Infertilidade masculina e COVID-19: Há alguma relação?

Autores

DOI:

https://doi.org/10.33448/rsd-v10i6.16059

Palavras-chave:

COVID-19; Doença por vírus COVID-19; Infecção por vírus COVID-19; SARS-CoV-2; Infertilidade masculina; Saúde reprodutiva.

Resumo

Nos testículos, a expressão de receptores da Enzima Conversora de Angiotensina 2, torna mais suscetível à infecção pelo Sars-CoV-2 e por conseguinte, à infertilidade masculina com significativos agravos à saúde do paciente. Por isso, este estudo objetivou analisar a fisiopatologia clínica e os mecanismos envolvidos na gênese da infertilidade masculina proveniente da COVID-19, através da análise crítica das principais evidências científicas sobre o assunto apresentadas até o momento. A partir de uma revisão integrativa da literatura contendo 30 estudos selecionados mediante critérios de inclusão no período de 2020-2021, observou-se no presente estudo os impactos diretos e indiretos sobre a fertilidade masculina em termos fisiopatológicos e psicossociais, além de opções terapêuticas, orientações de acolhimento e abordagem semiológica eficiente. Dessa forma, o impacto da pandemia, mesmo após um ano, é imensurável. Estudos adicionais para revelar as reais consequências e o mecanismo pelo qual a doença pode afetar a fertilidade masculina ainda são necessários. É fundamental oferecer mais atenção aos exames genitais masculinos em pacientes portadores de COVID-19. As consequências psicobiológicas da pandemia em pacientes inférteis não devem ser subestimadas.

Referências

Bahadur, G., Acharya, S., Muneer, A., Huirne, J., Łukaszuk, M., Doreski, P. A., & Homburg, R. (2020). SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility. Reproductive biomedicine online, 41(3), 365–369. https://doi.org/10.1016/j.rbmo.2020.05.014.

Batiha, O., Al-Deeb, T., Al-Zoubi, E., & Alsharu, E. (2020). Impact of COVID-19 and other viruses on reproductive health. Andrologia, 52(9), e13791. https://doi.org/10.1111/and.13791.

Bocchese, N. V., Dávila, N. G., Rodrigues, M. B. M., Araújo-Neto, I., Costa, M. O., Barbalho, D. M. G., Rêgo, A. C. M., & Araújo-Filho, I. (2020). COVID-19 and Liver Injury: Hepatology Perspectives. Journal of Clinical Gastroenterology and Treatment, 6(074), 1-5. https://doi.org/10.23937/2469-584X/1510074.

Bocchese, N. V., Dávila, N. G., Rodrigues, M. B. M., Monte, R. R. L., Melo, R. C., Rêgo, A. C. M., & Araújo-Filho, I. (2020). Covid-19: Gastroenterology Perspectives. Journal of clinical gastroenterology and treatment, 6(075), 1-8. https://doi.org/10.23937/2469-584X/1510075

Dantas, T. C; Gomes, A. C. A.; Lima, I. P. C; Lucas, B. B; Aguiar, M. R; Cavalcanti, T. C; Pinheiro, F. I. .; Rêgo, A. C. M; Araújo-filho,, I. Corticosteroid therapy in patients with severe COVID-19. Research, Society and Development, [S. l.], v. 10, n. 1, p. e58910112114, 2021. DOI: 10.33448/rsd-v10i1.12114. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12114. Acesso em: 11 may. 2021.

Dutta, S., & Sengupta, P. (2021). SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology. Reproductive sciences (Thousand Oaks, Calif.), 28(1), 23–26. https://doi.org/10.1007/s43032-020-00261-z.

Efremov, E. A., Kasatonova, E. V., Melnik, Y. I., & Nikushina, A. A. (2020). Urologiia (Moscow, Russia : 1999), (4), 104–110. PMID: 32897023.

Esposito, V., Rania, E., Lico, D., Pedri, S., Fiorenza, A., Strati, M. F., Conforti, A., Marrone, V., Carosso, A., Revelli, A., Zullo, F., Di Carlo, C., & Venturella, R. (2020). Influence of COVID-19 pandemic on the psychological status of infertile couples. European journal of obstetrics, gynecology, and reproductive biology, 253, 148–153. https://doi.org/10.1016/j.ejogrb.2020.08.025.

Fu, J., Zhou, B., Zhang, L., Balaji, K. S., Wei, C., Liu, X., Chen, H., Peng, J., & Fu, J. (2020). Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19. Molecular biology reports, 47(6), 4383–4392. https://doi.org/10.1007/s11033-020-05478-4.

Goés, A. B. M., Cardoso, B. B., Tavares, F. A. F., Monte, R. R. L., Melo, R. C., Araújo-Neto, I., Pinheiro, R. S. E., Rêgo, A. C. M., & Araújo-Filho, I. (2020). COVID-19 and Nervous System: Under Estimated Clinical and Prognostic Aspects. International journal of neurology and neurotherapy, 7(100), 1-7. https://doi.org/10.23937/2378-3001/1410100.

Haghpanah, A., Masjedi, F., Alborzi, S., Hosseinpour, A., Dehghani, A., Malekmakan, L., & Roozbeh, J. (2021). Potential mechanisms of SARS-CoV-2 action on male gonadal function and fertility: Current status and future prospects. Andrologia, 53(1), e13883. https://doi.org/10.1111/and.13883.

Hallak, J., & Esteves, S. C. (2020). Concise practice recommendations for the provision of andrological services and assisted reproductive technology for male infertility patients during the SARS-CoV-2 in Brazil. International braz j urol : official journal of the Brazilian Society of Urology, 46(6), 1082–1089. https://doi.org/10.1590/S1677-5538.IBJU.2020.06.03.

Holtmann, N., Edimiris, P., Andree, M., Doehmen, C., Baston-Buest, D., Adams, O., Kruessel, J. S., & Bielfeld, A. P. (2020). Assessment of SARS-CoV-2 in human semen-a cohort study. Fertility and sterility, 114(2), 233–238. https://doi.org/10.1016/j.fertnstert.2020.05.028.

Illiano, E., Trama, F., & Costantini, E. (2020). Could COVID-19 have an impact on male fertility?. Andrologia, 52(6), e13654. https://doi.org/10.1111/and.13654.

Li, R., Yin, T., Fang, F., Li, Q., Chen, J., Wang, Y., Hao, Y., Wu, G., Duan, P., Wang, Y., Cheng, D., Zhou, Q., Zafar, M. I., Xiong, C., Li, H., Yang, J., Qiao, J.. Potential risks of SARS-CoV-2 infection on reproductive health. Reprod Biomed Online. 2020 Jul;41(1):89-95. doi: 10.1016/j.rbmo.2020.04.018.

Li, X. P., Zhang, Y. D., Xia, K., Liu, G. H., & Deng, C. H. (2020). Zhonghua nan ke xue = National journal of andrology, 26(3), 215–218. PMID: 33346959.

Liu, X., Chen, Y., Tang, W., Zhang, L., Chen, W., Yan, Z., Yuan, P., Yang, M., Kong, S., Yan, L., & Qiao, J. (2020). Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes. Science China. Life sciences, 63(7), 1006–1015. https://doi.org/10.1007/s11427-020-1705-0.

Monte, R. R. L., Tavares, F. A. F., Cardoso, B. B., Goes, A. B. M., Silva, T. C. L., Silva, B. O., Araújo, Y. S. M., Rêgo, A. C. M., & Araújo-Filho, I. (2020). Covid-19 Pandemic and Health Professionals: Practical Approaches. International Journal of Critical Care and Emergency Medicine, 6(108), 1-9. https://doi.org/10.23937/2474-3674/1510108.

Olaniyan, O. T., Dare, A., Okotie, G. E., Adetunji, C. O., Ibitoye, B. O., Bamidele, O. J., & Eweoya, O. O. (2020). Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility. Journal of basic and clinical physiology and pharmacology, 31(6). https://doi.org/10.1515/jbcpp-2020-0156.

Pacchiarotti, A., Frati, G., & Saccucci, P. (2020). A surprising link with unexplained infertility: a possible Covid-19 paradox?. Journal of assisted reproduction and genetics, 37(11), 2661–2662. https://doi.org/10.1007/s10815-020-01911-6.

Pan, F., Xiao, X., Guo, J., Song, Y., Li, H., Patel, D. P., Spivak, A. M., Alukal, J. P., Zhang, X., Xiong, C., Li, P. S., & Hotaling, J. M. (2020). No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertility and sterility, 113(6), 1135–1139. https://doi.org/10.1016/j.fertnstert.2020.04.024.

Renu, K., Subramaniam, M. D., Chakraborty, R., Myakala, H., Iyer, M., Bharathi, G., Siva, K., Vellingiri, B., & Valsala Gopalakrishnan, A. (2020). The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis. Journal of reproductive immunology, 142, 103213. https://doi.org/10.1016/j.jri.2020.103213.

Segars, J., Katler, Q., McQueen, D. B., Kotlyar, A., Glenn, T., Knight, Z., Feinberg, E. C., Taylor, H. S., Toner, J. P., Kawwass, J. F., & American Society for Reproductive Medicine Coronavirus/COVID-19 Task Force (2020). Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known?. Fertility and sterility, 113(6), 1140–1149. https://doi.org/10.1016/j.fertnstert.2020.04.025.

Selvaraj, K., Ravichandran, S., Krishnan, S., Radhakrishnan, R. K., Manickam, N., & Kandasamy, M. (2021). Testicular Atrophy and Hypothalamic Pathology in COVID-19: Possibility of the Incidence of Male Infertility and HPG Axis Abnormalities. Reproductive sciences (Thousand Oaks, Calif.), 1–8. Advance online publication. https://doi.org/10.1007/s43032-020-00441-x.

Sheikhzadeh Hesari, F., Hosseinzadeh, S. S., & Asl Monadi Sardroud, M. A. (2021). Review of COVID-19 and male genital tract. Andrologia, 53(1), e13914. https://doi.org/10.1111/and.13914.

Shen, Q., Xiao, X., Aierken, A., Yue, W., Wu, X., Liao, M., & Hua, J. (2020). The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection. Journal of cellular and molecular medicine, 24(16), 9472–9477. https://doi.org/10.1111/jcmm.15541.

Tian, Y., & Zhou, L. Q. (2021). Evaluating the impact of COVID-19 on male reproduction. Reproduction (Cambridge, England), 161(2), R37–R44. https://doi.org/10.1530/REP-20-0523.

Trinchant, R. M., Cruz, M., Marqueta, J., & Requena, A. (2020). Infertility and reproductive rights after the COVID-19 pandemic. Reproductive biomedicine online, 41(2), 151–153. https://doi.org/10.1016/j.rbmo.2020.05.007.

Vishvkarma, R., & Rajender, S. (2020). Could SARS-CoV-2 affect male fertility?. Andrologia, 52(9), e13712. https://doi.org/10.1111/and.13712.

Younis, J. S., Abassi, Z., & Skorecki, K. (2020). Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection. American journal of physiology. Endocrinology and metabolism, 318(6), E878–E880. https://doi.org/10.1152/ajpendo.00183.2020.

Downloads

Publicado

07/06/2021

Como Citar

GOÉS, A. B. M. de .; ARAÚJO-NETO, I. .; ARAÚJO, N. M. .; VILLARIM, P. V. de O. .; SILVA, T. C. L. da .; VILLARIM, C. V. de O. .; RÊGO, A. C. M. .; ARAÚJO-FILHO, I. Infertilidade masculina e COVID-19: Há alguma relação?. Research, Society and Development, [S. l.], v. 10, n. 6, p. e46510616059, 2021. DOI: 10.33448/rsd-v10i6.16059. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/16059. Acesso em: 5 jul. 2024.

Edição

Seção

Artigos de Revisão