Bisfosfonatos e suas indicações para prevenir a perda de densidade óssea na terapia contra o câncer

Autores

DOI:

https://doi.org/10.33448/rsd-v11i4.21577

Palavras-chave:

Fraturas por osteoporose; Osteoporose; Fraturas fechadas; Bone density conservation agents.

Resumo

Objetivo: Estabelecer um protocolo para pacientes medicados com bisfosfonatos, por meio de revisão da literatura, para evitar a osteonecrose e fornecer orientação profissional para a realização do tratamento adequado. Metodologia: Foram realizadas buscas on-line para a construção deste artigo, as quais incluíram como bases de dados Web of Science, PUBMED Central, BVS / BIREME, Science Direct, The Cochrane Library e também PROSPERO. Resultados: As seguintes características foram observadas na pesquisa deste protocolo: Medicamentos com propriedades antireabsorção, Inibidor de RANK-L, Agentes antiangiogênicos, Manifestações clínicas, Fatores de risco relacionados a medicamentos, Fatores de risco locais a serem observados, Fatores de risco sistêmicos e demográficos, Elevados fatores de risco considerados. Conclusões: Os bisfosfonatos podem ser uma terapia útil para pacientes com consequências orgânicas relacionadas à terapia aplicada com eles. Anamnese adequada e avaliação das condições sistêmicas dos pacientes que os utilizam são requisitos obrigatórios antes de sua prescrição.

Referências

Abtahi J., Agholme F., Aspenberg P. (2013). Prevention of osteonecrosis of the jaw by mucoperiosteal coverage in a rat model. International Journal Oral Maxillofacial Surgery, v. 5, n. 42, p. 632- 636.

Badros A. (2006). Osteonecrosis of the jaw in multiple myeloma patients: clinical features and risk factors. Journal of Clinical Oncology, 24(6), 945-952.

Beech N., Robinson S., Batstone M. (2014). Dental management of patients irradiated for head and neck cancer. Australian Dental Journal, 59(1), 20-28. https://doi.org/10.1111/adj.12134

Carter, G. D., Goss, A. N. (2003) Bisphosphonates and avascular necrosis of the jaws. Australian Dental Journal, 48(8), 268.

Choudhary M., Ahmed AA., Williamson JG (2003). Sole bladder metastasis from breast cancer. Journal of Obstetrics and Gynaecology, 23(2), 212.

Cranney A., Waldegger L., Zytaruk N., Shea B., Weaver B., Papaioannou A., Robinson V., Wells G., Tugwell P., Adachi JD., Guyatt G. (2004) Risedronate for the prevention and treatment of postmenopausal osteoporosis. Cochrane Database of Systematic Reviews, 2(7), 254. Doi: 10.1002/14651858.CD004523.

Delanian S., Depondt J., Lefaix JL. (2005). Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial. Head & Neck – Wiley Online Library, 27(3), 114–123.

Eid A., Atlas J. (2014). The role of bisphosphonates in medical oncology and their association with jaw bone necrosis. Oral Maxillofacial Surgery Clinics of North America, 26 (5), 231-237.

Eriksen EF., Díez-Pérez A., Boonen S. (2014). Update on long-term treatment with bisphosphonates for postmenopausal osteoporosis: a systematic review. Bone. 58, 126–35. doi:10.1016/j.bone.2013.09.023.

Gauthier K., Bai A., Perras C., Cunningham J., Ahuja T., Richter T., Kovacs C. (2012). Denosumab, Raloxifene, and Zoledronic Acid for the Treatment of Postmenopausal Osteoporosis: Clinical Effectiveness and Harms. Rapid Response Report: Systematic Review. PMID 24278999.

Gracis S. (2013) Prosthetic and biomechanical factors affecting bone remodeling around implants. The European Journal of Esthetic Dentistry, 8 (2), 313-314.

Hewitt C., Farah CS. (2007) Bisphosphonate – related osteonecrosis of the jaws: a comprehensive review. Journal of Oral Pathology & Medicine, 36 (4), 319-328.

Allen CS., Yeung JH., Vandermeer B., Homik J. (2004). Bisphosphonates for steroid induced osteoporosis. Cochrane Database of Systematic Reviews, 2 (4), 20. Doi: 10.1002/14651858.CD001347.pub2.

Hutchinson M., O´Ryan F., Chavez V., Lathon PV., Sanchez G., Hatcher SDC., Indresano AT., Lo JC. (2010). Radiographic findings in bisphosphonate-treated patients with stage 0 disease in the absence of bone exposure. Journal of Oral and Maxillofacial Surgery, 68 (9), 2232–2240. Doi: 10.1016/j.joms.2010.05.003.

Iyer, S., Balasubramanian, D. (2012). Management of radiation wounds. Indian Journal of Plastic Surgery, 45 (2), 325-331.

Key, J. E., Rahemtulla, F. G., Eleazer, P. D. (2006). Citotoxicity of a new root canal filling material on human gingival fibroblasts. Journal of Endodontics, 32 (8), 756-758.

Khosla, S. (2007). Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research. Journal of Bone and Mineral Research, 22 (10), 1479–1491.

Martins, M. A. T., Giglio, M., Martins, M. D., Pavesi, V. C. S., Lascala, C. A. (2009). Osteonecrose dos maxilares associada ao uso de bisfosfonatos: importante complicação do tratamento oncológico. Revista Brasileira de Hematologia e Hemoterapia, 31, (1), 41-46.

Maruotti ,N. (2012). Bisphosphonates: Effects on osteoblast. European Journal of Clinical Pharmacology, 68 (7),. 1013–1018.

Mawardi ,H. (2009). Sinus tracts – an early sign of bisphosphonate-associated osteonecrosis of the jaws? Journal Oral and Maxillofacial Surgery, 67, (8), 593-601.

Migliorati, C. A. (2005). Managing he care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper. The Journal of the American Dental Association, 136 (12), 1658-1668.

Nair, P. N. R. (2007). Falhas endodônticas: a patobiologia da periodontite apical pós-tratamento. In: Cohen S, Hargreaves KM. Caminhos da polpa. 9ª edição. Rio de Janeiro: Mosby. 918-43.

Otto, S. (2015). Osteonecroses maxilar associada a fármacos. Quintessence Internacional, 3 (2), 88-95.

Papapoulos, S. E., Cremers SC. (2007). Prolonged bisphosphonate release after treatment in children. The New England Journal of Medicine, 356, (10), 1075-1076.

Ruggiero, S. L. (2009). American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate related osteonecroses of the jaws 2009 update. Journal Oral and Maxillofacial Surgery, 2, (67), 2-12.

Ruggiero, T. (2014). Position Paper. American Association of Oral and Maxillofacial Surgery, 72 (10), 1938- 1940.

Ruggiero, S. L. (2014). Associação Americana Cirurgiões de Cirurgia Oral e Maxilofacial osteonecrose relacionada à medicação da mandíbula - atualização de 2014. Journal of Oral and Maxillofacial Surgery, 72 (10). 1938-1956.

Santos-Silva, A. R. (2013). Osteonecrosis of the mandible associated with bevacizumab therapy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 115 (4), 32-36.

Salvatore, L. (2014). American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw – 2014 Update. Journal of Oral Maxillofacial Surgery, 72 (10), 1938-1956.

Scully, C. (2013). Osteonecrosis mandibular relacionada con bifosfonatos. Diagnóstico diferencial por localización. LA Moreno López. Guía de Bolsillo de Enfermadades Orales 1. España: Elsevier, 157-328.

Serrano, A. J., Begoña, L., Anitua, E., Cobos, R., Orive, G. (2013). Systematic review and meta-analysis of the efficacy and safety of alendronate and zoledronate for the treatment of postmenopausal osteoporosis. Gynecol.Endocrinol. 29 (12): 1005–14. doi:10.3109/09513590.2013.813468. PMID 24063695. S2CID 20163452.

Sivolella, S. (2013). Denosumab and anti-angiogenetic drug-related osteonecrosis of the jaw: an uncommon but potentially severe disease. Anticancer Research, 33, (1), 1793-7.

Sjögren ,U., Sundgvist G., Nair P. N. R. Tisue reaction to guttapercha of various sizes when implanted subcutaneously in guinea pigs. European Journal of Oral Sciences,103 (5), 313-21.

Tarassoff P., Csermak K. Avascular necrosis of the jaws: risk factors in metastatic cancer patients. Journal Oral Maxillofacial Surgery, 61, (21), 1238-1239.

Tardasta A. (2015). Bisphosphonate associated osteomyelitis of the jaw in patients with bony exposure: prevention, a new way of thinking. Journal of Applied Oral Science, 23, (3), 310-11.

Tortora GJ., Funke BR., Case CL. (2000). Microbiologia. 6. ed. Porto Alegre: Artmed, 826-7.

Watts, N. B., Bilezikian, J. P., Camacho, P. M., Greenspan, S. L., Harris, S. T., Hodgson, S. F., Kleerekoper, M., Luckey, M. M., McClung, M. R., Pollack R. P., Petak, S. M. (2010). American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract. 16, 1–37. doi:10.4158/ep.16.s3.1. PMC 4876714. PMID 21224201.

Woo, S., Hellstein J., Kalmar J. (2006). Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws (PDF). Ann Intern Med. 144 (10): 753–61. doi:10.7326/0003-4819-144-10-200605160-00009. PMID 16702591. S2CID 53091343.

Yoneda, T. (2017). Antiresorptive agent-related osteonecrosis of the jaws: Position Paper 2017 of the Japanese Allied Committee on Osteonecrosis of the Jaw. Journal of Bone and Mineral Metabolism, 35 (4), 6-19.

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18/03/2022

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OLIVEIRA, K. L. de A. M. de .; SILVA, L. B. .; SAMPAIO, G. M. .; CUNHA, R. S. C. .; SANTOS NETO, A. P. dos .; FONSECA, F. L. de M. A. .; MARQUES FILHO, E. de Q. .; FREITAS, W. J. L. .; ATAÍDE FILHO, A. C. de .; MAIA, S. S. . Bisfosfonatos e suas indicações para prevenir a perda de densidade óssea na terapia contra o câncer. Research, Society and Development, [S. l.], v. 11, n. 4, p. e27611421577, 2022. DOI: 10.33448/rsd-v11i4.21577. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/21577. Acesso em: 23 dez. 2024.

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