Uso de plantas medicinales en el tratamiento del Síndrome de Ovario Poliquístico (SOP): Una revisión integradora

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i13.35916

Palabras clave:

Plantas medicinales; Síndrome de Ovario Poliquístico; Fitoterapia; Antiandrógenos.

Resumen

Contexto: El síndrome de ovario poliquístico (SOP) es una enfermedad multisistémica común que causa cambios reproductivos, metabólicos y psicológicos. Últimamente, el uso de plantas medicinales ha crecido considerablemente con la esperanza de reducir los efectos secundarios de las drogas sintéticas y en un intento por reducir daños y costos. Objetivo: Analizar el uso de las plantas medicinales que se utilizan en el SOP a partir de una revisión integrativa de la literatura, con el fin de verificar los efectos farmacológicos provocados por su uso en el SOP. Metodología: Se realizó una revisión integrativa de la literatura utilizando las guías Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) a través de búsquedas en las bases de datos PubMed, Scielo y Scopus para seleccionar estudios etnobotánicos, etnofarmacológicos, preclínicos y clínicos, publicados íntegramente en el últimos 10 años (2012 – 2022), en inglés, portugués y español utilizando descriptores de salud. Resultados: Las diez publicaciones analizadas mostraron diez familias y 11 especies de plantas, las cuales, en general, mostraron actividades antiandrogénicas. Conclusiones: Con la excepción de Foeniculum vulgare, todas las demás plantas medicinales analizadas en este estudio tienen efectos antiandrogénicos sobre el SOP. Sin embargo, estas especies necesitan mejores evaluaciones clínicas y toxicológicas con respecto a su uso para brindar una terapia segura y efectiva.

Citas

Abbott, D. H., & Bacha, F. (2013). Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood. Fertility and sterility, 100(1), 2-11.

Agra, L. C., Ferro, J. N., Barbosa, F. T., & Barreto, E. (2015). Triterpenes with healing activity: A systematic review Journalof Dermatological Treatment, 26(5), 465-470.

Amirkhanloo, F., Esmaeilzadeh, S., Mirabi, P., Abedini, A., Amiri, M., Saghebi, R., & Golsorkhtabaramiri, M. (2022). Comparison of Foeniculum Vulgare versus metformin on insulin resistance and anthropometric indices of women with polycystic ovary, an open-label controlled trial study. Obesity Medicine, 31, 100401.

Anand, P., Murali, K. Y., Tandon, V., Murthy, P. S., & Chandra, R. (2010). Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase, and GLUT4 translocation in experimental diabetic rats. Chemico-biological interactions, 186(1), 72-81.

Anderson, R. A., Broadhurst, C. L., Polansky, M. M., Schmidt, W. F., Khan, A., Flanagan, V. P., Schoene, N. W.,& Graves, D. J. (2004). Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. Journal of agricultural and food chemistry, 52(1), 65-70.

Anjos, E. G., Eduardo, G. N., Figueiredo, K. B. C. L., Brito, S. A., & Lucena, G. T. S. (2021). Prevalência da síndrome dos ovários policísticos em uma instituição de ensino superior da cidade de Cajazeiras–PB. Research, Society and Development, 10(4).

Arentz, S., Smith, C. A., Abbott, J. A., & Bensoussan, A. (2014). A survey of the use of complementary medicine by a self-selected community group of Australian women with polycystic ovary syndrome. BMC complementary and alternative medicine, 14, 472.

Ashkar, F., Eftekhari, M. H., Tanideh, N., Koohpeyma, F., Mokhtari, M., Irajie, C., & Iraji, A. (2020). Effect of hydroalcoholic extract of Berberis integerrima and resveratrol on ovarian morphology and biochemical parameters in Letrozole-induced polycystic ovary syndrome rat model: An experimental study. International journal of reproductive biomedicine, 18(8), 637–650.

Attia, G. R., Rainey, W. E., & Carr, B. R. (2001). Metformin directly inhibits androgen production in human thecal cells. Fertility and sterility, 76(3), 517-524.

Chen, T., Jia, F., Yu, Y., Zhang, W., Wang, C., Zhu, S., & Liu, X. (2022). Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review. Molecules, 27(14), 4476.

Dehghan, A., Esfandiari, A., & Bigdeli, S. M. (2012). Alternative treatment of ovarian cysts with Tribulus terrestris extract: a rat model. Reproduction in domestic animals, 47(1), e12-e15.

Derosa, G., D'Angelo, A., Bonaventura, A., Bianchi, L., Romano, D., & Maffioli, P. (2013). Effects of berberine on lipid profile in subjects with low cardiovascular risk. Expert opinion on biological therapy, 13(4), 475-482.

Diamanti-Kandarakis, E., Baillargeon, J. P., Iuorno, M. J., Jakubowicz, D. J., & Nestler, J. E. (2003). A modern medical quandary: polycystic ovary syndrome, insulin resistance, and oral contraceptive pills. The Journal of Clinical Endocrinology & Metabolism, 88(5), 1927-1932.

Ding, Z., Dai, Y., Hao, H., Pan, R., Yao, X., & Wang, Z. (2008). Anti-inflammatory effects of scopoletin and underlying mechanisms. Pharmaceutical Biology, 46(12), 854-860.

Eldar-Geva, T., Margalioth, E. J., Gal, M., Ben-Chetrit, A., Algur, N., Zylber-Haran, E., Brooks, B., Huerta, M., & Spitz, I. M. (2005). Serum anti-Mullerian hormone levels during controlled ovarian hyperstimulation in women with polycystic ovaries with and without hyperandrogenism. Human Reproduction, 20(7), 1814-1819.

Ercole, F. F., Melo, L. D., & Alcoforado, C. L. G. C. (2014). Integrative review versus systematic review. Rev Min Enferm, 18(1), 9-12.

Escobar-Morreale, H. F. (2018). Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nature Reviews Endocrinology, 14(5), 270-284.

Escobar-Morreale, H. F., Asunción, M., Calvo, R. M., Sancho, J., & San Millán, J. L. (2001). Receiver operating characteristic analysis of the performance of basal serum hormone profiles for the diagnosis of polycystic ovary syndrome in epidemiological studies.

Federação Brasileira das Associações de Ginecologia e Obstetrícia. (2006). Projeto Diretrizes.

Firouzi, S., Malekahmadi, M., Ghayour-Mobarhan, M., Ferns, G., & Rahimi, H. R. (2018). Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 11, 699.

Gharanjik, F., Shojaeifard, M. B., Karbalaei, N., & Nemati, M. (2022). The Effect of Hydroalcoholic Calendula Officinalis Extract on Androgen-Induced Polycystic Ovary Syndrome Model in Female Rat. BioMed research international, 2022, 7402598.

Ghosh, D., Griswold, J., Erman, M., & Pangborn, W. (2009). Structural basis for androgen specificity and oestrogen synthesis in human aromatase. Nature, 457(7226), 219-223.

Hadi, A., Arab, A., Ghaedi, E., Rafie, N., Miraghajani, M., & Kafeshani, M. (2019). Barberry (Berberis vulgaris L.) is a safe approach for management of lipid parameters: A systematic review and meta‐analysis of randomized controlled trials. Complementary Therapies in Medicine,43, 117-124.

Hajimonfarednejad, M., Nimrouzi, M., Heydari, M., Zarshenas, M. M., Raee, M. J.,& Jahromi, B. N. (2018). Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double‐blind placebo controlled clinical trial. Phytotherapy Research, 32(2), 276-283.

Harvey, P. W. (2016). Adrenocortical endocrine disruption. The Journal of steroid biochemistry and molecular biology, 155, 199-206.

Hewitt, S. C., Deroo, B. J., Hansen, K., Collins, J., Grissom, S., Afshari, C. A., & Korach, K. S. (2003). Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen. Molecular endocrinology, 17(10), 2070-2083

Homa, L., Rose, J., Hovmand, P. S., Cherng, S. T., Riolo, R. L., Kraus, A., Biswas, A., Burgess, K., Aungst, H., Stange, K. C., Brown, K., Brooks-Terry, M., Dec, E., Jackson, B., Gilliam, J., Kikano, G. E., Reichsman, A., Schaadt, D., Hilfer, J., Ticknor, C., Williams, C. (2015). A participatory model of the paradox of primary care. Annals of family medicine, 13(5), 456–465.

Hoseinpour, M. J., Ghanbari, A., Azad, N., Zare, A., Abdi, S., Sajadi, E., Abbaszadeh, H. A., Farahani, R. M., & Abdollahifar, M. A. (2019). Ulmus minor bark hydro-alcoholic extract ameliorates histological parameters and testosterone level in an experimental model of PCOS rats. Endocrine Regulations, 53(3), 146-153.

Huang, H. F., He, R. H., Sun, C. C., Zhang, Y., Meng, Q. X., & Ma, Y. Y. (2006). Function of aquaporins in female and male reproductive systems. Human reproduction update, 12(6), 785-795.

Hussain, T., Tan, B., Yin, Y., Blachier, F., Tossou, M. C., & Rahu, N. (2016). Oxidative stress and inflammation: what polyphenols can do for us? Oxidative medicine and cellular longevity, 2016.

Jiang, H., Shi, J., & Li, Y. (2011). Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz. Molecules, 16(4), 3146-3151.

Kakadia, N., Patel, P., Deshpande, S., & Shah, G. (2019). Effect of Vitex negundo L. seeds in letrozole induced polycystic ovarian syndrome. Journal of Traditional and Complementary Medicine, 9(4), 336-345.

Karateke, A., Dokuyucu, R., Dogan, H., Ozgur, T., Tas, Z. A., Tutuk, O., Agturk, G., & Tumer, C. (2018). Investigation of therapeutic effects of erdosteine on polycystic ovary syndrome in a rat model. Medical Principles and Practice, 27(6), 515-522.

Kasangana, P. B., Haddad, P. S., & Stevanovic, T. (2015). Study of polyphenol content and antioxidant capacity of Myrianthus arboreus (Cecropiaceae) root bark extracts. Antioxidants, 4(2), 410-426.

Khan, S., Riaz, N., Afza, N., Malik, A., Aziz-ur-Rehman, Iqbal, L., & Lateef, M. (2009). Antioxidant constituents from Cotoneaster racemiflora. Journal of Asian natural products research, 11(1), 44-48.

Leema, G., & Tamizhselvi, R. (2018). Protective effect of scopoletin against cerulein-induced acute pancreatitis and associated lung injury in mice. Pancreas, 47(5), 577-585.

Li, J., Li, X., Li, Z., Zhang, L., Liu, Y., Ding, H., & Yin, S. (2017). Isofraxidin, a coumarin component improves high-fat diet induced hepatic lipid homeostasis disorder and macrophage inflammation in mice. Food & function, 8(8), 2886-2896.

Li, J., Liu, Z., Wang, D., & Cheng, C. H. (2011). Insulin-like growth factor 3 is involved in oocyte maturation in zebrafish. Biology of reproduction, 84(3), 476-486.

Liang, Z. H., & Guo, Z. X. (2007). Structure characteristics of water-soluble polysaccharide of Atractylodes macrocephala Koidz. J. Mol. Sci, 23, 185-188.

Liu, L., Mu, Q., Li, W., Xing, W., Zhang, H., Fan, T., Yao, H., & He, L. (2015). Isofraxidin protects mice from LPS challenge by inhibiting pro-inflammatory cytokines and alleviating histopathological changes. Immunobiology, 220(3), 406-413.

Martín, D., García-Vallejo, M. C., Pajares, J. A., López, D., & Díez, J. J. (2004). Elm bark components and their potential influence on bark beetle feeding. Forest Systems, 13(1), 227-235.

Menezes, P. E., Dornelles, L. L., de Oliveira Fogaça, A., Boligon, A. A., Athayde, M. L., & Bertagnolli, S. M. M. (2016). Composição centesimal, compostos bioativos, atividade antioxidante e caracterização fenólica da polpa de goiaba. Disciplinarum Scientia| Saúde, 17(2), 205-217.

Mvondo, M. A., Mzemdem Tsoplfack, F. I., Awounfack, C. F., & Njamen, D. (2020). The leaf aqueous extract of Myrianthus arboreus P. Beauv.(Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats. BMC Complementary Medicine and Therapies, 20(1), 1-13.

O'Brien, J. E., Peterson, T. J., Tong, M. H., Lee, E. J., Pfaff, L. E., Hewitt, S. C., Korach, K. S., Weiss, J.,& Jameson, J. L. (2006). Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor α binding to classical estrogen response elements. Journal of Biological Chemistry, 281(36), 26683-26692.

Ogunlakin, A. D., Sonibare, M. A., Jabeen, A., Shaheen, F., & Shah, S. F. (2021). Antiproliferative and ameliorative effects of Tetracera potatoria and its constituent. Advances in Traditional Medicine, 21(4), 815-824.

OPAS - Organização Pan-Americana da Saúde. (2022). Medicinas tradicionais, complementares e integrativas. Brasília (DF).

Özbek, H., Öztürk, M., Bayram, İ., Uğraş, S., & Çitoğlu, G. S. (2003). Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats. Eastern journal of medicine, 8(2), 35-40.

Pachiappan, S., Ramalingam, K., & Balasubramanian, A. (2020). A review on phytomedicine and their mechanism of action on PCOS. Int. J. Cur. Res. Rev, 12(23), 81.

Pinto, S. V., Oliveira, A., Silva, C. S., Manso, M. C., & Ferreira da Vinha, A. (2019). Flores edíveis como recurso natural de compostos bioativos e propriedades biológicas. Egitania Sciencia, 2(25), 23-35.

Pyun, B. J., Yang, H., Sohn, E., Yu, S. Y., Lee, D., Jung, D. H., ... & Lee, H. W. (2018). Tetragonia tetragonioides (Pall.) kuntze regulates androgen production in a letrozole-induced polycystic ovary syndrome model. Molecules, 23(5), 1173.

Qu, F., Wang, F. F., Lu, X. E., Dong, M. Y., Sheng, J. Z., Lv, P. P., Ding, G. L., Shi, B. W., Zhang, D., & Huang, H. F. (2010). Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. Human Reproduction, 25(6), 1441-1450.

Rezaei-Golmisheh, A., Sadrkhanlou, R., Malekinejad, H., & Ahmadi, A. (2017). The ameliorative effects of lupeol and flutamide on dehydroepiandrosterone-induced uterine hyperfibrosis in mice. Studies in Medical Sciences, 27(10), 923-934.

Ryuk, J. A., Ko, B. S., Lee, H. W., Kim, D. S., Kang, S., Lee, Y. H., & Park, S. (2017). Tetragonia tetragonioides (Pall.) Kuntze protects estrogen-deficient rats against disturbances of energy and glucose metabolism and decreases proinflammatory cytokines. Experimental Biology and Medicine, 242(6), 593-605.

Sabahi, Z., Farmani, F., Soltani, F., & Moein, M. (2018). DNA protection, antioxidant and xanthine oxidase inhibition activities of polyphenol-enriched fraction of Berberis integerrima Bunge fruits. Iranian Journal of Basic Medical Sciences, 21(4), 411.

Samatadze, T. E., Zoshchuk, S. A., Hazieva, F. M., Yurkevich, O. Y., Svistunova, N. Y., Morozov, A. I., Amosova, A. V., & Muravenko, O. V. (2019). Phenotypic and molecular cytogenetic variability in calendula (Calendula officinalis L.) cultivars and mutant lines obtained via chemical mutagenesis. Scientific reports, 9(1), 1-11.

Sandeep, P. M., Bovee, T. F., & Sreejith, K. (2015). Anti-androgenic activity of Nardostachys jatamansi DC and Tribulus terrestris L. and their beneficial effects on polycystic ovary syndrome–Induced rat models. Metabolic syndrome and related disorders, 13(6), 248-254.

SBPC/ML. (2016). “Precisamos falar sobre a síndrome dos ovários policísticos”. Disponível gratuitamente no site http://www.sbpc.org.br. SBPC/ML

Sharma, P., Sharma, S., Agrawal, R. P., Agrawal, V., & Singhal, S. (2012). A randomised double blind placebo control trial of cinnamon supplementation on glycemic control and lipid profile in type 2 diabetes mellitus. Australian Journal of Herbal Medicine, 24(1), 4-9.

Shaw, C. Y., Chen, C. H., Hsu, C. C., Chen, C. C., & Tsai, Y. C. (2003). Antioxidant properties of scopoletin isolated from Sinomonium acutum. Phytotherapy research, 17(7), 823-825.

Shi, Y., Kong, X., Yin, H., Zhang, W., & Wang, W. (2019). Effect of hawthorn leaf flavonoids in dehydroepiandrosterone-induced polycystic ovary syndrome in rats. Pathobiology, 86(2-3), 102-110.

Siddique HR, Mishra SK, Karnes RJ, Saleem M. (2011b). Lupeol, a novel androgen receptor inhibitor: implications in prostate cancer therapy. Clin Cancer Res 17, 5379–5391.

Siddique, H. R., & Saleem, M. (2011a). Beneficial health effects of lupeol triterpene: a review of preclinical studies. Life sciences, 88(7-8), 285-293.

Silva, H., Gomes, T., Macedo, M., Júnior, P., Luz, P., Lopes, P., Júnior, R. & Côrtes, P. (2021) “síndrome dos ovários policísticos: uma breve revisão literária.” Revista Científica Integrada , 5(1), 1–2021.

Sun, L., Ji, C., Jin, L., Bi, Y., Feng, W., Li, P., Shen, S., & Zhu, D. (2016). Effects of Exenatide on metabolic changes, sexual hormones, inflammatory cytokines, adipokines, and weight change in a DHEA-treated rat model. Reproductive Sciences, 23(9), 1242-1249

Tesser, C. D., Sousa, I. M. C. D., & Nascimento, M. C. D. (2018). Práticas integrativas e complementares na atenção primária à saúde brasileira. Saúde em debate, 42, 174-188.

Tropicos.org. Missouri Botanical Garden. 21 Sep 2022 Disponível em <https://tropicos.org>

Turcu, A. F., & Auchus, R. J. (2015). Adrenal steroidogenesis and congenital adrenal hyperplasia. Endocrinology and Metabolism Clinics, 44(2), 275-296.

Valentine, R. J., Coughlan, K. A., Ruderman, N. B., & Saha, A. K. (2014). Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/491 through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Archives of biochemistry and biophysics, 562, 62-69

Vargas Laz, N. A. (2022). Estudio del tratamiento de la alopecia con las especies Serenoa repens, Cucurbita pepo L. y Pygeum africanum (Bachelor's thesis, Quito: UCE).

Verma, A., Dewangan, P., Kesharwani, D., & Kela, S. P. (2013). Hypoglycemic and hypolipidemic activity of scopoletin (coumarin derivative) in streptozotocin induced diabetic rats. Int J Pharm Sci Rev Res, 22(1), 79-83.

Vessal, M., Hemmati, M., & Vasei, M. (2003). Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 135(3), 357-364.

Victor, V. M., Rocha, M., Bañuls, C., Alvarez, A., de Pablo, C., Sanchez-Serrano, M., Gomez, M., & Hernandez-Mijares, A. (2011). Induction of oxidative stress and human leukocyte/endothelial cell interactions in polycystic ovary syndrome patients with insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 96(10), 3115-3122

Yin, Y., Liu, X., Liu, J., Cai, E., Zhu, H., Li, H., Zhang, L., Li, P., & Zhao, Y. (2018). Beta-sitosterol and its derivatives repress lipopolysaccharide/d-galactosamine-induced acute hepatic injury by inhibiting the oxidation and inflammation in mice. Bioorganic & Medicinal Chemistry Letters, 28(9), 1525-1533.

Zang, M., Zuccollo, A., Hou, X., Nagata, D., Walsh, K., Herscovitz, H., Brecher, P., Ruderman, N. B., & Cohen, R. A. (2004). AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. Journal of Biological Chemistry, 279(46), 47898-47905

Zangeneh, F. Z., Jafarabadi, M., Naghizadeh, M. M., Abedinia, N., & Haghollahi, F. (2012). Psychological distress in women with polycystic ovary syndrome from Imam Khomeini Hospital, Tehran. Journal of reproduction & infertility, 13(2), 111.

Zheng, L. H., Rana, S., Hussain, L., Asif, M., Mehmood, M. H., Imran, I., ... & Abed, S. N. (2022). Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies. Frontiers in Pharmacology, 13.

Zhou, J., Qu, F., Barry, J. A., Pan, J. X., Wang, F. F., Fu, Z. Z., Duez, P., & Hardiman, P. J. (2016). An atractylodes macrocephala koidz extract alleviates hyperandrogenism of polycystic ovarian syndrome. Int J Clin Exp Med, 9(2), 2758-67.

Zhu, H. T., Chen, J. Y., Chen, L., Tu, Z., & An, Z. B. (2006). Pharmacognosy studies on Atractylodes macrocephala Koidz. Lishizhen Med. Mater. Med. Res, 17, 1019-1020.

Publicado

13/10/2022

Cómo citar

ALBUQUERQUE, F. N. do N. .; ARAUJO, K. K. B. de .; SILVA, L. V. dos S.; SIQUEIRA, A. B. A. P. de .; SOUZA, A. T. M. .; MAGALHÃES, C. dos S. .; RANDAU, K. P. Uso de plantas medicinales en el tratamiento del Síndrome de Ovario Poliquístico (SOP): Una revisión integradora. Research, Society and Development, [S. l.], v. 11, n. 13, p. e495111335916, 2022. DOI: 10.33448/rsd-v11i13.35916. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/35916. Acesso em: 1 jul. 2024.

Número

Sección

Ciencias de la salud