Potential utilization of glycerol as crosslinker in starch films for application in Regenerative Dentistry

Simone Rodrigues; Mariana Fornazier; Denildo  Magalhães; Reinaldo Ruggiero

doi:10.33448/rsd-v10i16.23640

Autores

Simone Rodrigues Federal University of Uberlândia https://orcid.org/0000-0003-4466-2834
Mariana Fornazier Federal University of Uberlândia https://orcid.org/0000-0002-0218-5972
Denildo Magalhães Federal University of Uberlândia https://orcid.org/0000-0002-2428-682X
Reinaldo Ruggiero Federal University of Uberlândia https://orcid.org/0000-0001-7779-3457

DOI:

https://doi.org/10.33448/rsd-v10i16.23640

Palavras-chave:

Reticulação; Glicerol; Regeneração tecidual guiada; Amido.

Resumo

A doença periodontal resulta em danos ao aparelho de inserção dentária. Procedimentos regenerativos são propostos para substituir estruturas perdidas no contexto de técnicas de regeneração tecidual guiada (GTR), regeneração óssea guiada (GBR) e frequentemente associam substitutos ósseos a barreiras físicas visando maior longevidade e melhoria do padrão estético. Este estudo avalia a possibilidade da utilização do glicerol como agente modificador de filmes de amido, atuando como agente reticulante, sem comprometer seu efeito plastificante. Filmes biodegradáveis de amido de mandioca foram preparados incorporando glicerol nas concentrações de 0, 15, 20, 30 e 40% visando aplicação em procedimentos regenerativos odontológicos. A caracterização dos filmes por microscopia (SEM), análise térmica (DSC), espectroscópica (UV / Vis., FTIR, XRD), mecânica (Tração), e análise de intumescimento, degradação e difusão e temperatura fisiológica de proteínas mostraram que a incorporação de glicerol em até 20% atribuiu aos filmes um caráter plastificante e em maiores concentrações, conferiu uma maior interação do glicerol (reticulação) com as cadeias de amido e um tempo de degradação que permite a barreira física em RTG e ROG. Os filmes apresentaram resistência mecânica, maleabilidade e permissividade à difusão de proteínas nos ensaios in vitro, que atendem aos atuais atributos que norteiam a utilização desses recursos em biomateriais.

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Potencial utilização de glicerol como reticulador em filmes de amido para aplicação em Odontologia Regenerativa

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