Cáncer de tiroides en Brasil: un estudio descriptivo de los casos notificados entre 2013-2020

Autores/as

DOI:

https://doi.org/10.33448/rsd-v12i2.39974

Palabras clave:

Brasil; Epidemiología; Glándula Tiroides; Neoplasias de la Tiroides; Neoplasias.

Resumen

El objetivo es analizar los casos reportados de cáncer de tiroides en Brasil, asociando las variables: grupo de edad, género, unidad federativa del diagnóstico, año del diagnóstico, diagnóstico detallado y modalidad terapéutica. Por ello, realizamos un estudio epidemiológico descriptivo de carácter cuantitativo, utilizando los datos disponibles en la base de datos de notificación oficial del Ministerio de Sanidad/Brasil, el DATASUS. Y como se trata de datos secundarios y de dominio público, no fue necesario someter este estudio al Comité de Ética de la Investigación. De acuerdo con el período investigado, se reportaron un total de 19.122 casos de cáncer de tiroides, de los cuales 3.074 en hombres, equivalentes al 16,08% y 16.048 en mujeres, con un porcentaje del 83,92%. Además, se puede comprobar que los casos de cáncer de tiroides en hombres y mujeres tuvieron un aumento significativo en el periodo de 2018 a 2021, si se compara con los años anteriores. Sin embargo, los casos en el género femenino obtuvieron un aumento de 2017 a 2018 de unas 39 veces. Se concluye que la incidencia y prevalencia del cáncer de tiroides han aumentado en los últimos años, especialmente en el sexo femenino, siendo el grupo de edad de 50 a 54 años el más frecuente, obteniendo 944 casos, siendo la tasa más alta en el periodo analizado y entre los demás grupos de edad.

Biografía del autor/a

Rubens Barbosa Rezende, Universidade Federal de São Paulo

Graduado em Biomedicina (UNIFASAR - 2017/2021), com habilitação em Patologia Clínica, Imagenologia, Citologia Oncótica, Imunologia e em Hematologia. Especialista em Imunologia Clínica, Hematologia e Citologia Oncótica pela Faculdade UniBF; e em Imagenologia pela Faculdade Unyleya. Possui MBA em Gestão de Laboratórios pela Universidade Estácio de Sá. E atualmente é pós-graduando em Biotecnologia pela Universidade Federal de São Paulo e em Microbiologia Clínica e Laboratorial pela Academia de Ciência e Tecnologia. 

Citas

Almquist, M., Johansen, D., Bjorge, T., Ulmer, H., Lindkvist, B., Stocks, T., et al. (2011). Metabolic factors and risk of thyroid cancer in the Metabolic syndrome and Cancer project (Me-Can). Cancer Causes Control, 22, 743-751, 10.1007/s10552-011-9747-2

Asano, K., Kubo, M., Yonemoto, K., Doi, Y., Ninomiya, T., Tanizaki, Y., et al. (2008). Impact of serum total cholesterol on the incidence of gastric cancer in a population-based prospective study: the Hisayama study. Int. J. Canc., 122, 909-914, 10.1002/ijc.23191

Baloch, S., Baloch, M. A., Zheng, T., & Pei, X. (2020). The Coronavirus Disease 2019 (COVID-19) Pandemic. Tohoku J Exp Med. Apr; 250(4):271-278, 10.1620/tjem.250.271.

Bhaskaran K., et al. (2014). Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet. 30;384(9945):755-65.

Brasil. Ministério da Saúde. DATASUS. (2021). https://datasus.saude.gov.br/sobre-o-datasus/.

Brasil. Ministério da Saúde. Fundação Nacional de Saúde. (2001). Manual de procedimentos do sistema de informações sobre mortalidade. Brasília: Funasa.

Bray, F., et al. (2017) Cancer incidence in five Continents, Vol. XI [Internet]. Lyon: International Agency for Research on Cancer. https://ci5.iarc.fr/CI5-XI/Default.aspx

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424. 10.3322/caac.21492

Chen, G., Xu, S., Renko, K., & Derwahl, M. (2012). Metformin inhibits growth of thyroid carcinoma cells, suppresses self-renewal of derived cancer stem cells, and potentiates the effect of chemotherapeutic agentes. J. Clin. Endocrinol. Metab., 97, 510-520, 10.1210/jc.2011-1754

Coeli, C. M., et al. (2005). Incidence and mortality from thyroid cancer in Brazil. Arq Bras Endocrinol Metabol. 49(4):503-9.

Davies, L., & Welch, H. G. (2006). Increasing incidence of thyroid cancer in the United States, 1973-2002. Jama-Journal Am. Med. Assoc., 295, p. 2164-2167. 10.1001/jama.295.18.2164

Diehl, A. A. (2004). Pesquisa em ciências sociais aplicadas: métodos e técnicas. Prentice Hall.

Dietrich, S., Floegel, A., Weikert, C., Pischon, T., Boeing, H., & Drogan, D. (2016). Identification of serum metabolites associated with incident hypertension in the European prospective investigation into cancer and nutrition-potsdam study. Hypertension, 68, 471-477, 10.1161/hypertensionaha.116.07292

Djiogue, S., Nwabo Kamdje, A. H., Vecchio, L., Kipanyula, M. J., Farahna, M., Aldebasi, Y., & Seke Etet, P. F. (2013). Insulin resistance and cancer: the role of insulin and IGFs. Endocr. Relat. Canc., 20, 1-17, 10.1530/erc-12-0324

Garcia, A. C., Cavalcanti, T. C., Collaço, L. M., & Graf, H. (2022). Biossinalização do câncer de tireoide. Research, Society and Development, 11(3), e41811326619. https://doi.org/10.33448/rsd-v11i3.26619

Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schunemann. J. P. (2008). GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Br. Med. J., 336, 924-926, 10.1136/bmj.39489.470347.AD

Hiatt, R. A., & Fireman. B. H. (1986). Serum cholesterol and the incidence of cancer in a large cohort. J. Chron. Dis., 39, 861-870.

Hsu, P. P., & Sabatini, D. M. (2008). Cancer cell metabolism: warburg and beyond. Cell, 134, 703-707, 10.1016/j.cell.2008.08.021

Ibrahim, E. Y., & Busaidy, N. L. (2017). Treatment and surveillance of advanced, metastatic iodine-resistant differentiated thyroid cancer. Curr. Opin. Oncol. 29, 151–158, 10.1097/CCO.0000000000000349

Instituto Nacional de Câncer – INCA. (2021). Ministério da Saúde. Câncer de tireoide. https://www.inca.gov.br/tipos-de-cancer/cancer-de-tireoide

Jozwiak, P., Krzeslak, A., Brys, M., & Lipinska. A. (2015). Glucose-dependent glucose transporter 1 expression and its impact on viability of thyroid cancer cells, Oncol. For. Rep., 33, 913-920, 10.3892/or.2014.3673

Jung, U. J., & Choi. M. S. (2014). Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int. J. Mol. Sci., 15, 6184-6223, 10.3390/ijms15046184

La Vecchia, C., et al. (2015). Thyroid cancer mortality and incidence: a global overview. Int J Cancer [Internet]136(9):2187-95. https://doi.org/10.1002/ijc.29251

Lima-Costa, M. F., & Barreto, S. M. (2003). Tipos de estudos epidemiológicos: conceitos básicos e aplicações na área do envelhecimento. Epidemiologia e Serviços de Saúde, 12(4), 189-201. https://dx.doi.org/10.5123/S1679-49742003000400003

Marcello, M. A., Calixto, A. R., Martins de Almeida, J. F., Martins, M. B., Cunha, L. L., Amano Cavalari, C. A., et al. (2015). Polymorphism in LEP and LEPR may modify leptin levels and represent risk factors for thyroid câncer. Internet J. Endocrinol., 8, 10.1155/2015/173218

Martins, J. R. M., Villagelin, D. G., Carvalho, G. A., Vaisman, F., Teixeira, P. F., Scheffel, R. S., & Sgarbi, J. A. (2021). Management of thyroid disorders during the COVID-19 outbreak: a position statement from the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM). Archives of Endocrinology and Metabolism, 65(3), 368-375, 10.20945/2359-3997000000352

Milan, A., Puglisi, E., Ferrari, L., Bruno, G., Losano, I., & Veglio. F. (2014). Arterial hypertension and câncer. Int. J. Canc., 134, 2269-2277, 10.1002/ijc.28334

Mondul, A. M., Weinstein, S. J., Virtamo, J., & Albanes, D. (2011). Serum total and HDL cholesterol and risk of prostate câncer. Cancer Causes Control, 22, p. 1545-1552, 10.1007/s10552-011-9831-7

Nguyen, Q. T., Lee, E. J., Huang, M. G., Park, Y. I., Khullar, A., & Plodkowski, R. A. (2015). Diagnosis and treatment of patients with thyroid cancer. Am. Health Drug Benefits, 8, 30–40. PMC4415174

Pappa, T., & Alevizaki, M. (2014). Obesity and thyroid cancer: a clinical update. Thyroid, 24, 190-199, 10.1089/thy.2013.0232

Park, J., & Scherer. P. E. (2011). Leptin and cancer: from cancer stem cells to metastasis. Endocr. Relat. Canc., 18, 25-29, 10.1530/erc-11-0163

Pazaitou-Panayiotou, K., Panagiotou, G., Polyzos, S. A., & Mantzoros, C. S. (2016). Serum adiponectin and insulin-like growth factor 1 in predominantly female patients with thyroid cancer: association with the histologic characteristics of the tumor Endocr. Pract., 22, 68-75,10.4158/ep15814.or

Pellegriti G., et al. (2013). Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J Cancer Epidemiol. e-965212.

Radišauskas, R., Kuzmickienė, I., Milinavičienė, E., & Everatt. R. (2016). Hypertension, serum lipids and cancer risk: a review of epidemiological evidence. Medicina, 52, 89-98, 10.1016/j.medici.2016.03.002

Rehem, R. A., Elwafa, W. A., Elwafa, R. A., & Abdel-Aziz. T. E. (2014). Study of serum leptin in well-differentiated thyroid carcinoma: correlation with patient and tumor characteristics. World J. Surg., 38, 2621-2627, 10.1007/s00268-014-2634-8

Santos, L. M., et al. (2016). Evolução temporal da mortalidade por câncer de tireoide no Brasil no período de 2000 a 2012. RBAC. 48(2):133-7.

Schlaich, M., Straznicky, N., Lambert, E., & Lambert, G. (2015). Metabolic syndrome: a sympathetic disease? Lancet Diabetes Endocrinol, 3, 148-157, 10.1016/s2213-8587(14)70033-6

Stjepanovic, N., & Capdevila, J. (2014). Multikinase inhibitors in the treatment of thyroid cancer: Specific role of lenvatinib. Biol. Targets Ther. 2014, 8, 129–139.

Strasak, A. M., Pfeiffer, R. M., Brant, L. J., Rapp, K., Hilbe, W., Oberaigner, W., et al. (2009). Time-dependent association of total serum cholesterol and cancer incidence in a cohort of 172,210 men and women: a prospective 19-year follow-up study. Ann. Oncol., 20, 1113-1120, 10.1093/annonc/mdn736

Tseng, C. H. (2014). Metformin reduces thyroid cancer risk in taiwanese patients with type 2 diabetes. PLoS One, 9 (2014), Article e109852 http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L600125353

Tsumagari, K., Abd Elmageed, Z. Y., Sholl, A. B., Friedlander, P., Abdraboh, M., Xing, M., et al. (2015). Simultaneous suppression of the MAP kinase and NF-kappaB pathways provides a robust therapeutic potential for thyroid câncer. Canc. Lett., 368, 46-53, 10.1016/j.canlet.2015.07.011

Vaccarella S., et al. (2015). The impact of diagnostic changes on the rise in thyroid cancer incidence: a population-based study in selected high-resource countries. Thyroid [Internet]. 25(10):1127-36. 10.1089/thy.2015.0116

Weikert, S., Boeing, H., Pischon, T., Weikert, C., Olsen, A., Tjonneland, A. et al. (2008). Blood pressure and risk of renal cell carcinoma in the European prospective investigation into cancer and nutrition. Am. J. Epidemiol., 167, 438-446, 10.1093/aje/kwm321

Xiao, J., Shen, C., Chu, M. J., Gao, Y. X., Xu, G. F., Huang, J. P., Xu, Q. Q., & Cai. H. (2016). Physical activity and sedentary behavior associated with components of metabolic syndrome among people in rural China. PLoS One, 11, e0147062, 10.1371/journal.pone.0147062

Yin, D. T., He, H., Yu, K., Xie, J., Lei, M., Ma, R., Li, H., Wang, Y., & Liu, Z. (2018). The association between thyroid cancer and insulin resistance, metabolic syndrome and its components: A systematic review and meta-analysis. International journal of surgery (London, England), 57, 66–75. 10.1016/j.ijsu.2018.07.013

Publicado

20/01/2023

Cómo citar

REZENDE, R. B. Cáncer de tiroides en Brasil: un estudio descriptivo de los casos notificados entre 2013-2020. Research, Society and Development, [S. l.], v. 12, n. 2, p. e6612239974, 2023. DOI: 10.33448/rsd-v12i2.39974. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/39974. Acesso em: 27 jul. 2024.

Número

Sección

Ciencias de la salud