Diagnóstico molecular e sorológico da leptospirose: uma revisão (2014–2020)
DOI:
https://doi.org/10.33448/rsd-v11i2.25471Palavras-chave:
Testes sorológicos; Testes imunoquímicos; Diagnóstico molecular; Leptospirose; Proteínas recombinantes.Resumo
A leptospirose é uma zoonose causada por bactérias patogênicas do gênero Leptospira. Esta doença afeta vários animais e humanos. Os sintomas da leptospirose podem variar de leves a graves, podendo em alguns casos levar à morte. Para o diagnóstico de leptospirose, o teste de aglutinação microscópica é considerado o “padrão ouro”; entretanto, apresenta limitações e estudos estão sendo realizados para desenvolver métodos alternativos de rastreamento e diagnóstico da leptospirose. Testes sorológicos e imunoquímicos utilizando antígenos recombinantes de Leptospira, em combinação com testes moleculares, podem ser uma alternativa. Neste estudo, relatamos os avanços alcançados de 2014 a 2020 no controle da leptospirose com base em testes sorológicos com antígenos recombinantes e diagnóstico molecular.
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