Herbal medicines for treating HIV infection and AIDS: a systematic review and meta-analysis
DOI:
https://doi.org/10.33448/rsd-v11i9.21157Palavras-chave:
Meta-análise; HIV; Plantas medicinais; Contagem CD4 ; Fitoterápicos; Terapia anti-retroviral.Resumo
The present meta-analysis evaluated the use of medicinal plants, phytotherapics and/or phytopharmaceuticals associated or not to antiretroviral therapy, using as primary outcome the lymphocyte count, and, among which, the CD4+ count. Studies were considered eligible for the present systematic review if they comprised the following criteria: randomized clinical trials using as intervention medicinal plants, phytotherapics, and/or phytopharmaceuticals associated or not with antiretroviral therapy. The search strategy included terms related to the intervention (medicinal plants, medicinal plants extracts, phytotherapics, and/or phytopharmaceuticals associated or not with antiretroviral therapy), to the primary outcome (in which was verified if there was a decreasing in lymphocytes, among which CD4+ cells), as well as terms that were used to improve sensitivity in a search for clinical trials. From 2.747 records of potential relevance identified on the databases, remaining two eligible randomized placebo-controlled clinical trials. The present systematic review and meta-analysis showed on the forest plot that there was no difference between control and intervention groups when the two included studies were taken into consideration.
Referências
Ayuba, G. I., Jensen, G. S., Benson, K, F., Okubena, A. M., & Okubena, O. (2014). Clinical Efficacy of a West African Sorghum bicolor-Based Traditional Herbal Preparation Jobelyn Shows Increased Hemoglobin and CD4+ T-Lymphocyte Counts in HIV-Positive Patients. J Altern Complement Med, 20(1), 53–56. https://doi.org/10.1089/acm.2013.0125
Bonolo, P. F., Gomes, R. R. F. M., & Guimarães, M. D. C. (2007). Adesão à terapia anti-retroviral (HIV/aids): fatores associados e medidas da adesão. Epidemiol Serv Saúde, 16(4), 261-278. http://dx.doi.org/10.5123/S1679-49742007000400005
Burack, J. H., Cohen, M. R., Hahn, J. A., & Abrams, D. I. (1996). Pilot randomized controlled trial of Chinese herbal treatment for HIV-associated symptoms. J Acquir Immune Defic Syndr Hum Retrovirol, 12(4), 386-393. https://doi.org/10.1097/00042560-199608010-00009
Costa, T. L., Oliveira, D. C., & Formozo, G. A. (2015). Qualidade de vida e AIDS sob a ótica de pessoas vivendo com o agravo: contribuição preliminar da abordagem estrutural das representações sociais. Cad Saúde Pública, 31(2). http://dx.doi.org/10.1590/0102-311X00180613
Dabaghzadeh, F., Khalili, H., Dashti-Khavidaki, S., Abbasian, L., & Moeinifard, A. (2014). Ginger for prevention of antiretroviral-induced nausea and vomiting: a randomized clinical trial. Expert Opin Drug Saf, 13(7), 859-866. https://doi.org/10.1517/14740338.2014.914170
Ellis, R. J., Toperoff, W., & Vaida, F., Brande, G. V. D., Gonzales, J., Gouaux, B., Bentley, H., & Atkinson, J. H. (2009). Smoked Medicinal Cannabis for Neuropathic Pain in HIV: A Randomized, Crossover Clinical Trial. Neuropsychopharmacology, 34(3), 672-680. https://doi.org/10.1038/npp.2008.120.
Fernandes, A. C., Cromarty, A. D., Albrecht, C., & Van Rensburg, C. E. (2004). The antioxidant potential of Sutherlandia frutescens. J Ethnopharmacol, 95(1): 1–5. https://doi.org/10.1016/j.jep.2004.05.024
Galarza, C., Ramos, W., Chía, H., Ronceros, G., Santiani, J., Gutiérrez, E., Ñavincopa, M., Vilcarromero M., Ávila J., Hancco J., & Gámez, D. (2007). Eficacia y seguridade de la terapia tópica com capsaicina 0,075% versus mentol 1% em el tratamento del prurito de la foliculitis eosinofílica associada al vírus de la inmunodeficiencia adquirida. An Fac Med Lima, 68(3), 244-248.
Gil Del Valle, L., Serrano López, T., Calderón Fuentes, O., Sánchez F. N., Peraza R. D. T., & Avila, J. P. Effect of Vimang in HIV/AIDS patients. Rev Cubana Med Trop, 62(3), 200-206. PMID: 23437549
Jiang, F., Zhang, R., Gu, Z., Zhang, H., Guo, H., Deng, X., & Liang, J. (2013). Fuzhengpaidu granule regulates immune activation molecules CD38 and human leukocyte antigen-D related on CD4+ and CD8+ T cells in patients with acquired immunodeficiency syndrome/human immunodeficiency virus. J Tradit Chin Med, 33(4), 439-443. https://doi.org/10.1016/s0254-6272(13)60145-4.
Joshi, S. N., Dutta S., Kumar, B. K., Katti, U., Kulkarni, S., Risbud, A., & Mehendale, S. (2008). Expanded safety study of Praneem polyherbal vaginal tablet among HIV-uninfected women in Pune, India: a phase II clinical trial report. Sex Transm Infect, 84(5), 343-347. https://doi.org/10.1136/sti.2007.029207.
Lemos, L. A., Feijão, A. R., Gir, E., & Galvão, M. T. G. (2012). Aspectos da qualidade de vida de pacientes com coinfecção HIV/tuberculose. Acta Paul Enferm, 25(1), 41-47. https://doi.org/10.1590/S0103-21002012000800007
Liu, J, P., Manheimer, E., & Yang, M. (2005). Herbal medicines for treating HIV infection and AIDS. Cochrane Database of Systematic Reviews, Cochrane Database Syst Rev, 20 (3), CD003937. https://doi.org/10.1002/14651858.CD003937.pub2.
Lu, W. B. (1994). Preventing and treating HIV/AIDS. Beijing: People's Medical Publishing Hourse, 170-181.
MacKenzie, J., Koekemoer, T., Van de Venter, M., Dealtry, G., Roux, S. (2009). Sutherlandia frutescens limits the development of insulin resistance by decreasing plasma free fatty acid levels. Phytother Res, 23 (11), 1609-1614. https://doi.org/10.1002/ptr.2830.
Marques, S. S. F., Libonati, R. M. F., & Sabaa-Srur, A. U. O., Luo, R., Shejwalkar, P., Hara, K., Dobbs, T., & Smith, R. E. (2016). Evaluation of the effects of passion fruit peel flour (Passiflora edulis fo. flavicarpa) on metabolic changes in HIV patients with lipodystrophy syndrome secondary to antiretroviral therapy. Rev Bras de Farmacogn, 26(4), 420-426. https://doi.org/10.1016/j.bjp.2016.03.002
Matsabisa, M. G., Sekhoacha, M. P., Ibrahim, O., Moodley, P., & Faber, M. (2012). Nutritional content and a phase-i safety clinical trial of a herbal nutritional supplement (imuniti) with putative immune-modulating properties. Afr J Tradit Complement Altern Med, 13(9), 19‐23. https://doi.org/10.4314/ajtcam.v9i3s.3.
Mills, E., Foster, B. C., & Van Heeswijk, R., Phillips, E., Wilson, K., Leonard, B., Kosuge, K., & Kanfer, I. (2005). Impact of African herbal medicines on antiretroviral metabolism. AIDS, 19(1), 95–97. https://doi.org/10.1097/00002030-200501030-00013.
Minocha, M., Mandava, N. K., & Kwatra, D., Pall, D., Folk, W. R., Earla, R., & Mitra, A. K. (2011). Effect of short term and chronicadministration of Sutherlandia frutescens on pharmacokinetics of nevirapine in rats. Int J Pharm, 413(1-2), 44-50. https://doi.org/10.1016/j.ijpharm.2011.04.051.
Nikolaeva, L. G., Maystat, T. V., Pylypchuk, V. S., Volyanskii, Y. L., Masyuk, L. A., & Ktsyna, G. A. (2008). Effect of oral immunomodulator Dzherelo in TB/HIV co-infected patients receiving anti-tuberculosis therapy under DOTS. Int Immunopharmacol, 8(6), 845-851. https://doi.org/10.1016/j.intimp.2008.01.029
Oladele. O. S., Olatunya, A. M., Anyabolu, H. C., Adejuyigbe, & E. A., Oyelami, O. A. (2012). Preliminary Trial of Aloe Vera Gruel on HIV infection. J Altern Complement Med., 18(9), 850-853. https://doi.org/10.1089/acm.2010.0735
Onifade, A. A., Jewell, A. P., Ajadi, T. A., Rahamon, S. K., & Ogunrin, O. O. (2013). Effectiveness of a herbal remedy in six HIV patients in Nigeria. J Herbal Med, 3(3), 99-103. https://doi.org/10.1016/j.hermed.2013.04.006
Pereira, M. G., & Galvão, T. F. (2014). Heterogeneidade e viés de publicação em revisões sistemáticas. Epidemiol Serv Saúde, 23(4), 775-778. http://dx.doi.org/10.5123/S1679-49742014000400021
Petrilli, A. A., Souza, S. J., & Teixeira, A. M., et al. (2016). Effect of Chocolate and Yerba Mate Phenolic Compounds on Inflammatory and Oxidative Biomarkers in HIV/AIDS Individuals. Nutrients, 8(5), 132. http://dx.doi.org/10.3390/nu8050132
Robinson, K. A., & Dickersin, K. (2002). Development of a highly sensitive search strategy for the retrieval of reports of controlled trials using PubMed. Int J Epidemiol, 31(1), 150-153. https://doi.org/10.1093/ije/31.1.150
Santos, E. J. F., & Cunha, M. (2013). Interpretação crítica dos resultados estatísticos de uma meta-análise: estratégias metodológicas. Millenium, 44: 85-98.
Shi-Qing, J., Hong-Xin, S., Ying-Min, X., Yan-Ling, J., Jun-Wen, P, Hong-Ling W. (2011). Effects of Jingyuankang Capsules (精元康胶囊) on Leukocyte Level in AIDS Patients. J Tradit Chin Med, 31(1), 32-35. https://doi.org/10.1016/s0254-6272(11)60007-1
Timmins, G. S., & Deretic, V. (2006). Mechanisms of action of isoniazid. Mol Microbiol, 62(5), 1220–1227. https://doi.org/10.1111/j.1365-2958.2006.05467.x
Tobwala, S., Fan, W., Hines, C. J., Folk, W. R., & Ercal, N. (2014). Antioxidant potential of Sutherlandia frutescens and its protective effects against oxidative stress in various cell cultures. BMC Complementary and Alternative Medicine, 14:271.
Turner, L., Boutron, I., Hróbjartsson, A., Altman, D. G., & Moher, D. (2013). The evolution of assessing bias in Cochrane systematic reviews of interventions: celebrating methodological contributions of the Cochrane Collaboration. Syst Rev, 2:79. https://doi.org/10.1186/2046-4053-2-79
Unaids, 2015. Unaids. Global AIDS response progress reporting 2015. http://www.unaids.org/sites/default/files/media_asset/JC2702_GARPR2015guidelines_en.pdf.
Unaids, 2017. https://unaids.org.br/wp-content/uploads/2017/07/20170720_Data_book_2017_Brasil.pdf
Vella, S., & Palmisano L. (2000). Antiretroviral therapy: state of the HAART. Antiviral Research, 45:1–7. https://doi.org/10.1016/S0166-3542(99)00068-6
Villela, W. V., & Barbosa, R. M. (2017). Trajetórias de mulheres vivendo com HIV/aids no Brasil. Avanços e permanências da resposta à Epidemia. Ciênc Saúde coletiva, 22(1), 87-96. https://doi.org/10.1590/1413-81232017221.14222016
Wang, J., Yang, F. Z, Zhao, M., Zhang, Y., Zhang, Y., Liu, Y., Liu, W., Wang, F., Xu, S., Yu, Z., Xie, Y., Zhou, X., & Jiang, T. (2006). Randomized Double-blinded and Controlled Clinical Trial on Treatment of HIV/AIDS by Zhongyan-4. Chin J Integr Med, 12(1), 6-11. https://doi.org/10.1007/BF02857422.
Weber, R., Christen, L., Loy, M., Schaller, S., Christen, S., Joyce, C. R., Ledermann, U., Ledergerber, B., Cone, R., Luthy, R., & Cohen, M. R. (1999). Randomized, placebo-controlled trial of Chinese herb therapy for HIV-infected individuals. JAIDS, 22(1), 56–64. https://doi.org/10.1097/00042560-199909010-00007
Wilson, D., Goggin, K, Williams, K., Gerkovich, M. M., Gqaleni, N., Bartman, P., Jonhson, Q., & Folk, W. R. (2015). Consumption of Sutherlandia frutescens by HIV-Seropositive South African Adults: An Adaptive Double-Blind Randomized Placebo Controlled Trial. PLoS One, 10(7)1, 14. https://doi.org/10.1371/journal.pone.0128522
Zanon, B. P., Almeida, P. B., Brum, C. N., Paula C. C., Padoin, S. M. M., & Quintana, A. M. (2016). Revelação do diagnnóstico de HIV dos pais. Rev Bioét, 24(3), 557-566. https://doi.org/10.1590/1983-80422016243155
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2022 Saskya Araújo Fonseca; Thiago José Matos Rocha; Ingrid Sofia Vieira de Melo; Nassib Bezerra Bueno; Aldenir Feitosa dos Santos; Antônio Euzébio Goulart de Sant’Ana
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
