Psilocibina: Explorando o seu potencial de reversão das alterações neurofuncionais promovidas pelo Transtorno Depressivo Maior

Autores

DOI:

https://doi.org/10.33448/rsd-v13i5.44891

Palavras-chave:

Psilocibina; Uso terapêutico; Depressão.

Resumo

Introdução: O Transtorno Depressivo Maior afeta globalmente cerca de 5% da população, com etiologia complexa envolvendo interações entre cérebro, mente e ambiente. Cerca de 50% dos casos não respondem ao tratamento farmacológico padrão, destacando a necessidade de abordagens terapêuticas inovadoras. Objetivo: Este trabalho visa explorar o potencial terapêutico da psilocibina no transtorno depressivo maior, analisando sua interação com receptores serotoninérgicos, e investigando os efeitos da substância na conectividade cerebral. Metodologia: Trata-se de uma revisão narrativa da literatura, com busca de artigos na base de dados Pubmed. A seleção considerou critérios de inclusão, resultando em uma amostra de artigos relevantes para a análise. Resultados e Discussão: Os resultados revelam que a psilocibina, um agonista serotoninérgico, induz efeitos terapêuticos duradouros e rápidos, modulando receptores como 5-HT2AR. A substância promove neuroplasticidade, melhorando a conectividade cerebral e reduzindo sintomas depressivos. Conclusão: A eficácia da psilocibina no tratamento da depressão aponta para uma compreensão inovadora dos mecanismos neurobiológicos. Sua capacidade de induzir neuroplasticidade sugere implicações promissoras, destacando a segurança da combinação com terapias tradicionais.

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11/05/2024

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MENDES, L. F. da S. .; LEAL, A. K. M. P. .; BILIBIO, M. R. B. .; BRITO, S. R. S. .; NORONHA, M. Y. de C. .; MOURA, P. R. de S. e S. .; ARAÚJO JUNIOR, S. J. F. .; DIAS, J. O. R. . Psilocibina: Explorando o seu potencial de reversão das alterações neurofuncionais promovidas pelo Transtorno Depressivo Maior. Research, Society and Development, [S. l.], v. 13, n. 5, p. e4113544891, 2024. DOI: 10.33448/rsd-v13i5.44891. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/44891. Acesso em: 6 jan. 2025.

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v. 13 n. 5

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Ciências da Saúde

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Copyright (c) 2024 Lucas Ferrari da Silva Mendes; Anne Kaline Marques Portela Leal; Mauro Ricardo Barros Bilibio; Silana Rosa Soares Brito; Maria Yasmin de Carvalho Noronha; Paulo Ricardo de Sousa e Silva Moura; Stanley Janary Ferreira Araújo Junior; João Otávio Rodrigues Dias

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