Injertos, sustitutos óseos, mediadores bioactivos para regeneración ósea: Una revisión actualizada
DOI:
https://doi.org/10.33448/rsd-v13i6.46042Palabras clave:
Biomateriales para regeneración ósea; Biomateriales en regeneración ósea guiada; Material sintético para hueso; Biomateriales e implantes; Regeneración ósea guiada; Aumento óseo.Resumen
Objetivos: Proporcionar a los clínicos una actualización sobre los injertos óseos, sustitutos de biomateriales y mediadores bioactivos para técnicas de regeneración ósea. Materiales y Métodos: Se realizó una revisión narrativa en inglés, priorizando publicaciones de los últimos cinco años. La investigación se llevó a cabo en bases de datos, complementada con búsquedas manuales en revistas relevantes. Resultados: Los injertos autólogos mostraron la mayor ganancia ósea pero estaban asociados con más efectos adversos y complicaciones en el sitio donante. Los materiales ricos en plaquetas no mostraron complicaciones, ya sea individualmente o en combinación. Sin embargo, se necesita más investigación sobre factores de crecimiento, terapia celular y andamios impresos en 3D para mejorar la eficacia y seguridad en la regeneración ósea guiada. Conclusiones: La búsqueda continua del material óptimo es evidente. La habilidad del cirujano y la gestión del colgajo influyen en la regeneración ósea. La investigación futura debería centrarse en optimizar técnicas considerando variaciones clínicas individuales.
Citas
Afifi. (2019). Alveolar Ridge Reconstruction with Titanium Mesh and a Mixture of Autogenous Bone Graft and Algipore. Al-Azhar Journal of Dental Science, 22(3), 217-223. https://doi.org/10.21608/ajdsm.2019.108446
Anitua, E., Allende, M., & Alkhraisat, M. H. (2022). Unravelling Alveolar Bone Regeneration Ability of Platelet-Rich Plasma: A Systematic Review with Meta-Analysis. Bioengineering, 9(10), 506. https://doi.org/10.3390/bioengineering9100506
Asahina, I., Kagami, H., Agata, H., Honda, M. J., Sumita, Y., Inoue, M., Nagamura-Inoue, T., & Tojo, A. (2021). Clinical Outcome and 8-Year Follow-Up of Alveolar Bone Tissue Engineering for Severely Atrophic Alveolar Bone Using Autologous Bone Marrow Stromal Cells with Platelet-Rich Plasma and β-Tricalcium Phosphate Granules. Journal Of Clinical Medicine, 10(22), 5231. https://doi.org/10.3390/jcm10225231
Bartols, A., Kasprzyk, S., Walther, W., & Korsch, M. (2018). Lateral alveolar ridge augmentation with autogenous block grafts fixed at a distance versus resorbable Poly‐D‐L‐Lactide foil fixed at a distance: A single‐blind, randomized, controlled trial. Clinical Oral Implants Research, 29(8), 843-854. https://doi.org/10.1111/clr.13303
Chellathurai, B. N., Datla, M. D., Thiagarajan, R., & Rajaram, V. (2018). Platelet-rich Fibrin Application in Guided Bone Regeneration Using Autogenous Block Graft in Staged Dental Implant Placement: A Case Report. International Journal Of Oral Implantology And Clinical Research, 9(1-3), 37-41. https://doi.org/10.5005/jp-journals-10012-1177
Chiapasco, M., Zaniboni, M., & Boisco, M. (2006). Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants. Clinical Oral Implants Research, 17(S2), 136-159. https://doi.org/10.1111/j.1600-0501.2006.01357.x
Da Rosa, J., Sotto-Maior, B., De Oliveira Rosa, A., & Pereira, L. (2021). Clinical, Tomographic, and Histologic Evaluation of an Autogenous Bone Graft Harvested from the Maxillary Tuberosity for Guided Bone Regeneration: Case Report with a 4-Year Follow-up. The International Journal Of Periodontics & Restorative Dentistry/International Journal Of Periodontics & Restorative Dentistry, 41(4), e183-e190. https://doi.org/10.11607/prd.4587
Dragonas, P., Palin, C., Khan, S., Gajendrareddy, P. K., & Weiner, W. D. (2017). Complications Associated With the Use of Recombinant Human Bone Morphogenic Protein–2 in Ridge Augmentation: A Case Report. The Journal Of Oral Implantology The Journal Of Oral Implantology, 43(5), 351-359. https://doi.org/10.1563/aaid-joi-d-17-00101
Durrani, F., Singh, P., Pandey, A., Tripathi, K., Vishnu, J., Imran, F., & Taslim, A. (2023). Tent screws: Predictable guided bone regeneration. Journal Of Indian Society Of Periodontology (Print)/Journal Of Indian Society Of Periodontology (Online), 27(1), 104. https://doi.org/10.4103/jisp.jisp_728_21
Elamrousy, W., Osama, M., & Issa, D. R. (2021). Autogenous Bone and Bioactive Glass around Implants Placed Simultaneously with Ridge Splitting for the Treatment of Horizontal Bony Defects: A Randomised Clinical Trial. International Journal Of Dentistry, 2021, 1-9. https://doi.org/10.1155/2021/2457328
Ferreira, P. M., Da Silva, W. P. P., Ferreira, F. R., Ferreira, G. R., Yamaguti, P. F., Delanora, L. A., Consolaro, A., & Faverani, L. P. (2022). Oral rehabilitation through the application of a xenogenous bone graft prior to placement of a dental implant: a case report with 9 years of follow-up. Frontiers Of Oral And Maxillofacial Medicine, 4, 40. https://doi.org/10.21037/fomm-21-46
Friedmann, A., & Goetz, W. (2022). Combined Sinus Grafting and Lateral Augmentation by a Hyaluronic Acid-Facilitated Guided Bone Regeneration Protocol – Case Series Supported by Human Histologic Analysis. Journal Of Biomedical Research & Environmental Sciences, 3(1), 065-073. https://doi.org/10.37871/jbres1401
Garcia, M. Materiales de injerto substitutos óseos. Fosfato tricálcico β. Presentación de casos clínicos REVISTA MEXICANA DE PERIODONTOLOGÍA CASO CLÍNICO. https://www.medigraphic.com/pdfs/periodontologia/mp-2015/mp151f.pdf
Gillman, C. E., & Jayasuriya, A. C. (2021). FDA-approved bone grafts and bone graft substitute devices in bone regeneration. Materials Science & Engineering. C, Biomimetic Materials, Sensors And Systems, 130, 112466. https://doi.org/10.1016/j.msec.2021.112466
Gjerde, C., Mustafa, K., Hellem, S., Rojewski, M., Gjengedal, H., Yassin, M. A., Feng, X., Skaale, S., Berge, T., Rosen, A., Shi, X., Ahmed, A. B., Gjertsen, B. T., Schrezenmeier, H., & Layrolle, P. (2018). Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial. Stem Cell Research & Therapy, 9(1). https://doi.org/10.1186/s13287-018-0951-9
Gómez, A., Guido, B. A., Camilo, C. M., Luis, F. M., & Antonio, D. C. (s. f.). Regeneración ósea guiada: nuevos avances en la terapéutica de los defectos óseos. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072014000200007&lng=es&tlng=es
Griffin, T. J., & Cheung, W. S. (2004). The use of short, wide implants in posterior areas with reduced bone height: a retrospective investigation. The Journal Of Prosthetic Dentistry The Journal Of Prosthetic Dentistry, 92(2), 139-144. https://doi.org/10.1016/j.prosdent.2004.05.010
Huacon, V., Dau, R., & Ortiz, E. (2017). Comparative analysis between bone regeneration with and without fibrin-rich plasma. Dominio Cientifico, 3 (2): 545-556. http://dx.doi.org/10.23857/dom.cien.pocaip.2017.3.2.545-556
Işık, G., Günbay, T., Uyanıkgil, Y., Kısaog˘Lu, H., & Yüce, M. Ö. (2020). Comparison of Autogenous Block Bone Graft and Screw Tent-Pole Techniques for Vertical Bone Augmentation in the Posterior Mandible: A Split-Mouth Randomized Controlled Study. Journal Of Advanced Oral Research, 12(1), 159-169. https://doi.org/10.1177/2320206820976010
Işık, G., Yüce, M. Ö., Koçak-Topbaş, N., & Günbay, T. (2021). Guided bone regeneration simultaneous with implant placement using bovine-derived xenograft with and without liquid platelet-rich fibrin: a randomized controlled clinical trial. Clinical Oral Investigations, 25(9), 5563-5575. https://doi.org/10.1007/s00784-021-03987-5
Jensen, S. S., Aghaloo, T., Jung, R. E., Bertl, K., Buser, D., Chappuis, V., De Stavola, L., Monje, A., Pispero, A., Roccuzzo, A., Shahdad, S., Stefanini, M., Tavelli, L., Wang, H., & Zucchelli, G. (2023). Group 1 ITI Consensus Report: The role of bone dimensions and soft tissue augmentation procedures on the stability of clinical, radiographic, and patient‐reported outcomes of implant treatment. Clinical Oral Implants Research, 34(S26), 43-49. https://doi.org/10.1111/clr.14154
Kargozar, S., Milan, P. B., Baino, F., & Mozafari, M. (2019). Nanoengineered biomaterials for bone/dental regeneration. En Elsevier eBooks (pp. 13-38). https://doi.org/10.1016/b978-0-12-813355-2.00002-8
Kuster, I., Osterwalder, L., Valdec, S., Stadlinger, B., Wagner, M. E. H., Rücker, M., & Bichsel, D. (2020). Autogenous bone augmentation from the zygomatic alveolar crest: a volumetric retrospective analysis in the maxilla. International Journal Of Implant Dentistry, 6(1). https://doi.org/10.1186/s40729-020-00258-y
Lai, V. J., Michalek, J. E., Liu, Q., & Mealey, B. L. (2019). Ridge preservation following tooth extraction using bovine xenograft compared with porcine xenograft: A randomized controlled clinical trial. Journal Of Periodontology, 91(3), 361-368. https://doi.org/10.1002/jper.19-0211
Levin, L., & Clark‐Perry, D. (2020). Use of a Novel In Situ Hardening Biphasic Alloplastic Bone Grafting Material for Guided Bone Regeneration around Dental Implants – A Prospective Case Series. Clinical Advances In Periodontics, 12(1), 12-16. https://doi.org/10.1002/cap.10141
Li, P., Zhu, H., & Huang, D. (2018). Autogenous DDM versus Bio‐Oss granules in GBR for immediate implantation in periodontal postextraction sites: A prospective clinical study. Clinical Implant Dentistry And Related Research, 20(6), 923-928. https://doi.org/10.1111/cid.12667
MacBeth, N. D., Donos, N., & Mardas, N. (2022). Alveolar ridge preservation with guided bone regeneration or socket seal technique. A randomised, single‐blind controlled clinical trial. Clinical Oral Implants Research, 33(7), 681-699. https://doi.org/10.1111/clr.13933
Machado, A., Pereira, I., Costa, F., Brandão, A., Pereira, J. E., Maurício, A. C., Santos, J. D., Amaro, I., Falacho, R., Coelho, R., Cruz, N., & Gama, M. (2023). Randomized clinical study of injectable dextrin-based hydrogel as a carrier of a synthetic bone substitute. Clinical Oral Investigations, 27(3), 979-994. https://doi.org/10.1007/s00784-023-04868-9
Mangano, C., Giuliani, A., De Tullio, I., Raspanti, M., Piattelli, A., & Iezzi, G. (2021). Case Report: Histological and Histomorphometrical Results of a 3-D Printed Biphasic Calcium Phosphate Ceramic 7 Years After Insertion in a Human Maxillary Alveolar Ridge. Frontiers In Bioengineering And Biotechnology, 9. https://doi.org/10.3389/fbioe.2021.614325
Álvarez, O., Barone, A., Covani, U., Fernández, A., Guerra, J., Monsalve, L., Ortega, V.(2018). Injertos óseos y biomateriales en implantología oral. Avances En Odontoestomatología, 34(3), 111–119. http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0213-12852018000300002&lng=es&tlng=es.
Mendoza‐Azpur, G., De la Fuente, A., Chavez, E., Valdivia, E., & Khouly, I. (2019). Horizontal ridge augmentation with guided bone regeneration using particulate xenogenic bone substitutes with or without autogenous block grafts: A randomized controlled trial. Clinical Implant Dentistry And Related Research, 21(4), 521-530. https://doi.org/10.1111/cid.12740
Minamizato, T., Koga, T., I, T., Nakatani, Y., Umebayashi, M., Sumita, Y., Ikeda, T., & Asahina, I. (2018). Clinical application of autogenous partially demineralized dentin matrix prepared immediately after extraction for alveolar bone regeneration in implant dentistry: a pilot study. International Journal Of Oral And Maxillofacial Surgery/International Journal Of Oral & Maxillofacial Surgery, 47(1), 125-132. https://doi.org/10.1016/j.ijom.2017.02.1279
Minetti, E., Berardini, M., & Trisi, P. (2019). A New Tooth Processing Apparatus Allowing to Obtain Dentin Grafts for Bone Augmentation: The Tooth Transformer. The Open Dentistry Journal, 13(1), 6-14. https://doi.org/10.2174/1874210601913010006
Moore, W. R., Graves, S. E., & Bain, G. I. (2001). Synthetic bone graft substitutes. ANZ Journal Of Surgery/ANZ Journal Of Surgery, 71(6), 354-361. https://doi.org/10.1046/j.1440-1622.2001.02128.x
Mordini, L., Hur, Y., Ogata, Y., Finkelman, M., Cavani, F., & Steffensen, B. (2020). Volumetric changes following lateral guided bone regeneration. The International Journal Of Oral And Maxillofacial Implants The International Journal Of Oral & Maxillofacial Implants, 35(5), e77-e85. https://doi.org/10.11607/jomi.7524
Naik, C., Srinath, N., Ranganath, M. K., Umashankar, D. N., & Gupta, H. (2020). Evaluation of polycaprolactone scaffold for guided bone regeneration in maxillary and mandibular defects: A clinical study. National Journal Of Maxillofacial Surgery, 11(2), 207. https://doi.org/10.4103/njms.njms_35_20
Parize, G., Tunchel, S., Blay, A., Duailibi-Neto, E. F., Kim, Y. J., & Pallos, D. (2022). Maxillary Reconstruction with Xenogeneic Bone Graft, Platelet-Rich Fibrin, and Titanium Mesh for Rehabilitation with Implants: A 5-year Follow-Up Study. Case Reports In Dentistry/Case Reports In Dentistry, 2022, 1-8. https://doi.org/10.1155/2022/3412190
Parra, M., Moya, M. P., Rebolledo, C., Haidar, Z. S., Alister, J. P., & Olate, S. (2019). PLA/PGA and its co-Polymers in Alveolar Bone Regeneration. A Systematic Review. International Journal Of Odontostomatology, 13(3), 258-265. https://doi.org/10.4067/s0718-381x2019000300258
Pelegrine, A. A., De Macedo, L. G. S., Aloise, A. C., & Moy, P. K. (2020). Barbell Technique: A Novel Approach for Bidirectional Bone Augmentation: Technical Note. The Journal Of Oral Implantology The Journal Of Oral Implantology, 46(4), 446-452. https://doi.org/10.1563/aaid-joi-d-19-00323
Perez, A., Lazzarotto, B., Marger, L., & Durual, S. (2023). Alveolar ridge augmentation with 3D‐printed synthetic bone blocks: A clinical case series. Clinical Case Reports, 11(4). https://doi.org/10.1002/ccr3.7171
Pushparajan, S., Thiagarajan, R., Namasi, A., Emmadi, P., & Saravanan, H. (2013). Efficacy of Guided Bone Regeneration Using Composite Bone Graft and Resorbable Collagen Membrane in Seibert’s Class I Ridge Defects: Radiological Evaluation. The Journal Of Oral Implantology The Journal Of Oral Implantology, 39(4), 455-462. https://doi.org/10.1563/aaid-joi-d-10-00211
Saito, H., Couso‐Queiruga, E., Shiau, H. J., Stuhr, S., Prasad, H., Allareddy, T. V., Reynolds, M. A., & Avila‐Ortiz, G. (2020). Evaluation of poly lactic‐co‐glycolic acid‐coated β‐tricalcium phosphate for alveolar ridge preservation: A multicenter randomized controlled trial. Journal Of Periodontology, 92(4), 524-535. https://doi.org/10.1002/jper.20-0360
Sanz, M., Dahlin, C., Apatzidou, D., Artzi, Z., Bozic, D., Calciolari, E., De Bruyn, H., Dommisch, H., Donos, N., Eickholz, P., Ellingsen, J. E., Haugen, H. J., Herrera, D., Lambert, F., Layrolle, P., Montero, E., Mustafa, K., Omar, O., & Schliephake, H. (2019). Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. Journal Of Clinical Periodontology, 46(S21), 82-91. https://doi.org/10.1111/jcpe.13123
Saoud, K., Brad, B., & Alkhouli, M. (2021). Overall bone gaining after using calcium sulfate bone graft simultaneously to dental implantation. Journal Of Oral Medicine And Oral Surgery, 27(3), 44. https://doi.org/10.1051/mbcb/2021011
Shanbhag, S., Suliman, S., Pandis, N., Stavropoulos, A., Sanz, M., & Mustafa, K. (2019). Cell therapy for orofacial bone regeneration: A systematic review and meta‐analysis. Journal Of Clinical Periodontology, 46(S21), 162-182. https://doi.org/10.1111/jcpe.13049
Shawaheen, A. A., Khashaba, M., Elfaramawi, T., & Saleh, H. (2022). Evaluation of Bone Width Recovery After Using Modified Ridge Splitting Technique With and Without Beta-Tricalcium Phosphate Material (A randomized clinical trial). Egyptian Dental Journal /Egyptian Dental Journal, 68(4), 3141-3150. https://doi.org/10.21608/edj.2022.142588.2152
Shi, C., Yuan, Z., Han, F., Zhu, C., & Li, B. (2016). Polymeric biomaterials for bone regeneration. Annals Of Joint, 1, 27. https://doi.org/10.21037/aoj.2016.11.02
Spray, J. R., Black, C. G., Morris, H. F., & Ochi, S. (2000). The Influence of Bone Thickness on Facial Marginal Bone Response: Stage 1 Placement Through Stage 2 Uncovering. Annals Of Periodontology, 5(1), 119-128. https://doi.org/10.1902/annals.2000.5.1.119
Starch-Jensen, T., Deluiz, D., & Tinoco, E. M. B. (2019). Horizontal Alveolar Ridge Augmentation with Allogeneic Bone Block Graft Compared with Autogenous Bone Block Graft: a Systematic Review. eJournal Of Oral & Maxillofacial Research, 11(1). https://doi.org/10.5037/jomr.2020.11101
Stumbras, A., Januzis, G., Gervickas, A., Kubilius, R., & Juodzbalys, G. (2020). Randomized and Controlled Clinical Trial of Bone Healing After Alveolar Ridge Preservation Using Xenografts and Allografts Versus Plasma Rich in Growth Factors. The Journal Of Oral Implantology The Journal Of Oral Implantology, 46(5), 515-525. https://doi.org/10.1563/aaid-joi-d-19-00179
Sulijaya, B., & Koerniadi, F. H. (2022). Guided Bone Regeneration Prior to Implant Therapy in the Esthetic Zone: A Case Report. The Open Dentistry Journal, 16(1). https://doi.org/10.2174/18742106-v16-e2205090
Tan, W. L., Wong, T. L. T., Wong, M. C. M., & Lang, N. P. (2012). A systematic review of post‐extractional alveolar hard and soft tissue dimensional changes in humans. Clinical Oral Implants Research, 23(s5), 1–21. https://doi.org/10.1111/j.1600-0501.2011.02375.x
Tavelli, L., Ravidà, A., Barootchi, S., Chambrone, L., & Giannobile, W. (2020). Recombinant Human Platelet–Derived Growth Factor: A Systematic Review of Clinical Findings in Oral Regenerative Procedures. JDR Clinical And Translational Research, 6(2), 161-173. https://doi.org/10.1177/2380084420921353
Teng, F., Yu, D., Wei, L., Su, N., & Liu, Y. (2019). Preclinical application of recombinant human bone morphogenetic protein 2 on bone substitutes for vertical bone augmentation: A systematic review and meta-analysis. The Journal Of Prosthetic Dentistry The Journal Of Prosthetic Dentistry, 122(4), 355-363. https://doi.org/10.1016/j.prosdent.2018.09.008
Thoma, D. S., Bienz, S. P., Payer, M., Hüsler, J., Schmidlin, P. R., Hämmerle, C. H. F., Jakse, N., & Jung, R. E. (2019). Randomized clinical study using xenograft blocks loaded with bone morphogenetic protein‐2 or autogenous bone blocks for ridge augmentation – A three‐dimensional analysis. Clinical Oral Implants Research, 30(9), 872-881. https://doi.org/10.1111/clr.13492
Tunkel, J., De Stavola, L., & Kloss-Brandstätter, A. (2020). Alveolar ridge augmentation using the shell technique with allogeneic and autogenous bone plates in a split‐mouth design—A retrospective case report from five patients. Clinical Case Reports, 9(2), 947-959. https://doi.org/10.1002/ccr3.3626
Um, I., Kim, Y., Park, J., & Lee, J. (2018). Clinical application of autogenous demineralized dentin matrix loaded with recombinant human bone morphogenetic‐2 for socket preservation: A case series. Clinical Implant Dentistry And Related Research, 21(1), 4-10. https://doi.org/10.1111/cid.12710
Umebayashi, M., Ohba, S., Kurogi, T., Noda, S., & Asahina, I. (2020). Full Regeneration of Maxillary Alveolar Bone Using Autogenous Partially Demineralized Dentin Matrix and Particulate Cancellous Bone and Marrow for Implant-Supported Full Arch Rehabilitation. The Journal Of Oral Implantology The Journal Of Oral Implantology, 46(2), 122-127. https://doi.org/10.1563/aaid-joi-d-19-00315
Valladão, C. A. A., Monteiro, M. F., & Joly, J. C. (2020). Guided bone regeneration in staged vertical and horizontal bone augmentation using platelet-rich fibrin associated with bone grafts: a retrospective clinical study. International Journal Of Implant Dentistry, 6(1). https://doi.org/10.1186/s40729-020-00266-y
Zampara, E., Alshammari, M., De Bortoli, J., Mullings, O., Gkisakis, I. G., Jalkh, E. B. B., Tovar, N., Coelho, P. G., & Witek, L. (2022). A Histologic and Histomorphometric Evaluation of an Allograft, Xenograft, and Alloplast Graft for Alveolar Ridge Preservation in Humans: A Randomized Controlled Clinical Trial. The Journal Of Oral Implantology The Journal Of Oral Implantology, 48(6), 541-549. https://doi.org/10.1563/aaid-joi-d-21-00012
Zhao, R., Yang, R., Cooper, P. R., Khurshid, Z., Shavandi, A., & Ratnayake, J. (2021). Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments. Molecules/Molecules Online/Molecules Annual, 26(10), 3007. https://doi.org/10.3390/molecules26103007
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Derechos de autor 2024 Jessica Tamara Avila Narváez; Sebastián Mateo Mora Cajilima; Cristina Paola Carpio Cedillo
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