Avaliação da administração de coenzima Q10 na atenuação de respostas oxidativas da agregação β-Amiloide em modelos de doença de Alzheimer: Uma revisão sistemática de literatura
DOI:
https://doi.org/10.33448/rsd-v10i2.12751Palavras-chave:
Doença de Alzheimer; Estresse oxidativo; Coenzima Q10.Resumo
O objetivo deste estudo foi avaliar os efeitos da administração de CoQ10 na atenuação de respostas oxidativas por agregação β-Amiloide em modelos de doença de Alzheimer. O presente trabalho trata-se de uma revisão sistemática da literatura, constituída de etapas estabelecidas por estratégias de busca, identificação, seleção e elegibilidade de estudos. A CoQ10 ou ubi-quinona e ubidecarenona, é uma pró-vitamina sintetizada de forma endógena, esta tem sido utilizada em ensaios clínicos para avaliar seu potencial de neuroproteção e antioxidação. Os achados mostraram que a CoQ10 apresenta efeitos antioxidantes e de diminuição da deposição intracelular do composto beta-amilóide, exercendo o alívio oxidativo e efeito antiapoptótico. A administração de CoQ10 demonstrou resultados significativos na atenuação de respostas oxidativas de agregação β-Amiloide em modelos da DA.
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Copyright (c) 2021 Francisco Emanoel Alves de Araújo; João Matheus Caé da Rocha; Bruna Jéssica Dantas de Lucena; Sarah Vitória Gomes de Sousa; Maria Raquel Araújo de Sousa; Lucas Emmanuel Rocha de Moura Marques; João Lindemberg Bandeira de Lima; Kellyson Lopes da Silva Macedo; Salvador Viana Gomes Junior
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