Coagulopatia em gestantes com COVID-19

Autores

DOI:

https://doi.org/10.33448/rsd-v10i16.22040

Palavras-chave:

Gestantes; Coagulopatia; Doença sanguínea; Alterações hematológicas; COVID-19.

Resumo

A atual pandemia da COVID-19, causada pelo novo coronavírus SARSCoV-2, teve rápida disseminação e resultou em inúmeros casos fatais. A coagulopatia é uma das principais complicações dessa doença, sendo possível a ocorrência em qualquer paciente infectado pelo vírus; um dos grupos de risco, as pacientes obstétricas, requer maior atenção, devido às alterações coagulativas e hemostáticas já esperadas neste grupo. O objetivo da revisão foi realizar um levantamento bibliográfico de artigos que abordam a relação entre hipercoagulopatia e gestantes infectadas pelo vírus SARS-COV-2. A pesquisa foi efetuada nas bases de dados Google Acadêmico, Biblioteca Virtual em Saúde (BVS), Scientific Electronic Library Online (Scielo) e PubMed. Foram utilizados os seguintes descritores “gestantes”, “coagulopatia”, “doença sanguínea”, “COVID-19”, “alterações hematológicas”. Alterações de coagulação ocorrem em pacientes gestantes ou não infectadas pelo SARS-COV-2. As gestantes são um grupo mais susceptível à agravos, devido ao processo de hipercoagulabilidade que já ocorre naturalmente no período gestacional. Faz-se necessário mais estudos que evidenciem essa associação, a fim de prover os cuidados e atendimento adequados a tais pacientes.

Referências

Assunção, P., Costa, E & Dantas, E. (2017). Perfil epidemiológico das coagulopatias hereditárias no estado de alagoas no período de 2011 – 2015. Centro Universitário Tiradentes – UNIT.

Barca, D. et al. (2010). Hemovida web coagulopatias: um relato de seu processo de desenvolvimento e implementação. Hemovida web coagulopatias, 434-444.

Benhamou, D., Keita, H. & Ducloy-bouthors, A. S. (2020). Obstetric Anaesthesia and Critical Care Club Working Group (2020). Coagulation changes and thromboembolic risk in COVID-19 obstetric patients. Anaesthesia, critical care & pain medicine, 39 (3), 351–353. doi: 10.1016/j.accpm.2020.05.003.

Cubas, J. et al. (2020). Maternal mortality in pregnant woman with positive sars-cov-2 antibodies and severe preeclampsia. report of cases. Rev Peru Obstet. 2020; 66, 1-6.

Dashraath, P. et al. (2020). Coronavírus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol.

Geng, YJ et al. (2020). Pathophysiological characteristics and therapeutic approaches for pulmonary injury and cardiovascular complications of coronavirus disease 2019. Cardiovascular Pathology. 47..

Giannis, D., Ziogas, I. & Gianni, P. (2020) Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. Journal of Clinical Virology.

Gorziza, R. (2020). Avaliação laboratorial de coagulopatias e trombpfilias hereditárias. https://www.lume.ufrgs.br/bitstream/handle/10183/186447/Resumo_12373.pdf?sequence=l.

Gunduz, Z. (2021). Venous sinus thrombosis during COVID-19 infection in pregnancy: a case report. São Paulo Med J. doi: https://doi.org/10.1590/1516-3180.2020.0659.R1.08122020.

Iba, T. et al. (2020). Coagulopathy in COVID-19. J Thromb Haemost; 18, 2103– 2109. doi: https://doi.org/10.1111/jth.14975,

Iba, T. et al. (2020). Coagulopathy of Coronavirus Disease 2019. Critical care medicine, 48, (9), 1358-1364. doi: https://doi.org/10.1097/CCM.0000000000004458.

Javanmard, S., Heshmat-ghahdarijani, K. & Vaseghi, G. (2020). Angiotensin-converting-enzyme inhibitors (ACE inhibitors) and angiotensin II receptor blocker (ARB) use in COVID-19 prevention or treatment: A paradox. Infection Control & Hospital Epidemiology, 1-2.

Kadir, R. et al. (2020). Covid-19 coagulopathy in pregnancy: critical review, preliminary recommendations, and isth registry—communication from the isth ssc for women’s health. International Society on Thrombosis and Haemostasis. doi: doi: 10.1111/JTH.15072.

Kang, Y. et al. (2020). Cardiovascular manifestations and treatment considerations in COVID-19. Heart, 106(15), 1132-114.

Koumoutsea, E. et al. (2020). COVID-19 and acute coagulopathy in pregnancy. J Thromb Haemost, 18, 1648– 1652. doi: https://doi.org/10.1111/jth.14856.

Lin, L. et al. (2020). Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia. Emerging Microbes & Infections. 9(1), 727-732.

Makatsariya, A. et al. (2020). Thrombotic microangiopathy, DIC-syndrome and COVID-19: link with pregnancy prothrombotic state. The journal of maternal-fetal & neonatal medicine. doi: https://doi.org/10.1080/14767058.2020.1786811.

Ministério da Saúde (BR). (2002). Relatório estatístico do cadastro de coagulopatias hereditárias. Agência Nacional de Vigilância Sanitária (ANVISA). http://bvsms.saude.gov.br/bvs/publicacoes/perfil_coagulopatias_ hereditarias_2002.pdf.

Mongula, J. et al. (2020). Covid-19 during pregnancy: non-reassuring fetal heart rate, placental pathology and coagulopathy. Department of Obstetrics and Gynecology, Máxima Medical Centre. doi: https://doi.org/10.1002/uog.22189.

Moreira, A. et al. (2009). Fatores de risco associados a trombose em pacientes do estado do ceará. Revista brasileira de hematologia e hemoterapia, 132-136.

Nascimento, B., Scarpelini, S. & Rizoli, S. (2007). Coagulopatia no trauma. Medicina (Ribeirão Preto), 40 (4), 509-517. doi: 10.11606/issn.2176-7262.v40i4p509-517.

Nesr, G. et al. (2020). Immune thrombocytopenia flare with mild COVID-19 infection in pregnancy: A case report. British Society for Haematology and John Wiley & Sons Ltd. doi: https://doi.org/10.1111/bjh.16928.

Panigada, M. et al. (2020). Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis. J Thromb Haemost. https://pubmed.ncbi.nlm.nih.gov/32302438/.

Prabhu, M. et al. (2020). Pregnancy and postpartum outcomes in a universally tested population for sars-cov-2 in new york city: a prospective cohort study. An international Journal of obstetrics and gynecology – Royal College of obstetricians and gynecologists, p 1548 – 1556.

Ranucci, M. et al. (2020). The procoagulant pattern of patients with Covid-19 acute respiratory distress syndrome. J Thromb Haemost. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/32302448/.

Rodrigues, C., Baia, I., Domingues, R. & Barros, H. (2020). Pregnancy and breastfeeding during covid-19 pandemic: a systematic review of published pregnancy cases. Frontiers in public health, 8, 1-13.

Ronnie, L. et al. (2020). Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery. BMC Pregnancy Childbirth, 20, 511. doi: https://doi.org/10.1186/s12884-020-03172-8.

Rostami, M. & Mansouritorghabeh, H. (2020). D-dimer level in COVID-19 infection: a systematic review. Expert review of hematology, 13 (11), 1265–1275. doi: https://doi.org/10.1080/17474086.2020.1831383 .

Saposnik, G. et al. (2011). Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals. American Heart Association/American Stroke Association, 42 (4), 1158-92. doi: http://doi.org/10.1161/STR.0b013e31820a8364.

Servante, J. et al. (2021). Haemostatic and thrombo-embolic complications in pregnant women with COVID-19: a systematic review and critical analysis. BMC Pregnancy Childbirth, 21, 108. doi: https://doi.org/10.1186/s12884-021-03568-0.

Su, S. et al. (2016). Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses. Trends in Microbiology, 24 (6), 490-502.

Tang, N. et al. (2020). Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost, 18, 844–847. doi: https://pubmed.ncbi.nlm.nih.gov/32073213/.

Vivas, D. et al. (2020). Recomendaciones sobre el tratamiento antitrombótico durante la pandemia COVID-19. Posicionamiento del Grupo de Trabajo de Trombosis Cardiovascular de la Sociedad Española de Cardiología. Revista Española de Cardiología, 73(9), 749-757.

Wiersinga, W. et al. (2020). Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19). JAMA, 324(8), 782.

Wisniewski, D. & Kluthcovsky, A. (2008). O Perfil dos Pacientes Portadores de Coagulopatias de uma Região do Sul do Brasil. Cogitare Enferm. doi: http://dx.doi.org/10.5380/ce.v13i2.12485.

Xu, Y. et al. (2020). Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. Journal of Infection, 80(4), 394-400.

Yao, X. et al. (2020). Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient. Cell Research, 30(6), 541-543.

Zhu, N. et al. (2020). A novel Coronavirus from patients with pneumonia in China, 2019. N Eng J Med, 1-7. doi: 10.1056/NEJMoa2001017.

Zoller, M., Irlbeck, M. & Zwissler, B. (2020). Coronavirus Disease. Der Anaesthesist, 222-223.

Downloads

Publicado

04/12/2021

Como Citar

SANTOS, J. de L. .; ARAÚJO, T. S. .; TELIS, J. J. S. .; SANTOS, M. S. dos .; ALMEIDA, J. S. de .; SANTOS, T. G.; BERNARDES, N. B. . Coagulopatia em gestantes com COVID-19 . Research, Society and Development, [S. l.], v. 10, n. 16, p. e01101622040, 2021. DOI: 10.33448/rsd-v10i16.22040. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/22040. Acesso em: 22 jul. 2024.

Edição

Seção

Ciências da Saúde