Antihypertensives and COVID-19: Literature review

Thais Cristina Loyola da  Silva; Pedro Vilar de Oliveira  Villarim; Alyne Barreto Mesquita de  Goés; Vitória Ribeiro Dantas  Marinho; Natália Marcelino  Araújo; André Luiz Costa e  Silva; Amália Cinthia Meneses  Rêgo; Irami  Araújo-Filho

doi:10.33448/rsd-v10i6.15977

Autores

Thais Cristina Loyola da Silva Liga Norte Riograndense Contra o Câncer, Natal-RN, Brazil. https://orcid.org/0000-0003-1605-9923
Pedro Vilar de Oliveira Villarim Liga Norte Riograndense Contra o Câncer, Natal-RN, Brazil. https://orcid.org/0000-0002-9504-8589
Alyne Barreto Mesquita de Goés Liga Norte Riograndense Contra o Câncer, Natal-RN, Brazil. https://orcid.org/0000-0001-5187-6174
Vitória Ribeiro Dantas Marinho Liga Norte Riograndense Contra o Câncer, Natal-RN, Brazil. https://orcid.org/0000-0002-8514-1560
Natália Marcelino Araújo Liga Norte Riograndense Contra o Câncer, Natal-RN, Brazil. https://orcid.org/0000-0003-3143-6299
André Luiz Costa e Silva Liga Norte Riograndense Contra o Câncer, Natal-RN, Brazil. https://orcid.org/0000-0001-7255-3833
Amália Cinthia Meneses Rêgo Potiguar University https://orcid.org/0000-0002-0575-3752
Irami Araújo-Filho Universidade Federal do Rio Grande do Norte https://orcid.org/0000-0003-2471-7447

DOI:

https://doi.org/10.33448/rsd-v10i6.15977

Palavras-chave:

Anti-hipertensivos; Inibidores da Enzima Conversora da Angiotensina; Hipertensão; SARS-CoV-2; COVID-19.

Resumo

Pacientes hipertensos com COVID-19 são suscetíveis às complicações da doença, portanto este estudo teve como objetivo analisar a ação de fármacos que atuam sobre a Angiotensina (AT) na presença de COVID-19 em comparação com outros anti-hipertensivos, bem como identificar os principais. evidências sobre o assunto apresentadas até o momento. Trata-se de uma revisão integrativa da literatura contendo 34 artigos selecionados segundo os critérios de inclusão, entre janeiro / 2020 a fevereiro / 2021, nas bases de dados PubMed, Embase, Scopus e Web of Science. Os resultados não mostram uma relação causal entre o aumento da infecção por COVID-19 e o uso de inibidores do RAAS, mas um possível efeito protetor destes contra a manifestação grave da doença devido à inibição das doenças pró-inflamatórias do AT II. Assim, cerca de ⅔ dos estudos defenderam a continuidade do uso e o fator de proteção dos bloqueadores RAAS em detrimento das demais classes de anti-hipertensivos que não modulam o RAAS. Verificou-se, então, que o tratamento anti-hipertensivo deve ser mantido, pois não piora o prognóstico diante da infecção pelo Sars-CoV-2. No entanto, os estudos são principalmente observacionais e, portanto, não podem estabelecer relações causais fortes. Por esse motivo, ensaios clínicos randomizados robustos são necessários para melhor compreender este tópico.

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Anti-hipertensivos e COVID-19: Revisão de literatura

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