Mortalidade e alterações de parâmetros laboratoriais na presença de culturas positivas para bactérias e fungos em pacientes críticos com COVID-19 em hospital terciário de ensino de Mato Grosso do Sul, Brasil
DOI:
https://doi.org/10.33448/rsd-v11i2.25992Palavras-chave:
COVID-19; Prognóstico; D-dímero; Perfil microbiológico.Resumo
O objetivo do presente estudo foi avaliar a mortalidade e as alterações de parâmetros laboratoriais na presença de culturas positivas para bactérias e fungos em pacientes COVID-19 positivos admitidos nos CTIs, em um hospital terciário de ensino de Mato Grosso do Sul. Trata-se de um estudo observacional retrospectivo realizado por meio de coleta de dados clínicos e laboratoriais de pacientes adultos admitidos nos CTIs, com diagnóstico confirmado para SARS-CoV-2, entre os meses de julho e agosto de 2020. A presença de ao menos uma cultura positiva em pacientes críticos com COVID-19 foi associada a maiores taxas de mortalidade, maiores períodos de internação, e a maiores níveis de D-dímero e PCR. Pacientes do sexo masculino foram mais propensos a culturas positivas, e idades mais avançadas foram associadas a contagens plaquetárias mais baixas. Contagens de leucócitos mais elevadas e contagens plaquetárias mais baixas foram também associadas a maiores taxas de mortalidade. As culturas que apresentaram maior taxa de positividade foram as culturas de aspirado traqueal. Os principais microrganismos encontrados nos exames de cultura foram a levedura Candida albicans e as espécies de Staphylococcus coagulase negativas. As bactérias Acinetobacter baumannii e Klebsiella pneumoniae destacaram-se por apresentarem perfis de resistência mais frequentes. Nota-se, portanto, a importância da adoção de medidas que previnam infecções hospitalares secundárias em pacientes com COVID-19 e o desenvolvimento de mecanismos de resistência por microrganismos de relevância clínica. O laboratório destaca-se na identificação desses microrganismos e no direcionamento para o uso de antibióticos e antifúngicos mais apropriados para cada caso específico.
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Copyright (c) 2022 Giulia Rodrigues Stringhetta; Bruna Abdul Ahad Saad; Eliane Borges de Almeida
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
