Características Clínico-Patológicas do Carcinoma de Células Renais no Prof. I.G.N.G. Hospital Geral de Ngoerah 2018 – 2022

Autores

DOI:

https://doi.org/10.33448/rsd-v12i13.44402

Palavras-chave:

Carcinoma de células renais; Epidemiologia; Característica.

Resumo

O CCR é um tumor que se manifesta nas células epiteliais do túbulo proximal e é responsável por 3% do total de casos neoplásicos em adultos. Na Indonésia, os casos de CCR ainda são considerados baixos, mas mostram uma tendência a aumentar anualmente. O objetivo deste estudo é fornecer uma descrição das características clinicopatológicas dos pacientes com CCR no Prof. I.G.N.G. Hospital Geral Ngoerah na província de Bali de 2018 a 2022. Este é um estudo transversal que implementou amostragem total na coleta de dados secundários do laboratório de anatomia patológica do Prof. I.G.N.G. Hospital Geral de Ngoerah. Houve 38 casos de CCR de um total de 108 casos renais submetidos a exames histopatológicos. A análise descritiva mostrou que a maioria dos casos de CCR foi encontrada na faixa etária de 51 a 60 anos (36,8%), sexo masculino (76,3%), lateralidade do tumor esquerdo (57,9%), procedimentos operatórios para coleta de espécimes (94,7%), subtipo CCRcc (63,2%), tamanho tumoral >10 cm (50,0%), grau III – IV (57,9%) e estágio pT3a (47,4%). A combinação desses achados clínico-patológicos sugeriu que os pacientes com CCR em Bali demonstraram estar associados a pior prognóstico e deveriam considerar estudos analíticos adicionais.

Referências

Anand, S., Barsouk, A., & Chaitanya, K. (2020). Epidemiology of Renal Cell Carcinoma. World Journal of Oncology, 11(3), 79–87. https://doi.org/10.14740/wjon1279

Andreotti, G., Freeman, L. E. B., Shearer, J. J., Lerro, C. C., Koutros, S., Parks, C. G., Blair, A., Lynch, C. F., Lubin, J. H., Sandler, D. P., & Hofmann, J. N. (2020). Occupational Pesticide Use and Risk of Renal Cell Carcinoma in the Agricultural Health Study. Environmental Health Perspectives, 128(6), 1–10. https://doi.org/10.1289/EHP6334

Brannon, A. R., Haake, S. M., Hacker, K. E., Pruthi, R. S., Wallen, E. M., Nielsen, M. E., & Rathmell, W. K. (2012). Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology. European Urology, 61(2), 258–268. https://doi.org/10.1016/j.eururo.2011.10.007.Meta-analysis

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global Cancer Statistics 2018 : GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492

Capitanio, U., Coleman, J., Gore, J. L., Sun, M., Wood, C., Russo, P., & Novara, G. (2019). Epidemiology of Renal Cell Carcinoma. European Urology, 75(1), 74–84. https://doi.org/10.1016/j.eururo.2018.08.036

Carrero, J. J., Hecking, M., Chesnaye, N. C., & Jager, K. J. (2018). Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease. Nature Reviews Nephrology, 14(3), 151–164. https://doi.org/10.1038/nrneph.2017.181

Chen, Y., Sun, Y., Rao, Q., Xu, H., Li, L., & Chang, C. (2015). Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status. Oncotarget, 6(31), 31203–31215. https://doi.org/10.18632/oncotarget.4522

Doumas, M., Papademetriou, V., Faselis, C., & Kokkinos, P. (2013). Gender Differences in Hypertension : Myths and Reality. Current Hypertension Reports, 15(4), 321–330. https://doi.org/10.1007/s11906-013-0359-y

Duha, D. A., Harahap, E. U., Santoso, R. B., & Bramono, I. A. (2022). Kidney Cancer Profile in National Cancer Center ( NCC ) - Dharmais Cancer Hospital. Indonesian Journal of Cancer, 16(4), 226–230. https://doi.org/10.33371/ijoc.v16i4.904

Dy, G. W., Gore, J. L., Forouzanfar, M. H., Naghavi, M., Fitzmaurice, C., & Catto, J. (2017). Global Burden of Urologic Cancers , 1990 – 2013. European Urology, 71(3), 437–446. https://doi.org/10.1016/j.eururo.2016.10.008

Gelfond, J., Al-bayati, O., Kabra, A., Iffrig, K., Kaushik, D., & Liss, M. A. (2018). Modifiable risk factors to reduce renal cell carcinoma incidence : Insight from the PLCO trial. Urologic Oncology: Seminars and Original Investigations, 36(7), 340. https://doi.org/10.1016/j.urolonc.2018.04.011

Guo, S., Yao, K., He, X., Wu, S., Ye, Y., Chen, J., & Wu, C.-L. (2019). Prognostic significance of laterality in renal cell carcinoma : A population ‐ based study from the surveillance , epidemiology , and end results (SEER) database. Cancer Medicine, 8(12), 5629–5637. https://doi.org/10.1002/cam4.2484

Halverson, S. J., Kunju, L. P., Bhalla, R., Gadzinski, A. J., Alderman, M., Miller, D. C., Montgomery, J. S., Weizer, A. Z., Wu, A., Hafez, K. S., & Wolf Jr, J. S. (2013). Accuracy of Determining Small Renal Mass Management with Risk Stratified Biopsies : Confirmation by Final Pathology. The Journal of Urology, 189(2), 441–446. https://doi.org/10.1016/j.juro.2012.09.032

Hew, M. N., Zonneveld, R., Kümmerlin, P. E. D., Opondo, D., Rosette, J. J. M. C. H. De, & Laguna, M. P. (2012). Age and gender related differences in renal cell carcinoma in a European cohort. The Journal of Urology, 188(1), 33–38. https://doi.org/10.1016/j.juro.2012.02.2573

Howlander, N., Noone, A., Krapcho, M., Miller, D., Brest, A., Yu, M., Ruhl, J., Tatalovich, Z., Mariotto, A., Lewis, D., Chen, H., Feuer, E., & Cronin, K. (2020). SEER Cancer Statistics Review (CSR) 1975-2016. National Cancer Institute; National Cancer Institute. https://seer.cancer.gov/csr/1975_2016/

Keegan, K. A., Schupp, C. W., Chamie, K., Hellenthal, N. J., Evans, C. P., & Koppie, T. M. (2012). Histopathology in Surgically Treated Renal Cell Carcinoma: Survival Differences by Subtype and Stage. The Journal of Urology, 188(2), 391–397. https://doi.org/10.1016/j.juro.2012.04.006.Histopathology

Klatte, T., Rossi, S. H., & Stewart, G. D. (2018). Prognostic factors and prognostic models for renal cell carcinoma : a literature review. World Journal of Urology, 36(12), 1943–1952. https://doi.org/10.1007/s00345-018-2309-4

Kurban, L. A. S., Vosough, A., Jacob, P., Prasad, D., Lam, T., Scott, N., Somani, B. K., & Somani, B. K. (2017). Pathological nature of renal tumors ‑ does size matter ? Urology Annals, 9(4), 330–334. https://doi.org/10.4103/UA.UA_17_17

Laskar, R. S., Muller, D. C., Li, P., Machiela, M. J., Ye, Y., Gaborieau, V., Foll, M., Hofmann, J. N., Colli, L., Sampson, J. N., Wang, Z., Anne, D. B., Behnoush, B., Durand, A. G., Le, F., Robinot, N., Blanche, H., Prokhortchouk, E., Skryabin, K. G., & Scelo, G. (2019). Sex specific associations in genome wide association analysis of renal cell carcinoma. European Journal of Human Genetics, 27(10), 1589–1598. https://doi.org/10.1038/s41431-019-0455-9

Macleod, L. C., Hotaling, J. M., Wright, J. L., Davenport, M. T., Gore, J. L., Harper, J., & White, E. (2013). Risk Factors for Renal Cell Carcinoma in the Vitamin and Lifefstyle (VITAL) Study. The Journal of Urology, 190(5), 1657–1661. https://doi.org/10.1016/j.juro.2013.04.130.Risk

Mancini, M., Righetto, M., & Baggio, G. (2020). Gender-Related Approach to Kidney Cancer Management : Moving Forward. International Journal of Molecular Sciences, 21(9), 3378. https://doi.org/10.3390/ijms21093378

Melisa, J., Monoarfa, A., & Tjandra, F. (2016). Profil penderita karsinoma sel ginjal (renal cell carcinoma) di RSUP Prof. Dr. R. D. Kandou Manado periode 2013-2015. E-CliniC, 4(2). https://doi.org/10.35790/ecl.v4i2.14501

Merchán-Hamann, E., & Tauil, P. L. (2021). Proposal for classifying the different types of descriptive epidemiological studies. Epidemiology and Health Services, 30(1). https://doi.org/10.1590/S1679-49742021000100026

Moch, H., Amin, M. B., Argani, P., Cheville, J., Delahunt, B., Martignoni, G., Medeiros, L. J., Srigley, J. R., Tan, P. H., & Tickoo, S. K. (2016). Introduction. In H. Moch, P. A. Humphrey, T. M. Ulbright, & V. E. Reuter (Eds.), WHO Classification of Tumours of the Urinary System and Male Genital Organs (4th Ed., pp. 14–17). World Health Organization.

Mutuiri, A., & Gakinya, S. (2022). Clinicopathologic features of renal cell carcinomas seen at the Aga Khan University Hospital in Kenya. Frontiers in Medicine, 9, 981305. https://doi.org/10.3389/fmed.2022.981305

Noh, S. J., Kang, M. J., Kim, K. M., Bae, J. S., Park, H. S., Moon, W. S., Chung, M. J., Lee, H., Lee, D. G., & Jang, K. Y. (2013). Acetylation status of P53 and the expression of DBC1 , SIRT1 , and androgen receptor are associated with survival in clear cell renal cell carcinoma patients. Pathology, 45(6), 574–580. https://doi.org/10.1097/PAT.0b013e3283652c7a

Pallagani, L., Choudhary, G. R., Himanshu, P., Madduri, V. K. S., Gupta, P., Shrivastava, N., Baid, G., Meenakshi, R., Aasma, N., & Sanjeev, M. (2021). Epidemiology and Clinicopathological Profile of Renal Cell Carcinoma : A Review from Tertiary Care Referral Centre. Journal of Kidney Cancer and VHL, 8(1), 1–6. https://doi.org/10.15586/jkcvhl.2021.154

Peired, A. J., Antonelli, G., Angelotti, M. L., Allinovi, M., Guzzi, F., Sisti, A., Semeraro, R., Conte, C., Mazzinghi, B., Nardi, S., Melica, M. E., Chiara, L. De, Lazzeri, E., Lasagni, L., Lottini, T., Landini, S., Giglio, S., Mari, A., Maida, F. Di, … Romagnani, P. (2020). Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells. Science Translational Medicine, 12(536), 1–17. https://doi.org/10.1126/scitranslmed.aaw6003

Peired, A. J., Campi, R., Angelotti, M. L., Antonelli, G., Conte, C., Lazzeri, E., Becherucci, F., Calistri, L., Serni, S., & Romagnani, P. (2021). Sex and Gender Differences in Kidney Cancer : Clinical and Experimental Evidence. Cancers, 13(18), 4588. https://doi.org/10.3390/cancers13184588

Pesch, B., Haerting, J., Ranft, U., Klimpel, A., Oelschlägel, B., & Schill, W. (2000). Occupational risk factors for renal cell carcinoma : agent-specific results from a case-control study in Germany. International Journal of Epidemiology, 29(6), 1014–1024. https://doi.org/10.1093/ije/29.6.1014

Rabjerg, M., Gerke, O., Engvad, B., & Marcussen, N. (2021). Comparing World Health Organization / International Society of Urological Pathology Grading and Fuhrman Grading with the Prognostic Value of Nuclear Area in Patients with Renal Cell Carcinoma. Uro, 1(1), 2–13. https://doi.org/10.3390/uro1010002

Seno, D. W. H., Mochtar, C. A., & Umbas, R. (2011). Terapi Sistemik Terkini pada Karsinoma. Indonesian Journal of Cancer, 5(3). https://doi.org/10.33371/ijoc.v5i3.151

Setiawan, V. W., Kolonel, L. N., & Henderson, B. E. (2009). Menstrual and Reproductive Factors and Risk of Renal Cell Cancer in the Multiethnic Cohort. Cancer Epidemiology, Biomarkers & Prevention, 18(1), 337–340. https://doi.org/10.1158/1055-9965.EPI-08-0790.Menstrual

Shrestha, D., Liu, S., Hammond, S. K., Lavalley, M. P., Weiner, D. E., Eisen, E. A., & Applebaum, K. M. (2016). Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers. Occupational and Environmental Medicine, 73(10), 656–662. https://doi.org/10.1136/oemed-2016-103769.Risk

Strauss, A., Uhlig, J., Lotz, J., Trojan, L., & Uhlig, A. (2019). Tumor laterality in renal cancer as a predictor of survival in large patient cohorts: A STROBE compliant study. Medicine, 17, e15346. https://doi.org/10.1097/MD.0000000000015346

Taneja, K., Cheng, L., Al-Obaidy, K., Kao, C.-S., Barletta, J., Howitt, B. E., Wasco, M. J., Palanisamy, N., Gupta, N. S., Rogers, C. G., Carskadon, S., Chen, Y.-B., Antic, T., Tretiakova, M., & Williamson, S. R. (2019). Clear Cell Renal Cell Carcinoma With a Poorly-Differentiated Component: A Novel Variant Causing Potential Diagnostic Difficulty. Mod Pathol, 32, 147–148.

Vargas, H. A., Chaim, J., Lefkowitz, R. A., Lakhman, Y., Zheng, J., Moskowitz, C. S., Sohn, M. J., Schwartz, L. H., Russo, P., & Akin, O. (2012). Renal cortical tumors: Use of multiphasic contrast-enhanced MR imaging to differentiate benign and malignant histologic subtypes. Radiology, 264(3), 779–788. https://doi.org/10.1148/radiol.12110746

Williamson, S. R. (2019). The expanding role of renal mass biopsy. Diagnostic Histopathology, 25(10), 379–389. https://doi.org/10.1016/j.mpdhp.2019.07.003

Xie, Y., Xu, P., Wang, M., Zheng, Y., Tian, T., Yang, S., Deng, Y., Wu, Y., Zhai, Z., Hao, Q., Song, D., Zhang, D., & Dai, Z. (2020). Antihypertensive medications are associated with the risk of kidney and bladder cancer : a systematic review and meta-analysis. Aging, 12(2), 1545–1562. https://doi.org/10.18632/aging.102699

Xu, X., & Zhu, D. (2021). Prognostic significance of subclassifying stage pT3a renal tumors with fat invasion : a retrospective study of 99 patients. Journal of International Medical Research, 49(8). https://doi.org/10.1177/03000605211033178

Yu, C., Ho, J., Huang, Y., Cha, T., Sun, G., Yu, D., Chang, F., Chen, S., & Hsu, R. (2013). Estrogen Inhibits Renal Cell Carcinoma Cell Progression through Estrogen Receptor-β Activation. PLoS ONE, 8(2), e56667. https://doi.org/10.1371/journal.pone.0056667

Zhi, Y., Li, X., Qi, F., Hu, X., & Xu, W. (2020). Association of Tumor Size with Risk of Lymph Node Metastasis in Clear Cell Renal Cell Carcinoma : A Population-Based Study. Journal of Oncology, 20, 8887782. https://doi.org/10.1155/2020/8887782

Zhu, D., Cao, J., Zhi, C., Guo, T., Li, Y., Lang, Z., & Li, G. (2020). Prognostic significance of the sub-classification of stage pT3a renal tumors by perinephric and sinus fat invasion. Oncology Letters, 19, 1721–1726. https://doi.org/10.3892/ol.2020.11281

Zhu, G., Liang, L., Li, L., Dang, Q., Song, W., Yeh, S., He, D., & Chang, C. (2014). The Expression and Evaluation of Androgen Receptor in Human Renal Cell Carcinoma. Urology, 83(2), 19–24. https://doi.org/10.1016/j.urology.2013.10.022

Zucchetto, A., Talamini, R., Maso, L. D., Negri, E., Polesel, J., Ramazzotti, V., Montella, M., Canzonieri, V., Serraino, D., Vecchia, C. La, & Franceschi, S. (2008). Reproductive, menstrual, and other hormone-related factors and risk of renal cell cancer. International Journal of Cancer, 123(9), 2213–2216. https://doi.org/10.1002/ijc.23750

Downloads

Publicado

05/12/2023

Como Citar

JUNIOR, D.; WINARTI, N. W.; SRIWIDYANI, N. P.; DEWI, I. G. A. S. M. Características Clínico-Patológicas do Carcinoma de Células Renais no Prof. I.G.N.G. Hospital Geral de Ngoerah 2018 – 2022. Research, Society and Development, [S. l.], v. 12, n. 13, p. e105121344402, 2023. DOI: 10.33448/rsd-v12i13.44402. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/44402. Acesso em: 22 nov. 2024.

Edição

v. 12 n. 13

Seção

Ciências da Saúde

Licença

Copyright (c) 2023 Darren Junior; Ni Wayan Winarti; Ni Putu Sriwidyani; I Gusti Ayu Sri Mahendra Dewi

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

Autores que publicam nesta revista concordam com os seguintes termos:

1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.

2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.

3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.