Características, comparaciones y resultados de la hospitalización y mortalidad por COVID-19 en la población obstétrica y no obstétrica: Estudio de cohortes
DOI:
https://doi.org/10.33448/rsd-v13i12.47807Palabras clave:
COVID-19; Embarazo; Periodo posparto; Hospitalización; Mortalidad materna.Resumen
Objetivo: Explorar el impacto del COVID-19 en la morbilidad y mortalidad entre las mujeres embarazadas, puérperas y no embarazadas hospitalizadas en Brasil. Método: Se trata de un estudio de cohortes retrospectivo que utiliza datos del Sistema de Información de Vigilancia Epidemiológica de Brasil (SIVEP-Gripe), abarcando las semanas epidemiológicas del 29 de diciembre de 2019 al 02 de enero de 2021.Los datos se recopilaron a través del SIVEP-Gripe brasileño; estos datos incluyen aspectos sociodemográficos, comorbilidades y otros resultados derivados de la hospitalización. Resultados: 40.640 mujeres hospitalizadas entre 10 y 49 años, categorizadas en gestantes (n=3.372), puérperas (n=794) y no gestantes (n=36.474). El 19,3% de las mujeres no embarazadas y no puérperas no tenían comorbilidades asociadas, en comparación con el 57,7% de las embarazadas y el 73,3% de las puérperas. Hubo un mayor riesgo de saturación de oxígeno inferior al 95% en las puérperas en comparación con las embarazadas. Conclusión: Del mismo modo, se observó un mayor riesgo de mortalidad en las puérperas en comparación con las embarazadas. No hubo diferencias en el riesgo de morbilidad y mortalidad asociado a la COVID-19 entre las mujeres no embarazadas y las embarazadas.
Citas
Alves, R. P., Souza, V. R de., Costa, A. J da., Cardoso, T. C dos S. F., Freitas, V. L et al. (2022). Maternal mortality in times of the COVID-19 pandemic: An integrative review. RSD, 11(4), e28711426942. https://doi.org/10.33448/rsd-v11i4.26942
Amorim, M. M. R., Soligo Takemoto, M. L. & Fonseca, E. B. D. (2020). Maternal deaths with coronavirus disease 2019: a different outcome from low- to middle-resource countries? Am J Obstet Gynecol. 223(2), 298-99. https://doi.org/10.1016/j.ajog.2020.04.023
Badr, D. A., Mattern, J., Carlin, A., Cordier, A. G., Maillart, E., El Hachem, L et al. (2020). Are clinical outcomes worse for pregnant women at ≥20 weeks' gestation infected with coronavirus disease 2019? A multicenter case-control study with propensity score matching. American journal of obstetrics and gynecology, 223(5), 764–768. https://doi.org/10.1016/j.ajog.2020.07.045
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. (2022). Boletim epidemiológico. Doença pelo coronavírus COVID-19. Semana Epidemiológica 48 - 27/11/2022 a 3/12/2022. Brasília: Ministério da Saúde. Secretaria de Vigilância em Saúde. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins/epidemiologicos/covid-19/2022/boletim-epidemiologico-no-142-boletim-coe-coronavirus/view
Breslin, N., Baptiste, C., Miller, R., Fuchs, K., Goffman, D., Gyamfi-Bannerman, C., D'Alton, M et al. (2020). Coronavirus disease 2019 in pregnancy: early lessons. Am J Obstet Gynecol MFM, 2(2), 100111. https://doi.org/10.1016/j.ajogmf.2020.10011
Chen, H., Guo, J., Wang, C., et al. (2020). Clinical Characteristics and Intrauterine Vertical Transmission Potential of COVID-19 Infection in Nine Pregnant Women: a Retrospective Review of Medical Records. Lancet, 395(10226), 809-815. https://doi.org/10.1016/S0140-6736(20)30360-3
Collin, J., Byström, E., Carnahan, A. & Ahrne, M. (2020). Public Health Agency of Sweden's Brief Report: Pregnant and postpartum women with severe acute respiratory syndrome coronavirus 2 infection in intensive care in Sweden. Acta Obstet Gynecol Scand. 99 (7): 819-22. 10.1111/aogs.13901
Costa, R., Barata, C., Dias, H. et al. (2022). Regional differences in the quality of maternal and neonatal care during the COVID-19 pandemic in Portugal: Results from the IMAgiNE EURO study. Int J Gynecol Obstet. 159 (Suppl. 1): 137-53. 10.1002/ijgo.14507
Di Toro, F., Gjoka, M., Di Lorenzo, G., De Santo, D., De Seta, F., Maso, G., Risso, F. M., Romano, F., Wiesenfeld, U., Levi-D'Ancona, R., Ronfani, L., & Ricci, G. (2021). Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 27(1), 36–46. https://doi.org/10.1016/j.cmi.2020.10.007
Dos Santos, G. G., de Andrade, L. H., de Sordi, M. A. P., Nunes, H. R. C., & Parada, C. M. G. L. (2022). Progression of COVID-19 Among Black Pregnant Women: Population-Based Study. Clinical nursing research, 31(4), 733–746. https://doi.org/10.1177/10547738221078899
Elshafeey, F., Magdi, R., Hindi, N., Elshebiny, M., Farrag, N., Mahdy, S., Sabbour, M., Gebril, S., Nasser, M., Kamel, M., Amir, A., Maher Emara, M., & Nabhan, A. (2020). A systematic scoping review of COVID-19 during pregnancy and childbirth. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 150(1), 47–52. https://doi.org/10.1002/ijgo.13182
Góes, E. F., Ferreira, A. J. F., & Ramos, D. (2023). Anti-Black racism and maternal death from COVID-19: what have we seen in the Pandemic?. Racismo antinegro e morte materna por COVID-19: o que vimos na Pandemia?. Ciencia & saude coletiva, 28(9), 2501–2510. https://doi.org/10.1590/1413-81232023289.08412022
Gonzalez, I., Lea, M. L. M., Magalhães, P. A. P. de, Paes, L. B. de O., Santana, M. L. C., & Pagliuco, T. (1970, January 1). Mortalidade Materna Por Covid-19: Uma Revisão Sistemática da Literatura. CuidArte, Enferm. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1367501
Guimarães, R. M., Reis, L. G. C., de Souza Mendes Gomes, M. A., Magluta, C., de Freitas, C. M., & Portela, M. C. (2023). Tracking excess of maternal deaths associated with COVID-19 in Brazil: a nationwide analysis. BMC pregnancy and childbirth, 23(1), 22. https://doi.org/10.1186/s12884-022-05338-y
Hantoushzadeh, S., Shamshirsaz, A. A., Aleyasin, A., Seferovic, M. D., Aski, S. K., Arian, S. E., Pooransari, P., Ghotbizadeh, F., Aalipour, S., Soleimani, Z., Naemi, M., Molaei, B., Ahangari, R., Salehi, M., Oskoei, A. D., Pirozan, P., Darkhaneh, R. F., Laki, M. G., Farani, A. K., Atrak, S., Aagaard, K. (2020). Maternal death due to COVID-19. American journal of obstetrics and gynecology, 223(1), 109.e1–109.e16. https://doi.org/10.1016/j.ajog.2020.04.030
Helms, J., Tacquard, C., Severac, F., Leonard-Lorant, I., Ohana, M., Delabranche, X et al. (2020). High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive care medicine, 46(6), 1089–1098. https://doi.org/10.1007/s00134-020-06062-x
Jani, S., Jacques, S. M., Qureshi, F., Natarajan, G., Bajaj, S., Velumula, P., Agu, C., & Bajaj, M. (2021). Clinical Characteristics of Mother-Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population. AJP reports, 11(1), e15–e20. https://doi.org/10.1055/s-0040-1721673
Kamel, H., Navi, B. B., Sriram, N., Hovsepian, D. A., Devereux, R. B., & Elkind, M. S. (2014). Risk of a thrombotic event after the 6-week postpartum period. The New England journal of medicine, 370(14), 1307–1315. https://doi.org/10.1056/NEJMoa1311485
Kasraeian, M., Zare, M., Vafaei, H., Asadi, N., Faraji, A., Bazrafshan, K., & Roozmeh, S. (2022). COVID-19 pneumonia and pregnancy; a systematic review and meta-analysis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 35(9), 1652–1659. https://doi.org/10.1080/14767058.2020.1763952
Knight, M., Bunch, K., Vousden, N., Morris, E., Simpson, N., Gale, C., O'Brien, P., Quigley, M., Brocklehurst, P., Kurinczuk, J. J., & UK Obstetric Surveillance System SARS-CoV-2 Infection in Pregnancy Collaborative Group (2020). Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ (Clinical research ed.), 369, m2107. https://doi.org/10.1136/bmj.m2107
Liu, D., Li, L., Wu, X., Zheng, D., Wang, J., Yang, L., Zheng, C et al. (2020a). Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. AJR Am J Roentgenol, 215(1), 127-132. https://doi.org/10.2214/AJR.20.23072
Liu, Y., et al. (2020b). Withdrawn: Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy. J Infect. https://doi.org/10.1016/j.jinf.2020.02.028
Martínez-Perez, O., Vouga, M., Cruz Melguizo, S., Forcen Acebal, L., Panchaud, A., Muñoz-Chápuli, M., & Baud, D. (2020). Association Between Mode of Delivery Among Pregnant Women With COVID-19 and Maternal and Neonatal Outcomes in Spain. JAMA, 324(3), 296–299. https://doi.org/10.1001/jama.2020.10125
Martinez-Portilla, R. J., Sotiriadis, A., Chatzakis, C., Torres-Torres, J., Espino Y Sosa, S., Sandoval-Mandujano, K., Castro-Bernabe, D. A., Medina-Jimenez, V., Monarrez-Martin, J. C., Figueras, F., & Poon, L. C. (2021). Pregnant women with SARS-CoV-2 infection are at higher risk of death and pneumonia: propensity score matched analysis of a nationwide prospective cohort (COV19Mx). Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 57(2), 224–231. https://doi.org/10.1002/uog.23575
Menezes, M. O., Takemoto, M. L. S., Nakamura-Pereira, M., Katz, L., Amorim, M. M. R., Salgado, H. O., Melo, A., Diniz, C. S. G., de Sousa, L. A. R., Magalhaes, C. G., Knobel, R., Andreucci, C. B., & Brazilian Group of Studies for COVID-19, Pregnancy (2020). Risk factors for adverse outcomes among pregnant and postpartum women with acute respiratory distress syndrome due to COVID-19 in Brazil. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 151(3), 415–423. https://doi.org/10.1002/ijgo.13407
Mullins, E., Evans, D., Viner, R. M., O'Brien, P., & Morris, E. (2020). Coronavirus in pregnancy and delivery: rapid review. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 55(5), 586–592. https://doi.org/10.1002/uog.22014
Santos, G. G. dos, Andrade, L. H. de, Maria Garcia de Lima Parada, C., & Frassom da Silva Magaton, A. P. (2021). Efeitos da Covid-19 Entre Gestantes pretas e Pardas: Revisão Integrativa da Literatura. https://doi.org/10.33448/rsd-v10i6.15531
Santos, M. P. A. D., Nery, J. S., Goes, E. F., Silva, A. D., Santos, A. B. S. D., Batista, L. E., & Araújo, E. M. D. (2020, July 10). População Negra E covid-19: Reflexões sobre racismo e Saúde. Estudos Avançados. https://www.scielo.br/j/ea/a/LnkzjXxJSJFbY9LFH3WMQHv/
Sentilhes, L., De Marcillac, F., Jouffrieau, C., Kuhn, P., Thuet, V., Hansmann, Y., Ruch, Y., Fafi-Kremer, S., & Deruelle, P. (2020). Coronavirus disease 2019 in pregnancy was associated with maternal morbidity and preterm birth. American journal of obstetrics and gynecology, 223(6), 914.e1–914.e15. https://doi.org/10.1016/j.ajog.2020.06.022
Silva, I. de L. da, Barreto, R. A. R., Soares, B. K. P., Matias, A. D., Souza, F. M. de L. C et al. (2021). Predictors of maternal mortality by COVID-19: an integrative review. RSD, 10(10), e435101018888. https://doi.org/10.33448/rsd-v10i10.18888
Takemoto, M. L. S., Menezes, M. O., Andreucci, C. B., Nakamura-Pereira, M., Amorim, M. M. R., Katz, L., & Knobel, R. (2020). The tragedy of COVID-19 in Brazil: 124 maternal deaths and counting. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 151(1), 154–156. https://doi.org/10.1002/ijgo.13300
Testa, C. B. et al. (2023). Cardiovascular diseases worsen the maternal prognosis of COVID-19. PLoS One, 18(2), e0266792. https://doi.org/10.1371/journal.pone.0266792
Vandenbroucke, J. P. et al. (2007). Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration. https://www.equator-network.org/reporting-guidelines/strobe/
Wang, L., Wang, Y., Ye, D., & Liu, Q. (2020a). Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence. Int J Antimicrob Agents, 55(6), 105948. https://doi.org/10.1016/j.ijantimicag.2020
Wang, X., Zhou, Z., Zhang, J., Zhu, F., Tang, Y., Shen, X et al. (2020b). A Case of 2019 Novel Coronavirus in a Pregnant Woman With Preterm Delivery. Clin Infect Dis, 71(15), 844-846. https://doi.org/10.1093/cid/ciaa200
World Health Organization. (2020a). Coronavirus disease 2019 (Covid-19). Situation Report (SR) – 81. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200410-sitrep-81-covid 19.pdf?sfvrsn=ca96eb84_2
World Health Organization. (2020b). Coronavirus disease 2019 (Covid-19). Situation Report (SR) – 51. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200410-sitrep-81-covid 19.pdf?sfvrsn=ca96eb84_2
Yu, N., Li, W., Kang, Q., Xiong, Z., Wang, S., Lin, X et al. (2020). Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis, 20(5), 559-564. https://doi.org/10.1016/S1473-3099(20)30176-6
Zaigham, M., & Andersson, O. (2020). Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand, 99(7), 823-829. https://doi.org/10.1111/aogs.13867
Zambrano, L. D. et al. (2020). Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep, 69(44), 1641-1647. https://doi.org/10.15585/mmwr.mm6944e3
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Derechos de autor 2024 Gustavo Gonçalves dos Santos; Fátima León Larios; Cristian Martín-Vázquez; Lara Beatriz de Sousa Coelho; Marcelo Victor Freitas Nascimento; Edson Silva do Nascimento; Anderson Lima Cordeiro da Silva; Leticia de Almeida Dionizio; Luis Henrique de Andrade; Beatriz María Bermejo Gil; Leticia López Pedraza; Giovana Aparecida Gonçalves Vidotti
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