Epidemiologia molecular de bacilos Gram-negativos multidroga resistente produtores de carbapenemases isoladas de diferentes sítios de infecção
DOI:
https://doi.org/10.33448/rsd-v10i9.18070Palavras-chave:
Bactérias gram-negativas; Carbapenemase; Multidroga resistente; Epidemiologia molecular.Resumo
A resistência a carbapenemases em bacilos gram-negativas (BGN) tornou-se um problema mundial, elevando a taxa de morbidade e mortalidade. O método automatizado foi utilizado para identificação e suscetibilidade dos isolados. E o método molecular foi aplicado na detecção de bacilos gram-negativas (BGN) produtoras de carbapenemase. Um total de 205 BGN foram recuperados a partir de diferentes amostras clínicas, resistentes a carbapenemases. Os genes de resistência blaKPC (57,5%), blaVIM (30,2%), blaGES (17%), blaNDM (15%) e blaSPM (2,4%) foram recuperados a partir de isolados clínicos. O gene blaIMP não foi detectado em nenhum dos isolados. É preocupante que Pseudomonas aeruginosa e Acinetobacter baumannii representem a maioria dos isolados (61,6%) recuperados de infecções de diferentes sítios, com alta resistência a carbapenêmicos, carregando simultaneamente os genes blaKPC, blaGES e blaVIM, assim como encontrados também em Enterobactericeae. A carbapenemase mais prevalente foi blaKPC e blaVIM, seguida de blaNDM dentre os isolados multidroga resistentes. Esses resultados são um ameaça à saúde pública, configurando altas taxas de resistência, limitando as opções terapêuticas.
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Copyright (c) 2021 Cynthia Regina Pedrosa Soares; Felipe Rogerio Ferreira da Silva ; Jorge Belém Oliveira Júnior; Paulo Sérgio Ramos de Araújo; Elza Ferreira Firmo
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