Óleo essencial de lavanda (Lavandula officinalis) previne a hepatotoxicidade induzida pelo paracetamol ao diminuir o estresse oxidativo e a resposta inflamatória
DOI:
https://doi.org/10.33448/rsd-v10i3.13461Palavras-chave:
Lesão hepática aguda; Óleo Essencial de Lavanda; Estresse oxidativo; Antioxidante; Hepatotoxicidade.Resumo
O acetaminofeno (N-acetil-p-aminofenol, APAP) é o medicamento popular mais recomendado e consumido para o alívio da dor e febre leves e moderadas. Embora eficaz em doses terapêuticas, a overdose de APAP induz hepatotoxicidade, causando insuficiência hepática aguda. Neste estudo, os efeitos hepatoprotetores e os mecanismos subjacentes do óleo essencial de Lavandula officinalis (LEO) foram investigados na hepatotoxicidade induzida por APAP. Para avaliar o efeito hepatoprotetor, camundongos Balb/c foram pré-tratados com LEO nas doses de 200 e 400 mg/kg, uma vez ao dia, durante sete dias. No sétimo dia, os camundongos foram tratados com APAP (250 mg/kg) para induzir a hepatotoxicidade. LEO diminuiu significativamente os níveis séricos de alanina aminotransferase (ALT), aspartato aminotransferase (AST), fosfatase alcalina (ALP) e gama-glutamil transferase (γ-GT) em comparação com o grupo APAP. Além disso, uma diminuição na atividade da mieloperoxidase (MPO), óxido nítrico (NO) e níveis de citocinas pró-inflamatórias foram observados em amostras de fígado dos camundongos tratados com LEO. Além disso, o pré-tratamento com LEO apresentou atividade antioxidante significativa pela diminuição dos níveis de malondialdeído (MDA), proteínas carboniladas, espécies reativas de oxigênio (ROS) e glutationa (GSH), além de aumentar os níveis da superóxido dismutase hepática (SOD), catalase (CAT) e glutationa oxidada (GSSG). Nossos resultados mostraram que o LEO melhorou as funções hepáticas alteradas pelo APAP ao inibir o estresse oxidativo e a inflamação induzida pelo APAP.
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Copyright (c) 2021 Gabriel Fernando Esteves Cardia; Francielli Maria de Souza Silva-Comar ; Expedito Leite Silva; Edvalkia Magna Teobaldo da Rocha; Jurandir Fernando Comar; Saulo Euclides Silva-Filho; Mayara Zagotto; Nancy Sayuri Uchida; Ciomar Aparecida Bersani-Amado; Roberto Kenji Nakamura Cuman
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