Child-juvenile primary hyperidrose treatment: a integrative review
DOI:
https://doi.org/10.33448/rsd-v12i4.41231Keywords:
Hyperhidrosis; Pediatrics; Therapeutics.Abstract
Objective: To highlight the main treatments performed for primary hyperhidrosis in children and adolescents up to 19 years of age. Methods: This is an integrative literature review, through articles published in the PubMed and MEDLINE databases that addressed the theme. Results: Hyperhidrosis is a chronic condition in which there is excessive sweat production in some regions of the body, such as armpits, palms, soles and craniofacial areas. Despite being a disease that mostly affects adults, it is in children that the negative effects become potentiated during biopsychosocial development. However, although it is a treatable condition, a large part of the population, especially the pediatric population, does not adhere to therapy due to lack of information about their own disease and existing treatments. Thus, based on the analyzed articles, a good response and few adverse effects were observed in the use of botulinum toxin type A for the initial treatment of pediatric patients. In addition, the use of anticholinergics such as oxybutynin and glycopyrronic torsylate, iontophoresis and video-assisted thoracoscopic sympathectomy stand out as possible treatments for hyperhidrosis in childhood, with good efficacy and improvement in quality of life. Final considerations: There is a scarcity of data on the treatment of pediatric patients with primary hyperhidrosis, with the need for further studies to assess the real indication, risks and benefits of surgical treatment in pediatric patients. Added to this, there are well-indicated non-surgical treatments, with good response and few adverse effects.
References
Adorisio, O., Davoli, E., Ceriati, E., Battaglia, S., Camanni, D., & De Peppo, F. (2022) Effectiveness of unilateral sequential video-assisted sympathetic chain blockage for primary palmar hyperidrosis in children and adolescents. Front Pediatr. 23(10), 1067141. 10.3389/fped.2022.1067141. P
Coutinho L.H.S., Gomes, A.M., Giraldi, S., Abagge, K.T., & Marinoni, L.P. (2009). Palmar hyperhidrosis: long-term follow-up of nine children and adolescents treated with botulinum toxin type A. Pediatr Dermatol.;26(4):439-44. 10.1111/j.1525-1470.2009.00949.x.
Del Boz, J., Millán-Cayetano, J.F., Blázquez-Sánchez, N., & de Troya, M. (2016). Individualized Dosing of Oral Oxybutynin for the Treatment of Primary Focal Hyperhidrosis in Children and Teenagers. Pediatr Dermatol.;33(3):327-31. 10.1111/pde.12857.
Dogruk, K.S., Ozuguz, P., Eroglu, S., Polat, S., & Karaca, S. (2014). Treatment of primary hyperhidrosis with tap water iontophoresis in paediatric patients: a retrospective analysis. Cutan Ocul Toxicol.;33(4):313-6. 10.3109/15569527.2013.875559.
Glaser, D.A., Hebert, A.A., Nast, A., Werschler, W.P., Green, L., Mamelok, R.D., Quiring, J., Drew, J., & Pariser, D.M. (2019). A 44-Week Open-Label Study Evaluating Safety and Efficacy of Topical Glycopyrronium Tosylate in Patients with Primary Axillary Hyperhidrosis. Am J Clin Dermatol.;20(4):593-604. 10.1007/s40257-019-00446-6.
Hebert, A.A., Glaser, D.A., Green, L., Werschler, W.P., Forsha, D.W., Drew, J., Gopalan, R., & Pariser, D.M. (2019). Glycopyrronium tosylate in pediatric primary axillary hyperhidrosis: Post hoc analysis of efficacy and safety findings by age from two phase three randomized controlled trials. Pediatr Dermatol. 36(1):89-99. 10.1111/pde.13723.
Hebert, A.A., Glaser, D.A., Green, L., Hull, C., Cather, J., Drew, J., Gopalan, R., & Pariser, D.M. (2020). Long-term efficacy and safety of topical glycopyrronium tosylate for the treatment of primary axillary hyperhidrosis: Post hoc pediatric subgroup analysis from a 44-week open-label extension study. Pediatr Dermatol.;37(3):490-497. 10.1111/pde.14135.
Lima, S., Almeida, M. T. B., Rocha, F. R., Santos, R. S., Andrade, R. L. B., & Jesus, C. V. F. (2019). Perfil Epidemiológico e Qualidade de Vida dos Estudantes de Medicina. Revista Brasileira de Educação Médica, 43 (1): 387-394.
Lima, S., Jesus, C.V.F., Ferrari, Y.A.C., Santos, R.S., Dias, E.S., Menezes, L.O., Silva, R.N., Andrade, R.L.B., Carvalho, F.M.A., & Santana, V.R. (2020). Prevalência de hiperidrose primária e fatores associados em uma capital do nordeste do Brasil: estudo baseado em população. Revista Eletrônica Acervo Saúde, 12 (9): e3815.
Laje, P., Rhodes, K., Magee, L., & Klarich, M.K. (2017). Thoracoscopic bilateral T3 sympathectomy for primary focal hyperhidrosis in children. J Pediatr Surg.;52(2):313-316. 10.1016/j.jpedsurg.2016.11.030.
Lamb, Y.N. (2019). Topical Glycopyrronium Tosylate in Primary Axillary Hyperhidrosis: A Profile of Its Use. Clin Drug Investig.;39(11):1141-1147. 10.1007/s40261-019-00853-x. Erratum in: Clin Drug Investig. 40(1):103.
Mirkovic, S.E., Rystedt, A., Balling, M., & Swartling, C. (2018). Hyperhidrosis Substantially Reduces Quality of Life in Children: A Retrospective Study Describing Symptoms, Consequences and Treatment with Botulinum Toxin. Acta Derm Venereol. 98(1):103-107. 10.2340/00015555-2755.
Mol, A., & Muensterer, O. J. (2021). Over a decade of single-center experience with thoracoscopic sympathicolysis for primary palmar hyperhidrosis: a case series. Surgical endoscopy, 35(7), 3313–3319. https://doi.org/10.1007/s00464-020-07769-0
Neves, S., Pires-Davidson, J.R., Leiderman, D.B.D., & Wolosker, N. (2018). Hyperhidrosis in Children. In: Hyperhidrosis. Springer, Cham,: 39-44.
Neves, S., Uchoa, P.C., Wolosker, N., Munia, M.A., Kauffman, P., de Campos, J.R., & Puech-Leão, P. (2012). Long-term comparison of video-assisted thoracic sympathectomy and clinical observation for the treatment of palmar hyperhidrosis in children younger than 14. Pediatr Dermatol.;29(5):575-9. 10.1111/j.1525-1470.2012.01751.x.
Pariser, D. M., Lain, E. L., Mamelok, R. D., Drew, J., & Mould, D. R. (2021). Limited Systemic Exposure with Topical Glycopyrronium Tosylate in Primary Axillary Hyperhidrosis. Clinical pharmacokinetics, 60(5), 665–676. https://doi.org/10.1007/s40262-020-00975-y
Pariser, D.M., Glaser, D.A., Hebert, A.A., Nast, A., Werschler, W.P., Green, L., Mamelok, R., Drew, J., & Quiring, J., (2019). Topical glycopyrronium tosylate for the treatment of primary axillary hyperhidrosis: Results from the ATMOS-1 and ATMOS-2 phase 3 randomized controlled trials. J Am Acad Dermatol.;80(1):128-138.e2. 10.1016/j.jaad.2018.07.002.
Park, H. H., Conic, R. R. Z., Zhang, S., Lieu, A., Haft, M., & Hightower, G. K. (2021). Oral glycopyrrolate for primary focal hyperhidrosis in a pediatric population: A cross-sectional study. JAAD international, 4, 65–66. https://doi.org/10.1016/j.jdin.2021.07.002
Pecha, J.D., Yen, K.G., Moisiuc, A., & Cantor, A. (2022). Anisocoria secondary to antiperspirant wipes in a pediatric population: a case series. J AAPOS.;26(1):42-43. 10.1016/j.jaapos.2021.08.301.
Reis, G.M.D., Guerra, A.C.S., & Ferreira, J.P.A. (2011). “Estudo De Pacientes Com Hiperidrose, Tratados Com Toxina Botulínica: Análise Retrospectiva De 10 Anos”. Revista Brasileira De Cirurgia Plástica, vol. 26, no. Rev. Bras. Cir. Plást., 2011 26(4), Sociedade Brasileira de Cirurgia Plástica, 26 (4). doi:10.1590/S1983-51752011000400008
Souza, M.T., Silva, M.D., & Carvalho, R. (2010). Revisão integrativa: o que é e como fazer. Einstein (São Paulo), 8 (1). 10.1590/S1679-45082010RW1134
Stuart, M. E., Strite, S. A., & Gillard, K. K. (2020). A systematic evidence-based review of treatments for primary hyperhidrosis. Journal of drug assessment, 10(1), 35–50. https://doi.org/10.1080/21556660.2020.1857149
Verhaegh, A. J. F. P., Kuijpers, M., Boon, M., DeJongste, M. J. L., Bouma, W., Mariani, M. A., & Klinkenberg, T. J. (2020). Thoracoscopic sympathicotomy for the treatment of intolerable palmar and axillary hyperhidrosis in children is associated with high recurrence rates. Pediatric dermatology, 37(5), 987–992. https://doi.org/10.1111/pde.14273
Wolosker, N., Schvartsman, C., Krutman, M., Campbell, T.P., Kauffman, P., de Campos, J.R., & Puech-Leão, P. (2014). Efficacy and quality of life outcomes of oxybutynin for treating palmar hyperhidrosis in children younger than 14 years old. Pediatr Dermatol.;31(1):48-53. 10.1111/pde.12142.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Isabella Bittencourt Oliveira Nascimento; Gabriel Ferreira Setton Matias; Laíse Andrade Oliveira; Beatriz Bittencourt Oliveira Nascimento; Daniel Oliveira Santos ; Maria Bernadete Galrão de Almeida Figueiredo
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
