A proteômica por trás das alterações clínicas e temporais na Doença de Parkinson: uma revisão de literatura
DOI:
https://doi.org/10.33448/rsd-v11i5.28475Palavras-chave:
Doença de Parkinson; Proteínas PARK; Percepção temporal.Resumo
A Doença de Parkinson (DP) é caracterizada pela neurodegeneração progressiva dos neurônios dopaminérgicos, de caráter crônico e resultante em distúrbios do movimento e comportamentais. Ainda há muitas lacunas sobre a etiologia e patogenia da DP. Desse modo, visando fortalecer evidências que sirvam de ferramenta para auxílio diagnóstico e futuros tratamentos, esta revisão sistemática tem como objetivo relacionar e analisar estudos de proteômica das PARK, ou seja, da classe de proteínas parks expressas que estejam associadas a patogênese, alterações clínicas e temporais da DP. Foram selecionados 261 trabalhos para análise de elegibilidade com base em seu título e resumo, resultando em 56 trabalhos, com leitura completa, incluídos nesse estudo. O resultado observado direciona para a compreensão da expressão genética para uma classe de proteínas que participam das vias metabólicas celulares associadas a etiologia da DP. Estudos genéticos aplicados a proteômica investigaram loci ligados à doença dos genes PARK e sua expressão gênica para assim relacionar as vias celulares que contribuem para a DP. Observou-se que as proteínas PARK corroboram para a patogenia da DP, destacamos a hipótese de alteração na percepção do tempo. Portanto, estudos exploratórios e sistemáticos podem direcionar futuras investigações e fortalecer evidências aplicadas a clínica.
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Copyright (c) 2022 Valécia Natália Carvalho da Silva; Francisco Magalhães; Jacks Renan Neves Fernandes; Antonio Thomaz de Oliveira; Hoanna Izabely Rego Castro; Thayaná Ribeiro Silva Fernandes ; Valéria de Fátima Veras de Castro
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