Tratamientos quirúrgicos de la osteonecrosis de los maxilares relacionada con medicamentos: ventajas y limitaciones
DOI:
https://doi.org/10.33448/rsd-v12i4.41161Palabras clave:
Osteonecrosis; Osteonecrosis de los maxilares asociada a difosfonatos; Procedimientos quirúrgicos orales; Enfermedades maxilomandibulares.Resumen
Objetivo: El objetivo de este trabajo es discutir los métodos quirúrgicos disponibles para el tratamiento de la MRONJ, señalando sus ventajas y limitaciones. Metodología: Se realizó una revisión integradora de la literatura mediante una búsqueda realizada en la base de datos virtual PubMed, utilizando el término MeSH "bisphosphonate associated osteonecrosis of the jaw/surgery" e incluyendo 26 publicaciones. Resultados: La intervención quirúrgica es una opción de tratamiento que busca reducir la progresión de la enfermedad, y que puede predecir resultados beneficiosos. Los abordajes quirúrgicos confieren resultados superiores a los regímenes terapéuticos conservadores, con tasas de éxito del 80-90% y del 10-62%, respectivamente. Para instaurar el tratamiento, debe tenerse en cuenta la eliminación del hueso necrótico, realizada mediante curetaje, sequestrectomía y resección quirúrgica. Para el abordaje de los tejidos blandos, pueden realizarse diferentes colgajos. Conclusión: El tratamiento quirúrgico demostró el mantenimiento de la cobertura de la mucosa, la mejora de la calidad de vida y el rápido retorno de la terapia antirreabsortiva para todos los estadios de la enfermedad, presentando elevadas tasas de éxito terapéutico. Por lo tanto, se deben estimar los esfuerzos de investigación del mejor tratamiento para esta patología.
Citas
Aljohani, S., Troeltzsch, M., Hafner, S., Kaeppler, G., Mast, G., & Otto, S. (2019). Surgical treatment of medication-related osteonecrosis of the upper jaw: Case series. Oral diseases, 25(2), 497–507. https://doi.org/10.1111/odi.12992
Caldroney, S., Ghazali, N., Dyalram, D., & Lubek, J. E. (2017). Surgical resection and vascularized bone reconstruction in advanced stage medication-related osteonecrosis of the jaw. International journal of oral and maxillofacial surgery, 46(7), 871–876. https://doi.org/10.1016/j.ijom.2017.01.023
Choi, N. R., Lee, J. H., Park, J. Y., & Hwang, D. S. (2020). Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study. International journal of environmental research and public health, 17(23), 8801. https://doi.org/10.3390/ijerph17238801
El-Rabbany, M., Blanas, N., Sutherland, S., Lam, D. K., Shah, P. S., & Azarpazhooh, A. (2022). Surgical Therapy in Patients With Medication-Related Osteonecrosis of the Jaw Is Associated With Disease Resolution and Improved Quality of Life: A Prospective Cohort Study. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 80(6), 1084–1093. https://doi.org/10.1016/j.joms.2022.01.012
El-Rabbany, M., Lam, D. K., Shah, P. S., & Azarpazhooh, A. (2019). Surgical Management of Medication-Related Osteonecrosis of the Jaw Is Associated With Improved Disease Resolution: A Retrospective Cohort Study. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 77(9), 1816–1822. https://doi.org/10.1016/j.joms.2019.03.040
Favia, G., Tempesta, A., Limongelli, L., Crincoli, V., & Maiorano, E. (2018). Medication-related osteonecrosis of the jaw: Surgical or non-surgical treatment? Oral diseases, 24(1-2), 238–242. https://doi.org/10.1111/odi.12764
Giudice, A., Barone, S., Diodati, F., Antonelli, A., Nocini, R., & Cristofaro, M. G. (2020). Can Surgical Management Improve Resolution of Medication-Related Osteonecrosis of the Jaw at Early Stages? A Prospective Cohort Study. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 78(11), 1986–1999. https://doi.org/10.1016/j.joms.2020.05.037
Guo, Y., & Guo, C. (2021). Enhancement of bone perfusion through cortical perforations to improve healing of medication-related osteonecrosis of the jaw: a retrospective study. International journal of oral and maxillofacial surgery, 50(6), 740–745. https://doi.org/10.1016/j.ijom.2020.07.036
Hallmer, F., Andersson, G., Götrick, B., Warfvinge, G., Anderud, J., & Bjørnland, T. (2018). Prevalence, initiating factor, and treatment outcome of medication-related osteonecrosis of the jaw-a 4-year prospective study. Oral surgery, oral medicine, oral pathology and oral radiology, 126(6), 477–485. https://doi.org/10.1016/j.oooo.2018.08.015
Hauer, L., Jambura, J., Hrusak, D., Chalupova, M., Posta, P., Rusnak, S., & Vyskocil, V. (2020). Surgical therapy for medication-related osteonecrosis of the jaw in osteoporotic patients treated with antiresorptive agents. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 164(1), 100–107. https://doi.org/10.5507/bp.2018.081
Hayashida, S., Soutome, S., Yanamoto, S., Fujita, S., Hasegawa, T., Komori, T., Kojima, Y., Miyamoto, H., Shibuya, Y., Ueda, N., Kirita, T., Nakahara, H., Shinohara, M., & Umeda, M. (2017). Evaluation of the Treatment Strategies for Medication-Related Osteonecrosis of the Jaws (MRONJ) and the Factors Affecting Treatment Outcome: A Multicenter Retrospective Study with Propensity Score Matching Analysis. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research, 32(10), 2022–2029. https://doi.org/10.1002/jbmr.3191
Jose, A., Rawat, A., Nagori, S. A., Arya, S., & Shukla, D. (2022). Outcomes of sequestrectomy and buccal fat pad reconstruction in the management of medication-related osteonecrosis of the jaws. Oral and maxillofacial surgery, 26(1), 147–153. https://doi.org/10.1007/s10006-021-00973-9
Kagami, H., Inoue, M., Kobayashi, A., Taguchi, A., Li, X., & Yoshizawa, M. (2018). Issues with the surgical treatment of antiresorptive agent-related osteonecrosis of the jaws. Oral diseases, 24(1-2), 52–56. https://doi.org/10.1111/odi.12783
Kim, H. Y., Lee, S. J., Kim, S. M., Myoung, H., Hwang, S. J., Choi, J. Y., Lee, J. H., Choung, P. H., Kim, M. J., & Seo, B. M. (2017). Extensive Surgical Procedures Result in Better Treatment Outcomes for Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Osteoporosis. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 75(7), 1404–1413. https://doi.org/10.1016/j.joms.2016.12.014
Lemound, J., Muecke, T., Zeller, A. N., Lichtenstein, J., Eckardt, A., & Gellrich, N. C. (2018). Nasolabial Flap Improves Healing in Medication-Related Osteonecrosis of the Jaw. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 76(4), 877–885. https://doi.org/10.1016/j.joms.2017.09.021
Moll, S., Mueller, S., Meier, J. K., Reichert, T. E., Ettl, T., & Klingelhöffer, C. (2021). Patients' quality of life improves after surgical intervention of stage III medication-related osteonecrosis of the jaw. Oral and maxillofacial surgery, 25(3), 359–366. https://doi.org/10.1007/s10006-020-00927-7
Nisi, M., Izzetti, R., Gennai, S., Bellini, P., Graziani, F., & Gabriele, M. (2020). Surgical Management of Medication-Related Osteonecrosis of the Jaw Patients Related to Dental Implants. The Journal of craniofacial surgery, 31(4), 1037–1041. https://doi.org/10.1097/SCS.0000000000006283
Nisi, M., Karapetsa, D., Gennai, S., Ramaglia, L., Graziani, F., & Gabriele, M. (2018). Conservative surgical treatment of medication related osteonecrosis of the jaw (MRONJ) lesions in patients affected by osteoporosis exposed to oral bisphosphonates: 24 months follow-up. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 46(7), 1153–1158. https://doi.org/10.1016/j.jcms.2018.05.003
Nonnenmühlen, N., Burnic, A., Bartella, A., Lethaus, B., Gerhards, F., Ristow, O., Pautke, C., Hölzle, F., & Steiner, T. (2019). Comparison of mucosal and mucoperiosteal wound cover for the treatment of medication-related osteonecrosis of the jaw lesions: a retrospective cohort study. Clinical oral investigations, 23(1), 351–359. https://doi.org/10.1007/s00784-018-2443-9
Oteri, G., De Ponte, F. S., Runci, M., Peditto, M., Marcianò, A., & Cicciù, M. (2018). Oral-Health-Related Quality of Life After Surgical Treatment of Osteonecrosis of the Jaws. The Journal of craniofacial surgery, 29(2), 403–408. https://doi.org/10.1097/SCS.0000000000004087
Palla, B., Burian, E., Deek, A., Scott, C., Anderson, J., Callahan, N., & Carlson, E. R. (2021). Comparing the Surgical Response of Bisphosphonate-Related Versus Denosumab-Related Osteonecrosis of the Jaws. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 79(5), 1045–1052. https://doi.org/10.1016/j.joms.2020.11.017
Ristow, O., Rückschloß, T., Bodem, J., Berger, M., Bodem, E., Kargus, S., Engel, M., Hoffmann, J., & Freudlsperger, C. (2018). Double-layer closure techniques after bone surgery of medication-related osteonecrosis of the jaw - A single center cohort study. Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery, 46(5), 815–824. https://doi.org/10.1016/j.jcms.2018.03.005
Rothweiler, R., Voss, P. J., Schmelzeisen, R., & Metzger, M. C. (2021). Medication-related osteonecrosis of the mandible: an unusual presentation and treatment. International journal of oral and maxillofacial surgery, 50(4), 511–515. https://doi.org/10.1016/j.ijom.2020.07.033
Ruggiero, S. L., Dodson, T. B., Aghaloo, T., Carlson, E. R., Ward, B. B., & Kademani, D. (2022). American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update. Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 80(5), 920–943. https://doi.org/10.1016/j.joms.2022.02.008
Sacco, R., Sacco, N., Hamid, U., Ali, S. H., Singh, M., & Blythe, J. S. J. (2018). Microsurgical Reconstruction of the Jaws Using Vascularised Free Flap Technique in Patients with Medication-Related Osteonecrosis: A Systematic Review. BioMed research international, 2018, 9858921. https://doi.org/10.1155/2018/9858921
Sacco, R., Umar, G., Guerra, R. C., & Akintola, O. (2021). Evaluation of segmental mandibular resection without microvascular reconstruction in patients affected by medication-related osteonecrosis of the jaw: a systematic review. The British journal of oral & maxillofacial surgery, 59(6), 648–660. https://doi.org/10.1016/j.bjoms.2020.12.014
Souza, M. T. de., Silva, M. D. da, & Carvalho, R. de.. (2010). Integrative review: what is it? How to do it?. Einstein (são Paulo), 8(einstein (São Paulo), 2010 8(1)), 102–106. https://doi.org/10.1590/S1679-45082010RW1134
Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology. Journal of advanced nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x
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Derechos de autor 2023 Nicole Serqueira da Silva ; Susana Braga Santoro Santiago; Daniel Neto Campos; Livia Cristina Buriche Ferreira da Silva; Juliana Lima de Oliveira Amorim Cabral ; Emanuel Mendes Sousa ; Inger Teixeira de Campos Tuñas
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