Lesões bucais em pacientes infectados por SARS-CoV-2: série de casos

Autores

DOI:

https://doi.org/10.33448/rsd-v10i4.14349

Palavras-chave:

SARS-CoV-2; COVID-19; Assistência odontológica; Diagnóstico bucal; Manifestações bucais; Unidade hospitalar de odontologia.

Resumo

À medida que a pandemia pelo COVID-19 se espalha pelo mundo, os profissionais devem se preparar para um aumento no número de pacientes gravemente enfermos. Considerando que os profissionais que realizam higiene bucal, principalmente a equipe de saúde bucal, são os mais expostos à SARS-CoV-2, e que a saliva pode ser o principal vetor na transmissão de pessoa a pessoa, é fundamental que tenham o apoio da melhor evidência de seu desempenho com redução de risco. De acordo com a literatura, os estudos clínicos de COVID-19 não costumam descrever sintomas orais e ainda não se sabe se essas manifestações podem ser um padrão clínico típico resultante de infecção direta por SARS-CoV-2 ou uma consequência sistêmica, devido a possibilidade de co-infecções, comprometimento do sistema imunológico e reações adversas a medicamentos. Como a prevalência das manifestações clínicas ainda é desconhecida, a possível manifestação da COVID-19 na cavidade oral tem sido considerada de amplo e atual interesse. Portanto, o objetivo deste estudo foi relatar uma série de casos de lesões orais em pacientes infectados com SARS-CoV-2.

Referências

Amorim Dos Santos, J., Normando, A., Carvalho da Silva, R. L., De Paula, R. M., Cembranel, A. C., Santos-Silva, A. R., & Guerra, E. (2020). Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations? International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases, 97, 326–328. https://doi.org/10.1016/j.ijid.2020.06.012

Bao, L., Zhang, C., Dong, J., Zhao, L., Li, Y., & Sun, J. (2020). Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection. Frontiers in microbiology, 11, 1840. https://doi.org/10.3389/fmicb.2020.01840

Brandão, T. B., Gueiros, L. A., Melo, T. S., Prado-Ribeiro, A. C., Nesrallah, A., Prado, G., Santos-Silva, A. R., & Migliorati, C. A. (2021). Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ?. Oral surgery, oral medicine, oral pathology and oral radiology, 131(2), e45–e51. https://doi.org/10.1016/j.oooo.2020.07.014

Cebeci Kahraman, F., & Çaşkurlu, H. (2020). Mucosal involvement in a COVID-19-positive patient: A case report. Dermatologic therapy, 33(4), e13797. https://doi.org/10.1111/dth.13797

Chan, J. F., Yuan, S., Kok, K. H., To, K. K., Chu, H., Yang, J., Xing, F., Liu, J., Yip, C. C., Poon, R. W., Tsoi, H. W., Lo, S. K., Chan, K. H., Poon, V. K., Chan, W. M., Ip, J. D., Cai, J. P., Cheng, V. C., Chen, H., Hui, C. K., & Yuen, K. Y. (2020). A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet (London, England), 395(10223), 514–523. https://doi.org/10.1016/S0140-6736(20)30154-9.

Ciccarese, G., Drago, F., Boatti, M., Porro, A., Muzic, S. I., & Parodi, A. (2021). Oral erosions and petechiae during SARS-CoV-2 infection. Journal of medical virology, 93(1), 129–132. https://doi.org/10.1002/jmv.26221

Corchuelo, J., & Ulloa, F. C. (2020). Oral manifestations in a patient with a history of asymptomatic COVID-19: Case report. International journal of infectious diseases: IJID : official publication of the International Society for Infectious Diseases, 100, 154–157. https://doi.org/10.1016/j.ijid.2020.08.071

Cruz Tapia, R. O., Peraza Labrador, A. J., Guimaraes, D. M., & Matos Valdez, L. H. (2020). Oral mucosal lesions in patients with SARS-CoV-2 infection. Report of four cases. Are they a true sign of COVID-19 disease? Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry, 40(6), 555–560. https://doi.org/10.1111/scd.12520

Dziedzic, A., & Wojtyczka, R. (2020). The impact of coronavirus infectious disease 19 (COVID-19) on oral health. Oral diseases, 10.1111/odi.13359. Advance online publication. https://doi.org/10.1111/odi.13359

Forbes, H., Warne, B., Doelken, L., Brenner, N., Waterboer, T., Luben, R., Wareham, N. J., Warren-Gash, C., & Gkrania-Klotsas, E. (2019). Risk factors for herpes simplex virus type-1 infection and reactivation: Cross-sectional studies among EPIC-Norfolk participants. PloS one, 14(5), e0215553. https://doi.org/10.1371/journal.pone.0215553

Gianotti, R. (2020). COVID 19 and the skin—heuristic review. DermoSprint. In press.

Jin, Y. H., Cai, L., Cheng, Z. S., Cheng, H., Deng, T., Fan, Y. P., Fang, C., Huang, D., Huang, L. Q., Huang, Q., Han, Y., Hu, B., Hu, F., Li, B. H., Li, Y. R., Liang, K., Lin, L. K., Luo, L. S., Ma, J., & Ma, L. L., For the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM) (2020). A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Military Medical Research, 7(1), 4. https://doi.org/10.1186/s40779-020-0233-6

La Rosa, G., Libra, M., De Pasquale, R., Ferlito, S., & Pedullà, E. (2021). Association of Viral Infections With Oral Cavity Lesions: Role of SARS-CoV-2 Infection. Frontiers in medicine, 7, 571214. https://doi.org/10.3389/fmed.2020.571214

Lee, J. S., Kossard, S., & McGrath, M. A. (2008). Lymphocytic thrombophilic arteritis: a newly described medium-sized vessel arteritis of the skin. Archives of dermatology, 144(9), 1175–1182. https://doi.org/10.1001/archderm.144.9.1175

Manalo, I. F., Smith, M. K., Cheeley, J., & Jacobs, R. (2020). A dermatologic manifestation of COVID-19: Transient livedo reticularis. Journal of the American Academy of Dermatology, 83(2), 700. https://doi.org/10.1016/j.jaad.2020.04.018

Mariz, B., Brandão, T. B., Ribeiro, A., Lopes, M. A., & Santos-Silva, A. R. (2020). New Insights for the Pathogenesis of COVID-19-Related Dysgeusia. Journal of dental research, 99(10), 1206. https://doi.org/10.1177/0022034520936638

Martín Carreras-Presas, C., Amaro Sánchez, J., López-Sánchez, A. F., Jané-Salas, E., & Somacarrera Pérez, M. L. (2020). Oral vesiculobullous lesions associated with SARS-CoV-2 infection. Oral diseases, 10.1111/odi.13382. Advance online publication. https://doi.org/10.1111/odi.13382

Peng, X., Xu, X., Li, Y., Cheng, L., Zhou, X., & Ren, B. (2020). Transmission routes of 2019-nCoV and controls in dental practice. Int J Oral Sci. 12(1):9. 10.1038/s41368-020-0075-9.

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa cientifica. UFSM.

Prajapat, M., Sarma, P., Shekhar, N., Avti, P., Sinha, S., Kaur, H., Kumar, S., Bhattacharyya, A., Kumar, H., Bansal, S., & Medhi, B. (2020). Drug targets for corona virus: A systematic review. Indian journal of pharmacology, 52(1), 56–65. https://doi.org/10.4103/ijp.IJP_115_20

Riad, A., Kassem, I., Hockova, B., Badrah, M., & Klugar, M. (2020). Tongue ulcers associated with SARS-CoV-2 infection: A case series. Oral diseases, 10.1111/odi.13635. Advance online publication. https://doi.org/10.1111/odi.13635

Sabino-Silva, R., Jardim, A., & Siqueira, W. L. (2020). Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis. Clinical oral investigations, 24(4), 1619–1621. https://doi.org/10.1007/s00784-020-03248-x

Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020). Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2. Frontiers in medicine, 7, 594495. https://doi.org/10.3389/fmed.2020.594495

Sleiwah, A., Nair, G., Mughal, M., Lancaster, K., & Ahmad, I. (2020). Perioral pressure ulcers in patients with COVID-19 requiring invasive mechanical ventilation. European journal of plastic surgery, 1–6. Advance online publication. https://doi.org/10.1007/s00238-020-01737-6

Soares, C. D., Carvalho, R. A., Carvalho, K. A., Carvalho, M. G., & Almeida, O. P. (2020). Letter to Editor: Oral lesions in a patient with Covid-19. Medicina oral, patologia oral y cirugia bucal, 25(4), e563–e564. https://doi.org/10.4317/medoral.24044

Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K. B., Yoshida, M., Barnes, J. L., & HCA Lung Biological Network (2020). SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature medicine, 26(5), 681–687. https://doi.org/10.1038/s41591-020-0868-6

Tong, J. Y., Wong, A., Zhu, D., Fastenberg, J. H., & Tham, T. (2020). The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery, 163(1), 3–11. https://doi.org/10.1177/0194599820926473

Tysiąc-Miśta, M., & Dziedzic, A. (2020). The Attitudes and Professional Approaches of Dental Practitioners during the COVID-19 Outbreak in Poland: A Cross-Sectional Survey. International journal of environmental research and public health, 17(13), 4703. https://doi.org/10.3390/ijerph17134703

World Health Organization (2020). Considerations for quarantine of individuals in the context of containment for coronavirus disease (‎‎ COVID-19)‎‎: interim guidance. No. WHO/2019-nCoV/IHR_Quarantine/2020.2. World Health Organization.

Xu, J., Li, Y., Gan, F., Du, Y., & Yao, Y. (2020). Salivary Glands: Potential Reservoirs for COVID-19 Asymptomatic Infection. Journal of dental research, 99(8), 989. https://doi.org/10.1177/0022034520918518

Xu, H., Zhong, L., Deng, J., Peng, J., Dan, H., Zeng, X., Li, T., & Chen, Q. (2020). High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. International journal of oral science, 12(1), 8. https://doi.org/10.1038/s41368-020-0074-x

Wang, Z., & Xu, X. (2020). scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells, 9(4), 920. https://doi.org/10.3390/cells9040920

Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. D., Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., Zheng, X. S., & Shi, Z. L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273. https://doi.org/10.1038/s41586-020-2012-7

Zingarelli, E. M., Ghiglione, M., Pesce, M., Orejuela, I., Scarrone, S., & Panizza, R. (2020). Facial Pressure Ulcers in a COVID-19 50-year-old Female Intubated Patient. Indian journal of plastic surgery: official publication of the Association of Plastic Surgeons of India, 53(1), 144–146. https://doi.org/10.1055/s-0040-1710403

Zou, X., Chen, K., Zou, J., Han, P., Hao, J., & Han, Z. (2020). Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Frontiers of medicine, 14(2), 185–192. https://doi.org/10.1007/s11684-020-0754-0

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18/04/2021

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BAEDER, F. M. .; ALBUQUERQUE, A. C. L. de; CORAZZA, P. F. L. .; WEIGERT, K. . L.; PURICELLI, E.; PASETTI, L. A.; FERREIRA, A. M.; SERRÃO, M. do C. P. N. .; CARDOSO, A. M. R. .; BRITO FILHO, M. T. de .; TEODÓSIO, G. C.; BOMFIM, M. A. C.; SOBRINHO, A. C. P. .; FORGHIERI, A. A.; SILVA, D. F. . Lesões bucais em pacientes infectados por SARS-CoV-2: série de casos . Research, Society and Development, [S. l.], v. 10, n. 4, p. e45410414349, 2021. DOI: 10.33448/rsd-v10i4.14349. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/14349. Acesso em: 17 jul. 2024.

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Ciências da Saúde