Desarrollo de gránulos de alginato para la entrega del derivado tiofénico 5CN06 por gelificación ionotrópica
DOI:
https://doi.org/10.33448/rsd-v11i14.35898Palabras clave:
Gránulos; Derivado Tiofénico; Gelificación Ionotrópica; Alginato.Resumen
Se ha reportado el uso de polisacáridos biodegradables con capacidad gelificante para producir gránulos, pero no existen reportes en la literatura asociados a nuevos derivados del 2-aminotiofeno, que hayan demostrado actividad biológica antifúngica selectiva. Por lo tanto, el objetivo de este estudio fue evaluar la formación de gránulos de alginato para la entrega del derivado tiofénico e Ingrediente Farmacéutico Activo (IFA) 5CN06 por gelificación ionotrópica. Se produjo una emulsión de 5CN06 al 0,1%, una solución de alginato de sodio al 3% y una solución de CaCl2 al 10%. La emulsión y el alginato se mezclaron a diferentes volúmenes y, por goteo, en la solución de CaCl2, se formaron los gránulos. Cambiar la proporción de polímero interfiere con este rendimiento, que es igual y superior a 79,50% ± 0,03. En medio ácido, pH 1,2, el gránulo no tiene una tasa de hinchamiento significativa después de 180 min. En un medio pH 7,4 se disuelve por la presencia de Na+. Usando 10 ml de las mezclas de emulsión que contenían el fármaco y 10 ml de solución de alginato de sodio al 3%, se obtuvieron gránulos con mejor eficiencia de encapsulación (65,7%). La mayor proporción de mezcla interfirió en la capacidad de hinchamiento y en la estabilización térmica del fármaco. Así, el estudio de este sistema resultó prometedor, a partir de las condiciones experimentales, para la comprensión de la formación de gránulos para la liberación del compuesto derivado tiofénico 5CN06, con acción antifúngica.
Citas
Ahirrao, S. P., Gide, P. S., Shrivastav, B., & Sharma, P. (2014). Ionotropic Gelation: A Promising Cross Linking Technique for Hydrogels. Research and Reviews: Journal of Pharmaceutics and Nanotechnology, 2(1).
Cáceres, D., Giménez, B., Márquez-Ruiz, G., Holgado, F., Vergara, C., Romero-Hasler, P., Soto-Bustamante, E., & Robert, P. (2022). Incorporation of hydroxytyrosol alkyl esters of different chain length as antioxidant strategy in walnut oil spray-dried microparticles with a sodium alginate outer layer. Food Chemistry, 395, 133595. https://doi.org/10.1016/j.foodchem.2022.133595
Cruz, R. M. D., Mendonça-Junior, F. J. B., de Mélo, N. B., Scotti, L., de Araújo, R. S. A., de Almeida, R. N., & de Moura, R. O. (2021). Thiophene-based compounds with potential anti-inflammatory activity. Pharmaceuticals, 14(7), 692.
Flores-Hernández, C. G., Cornejo-Villegas, M. L. A., Moreno-Martell, A., & Real, A. del. (2021). Synthesis of a biodegradable polymer of poly (Sodium alginate/ethyl acrylate). Polymers, 13(4), 1–12. https://doi.org/10.3390/polym13040504
Freitas, E. D., Freitas, V. M. S., Rosa, P. C. P., da Silva, M. G. C., & Vieira, M. G. A. (2021). Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents. Materials Science and Engineering C, 118. https://doi.org/10.1016/j.msec.2020.111412
Gonçalves, V. S. S., Gurikov, P., Poejo, J., Matias, A. A., Heinrich, S., Duarte, C. M. M., & Smirnova, I. (2016). Alginate-based hybrid aerogel microparticles for mucosal drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 107, 160–170. https://doi.org/10.1016/j.ejpb.2016.07.003
Hadi, A., Nawab, A., Alam, F., & Zehra, K. (2022). Alginate/aloe vera films reinforced with tragacanth gum. Food Chemistry: Molecular Sciences, 4. https://doi.org/10.1016/j.fochms.2022.100105
Jana, P., Shyam, M., Singh, S., Jayaprakash, V., & Dev, A. (2021). Biodegradable polymers in drug delivery and oral vaccination. In European Polymer Journal (Vol. 142). Elsevier Ltd. https://doi.org/10.1016/j.eurpolymj.2020.110155
Joye, I. J., & McClements, D. J. (2014). Biopolymer-based nanoparticles and microparticles: Fabrication, characterization, and application. In Current Opinion in Colloid and Interface Science (Vol. 19, Issue 5, pp. 417–427). Elsevier Ltd. https://doi.org/10.1016/j.cocis.2014.07.002
Kalidason, A., & Kuroiwa, T. (2022). Synthesis of chitosan–magnetite gel microparticles with improved stability and magnetic properties: A study on their adsorption, recoverability, and reusability in the removal of monovalent and multivalent azo dyes. Reactive and Functional Polymers, 173. https://doi.org/10.1016/j.reactfunctpolym.2022.105220
Kazemi-Andalib, F., Mohammadikish, M., Divsalar, A., & Sahebi, U. (2022). Hollow microcapsule with pH-sensitive chitosan/polymer shell for in vitro delivery of curcumin and gemcitabine. European Polymer Journal, 162. https://doi.org/10.1016/j.eurpolymj.2021.110887
Khoshdouni Farahani, Z., Mousavi, M., Seyedain Ardebili, S. M., & Bakhoda, H. (2022). Modification of sodium alginate by octenyl succinic anhydride to fabricate beads for encapsulating jujube extract. Current Research in Food Science, 5, 157–166. https://doi.org/10.1016/j.crfs.2021.11.014
Kim, E. S., Lee, J. S., & Lee, H. G. (2016). Calcium-alginate microparticles for sustained release of catechin prepared via an emulsion gelation technique. Food Science and Biotechnology, 25(5), 1337–1343. https://doi.org/10.1007/s10068-016-0210-8
Kost, B., Kunicka-Styczyńska, A., Plucińska, A., Rajkowska, K., Basko, M., & Brzeziński, M. (2022). Microfluidic preparation of antimicrobial microparticles composed of l-lactide/1,3-dioxolane (co)polymers loaded with quercetin. Food Chemistry, 396, 133639. https://doi.org/10.1016/j.foodchem.2022.133639
Li, W., Chen, J., Zhao, S., Huang, T., Ying, H., Trujillo, C., Molinaro, G., Zhou, Z., Jiang, T., Liu, W., Li, L., Bai, Y., Quan, P., Ding, Y., Hirvonen, J., Yin, G., Santos, H. A., Fan, J., & Liu, D. (2022). High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-28787-7
Lobo, C., Castellari, J., Colman Lerner, J., Bertola, N., & Zaritzky, N. (2020). Functional iron chitosan microspheres synthesized by ionotropic gelation for the removal of arsenic (V) from water. International Journal of Biological Macromolecules, 164, 1575–1583. https://doi.org/10.1016/j.ijbiomac.2020.07.253
Lopes, A. M., Santos-Ebinuma, V. D. C., Apolinário, A. C., Mendonça, F. J. B., Damasceno, B. P. G. D. L., Pessoa, A., & da Silva, J. A. (2014). 5CN05 partitioning in an aqueous two-phase system: A new approach to the solubilization of hydrophobic drugs. Process Biochemistry, 49(9), 1555–1561. https://doi.org/10.1016/j.procbio.2014.05.017
Luna, I., Neves, W. W., De Lima-Neto, R.G., Albuquerque, A. P. B., Pitta, M. G. R.; Rêgo, M. J. B. M., Neves, R. P., Scotti, M. T., Mendonça-Junior, F. J. B. (2021). Design, Synthesis and Antifungal Activity of New Schiff Bases Bearing 2-Aminothiophene Derivatives Obtained by Molecular Simplification. Journal od the Brazilian Chemical Society. 32 (5), 1017-1029. https://doi.org/10.21577/0103-5053.20210004
Lutfi, Z., Kalim, Q., Shahid, A., & Nawab, A. (2021). Water chestnut, rice, corn starches and sodium alginate. A comparative study on the physicochemical, thermal and morphological characteristics of starches after dry heating. International Journal of Biological Macromolecules, 184, 476–482. https://doi.org/10.1016/j.ijbiomac.2021.06.128
Mendonça-Junior, F. J. B., Lima-Neto, R. G., Oliveira, T. B., Lima, M. C. A., Pitta, I. R., Galdino, S. L., Cruz, R. M. D., Araújo, R. S. A., & Neves, R. P. (2011). Synthesis and Evaluation of the Antifungal Activity of 2-(Substituted-Amino)-4,5-Dialkyl-Thiophene-3-Carbonitrile Derivatives Antileishmanial Activity of new Thiophene-indole Hybrids View project. https://www.researchgate.net/publication/265725723
Moreira, A. I., Campos, J. B. L. M., & Miranda, J. M. (2022). Characterization of gelatin microparticle production in a flow focusing microfluidic system. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 647. https://doi.org/10.1016/j.colsurfa.2022.129079
Neves, W. W., Neves, R. P., Macêdo, D. P. C., Eleamne, G. R. A., Kretzchmar, E. A. M., Oliveira, E. E., Medonça-Junior, F. J. B., Lima-Neto, R. G. (2020). Incorporation of 2-amino-thiophene derivative in nanoparticles: enhancement of antifungal activity. Brazilian Journal do Microbiology, 20, 647-655. https://doi.org/10.1007/s42770-020-00248-7
Nyamweya, N. N. (2021). Applications of polymer blends in drug delivery. Future Journal of Pharmaceutical Sciences, 7(1). https://doi.org/10.1186/s43094-020-00167-2
Oliveira, V. S., Cruz, M. M., Bezerra, G. S., Silva, N. E. S., Nogueira, F. H. A., Chaves, G. M.; Sobrinho, J. L. S., Mendonça-Júnior, F. J. B., Damasceno, B. P. G. L., Converti, A., Lima, A. A. N. (2022). Chitosan-Based Films with 2-Aminothiophene Derivative: Formulation, Characterization and Potential Antifungal Activity. Marine Drugs, 20, 103. https://doi.org/10.3390/md20020103
Pinto, E., Queiroz, M. J. R. P., Vale-Silva, L. A., Oliveira, J. F., Begouin, A., Begouin, J. M., & Kirsch, G. (2008). Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety. Bioorganic and Medicinal Chemistry, 16(17), 8172–8177. https://doi.org/10.1016/j.bmc.2008.07.042
Reddy, S. G. (2022). Alginates-A Seaweed Product: Its Properties and Applications. In I. Deniz & E. Imamoglu (Eds.), Properties and Applications of Alginates (1st ed., Vol. 1, pp. 0–174). https://doi.org/10.5772/intechopen.94635
Roy, H., Nayak, B. S., Maddiboyina, B., & Nandi, S. (2022). Chitosan based urapidil microparticle development in approach to improve mechanical strength by cold hyperosmotic dextrose solution technique. Journal of Drug Delivery Science and Technology, 103745. https://doi.org/10.1016/j.jddst.2022.103745
Saqib, Md. N., Khaled, B. M., Liu, F., Zhong, F. (2022) Hydrogel beads for designing future foods: Structures, mechanisms, applications, and challenges. Food Hydrocolloids for Health 2, 100073. https://doi.org/10.1016/j.fhfh.2022.100073
Shaikh, M. A. J., Gilhotra, R., Pathak, S., Mathur, M., Iqbal, H. M. N., Joshi, N., & Gupta, G. (2021). Current update on psyllium and alginate incorporate for interpenetrating polymer network (IPN) and their biomedical applications. In International Journal of Biological Macromolecules (Vol. 191, pp. 432–444). Elsevier B.V. https://doi.org/10.1016/j.ijbiomac.2021.09.115
Soeiro, V. S., Tundisi, L. L., Novaes, L. C. L., Mazzola, P. G., Aranha, N., Grotto, D., Júnior, J. M. O., Komatsu, D., Gama, F. M. P., Chaud, M. v., & Jozala, A. F. (2021). Production of bacterial cellulose nanocrystals via enzymatic hydrolysis and evaluation of their coating on alginate particles formed by ionotropic gelation. Carbohydrate Polymer Technologies and Applications, 2. https://doi.org/10.1016/j.carpta.2021.100155
Sousa, V.D., Driessanack, M., Mendes, I. A. C. (2007) An overview of research designs relevant to nursing: part 1: quantitative research designs. Rev Latino-am Enfermagem, 15(3) 502-7. https://doi.org/10.1590/S0104-11692007000300022
Szabó, T., Mihály, J., Sajó, I., Telegdi, J., & Nyikos, L. (2014). One-pot synthesis of gelatin-based, slow-release polymer microparticles containing silver nanoparticles and their application in anti-fouling paint. Progress in Organic Coatings, 77(7), 1226–1232. https://doi.org/10.1016/j.porgcoat.2014.02.007
Szekalska, M., Sosnowska, K., Czajkowska-Kósnik, A., & Winnicka, K. (2018). Calcium chloride modified alginate microparticles formulated by the spray drying process: A strategy to prolong the release of freely soluble drugs. Materials, 11(9). https://doi.org/10.3390/ma11091522
Trinh, K. T. L., Le, N. X. T., & Lee, N. Y. (2021). Microfluidic-based fabrication of alginate microparticles for protein delivery and its application in the in vitro chondrogenesis of mesenchymal stem cells. Journal of Drug Delivery Science and Technology, 66. https://doi.org/10.1016/j.jddst.2021.102735
Upadhyay, M., Vardhan, H., & Mishra, B. (2020). Natural polymers composed mucoadhesive interpenetrating buoyant hydrogel beads of capecitabine: Development, characterization and in vivo scintigraphy. Journal of Drug Delivery Science and Technology, 55. https://doi.org/10.1016/j.jddst.2019.101480
Wang, X., Hou, X., Zou, P., Huang, A., Zhang, M., & Ma, L. (2022). Cationic starch modified bentonite-alginate nanocomposites for highly controlled diffusion release of pesticides. International Journal of Biological Macromolecules, 213, 123–133. https://doi.org/10.1016/j.ijbiomac.2022.05.148
Winnicka, K. (2021). Special issue: Advanced materials in drug release and drug delivery systems. In Materials (Vol. 14, Issue 4, pp. 1–4). MDPI AG. https://doi.org/10.3390/ma14041042
Yang, D., Gao, K., Bai, Y., Lei, L., Jia, T., Yang, K., & Xue, C. (2021). Microfluidic synthesis of chitosan-coated magnetic alginate microparticles for controlled and sustained drug delivery. International Journal of Biological Macromolecules, 182, 639–647. https://doi.org/10.1016/j.ijbiomac.2021.04.057
Yang, N., Liu, S., & Yang, X. (2015). Molecular simulation of preferential adsorption of CO2over CH4in Na-montmorillonite clay material. Applied Surface Science, 356, 1262–1271. https://doi.org/10.1016/j.apsusc.2015.08.101
Yu, L., Sun, Q., Hui, Y., Seth, A., Petrovsky, N., & Zhao, C. X. (2019). Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release. Journal of Colloid and Interface Science, 539, 497–503. https://doi.org/10.1016/j.jcis.2018.12.075
Zhang, C., Grossier, R., Candoni, N., & Veesler, S. (2021). Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods. In Biomaterials Research (Vol. 25, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s40824-021-00243-5
Zheng, W., Zhang, H., Wang, J., Wang, J., Yan, L., Liu, C., & Zheng, L. (2022). Pickering emulsion hydrogel based on alginate-gellan gum with carboxymethyl chitosan as a pH-responsive controlled release delivery system. International Journal of Biological Macromolecules, 216, 850–859. https://doi.org/10.1016/j.ijbiomac.2022.07.223
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2022 Kaline de Araújo Medeiros; Michelle de Oliveira Pedrosa Rolim; Rayane Santa Cruz Martins de Queiroz Antonino ; Dayanne Tomaz Casimiro da Silva ; Francisco Jaime Bezerra Mendonça Junior; José Alexsandro da Silva; Bolívar Ponciano Goulart de Lima Damasceno
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Los autores que publican en esta revista concuerdan con los siguientes términos:
1) Los autores mantienen los derechos de autor y conceden a la revista el derecho de primera publicación, con el trabajo simultáneamente licenciado bajo la Licencia Creative Commons Attribution que permite el compartir el trabajo con reconocimiento de la autoría y publicación inicial en esta revista.
2) Los autores tienen autorización para asumir contratos adicionales por separado, para distribución no exclusiva de la versión del trabajo publicada en esta revista (por ejemplo, publicar en repositorio institucional o como capítulo de libro), con reconocimiento de autoría y publicación inicial en esta revista.
3) Los autores tienen permiso y son estimulados a publicar y distribuir su trabajo en línea (por ejemplo, en repositorios institucionales o en su página personal) a cualquier punto antes o durante el proceso editorial, ya que esto puede generar cambios productivos, así como aumentar el impacto y la cita del trabajo publicado.
