O efeito de probióticos em sintomas depressivos: Uma meta-análise de estudos clínicos randomizados
DOI:
https://doi.org/10.33448/rsd-v10i9.18359Palavras-chave:
Probióticos; Depressão; Transtornos do humor; Microbioma gastrointestinal.Resumo
Cada vez mais evidências indicam que a comunicação bidirecional ocorre entre o intestino e o cérebro por meio do eixo microbioma-intestino-cérebro. Assim, vários estudos apontam para um efeito positivo dos probióticos na sintomatologia depressiva. Nosso estudo teve como objetivo fornecer uma meta-análise atualizada sobre o assunto. Realizamos uma busca sistemática de ensaios clínicos randomizados em vários bancos de dados. A análise dos dados foi realizada usando o Review Manager 5.4. Revisamos 26 estudos, totalizando 2.170 participantes. O uso de probióticos teve um efeito significativo na redução dos sintomas depressivos (SMD: - 0,22; IC 95%: - 0,30 a - 0,13; p <0,0001) em comparação com o placebo. As análises de subgrupo mostraram que os probióticos influenciaram os resultados em participantes com depressão (SMD: - 0,67; IC 95%: - 0,93 a - 0,41; p <0,00001) e com outros diagnósticos clínicos (SMD: - 0,23; IC 95%: - 0,36 a - 0,09; p = 0,0008), mas não participantes saudáveis (SMD: - 0,11; IC 95%: - 0,23 a 0,02; p = 0,100). O uso de probióticos pode ser uma abordagem promissora para melhorar o tratamento da depressão. É importante a realização de mais estudos para avaliar melhor a eficácia do probiótico como tratamento adjuvante aos medicamentos antidepressivos, bem como suas dosagens mais eficazes.
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