Efectos de la estimulación de corriente continua transcraneal (tDCS) sobre las citoquinas pro-inflamatorias: una revisión sistemática
DOI:
https://doi.org/10.33448/rsd-v11i13.35013Palabras clave:
TDCS; Animales; Citoquinas; Citoquinas.Resumen
La estimulación con corriente continua transcraneal (tDCS) es una técnica de neuromodulación que provoca alteraciones en la síntesis de varias proteínas, incluidas las citocinas (por ejemplo, las interleucinas). Las citocinas proinflamatorias se asocian con la presencia de dolor y su reducción ocurre en diversas patologías. El objetivo de este estudio fue investigar los efectos de tDCS en la variación de los niveles tisulares y sanguíneos de citocinas proinflamatorias y su relación con los cambios de comportamiento, a través de una revisión sistemática. Se realizaron búsquedas en las bases de datos PubMed, Embase y Lilacs de artículos publicados en todos los idiomas antes del 1 de octubre de 2020. La búsqueda se basó en las palabras clave "Transcranial Direct Current Stimulation" o "tDCS" y "IL-1alpha" o "IL- 1Beta" o "IL-6" o "IL-8" o "IL-17" o " ou\ "Tumoral necrosis factor alpha" o "TNF-alpha". El protocolo de revisión sistemática se registró en PROSPERO (CRD42021283417). Inicialmente se identificaron 416 estudios en las bases de datos electrónicas, de los cuales 40 fueron eliminados por estar duplicados. De los 376 restantes, 358 fueron excluidos después del análisis del título y el resumen (etapa de selección) y 09 fueron excluidos después de la lectura completa. Nueve estudios fueron considerados para evaluación. Los resultados demuestran que tDCS puede alterar los niveles de citoquinas proinflamatorias y modificar comportamientos en animales, sin embargo, estos hallazgos son variables. Aún así, la relación de causa y efecto entre los niveles de citoquinas y los cambios de comportamiento encontrados no fue concluyente. Se necesitan más estudios para establecer los mecanismos implicados en la acción de tDCS sobre los niveles de citocinas proinflamatorias.
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Abbas, A. K., Lichtman, A. H., & Pillai, S. (2014). Imunologia Básica: Funções e distúrbios do sistema imunológico. Elsevier, 539.
Allard-chamard, H., Mishra, H. K., Nandi, M., & Mayhue, M. (2020). Cytokine Interleukin-15 in autoimmunity. Cytokine, 136(August), 155258. https://doi.org/10.1016/j.cyto.2020.155258
Anderson, D. M., Kumaki, S., Ahdieh, M., Bertles, J., Tometsko, M., Loomis, A., Giri, J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Valentine, V., Shapiro, D. N., Morris, S. W., Park, L. S., & Cosman, D. (1995). Functional characterization of the human interleukin-15 receptor α chain and close linkage of IL15RA and IL2RA genes. Journal of Biological Chemistry, 270(50), 29862–29869. https://doi.org/10.1074/jbc.270.50.29862
Baggiolini, M., & Clark-Lewis, I. (1992). Interleukin-8, a chemotactic and inflammatory cytokine. FEBS Letters, 307(1), 97–101. https://doi.org/10.1016/0014-5793(92)80909-Z
Barres, B. A., & Barde, Y. (2000). Neuronal and glial cell biology. 642–648.
Bingham, C. O. (2002). The pathogenesis of rheumatoid arthritis: Pivotal cytokines involved in bone degradation and imflammation. Journal of Rheumatology, 29(SUPPL. 65), 3–9.
Callai, E. M. M., Scarabelot, V. L., Fernandes Medeiros, L., de Oliveira, C., de Souza, A., Macedo, I. C., Cioato, S. G., Finamor, F., Caumo, W., Quevedo, A. da S., & Torres, I. L. S. (2019). Transcranial direct current stimulation (tDCS) and trigeminal pain: A preclinical study. Oral Diseases, 25(3), 888–897. https://doi.org/10.1111/odi.13038
Campos Kraychete, D., Thais de Andrade Calasans, M., & Motta Leal Valente, C. (2006). Citocinas Pró-inflamatórias e Dor Pro-inflammatory Cytokines and Pain. Rev Bras Reumatol, 46(3), 199–206.
Carswell, E. A., & Old, L. J. (1975). An endotoxin-induced serum factor that causes necrosis of tumors Immunology : 72(9), 3666–3670.
Cioato, S. G., Medeiros, L. F., Marques Filho, P. R., Vercelino, R., De Souza, A., Scarabelot, V. L., De Oliveira, C., Adachi, L. N. S., Fregni, F., Caumo, W., & Torres, I. L. S. (2016). Long-Lasting Effect of Transcranial Direct Current Stimulation in the Reversal of Hyperalgesia and Cytokine Alterations Induced by the Neuropathic Pain Model. Brain Stimulation, 9(2), 209–217. https://doi.org/10.1016/j.brs.2015.12.001
Covey, W. C., Ignatowski, T. A., Knight, P. R., & Spengler, R. N. (2000). Brain-derived TNFα : Involvement in neuroplastic changes implicated in the conscious perception of persistent pain. Brain Research, 859(1), 113–122. https://doi.org/10.1016/S0006-8993(00)01965-X
Cunha, F. Q., Poole, S., Lorenzetti, B. B., & Ferreira, S. H. (1992). The pivotal role of tumour necrosis factor a in the development of inflammatory hyperalgesia. 660–664.
Cycles, S. (1989). Chapter 9 Chapter 9. Cycle, 1897(Figure 1), 44–45.
de Oliveira, C., de Freitas, J. S., Macedo, I. C., Scarabelot, V. L., Ströher, R., Santos, D. S., Souza, A., Fregni, F., Caumo, W., & Torres, I. L. S. (2019). Transcranial direct current stimulation (tDCS) modulates biometric and inflammatory parameters and anxiety-like behavior in obese rats. Neuropeptides, 73(April 2018), 1–10. https://doi.org/10.1016/j.npep.2018.09.006
de Oliveira, C. M. B., Sakata, R. K., Issy, A. M., Gerola, L. R., & Salomão, R. (2011). Cytokines and Pain. Brazilian Journal of Anesthesiology, 61(2), 255–265. https://doi.org/10.1016/s0034-7094(11)70029-0
Deuis, J. R., Dvorakova, L. S., & Vetter, I. (2017). Methods used to evaluate pain behaviors in rodents. Frontiers in Molecular Neuroscience, 10(September), 1–17. https://doi.org/10.3389/fnmol.2017.00284
Dubový, P., Brázda, V., Klusáková, I., & Hradilová-Svíženská, I. (2013). Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve. Journal of Neuroinflammation, 10, 1–22. https://doi.org/10.1186/1742-2094-10-55
Floege, J., Lüscher, B., & Müller-newen, G. (2012). European Journal of Cell Biology Cytokines and inflammation. European Journal of Cell Biology, 91(6–7), 427. https://doi.org/10.1016/j.ejcb.2012.01.003
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., Blanchard, D., Gaillard, C., Das Mahapatra, B., Rouvier, E., Golstein, P., Banchereau, J., & Lebecque, S. (1996). T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. Journal of Experimental Medicine, 183(6), 2593–2603. https://doi.org/10.1084/jem.183.6.2593
Fregni, F., Boggio, P. S., Lima, M. C., Ferreira, M. J. L., Wagner, T., Rigonatti, S. P., Castro, A. W., Souza, D. R., Riberto, M., Freedman, S. D., Nitsche, M. A., & Pascual-Leone, A. (2006). A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain, 122(1–2), 197–209. https://doi.org/10.1016/j.pain.2006.02.023
Gu, C., Wu, L., & Li, X. (2013). IL-17 family: Cytokines, receptors and signaling. Cytokine, 64(2), 477–485. https://doi.org/10.1016/j.cyto.2013.07.022
Guo, T., Fang, J., Tong, Z. Y., He, S., & Luo, Y. (2020). Transcranial Direct Current Stimulation Ameliorates Cognitive Impairment via Modulating Oxidative Stress, Inflammation, and Autophagy in a Rat Model of Vascular Dementia. Frontiers in Neuroscience, 14(January). https://doi.org/10.3389/fnins.2020.00028
Hedges, J. C., Singer, C. A., & Gerthoffer, W. T. (2000). Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes. American Journal of Respiratory Cell and Molecular Biology, 23(1), 86–94. https://doi.org/10.1165/ajrcmb.23.1.4014
Heinricher, M. ., Tavares, I., Leith, J. L., & Lumb, B. M. (2010). Descending control of nociception. Brain, 60(1), 214–225. https://doi.org/10.1016/j.brainresrev.2008.12.009.Descending
Hooijmans, C. R., Rovers, M. M., De Vries, R. B. M., Leenaars, M., Ritskes-Hoitinga, M., & Langendam, M. W. (2014). SYRCLE’s risk of bias tool for animal studies. BMC Medical Research Methodology, 14(1), 1–9. https://doi.org/10.1186/1471-2288-14-43
Horváth, G., Gölöncsér, F., Csölle, C., Király, K., Andó, R. D., Baranyi, M., Koványi, B., Máté, Z., Hoffmann, K., Algaier, I., Baqi, Y., Müller, C. E., Von Kügelgen, I., & Sperlágh, B. (2014). Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents. Neurobiology of Disease, 70, 162–178. https://doi.org/10.1016/j.nbd.2014.06.011
Ignatowski, T. A., Covey, W. C., Knight, P. R., Severin, C. M., Nickola, T. J., & Spengler, R. N. (1999). Brain-derived TNFα mediates neuropathic pain. Brain Research, 841(1–2), 70–77. https://doi.org/10.1016/S0006-8993(99)01782-5
Jaiswal. (2014). 基因的改变NIH Public Access. Bone, 23(1), 1–7. https://doi.org/10.1016/j.cyto.2013.07.022.IL-17
Kostrzewa-Janicka, J., Jurkowski, P., Nedzi-Gora, M., & Mierzwinska-Nastalska, E. (2012). Inflammatory markers in temporomandibular joint disorders. Central-European Journal of Immunology, 37(3), 290–293. https://doi.org/10.5114/ceji.2012.30809
Kumolosasi, E., Bonhomme, A., Beorchia, A., Foudrinier, F., Marx, C., Pluot, M., & Pinon, J. M. (1996). Kinetics study of the localization and quantitation of target antigens of immunoglobulin a antibodies in acquired and congenital toxoplasmosis. Parasitology Research, 82(5), 402–409. https://doi.org/10.1007/s004360050136
Laste, G., Caumo, W., Adachi, L. N. S., Rozisky, J. R., De MacEdo, I. C., Filho, P. R. M., Partata, W. A., Fregni, F., & Torres, I. L. S. (2012). After-effects of consecutive sessions of transcranial direct current stimulation (tDCS) in a rat model of chronic inflammation. Experimental Brain Research, 221(1), 75–83. https://doi.org/10.1007/s00221-012-3149-x
Lefaucheur, J. P. (2006). Myoclonus and transcranial magnetic stimulation. Neurophysiologie Clinique, 36(5–6), 293–297. https://doi.org/10.1016/j.neucli.2006.12.008
Li, Q. Y., Xu, H. Y., & Yang, H. J. (2017). Effect of proinflammatory factors TNF-α,IL-1β, IL-6 on neuropathic pain. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 42(19), 3709–3712. https://doi.org/10.19540/j.cnki.cjcmm.20170907.004
Liebetanz, D. (2002). Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain, 125(10), 2238–2247. https://doi.org/10.1093/brain/awf238
Lima, M. C., & Fregni, F. (2008). Motor cortex stimulation for chronic pain: Systematic review and meta-analysis of the literature. Neurology, 70(24), 2329–2337. https://doi.org/10.1212/01.wnl.0000314649.38527.93
Lin, E., Calvano, S. E., & Lowry, S. F. (2000). Inflammatory cytokines and cell response in surgery. Surgery, 127(2), 117–126. https://doi.org/10.1067/msy.2000.101584
Lüttjohann, A., Fabene, P. F., & van Luijtelaar, G. (2009). A revised Racine’s scale for PTZ-induced seizures in rats. Physiology and Behavior, 98(5), 579–586. https://doi.org/10.1016/j.physbeh.2009.09.005
Machado, S., Bittencourt, J., Minc, D., Portella, C. E., Velasques, B., Cunha, M., Budde, H., Basile, L. F., Chadi, G., Cagy, M., Piedade, R., & Ribeiro, P. (2008). Therapeutic applications of repetitive transcranial magnetic stimulation in clinical neurorehabilitation. Functional Neurology, 23(3), 113–122.
Migliorini, P., Italiani, P., Pratesi, F., Puxeddu, I., & Boraschi, D. (2020). The IL-1 family cytokines and receptors in autoimmune diseases. Autoimmunity Reviews, 19(9), 102617. https://doi.org/10.1016/j.autrev.2020.102617
Mihara, M., Hashizume, M., Yoshida, H., Suzuki, M., & Shiina, M. (2012). IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clinical Science, 122(4), 143–159. https://doi.org/10.1042/CS20110340
Nitsche, M. A., & Paulus, W. (2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. Journal of Physiology, 527(3), 633–639. https://doi.org/10.1111/j.1469-7793.2000.t01-1-00633.x
Nitsche, Michael A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., & Pascual-Leone, A. (2008). Transcranial direct current stimulation: State of the art 2008. Brain Stimulation, 1(3), 206–223. https://doi.org/10.1016/j.brs.2008.06.004
Nitsche, Michael A., & Paulus, W. (2001). Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology, 57(10), 1899–1901. https://doi.org/10.1212/WNL.57.10.1899
Page, M. J., Moher, D., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., Mcdonald, S., & Mckenzie, J. E. (2021). PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. The BMJ, 372. https://doi.org/10.1136/bmj.n160
Patidar, M., Yadav, N., & Dalai, S. K. (2016). Interleukin 15: A key cytokine for immunotherapy. Cytokine and Growth Factor Reviews, 31, 49–59. https://doi.org/10.1016/j.cytogfr.2016.06.001
Plow, E. B., Pascual-Leone, A., & MacHado, A. (2012). Brain stimulation in the treatment of chronic neuropathic and non-cancerous pain. Journal of Pain, 13(5), 411–424. https://doi.org/10.1016/j.jpain.2012.02.001
Regner, G. G., Torres, I. L. S., de Oliveira, C., Pflüger, P., da Silva, L. S., Scarabelot, V. L., Ströher, R., de Souza, A., Fregni, F., & Pereira, P. (2020). Transcranial direct current stimulation (tDCS) affects neuroinflammation parameters and behavioral seizure activity in pentylenetetrazole-induced kindling in rats. Neuroscience Letters, 735. https://doi.org/10.1016/j.neulet.2020.135162
Rice, T., Larsen, J., Rivest, S., & Yong, V. W. (2007). Characterization of the early neuroinflammation after spinal cord injury in mice. Journal of Neuropathology and Experimental Neurology, 66(3), 184–195. https://doi.org/10.1097/01.jnen.0000248552.07338.7f
Russo, R. C., Garcia, C. C., Teixeira, M. M., & Amaral, F. A. (2014). The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases. Expert Review of Clinical Immunology, 10(5), 593–619. https://doi.org/10.1586/1744666X.2014.894886
Scarabelot, V. L., de Oliveira, C., Medeiros, L. F., de Macedo, I. C., Cioato, S. G., Adachi, L. N. S., Paz, A. H., de Souza, A., Caumo, W., & Torres, I. L. S. (2019). Transcranial direct-current stimulation reduces nociceptive behaviour in an orofacial pain model. Journal of Oral Rehabilitation, 46(1), 40–50. https://doi.org/10.1111/joor.12726
Silvetti, M., Alexander, W., Verguts, T., & Brown, J. W. (2014). From conflict management to reward-based decision making: Actors and critics in primate medial frontal cortex. Neuroscience and Biobehavioral Reviews, 46(P1), 44–57. https://doi.org/10.1016/j.neubiorev.2013.11.003
Spezia Adachi, L. N., Quevedo, A. S., de Souza, A., Scarabelot, V. L., Rozisky, J. R., de Oliveira, C., Marques Filho, P. R., Medeiros, L. F., Fregni, F., Caumo, W., & Torres, I. L. S. (2015). Exogenously induced brain activation regulates neuronal activity by top-down modulation: conceptualized model for electrical brain stimulation. Experimental Brain Research, 233(5), 1377–1389. https://doi.org/10.1007/s00221-015-4212-1
Stagg, C. J., & Nitsche, M. A. (2011). Physiological basis of transcranial direct current stimulation. Neuroscientist, 17(1), 37–53. https://doi.org/10.1177/1073858410386614
Thelin, E. P., Hall, C. E., Tyzack, G. E., Frostell, A., Giorgi-Coll, S., Alam, A., Carpenter, K. L. H., Mitchell, J., Tajsic, T., Hutchinson, P. J., Patani, R., & Helmy, A. (2020). Delineating astrocytic cytokine responses in a human stem cell model of neural trauma. Journal of Neurotrauma, 37(1), 93–105. https://doi.org/10.1089/neu.2019.6480
Thornberry, C., Cimadevilla, J. M., & Commins, S. (2021). Virtual Morris water maze: Opportunities and challenges. Reviews in the Neurosciences, 32(8), 887–903. https://doi.org/10.1515/revneuro-2020-0149
Vanderwall, A. G., Milligan, E. D., & Talbot, S. (2019). Cytokines in Pain : Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management Peripheral Immune Actions in Pathological. 10(December), 1–15. https://doi.org/10.3389/fimmu.2019.03009
Watkins, L. R., Wiertelak, E. P., Goehler, L. E., Mooney-Heiberger, K., Martinez, J., Furness, L., Smith, K. P., & Maier, S. F. (1994). Neurocircuitry of illness-induced hyperalgesia. Brain Research, 639(2), 283–299. https://doi.org/10.1016/0006-8993(94)91742-6
Watkins, Linda R., & Maier, S. F. (2002). Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states. Physiological Reviews, 82(4), 981–1011. https://doi.org/10.1152/physrev.00011.2002
Wieseler-Frank, J., Maier, S. F., & Watkins, L. R. (2005). Central proinflammatory cytokines and pain enhancement. NeuroSignals, 14(4), 166–174. https://doi.org/10.1159/000087655
Yana, H. Q., Banes, M. A., Herregodtso, P., Hooghe, R., & Hooghe-petersb, E. L. (1992). Expression of interleukin ( IL ) = lp , IL-6 and their respective receptors in the normal rat brain and after injury ". 2963–2971.
Yasuda, K., Nakanishi, K., & Tsutsui, H. (2019). Interleukin-18 in health and disease. International Journal of Molecular Sciences, 20(3). https://doi.org/10.3390/ijms20030649
Zhou, H., & Rigoutsos, I. (2014). The emerging roles of GPRC5A in diseases. Oncoscience, 1(12), 765–776. https://doi.org/10.18632/oncoscience.104
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Derechos de autor 2022 Lucas Eduardo Galvagni; Ingrid Navarro Andrade; Vanessa Brunheri; Etiane Micheli Meyer Callai; Luciana Santa Catarina ; Daniela Müller de Quevedo; Deise Ponzoni; Alexandre Silva Quevedo
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