Suplementação nutracêutica e fitoterápica no tratamento da fibromialgia: revisão de literatura

Autores

DOI:

https://doi.org/10.33448/rsd-v10i14.12381

Palavras-chave:

Fibromialgia; Suplemento dietético; Nutracêutico; Estresse oxidativo.

Resumo

A Fibromialgia (FB) é uma doença multifatorial que atinge uma grande parcela da população e ainda tem o seu diagnóstico como motivo de controvérsia. É caracterizada pela dor crônica em múltiplos pontos do corpo. O presente artigo teve como objetivo identificar ativos nutracêuticos que pudessem contribuir ao tratamento da FB nos seus múltiplos aspectos e assim, melhorar a qualidade de vida de seus portadores. O levantamento bibliográfico delimitou-se na busca de artigos em português e inglês nas bases de dados PubMed, SciELO e LILAC, publicados no período de janeiro de 2015 a março de 2020. Os princípios ativos mais encontrados no tratamento da FB foram a coenzima Q10, 25-hidroxivitamina D, probióticos (Lactobacillus Rhamnosus, Casei, Acidophilus e Bifidobacterium Bifidus) e fitoterápicos como gengibre, acerola, Spiraea Ulmari, passiflora, Elymus repens, em associação com outros produtos, o Crocus Sativus (açafrão) além do Ganoderma lucidum que é um tipo de cogumelo. É de fundamental importância a compreensão de como os suplementos podem auxiliar no tratamento da FB promovendo uma terapêutica mais natural, menos dispendiosa e com menos efeitos colaterais para os seus portadores.

Biografia do Autor

Ana Paula Tardivo, Centro Universitário Filadélfia

Coordenadora do Curso de Pós-graduação em Nutrigenômica Ortomolecular e Longevidade - APC Cursos e UniFil

Thaís Cristina Coelho de Ornelas Salazar, Centro Universitário Filadélfia

Docente no Centro Universitário Filadélfia.

Victor Nascimento dos Santos, Universidade Estadual do Oeste do Paraná

Acadêmico do Curso de Medicina - Campus Cascavel

Referências

Arora, D. (1986). Mushrooms Demystified: A Comprehensive Guide to the Fleshy Fungi. Ten Speed Press.

Barmaki, M., Maindet-Dominici, C., Nizard, J., Baron, D., Russ, I., Fardellone, P., … Bertin, P. (2019). Multicenter, Prospective, Controlled Double-Blind Study Comparing Fib-19-01, A Phytotherapy Treatment, To A Dietary Supplement And To Conventional Care In Patients Suffering From Fibromyalgia. Alternative Therapies in Health and Medicine, 25(4), 46–53.

Binkiewicz-Glinska, A., Bakula, S., Tomczak, H., Landowski, J., Ruckemann-Dziurdzinska, K., Zaborowska-Sapeta, K., & Kiebzak, W. (2015). Fibromyalgia Syndrome - a multidisciplinary approach. Psychiatria Polska, 49(4), 801–810. https://doi.org/10.12740/psychiatriapolska.pl/online-first/4

Collado Mateo, D., Pazzi, F., Dominguez Munoz, F. J., Martin Martinez, J. P., Olivares, P. R., Gusi, N., & Adsuar, J. C. (2015). Ganoderma Lucidum Improves Physical Fitness In Women With Fibromyalgia. Nutricion Hospitalaria, 32(5), 2126–2135. https://doi.org/10.3 305/nh.2015.32.5.9601

Cordero, M. D., Alcocer-Gómez, E., de Miguel, M., Cano-García, F. J., Luque, C. M., Fernández-Riejo, P., & Sánchez-Alcazar, J. A. (2011). Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients. Mitochondrion, 11(4), 623–625. https://doi.org/10.1016/j.mito.2011.03.122

Cordero, M. D., de Miguel, M., Carmona-López, I., Bonal, P., Campa, F., & Moreno-Fernández, A. M. (2010). Oxidative stress and mitochondrial dysfunction in fibromyalgia. Neuro Endocrinology Letters, 31(2), 169–173.

de Carvalho, J. F., da Rocha Araujo, F. A. G., da Mota, L. M. A., Aires, R. B., & de Araujo, R. P. (2018). Vitamin D Supplementation Seems to Improve Fibromyalgia Symptoms: Preliminary Results. The Israel Medical Association Journal : IMAJ, 20(6), 379–381.

Di Pierro, F., Rossi, A., Consensi, A., Giacomelli, C., & Bazzichi, L. (2017). Role for a water-soluble form of CoQ10 in female subjects affected by fibromyalgia. A preliminary study. Clinical and Experimental Rheumatology, 35 Suppl 1(3), 20–27.

Dinan, T. G., & Quigley, E. M. (2011, December). Probiotics in the treatment of depression: science or science fiction? The Australian and New Zealand Journal of Psychiatry. England. https://doi.org/10.3109/00048674.2011.613766

Ellis, S. D., Kelly, S. T., Shurlock, J. H., & Hepburn, A. L. N. (2018). The role of vitamin D testing and replacement in fibromyalgia: a systematic literature review. BMC Rheumatology, 2, 28. https://doi.org/10.1186/s41927-018-0035-6

Häuser, W., Ablin, J., Fitzcharles, M.-A., Littlejohn, G., Luciano, J. V, Usui, C., & Walitt, B. (2015). Fibromyalgia. Nature Reviews. Disease Primers, 1, 15022. https://doi.org/10.1038/nrdp.2015.22

Hauser, W., Sarzi-Puttini, P., & Fitzcharles, M.-A. (2019). Fibromyalgia syndrome: under-, over- and misdiagnosis. Clinical and Experimental Rheumatology, 37 Suppl 1(1), 90–97.

Jorat, M. V., Tabrizi, R., Kolahdooz, F., Akbari, M., Salami, M., Heydari, S. T., & Asemi, Z. (2019, April 1). The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. Inflammopharmacology. Birkhauser Verlag AG. https://doi.org/10.1007/s10787-019-00572-x

Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Medicine, 6(7), e1000100. https://doi.org/10.1371/journal.pmed.1000100

Martins, Y. A., Cardinali, C. A. E. F., Ravanelli, M. I., & Brunaldi, K. (2020). Is hypovitaminosis D associated with fibromyalgia? A systematic review. Nutrition Reviews, 78(2), 115–133. https://doi.org/10.1093/nutrit/nuz033

Mazidi, M., Shemshian, M., Mousavi, S. H., Norouzy, A., Kermani, T., Moghiman, T., & Ferns, G. A. A. (2016). A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. Journal of Complementary & Integrative Medicine, 13(2), 195–199. https://doi.org/10.1515/jcim-2015-0043

Mirzaei, A., Zabihiyeganeh, M., Jahed, S. A., Khiabani, E., Nojomi, M., & Ghaffari, S. (2018). Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial. Medical Journal of the Islamic Republic of Iran, 32, 29. https://doi.org/10.14196/mjiri.32.29

Mizobuti, D. S., Fogaça, A. R., Moraes, F. dos S. R., Moraes, L. H. R., Mâncio, R. D., Hermes, T. de A., & Minatel, E. (2019). Coenzyme Q10 supplementation acts as antioxidant on dystrophic muscle cells. Cell Stress and Chaperones, 24(6), 1175–1185. https://doi.org/10.1007/s12192-019-01039-2

Mousavinejad, E., Ghaffari, M. A., Riahi, F., Hajmohammadi, M., Tiznobeyk, Z., & Mousavinejad, M. (2018). Coenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disorders. Psychiatry Research, 265, 62–69. https://doi.org/10.1016/j.psychres.2018.03.061

Pereira A.S. et al. (2018). Metodologia da pesquisa científica. UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?

Ramezani, M., Sahraei, Z., Simani, L., Heydari, K., & Shahidi, F. (2018). Coenzyme Q10 supplementation in acute ischemic stroke: Is it beneficial in short-term administration? Nutritional Neuroscience. https://doi.org/10.1080/1028415X.2018.1541269

Roman, P, Carrillo-Trabalón, F., Sánchez-Labraca, N., Cañadas, F., Estévez, A. F., & Cardona, D. (2018). Are probiotic treatments useful on fibromyalgia syndrome or chronic fatigue syndrome patients? A systematic review. Beneficial Microbes, 9(4), 603–611. https://doi.org/10.3920/BM2017.0125

Roman, Pablo, Estevez, A. F., Miras, A., Sanchez-Labraca, N., Canadas, F., Vivas, A. B., & Cardona, D. (2018). A Pilot Randomized Controlled Trial to Explore Cognitive and Emotional Effects of Probiotics in Fibromyalgia. Scientific Reports, 8(1), 10965. https://doi.org/10.1038/s41598-018-29388-5

Sahota, O. (2014). Understanding vitamin D deficiency. Age and Ageing, 43(5), 589–591. https://doi.org/10.1093/ageing/afu104

Sawaddiruk, P., Apaijai, N., Paiboonworachat, S., Kaewchur, T., Kasitanon, N., Jaiwongkam, T., & Chattipakorn, S. C. (2019). Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction. Free Radical Research, 53(8), 901–909. https://doi.org/10.1080/10715762.2019.1645955

Shakiba, M., Moazen-Zadeh, E., Noorbala, A. A., Jafarinia, M., Divsalar, P., Kashani, L., & Akhondzadeh, S. (2018). Saffron (Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trial. Avicenna Journal of Phytomedicine, 8(6), 513–523. Retrieved from https://pubmed.ncbi.nlm.nih.gov/30456199

Slyepchenko, A., Carvalho, A. F., Cha, D. S., Kasper, S., & McIntyre, R. S. (2014). Gut emotions - mechanisms of action of probiotics as novel therapeutic targets for depression and anxiety disorders. CNS & Neurological Disorders Drug Targets, 13(10), 1770–1786. https://doi.org/10.2174/1871527313666141130205242

Stewart, J. A., Mailler-Burch, S., Müller, D., Studer, M., von Känel, R., Grosse Holtforth, M., … Egloff, N. (2019). Rethinking the criteria for fibromyalgia in 2019: the ABC indicators. Journal of Pain Research, 12, 2115–2124. https://doi.org/10.2147/JPR.S205299

Theoharides, T. C., Tsilioni, I., Arbetman, L., Panagiotidou, S., Stewart, J. M., Gleason, R. M., & Russell, I. J. (2015). Fibromyalgia syndrome in need of effective treatments. The Journal of Pharmacology and Experimental Therapeutics, 355(2), 255–263. https://doi.org/10.1124/jpet.115.227298

Wolfe, F., Clauw, D. J., Fitzcharles, M.-A., Goldenberg, D. L., Katz, R. S., Mease, P., & Yunus, M. B. (2010). The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care & Research, 62(5), 600–610. https://doi.org/10.1002/acr.20140

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Publicado

31/10/2021

Como Citar

SANTOS, J. J. A. dos .; TARDIVO, A. P.; SALAZAR, T. C. C. de O. .; SANTOS, V. N. dos. Suplementação nutracêutica e fitoterápica no tratamento da fibromialgia: revisão de literatura. Research, Society and Development, [S. l.], v. 10, n. 14, p. e228101412381, 2021. DOI: 10.33448/rsd-v10i14.12381. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12381. Acesso em: 16 jul. 2024.

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Artigos de Revisão