Comparación entre los métodos de tratamiento de la mucositis intestinal en un modelo animal - revisión sistemática de la literatura
DOI:
https://doi.org/10.33448/rsd-v9i9.7221Palabras clave:
Quimioterapia; Modelos animales; Fluorouracilo.Resumen
Introducción: la mucositis es uno de los efectos secundarios más comunes que se manifiestan durante los tratamientos de quimioterapia contra los cánceres graves. Dichos tratamientos tienen el destacado fármaco 5-fluorouracilo (5-FU). Sin embargo, los pacientes sometidos a tratamientos contra el cáncer que incluyen 5-FU y otros fármacos citotóxicos en quimioterapia sufren efectos secundarios graves. Objetivos: evaluar cuál es actualmente el tratamiento más prometedor, en un modelo animal, para prevenir la mucositis intestinal inducida por 5-FU. Metodología: se realizó una búsqueda digital en las principales bases de datos en línea en el campo de la salud, tales como: "Pubmed", "VHL", "ScienceDirect", "SciELO" y MEDLINE ". La estrategia de búsqueda en todas las bases de datos fue ingresar los descriptores "tratamiento Y mucositis intestinal Y 5-fluorouracilo". Resultados: se encontraron 191 artículos. Después de analizar los criterios de inclusión y exclusión, se seleccionaron 51 artículos para un análisis exhaustivo de la metodología y los resultados. En cuanto a los parámetros de análisis de los artículos en esta revisión, se incluirán los siguientes: la metodología utilizada; los posibles sesgos de estudio; y los resultados obtenidos de análisis histológicos, enzimáticos, de citosina y, sobre todo, clínicos. Se analizaron los grupos de trabajo que utilizaron las sustancias: probióticos; fitoterapias; alopático; selenio y otros. Conclusión: fue posible percibir resultados más prometedores en el grupo de probióticos, con énfasis en Bidens pilosa L. (Asteraceae).
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Derechos de autor 2020 Jennifer Kelly Silva de Oliveira; Daniel Felipe Fernandes Paiva; Aurigena Antunes de Araújo; Gabriel Gomes da Silva; Francisca Jennifer Duarte de Oliveira; Luana Amorim Morais da Silva; Camila Alexandre Silva; Luiz Gustavo Xavier Filho
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