años, de los cuales el 75,2% eran hombres. La tasa de interrupción de la terapia dual con DTG más 3TC descrita en los estudios osciló entre el 0,0 % y el 22,4 %. Un total de 364 sujetos interrumpieron la terapia dual con DTG más 3TC, con una tasa de interrupción observada del 13,7 % (IC del 95 %: 13,0-14,4 %). Los principales motivos de suspensión fueron los eventos neuropsiquiátricos (19,5 %), el fracaso virológico (10,7 %) y la toxicidad gastrointestinal (8,8 %). Incluso con los beneficios proporcionados por la terapia dual, algunos factores aún contribuyen a la interrupción del tratamiento, y todavía es posible observar una alta tasa de interrupción del tratamiento utilizando la terapia dual de DTG más 3TC.
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Derechos de autor 2022 Marina Rezende da Silveira; Gabriel de Souza-Silva; Jullye Campos Mendes; Simone Furtado dos Santos; Clessius Ribeiro Ribeiro de Souza; Micheline Rosa Silveira
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3) Los autores tienen permiso y son estimulados a publicar y distribuir su trabajo en línea (por ejemplo, en repositorios institucionales o en su página personal) a cualquier punto antes o durante el proceso editorial, ya que esto puede generar cambios productivos, así como aumentar el impacto y la cita del trabajo publicado.
