A história de doença periodontal é um fator de risco para o declínio do estado cognitivo? Revisão Sistemática e Meta-análise
DOI:
https://doi.org/10.33448/rsd-v11i5.27931Palavras-chave:
Doença de Alzheimer; Declínio Cognitivo; Doença Periodontal; Perda de dente.Resumo
The aim of the study was to verify through a systematic review and meta-analysis whether the History of Periodontal Disease (HPD) is a risk factor for cognitive decline. Bibliographic searches in PubMed, Scopus, Web of Science and Cochrane databases totaled 378 records, after removing duplicates. Observational studies that verified HPD and/or tooth loss (≥22) resulting from HPD were selected to investigate an association with the decline in cognitive status. The quantitative synthesis resulted in two meta-analyzes (MA). MA1 (n=5) considered measures of association between HPD and decreased cognitive status; while MA2 (n=7) considered measures of association between tooth loss and decreased cognitive status. Meta-analyses were performed using the OpenMetaAnalyst software, using dichotomous random effects (p<0.05). Both meta-analyses showed that periodontal disease (OR=3.371; 95% CI=1.823-6.232; I²=65.42%) and tooth loss (OR=1.875; 95% CI=1.355-2.596; I²=56.74%) were related to the decline in cognitive status, as measured by the Mini-Mental State Examination. Patients with HPD and tooth loss resulting from periodontitis are more likely to deteriorate cognitive status, with possible association with Alzheimer's Disease.
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