Blocking tubules technologies for dentin hypersensitivity in periodontal patients – pilot study

Authors

DOI:

https://doi.org/10.33448/rsd-v10i13.20398

Keywords:

Dentin hypersensitivity; dentin hypersensitivity, root exposure, periodontal disease, periodontal treatment, desensitizing agents; Periodontal disease; Desensitizing agents.

Abstract

Periodontal patients often report dentin hypersensitivity (DH) caused by root surface exposure or periodontal treatment. Tubular blocking technologies in toothpastes are effective for pain relief, but no specific chemical/physical agent has been reported for periodontal patients. This double-blind randomized clinical trial compared the effects of three technologies in reducing DH in periodontal patients. Eighteen (18) participants were randomly assigned into three groups: SEN (NOVAMIN technology); REG (REFIX technology); REGK (REFIX technology + potassium citrate). Periodontal patients presenting with DH were evaluated at 6 moments: T1 and T2 - immediately before and after scaling and root planing procedures (SRP); T3 - after polishing sensitive areas with their assigned dentifrice and T4, T5, T6 - after 2, 4 and 8 weeks of SRP respectively. Sensitivity was assessed by air blast (Schiff scale) and patients’ perceptions using the visual analogue scale (VAS). Data were analyzed by two-way repeated measures ANOVA complemented by the Tukey test with significance set at 5% (p <0.05). Preliminary outcomes revealed SEN, REG and REGP reduced DH in periodontal patients (n=18). All patients initially presented moderate to severe pain (64.3) and after treatment they reported mild pain (21.3). Similarly, the dentist evaluation showed significant reduction in DH with the use of the three technologies (2.26 to 0.56). No statistically significant differences were found between the three study groups for patients (p=0.751) and dentist evaluations (p=0.632). According to these preliminary outcomes, all three technologies equally reduced DH in periodontal patients. Clinical trials #NCT04422184

References

Addy, M., & Dowell, P. (1983). Dentine hypersensitivity‐A review: Clinical and in vitro evaluation of treatment agents. Journal of clinical periodontology, 10(4), 351-363.

Amaechi, B. T., & Van Loveren, C. (2013). Fluorides and non-fluoride remineralization systems. Toothpastes, 23, 15-26.

Amaechi, B. T., Lemke, K. C., Saha, S., & Gelfond, J. (2018). Clinical efficacy in relieving dentin hypersensitivity of nanohydroxyapatite-containing cream: A randomized controlled trial. The open dentistry journal, 12, 572.

Boneta A. R. E., et al. Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity: a six-week randomized clinical study. J Dent 2013; 41: 34-41.

Burwell, A. K., Litkowski, L. J., & Greenspan, D. C. (2009). Calcium sodium phosphosilicate (NovaMin®): remineralization potential. Advances in Dental Research, 21(1), 35-39.

Canadian Advisory Board on Dentin Hypersensitivity. (2003). Consensus-based recommendations for the diagnosis and management of dentin hypersensitivity. Journal (Canadian Dental Association), 69(4), 221-226.

Cunha-Cruz, J., Wataha, J. C., Heaton, L. J., Rothen, M., Sobieraj, M., Scott, J., & Northwest Practice-based Research Collaborative in Evidence-based DENTistry. (2013). The prevalence of dentin hypersensitivity in general dental practices in the northwest United States. The Journal of the American Dental Association, 144(3), 288-296.

Docimo, R., Montesani, L., Maturo, P., Costacurta, M., Bartolino, M., DeVizio, W., & Mateo, L. (2009). Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy.

Hench, L. L., & Jones, J. R. (2015). Bioactive glasses: frontiers and challenges. Frontiers in bioengineering and biotechnology, 3, 194.

Hu, D., Stewart, B., Mello, S., Arvanitidou, L., Panagakos, F., De Vizio, W., & Yin, W. (2013). Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a negative control mouthwash on dentin hypersensitivity reduction. A randomized clinical trial. Journal of dentistry, 41, S26-S33.

Hu, M. L., Zheng, G., Zhang, Y. D., Yan, X., Li, X. C., & Lin, H. (2018). Effect of desensitizing toothpastes on dentine hypersensitivity: A systematic review and meta-analysis. Journal of dentistry, 75, 12-21.

Hughes, N., Mason, S., Jeffery, P., Welton, H., Tobin, M., O'Shea, C., & Browne, M. (2010). A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. The Journal of clinical dentistry, 21(2), 49-55.

Lippert, F. (2013). An introduction to toothpaste-its purpose, history and ingredients. In Toothpastes (Vol. 23, pp. 1-14). Karger Publishers.

Martins, C. C., Firmino, R. T., Riva, J. J., Ge, L., Carrasco-Labra, A., Brignardello-Petersen, R., & Schünemann, H. J. (2020). Desensitizing toothpastes for dentin hypersensitivity: a network meta-analysis. Journal of dental research, 99(5), 514-522.

Miglani, S., Aggarwal, V., & Ahuja, B. (2010). Dentin hypersensitivity: Recent trends in management. Journal of conservative dentistry: JCD, 13(4), 218.

Patil, S. A., Naik, B. D., & Suma, R. (2015). Evaluation of three different agents for in-office treatment of dentinal hypersensitivity: a controlled clinical study. Indian Journal of Dental Research, 26(1), 38.

Philip, N. (2019). State of the art enamel remineralization systems: the next frontier in caries management. Caries research, 53(3), 284-295.

Rösing, C. K., Fiorini, T., Liberman, D. N., & Cavagni, J. (2009). Dentine hypersensitivity: analysis of self-care products. Brazilian oral research, 23, 56-63.

Shen, P., Walker, G. D., Yuan, Y., Reynolds, C., Stanton, D. P., Fernando, J. R., & Reynolds, E. C. (2018). Importance of bioavailable calcium in fluoride dentifrices for enamel remineralization. Journal of dentistry, 78, 59-64.

Splieth, C. H., & Tachou, A. (2013). Epidemiology of dentin hypersensitivity. Clinical oral investigations, 17(1), 3-8.

Tomaz, P. L. S., de Sousa, L. A., de Aguiar, K. F., de Sá Oliveira, T., Matochek, M. H. M., Polassi, M. R., & D’Alpino, P. H. P. (2020). Effects of 1450-ppm fluoride-containing toothpastes associated with boosters on the enamel remineralization and surface roughness after cariogenic challenge. European journal of dentistry, 14(01), 161-170.

Van Loveren, C. (2013). Exposed cervical dentin and dentin hypersensitivity summary of the discussion and recommendations. Clinical oral investigations, 17(1), 73-76.

Vilhena, F. V., de Oliveira, S. M. L., Matochek, M. H. M., Tomaz, P. L. S., de Sá Oliveira, T., & D’Alpino, P. H. P. (2021). Biomimetic mechanism of action of fluoridated toothpaste containing proprietary REFIX technology on the remineralization and repair of demineralized dental tissues: an in vitro study. European Journal of Dentistry, 15(02), 236-241.

Vilhena, F. V., Polassi, M. R., Paloco, E. A., Alonso, R. C., Guiraldo, R. D., & D’Alpino, P. H. (2020). Effectiveness of toothpaste containing REFIX technology against dentin hypersensitivity: a randomized clinical study. J Contemp Dent Pract, 21(6), 609-614.

West, N. X., Seong, J., & Davies, M. (2015). Management of dentine hypersensitivity: efficacy of professionally and self‐administered agents. Journal of Clinical Periodontology, 42, S256-S302.

Downloads

Published

03/10/2021

How to Cite

ZANGRANDO, M. S. R. .; SILVA, G. F. F. .; BIGOTTO, M. L. B. .; CINTRA, F. M. R. N. .; DAMANTE, C. A. .; SANT’ANA, A. C. P. .; VILHENA, F. V. . Blocking tubules technologies for dentin hypersensitivity in periodontal patients – pilot study. Research, Society and Development, [S. l.], v. 10, n. 13, p. e35101320398, 2021. DOI: 10.33448/rsd-v10i13.20398. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/20398. Acesso em: 26 apr. 2024.

Issue

Section

Health Sciences