Avaliação dos modelos experimentais em ratos para indução de isquemia ovariana
DOI:
https://doi.org/10.33448/rsd-v11i14.36012Palavras-chave:
Torção ovariana; Traumatismo por reperfusão; Ratos.Resumo
As emergências ginecológicas são bastantes comuns, e a torção ovariana constitui a principal situação encontrada. Suas consequências podem ir de dor pélvica aguda unilateral até ocasionar infertilidade feminina, e para que isso seja evitado são necessários estudos os mais fidedignos possíveis. Assim, objetivou-se avaliar as técnicas utilizadas na isquemia ovariana em ratos. A partir disso foi feita uma análise dos métodos mais usados, análises bioquímicas e histopatológicas mais frequentes, para que pudesse estabelecer uma comparação com aqueles que podem ser mais eficientes na realização de estudos para amenizar os problemas causados pela torção ovariana. Foi feita uma pesquisa nas plataformas Pubmed, Scielo e Lilacs, nos anos de 2017 a 2022, com os descritores “ovarian torsion”, “Reperfusion injury” e “rats”, e selecionou 50 artigos. Os resultados foram que em 62% dos artigos utilizaram clamp vascular, o principal marcador bioquímico foi malondialdeído em 70%, e os marcadores histopatológicos foram relacionados com a integridade tecidual, como degeneração folicular, edema, infiltração leucocitária e congestão vascular. Dessa forma, pode-se inferir que são os métodos mais eficazes para simular isquemia ovariana.
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