Uso da própolis na cavidade oral em pacientes oncológicos: Uma revisão de literatura
DOI:
https://doi.org/10.33448/rsd-v13i11.47462Palavras-chave:
Higiene Oral; Manifestações Bucais; Odontologia; Oncologia; Própole.Resumo
A presença de alterações orais em pacientes oncológicos é frequente, devido a agressividade do tratamento quimioterápico ou radioterápico, ocasionando desconforto, dor e agravamento da qualidade de vida. Terapias coadjuvantes que auxiliam a prevenir e/ou minimizar essas alterações são frequentemente utilizadas, como o caso de medicamentos fitoterápicos. A própolis é um composto fitoterápico de escolha para o tratamento auxiliar dos efeitos colaterais das terapias oncológicas, em razão das suas propriedades antimicrobianas, anti-inflamatórias, antioxidantes e anticancerígenas. O objetivo dessa revisão de literatura foi abordar o uso da própolis em pacientes oncológicos como forma de prevenção e/ou tratamento dos efeitos adversos causados pela quimioterapia e radioterapia. Para isso, foram selecionados artigos das bases de dados PUBMED, LILACS e SCIELO, publicados entre 2014 e 2024, nos idiomas português, espanhol e inglês. Foram selecionados estudos de revisão, pesquisas experimentais e relatos de casos, excluindo artigos de opinião e monografias. O mecanismo de ação da própolis como adjuvante do tratamento oncológico tem demonstrado potencial de indução à apoptose celular, bem como potencializando os efeitos benéficos da quimioterapia e radioterapia. No entanto, seu uso deve ser cauteloso, pois, em razão do uso prolongado ou em doses elevadas, pode ocasionar reações adversas de hipersensibilidade e toxicidade. Seu uso é contraindicado para pacientes com histórico de alergia a produtos apícolas e aqueles que utilizam anticoagulantes. Em suma, a própolis emerge como um recurso promissor na oncologia, com capacidade de contribuir de forma significativa para o bem-estar e a qualidade de vida dos pacientes durante o tratamento contra o câncer.
Referências
AL-Ani, I., Zimmermann, S., Reichling, J., & Wink, M. (2018). Antimicrobial Activities of European Propolis Collected from Various Geographic Origins Alone and in Combination with Antibiotics. Medicines, 5(1), 2. https://doi.org/10.3390/medicines5010002.
Amaral, B. B., Sampaio, N. L. L. M., Filho, E. S. D. D., Peixoto, R. F., Carvalho, M., & Ferreira, S. J. (2021). Alterações bucais e qualidade de vida dos pacientes em tratamento quimioterápico. RSBO, 18(2), 235–42. https://doi.org/10.21726/rsbo.v18i2.1603.
Aminimoghadamfarouj, N., & Nematollahi, A. (2017). Propolis diterpenes as a remarkable bio-source for drug discovery development: A review. In International Journal of Molecular Sciences. 18(6). MDPI AG. https://doi.org/10.3390/ijms18061290.
Anjum, S. I., Ullah, A., Khan, K. A., Attaullah, M., Khan, H., Ali, H., Bashir, M. A., Tahir, M., Ansari, M. J., Ghramh, H. A., Adgaba, N., & Dash, C. K. (2019). Composition and functional properties of propolis (bee glue): A review. In Saudi Journal of Biological Sciences. 26(7), 1695–703. Elsevier B.V. https://doi.org/10.1016/j.sjbs.2018.08.013.
Baillie, R., Tan, S. T., & Itinteang, T. (2017). Cancer stem cells in oral cavity squamous cell carcinoma: A review. In Frontiers in Oncology, (7(jun). Frontiers Media S.A. https://doi.org/10.3389/fonc.2017.00112.
Bandara, H. M. H. N., & Samaranayake, L. P. (2019). Viral, bacterial, and fungal infections of the oral mucosa: Types, incidence, predisposing factors, diagnostic algorithms, and management. In Periodontology 2000. 80(1), 148–76). Blackwell Munksgaard. https://doi.org/10.1111/prd.12273.
Bankova, V., Popova, M., & Trusheva, B. (2014). Propolis volatile compounds: Chemical diversity and biological activity: A review. In Chemistry Central Journal. 8(1). BioMed Central Ltd. https://doi.org/10.1186/1752-153X-8-28.
Bobiş, O., Berretta, A. A., Vilas-Boas, M., & De Jong, D. (2023). Editorial: Therapeutic potential of propolis—from in vitro studies to clinical trials. In Frontiers in Pharmacology (Vol. 14). Frontiers Media S.A. https://doi.org/10.3389/fphar.2023.1192045.
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492.
C, K. (2018). Cancer Cell Growth - A Mini Review Part-1: Proliferation, Nutrient, Warburg Effect. Biochemistry & Analytical Biochemistry, 7(4). https://doi.org/10.4172/2161-1009.1000371.
Cao, X. P., Chen, Y. F., Zhang, J. L., You, M. M., Wang, K., & Hu, F. L. (2017). Mechanisms underlying the wound healing potential of propolis based on its in vitro antioxidant activity. Phytomedicine, 34, 76–84. https://doi.org/10.1016/j.phymed.2017.06.001.
Catchpole, O., Mitchell, K., Bloor, S., Davis, P., & Suddes, A. (2015). Antiproliferative activity of New Zealand propolis and phenolic compounds vs human colorectal adenocarcinoma cells. Fitoterapia, 106, 167–74. https://doi.org/10.1016/j.fitote.2015.09.004.
Cavalcante, L. T. C. & Oliveira, A. A. S. (2020). Métodos de revisão bibliográfica nos estudos científicos. Psicol. Rev. 26(1). https://doi.org/10.5752/P.1678-9563.2020v26n1p82-100.
Cornara, L., Biagi, M., Xiao, J., & Burlando, B. (2017). Therapeutic properties of bioactive compounds from different honeybee products. Frontiers in Pharmacology. 8 (JUN). Frontiers Media S.A. https://doi.org/10.3389/fphar.2017.00412.
Cruz, F. B. da, Ferreira, J. de F., Silveira, D., & Fonseca-Bazzo, Y. M. (2021). Avaliação da atividade anti-inflamatória de própolis de abelha Apis mellifera: uma revisão. Research, Society and Development, 10(14), e250101421817. https://doi.org/10.33448/rsd-v10i14.21817.
Carvalho, J. T. G., Baldivia, D. S., Leite, D. F., Araújo, L. C. A., Espindola, P. P. T., Antunes, K. A., Rocha, P. S., Souza, K. P., & Santos, E. L. (2019). Medicinal plants from Brazilian Cerrado: Antioxidant and anticancer potential and protection against chemotherapy toxicity. In Oxidative Medicine and Cellular Longevity (Vol. 2019). Hindawi Limited. https://doi.org/10.1155/2019/3685264.
Doğan, H., Silici, S., & Ozcimen, A. A. (2020). Biological Effects of Propolis on Cancer. Turkish Journal of Agriculture - Food Science and Technology, 8 (3), 573–579. https://doi.org/10.24925/turjaf.v8i3.573-579.2939.
Feitelson, M. A., Arzumanyan, A., Kulathinal, R. J., Blain, S. W., Holcombe, R. F., Mahajna, J., Marino, M., Martinez-Chantar, M. L., Nawroth, R., Sanchez-Garcia, I., Sharma, D., Saxena, N. K., Singh, N., Vlachostergios, P. J., Guo, S., Honoki, K., Fujii, H., Georgakilas, A. G., Bilsland, A., … Nowsheen, S. (2015). Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. In Seminars in Cancer Biology , 35, S25–S54. Academic Press.
Fernández-Calderón, M. C., Hernández-González, L., Gómez-Navia, C., Blanco-Blanco, M. T., Sánchez-Silos, R., Lucio, L., & Pérez-Giraldo, C. (2021). Antifungal and anti-biofilm activity of a new Spanish extract of propolis against Candida glabrata. BMC Complementary Medicine and Therapies, 21(1). https://doi.org/10.1186/s12906-021-03323-0.
Floriano, F. D., Ribeiro, P. F. A., Maragno, A. C., Rossi, K., & Simões, P. W. T. A. (2017). complicações orais em pacientes tratados com radioterapia ou quimioterapia em um hospital de santa catarina. oral complications in patients treated with radiotherapy or chemotherapy in a hospital in santa catarina. Rev. Odontol. Univ. Cid. São Paulo, 29(3), 230–36.
Forma, E., & Bryś, M. (2021). Anticancer activity of propolis and its compounds. In Nutrients. 13 (8). MDPI. https://doi.org/10.3390/nu13082594.
Foster, A., Rocha, L., Regina, S., Orrico, P., Maria, E., & Massucato, S. (2021). A importância do preparo da cavidade bucal antes e durante o tratamento oncológico The importance of preparing the oral cavity before and during cancer treatment. In ULAKES Journal of Medicine. Rocha et al. ULAKES J Med. 1 (3).
Freire, A. A. S., Suelen Medeiro Honorato, P. S. M., Macedo, S. B., & Araújo, C. S. (2016). manifestações bucais em pacientes submetidos a tratamento quimioterápico no hospital de câncer do acre bucal manifestations in patients submitted to chemotherapeutic treatment in the cancer hospital of acre. in Journal of Amazon Health Science (Vol. 2, Issue 1). Ciênc. saúde coletiva. 15 (suppl 1). https://doi.org/10.1590/S1413-81232010000700016.
Gajek, G., Marciniak, B., Lewkowski, J., & Kontek, R. (2020). Antagonistic effects of CAPE (a component of propolis) on the cytotoxicity and genotoxicity of irinotecan and SN38 in human gastrointestinal cancer cells in vitro. Molecules, 25(3).
Gómez, P. A. M., Jon, L. Y., Torres, D. J. M., Amaranto, R. E. B., Díaz, I. E. C., & Minchón Medina, C. A. (2021). Antibacterial, antibiofilm, and cytotoxic activities and chemical compositions of Peruvian propolis in an in vitro oral biofilm. F1000Research, 10, 1093. https://doi.org/10.12688/f1000research.73602.1.
Gomes, R. A., Coelho, A. D. C. O., Moura, D. C. A., Cruz, J. S. da, & Santos, K. B. (2018). Avaliação da qualidade de vida de pacientes com doença oncohematológica em quimioterapia. Revista de Enfermagem UFPE on Line, 12(5), 1200.
González-Arriagada, W. A., Ottaviani, G., Dean, D., Ottaviani, G., Santos-Silva, A. R., & Treister, N. S. (2023). Editorial: Oral complications in cancer patients. Frontiers in Oral Health (Vol. 3). Frontiers Media S.A. https://doi.org/10.3389/froh.2022.1116885
Guo, J., Wang, Z., Chen, Y., Cao, J., Tian, W., Ma, B., & Dong, Y. (2021). Active components and biological functions of royal jelly. Journal of Functional Foods (Vol. 82). Elsevier Ltd. https://doi.org/10.1016/j.jff.2021.104514.
Henatsch, D., Kross, F., & Stokroos, K. W. &. (2015). Honey and beehive products in otorhinolaryngology: a narrative review. Clin Otolaryngol. 41 (5):519-31. Doi: 10.1111/coa.12557. Epub 2016 Feb 9.
Hermansyah, D., Zulhendri, F., Perera, C. O., Firsty, N. N., Chandrasekaran, K., Abdulah, R., Herman, H., & Lesmana, R. (2022). The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers. In Integrative Cancer Therapies (Vol. 21). SAGE Publications Inc. https://doi.org/10.1177/15347354221096868.
Hustedt, N., & Durocher, D. (2017). The control of DNA repair by the cell cycle. In Nature Cell Biology. 19(1), 1–9. Nature Publishing Group. https://doi.org/10.1038/ncb3452.
Hwu, Y. J., & Lin, F. Y. (2014). Effectiveness of propolis on oral health: A meta-analysis. Journal of Nursing Research, 22(4), 221–9. https://doi.org/10.1097/jnr.0000000000000054.
Iqbal, M., Fan, T. ping, Watson, D., Alenezi, S., Saleh, K., & Sahlan, M. (2019). Preliminary studies: the potential anti-angiogenic activities of two Sulawesi Island (Indonesia) propolis and their chemical characterization. Heliyon, 5 (7). https://doi.org/10.1016/j.heliyon.2019.e01978.
Ishida, Y., Gao, R., Shah, N., Bhargava, P., Furune, T., Kaul, S. C., Terao, K., & Wadhwa, R. (2018). Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With γ-Cyclodextrin. Integrative Cancer Therapies, 17(3), 867–73. https://doi.org/10.1177/1534735417753545.
Jacob, A., Parolia, A., Pau, A., & Davamani Amalraj, F. (2015). The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process. BMC Complementary and Alternative Medicine, 15 (1).
Júnior, J. H. D. C. F., Valadas, L. A. R., Fonseca, S. G. D. C., Lobo, P. L. D., Calixto, L. H. M., Lima, A. G. F., Aguiar, M. H. R., Arruda, I. S., Lotif, M. A. L., Neto, E. M. R., & Fonteles, M. M. D. F. (2020). Clinical and Microbiological Evaluation of Brazilian Red Propolis Containing-Dentifrice in Orthodontic Patients: A Randomized Clinical Trial. Evidence-Based Complementary and Alternative Medicine, 2020. https://doi.org/10.1155/2020/8532701
Kubina, R., Kabała-Dzik, A., Dziedzic, A., Bielec, B., Wojtyczka, R. D., Bułdak, R. J., Wyszyńska, M., Stawiarska-Pięta, B., & Szaflarska-Stojko, E. (2015). The ethanol extract of polish propolis exhibits anti-proliferative and/or pro-apoptotic effect on HCT 116 colon cancer and Me45 Malignant melanoma cells in vitro conditions. Advances in Clinical and Experimental Medicine, 24(2), 203–12. https://doi.org/10.17219/acem/31792.
Kurek‐Górecka, A., Górecki, M., Rzepecka‐Stojko, A., Balwierz, R., & Stojko, J. (2020). Bee products in dermatology and skin care. In Molecules. 25(3). MDPI AG. https://doi.org/10.3390/molecules25030556.
Leal-Esteban, L. C., & Fajas, L. (2020). Cell cycle regulators in cancer cell metabolism. In Biochimica et Biophysica Acta - Molecular Basis of Disease (Vol. 1866, Issue 5). Elsevier B.V. https://doi.org/10.1016/j.bbadis.2020.165715.
Lesmana, R., Zulhendri, F., Fearnley, J., Irsyam, I. A., Rasyid, R. P. H. N., Abidin, T., Abdulah, R., Suwantika, A., Paradkar, A., Budiman, A. S., & Pasang, T. (2022). The Suitability of Propolis as a Bioactive Component of Biomaterials. Frontiers in Pharmacology (Vol. 13). Frontiers Media S.A. https://doi.org/10.3389/fphar.2022.930515.
Lin, Y. M., Chen, C. I., Hsiang, Y. P., Hsu, Y. C., Cheng, K. C., Chien, P. H., Pan, H. L., Lu, C. C., & Chen, Y. J. (2018). Chrysin attenuates cell viability of human colorectal cancer cells through autophagy induction unlike 5-fluorouracil/oxaliplatin. International Journal of Molecular Sciences, 19(6). https://doi.org/10.3390/ijms19061763.
Magnavacca, A., Sangiovanni, E., Racagni, G., & Dell’Agli, M. (2022). The antiviral and immunomodulatory activities of propolis: An update and future perspectives for respiratory diseases. In Medicinal Research Reviews. 42(2), 897–945). John Wiley and Sons Inc. https://doi.org/10.1002/med.21866.
Masadah, R., Ikram, D., & Rauf, S. (2021). Effects of propolis and its bioactive components on breast cancer cell pathways and the molecular mechanisms involved. In Breast Disease. 40(S1), S15–S25. IOS Press BV. https://doi.org/10.3233/BD-219003.
Meto, A., Colombari, B., Meto, A., Boaretto, G., Pinetti, D., Marchetti, L., Benvenuti, S., Pellati, F., & Blasi, E. (2020). Propolis affects pseudomonas aeruginosa growth, biofilm formation, eDNA release and phenazine production: Potential involvement of polyphenols. Microorganisms, 8(2). https://doi.org/10.3390/microorganisms8020243.
Mitchell, D. A., Kanatas, A., Murphy, C., Chengot, P., Smith, A. B., & Ong, T. K. (2018). Margins and survival in oral cancer. British Journal of Oral and Maxillofacial Surgery, 56(9), 820–9. https://doi.org/10.1016/j.bjoms.2018.06.021.
Nyman, G. S. A., Tang, M., Inerot, A., Osmancevic, A., Malmberg, P., & Hagvall, L. (2019). Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis, 81(2), 110–16. https://doi.org/10.1111/cod.13306.
Oršolić, N. (2022). Allergic Inflammation: Effect of Propolis and Its Flavonoids. In Molecules. 27(19). MDPI. https://doi.org/10.3390/molecules27196694.
Oršolić, N., Jurčević, I. L., Đikić, D., Rogić, D., Odeh, D., Balta, V., Junaković, E. P., Terzić, S., & Jutrić, D. (2019). Effect of Propolis on Diet-induced hyperlipidemia and atherogenic indices in mice. Antioxidants, 8(6). https://doi.org/10.3390/antiox8060156.
Oršolić, N., Skurić, J., Crossed D Signikić, D., & Stanić, G. (2014). Inhibitory effect of a propolis on Di-n-Propyl Disulfide or n-Hexyl salycilate-induced skin irritation, oxidative stress and inflammatory responses in mice. Fitoterapia, 93, 18–30. https://doi.org/10.1016/j.fitote.2013.12.007.
Oryan, A., Alemzadeh, E., & Moshiri, A. (2016). Biological properties and therapeutic activities of honey in wound healing: A narrative review and meta-analysis. Journal of Tissue Viability, 25(2), 98–118. https://doi.org/10.1016/j.jtv.2015.12.002.
Otto, T., & Sicinski, P. (2017). Cell cycle proteins as promising targets in cancer therapy. In Nature Reviews Cancer. 17(2), 93–115. Nature Publishing Group. https://doi.org/10.1038/nrc.2016.138.
Paris, E. H., Peraza Lope, C., Masson, M. A., Delgado Kú, P. C., & Escamilla Ojeda, B. C. (2018). The organization of stingless beekeeping (Meliponiculture) at Mayapán, Yucatan, Mexico. Journal of Anthropological Archaeology, 52, 1–22. https://doi.org/10.1016/j.jaa.2018.07.004.
Pasupuleti, V. R., Sammugam, L., Ramesh, N., & Gan, S. H. (2017). Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits. In Oxidative Medicine and Cellular Longevity (Vol. 2017). Hindawi Limited. https://doi.org/10.1155/2017/1259510.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). metodologia da pesquisa científica. Santa Maria: UAB / NTE / UFSM.
Piredda, M., Facchinetti, G., Biagioli, V., Giannarelli, D., Armento, G., Tonini, G., & De Marinis, M. G. (2017). Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. European Journal of Cancer Care, 26(6). https://doi.org/10.1111/ecc.12757.
Pobiega, K., Kraśniewska, K., & Gniewosz, M. (2019). Application of propolis in antimicrobial and antioxidative protection of food quality – A review. In Trends in Food Science and Technology. 83, 53–62. Elsevier Ltd. https://doi.org/10.1016/j.tifs.2018.11.007.
Popova, M., Trusheva, B., & Bankova, V. (2021). Propolis of stingless bees: A phytochemist’s guide through the jungle of tropical biodiversity. In Phytomedicine (Vol. 86). Elsevier GmbH. https://doi.org/10.1016/j.phymed.2019.153098.
Reis, J. H.O., Barreto, G.A., Cerqueira, J. C., Anjos, J. P., Andrade, L. N., Padilha, F. F., Druzian, J. I., & Machado, B. A. S. (2019). Evaluation of the antioxidant profile and cytotoxic activity of red propolis extracts from different regions of northeastern Brazil obtained by conventional and ultrasoundassisted extraction. PLoS ONE, 14(7). https://doi.org/10.1371/journal.pone.0219063.
Reolon, L. Z., Rigo, L., Conto, F. de, & Ce, L. C. (2017). Impacto da laserterapia na qualidade de vida de pacientes oncológicos portadores de mucosite oral. Revista de Odontologia Da UNESP, 46(1), 19–27. https://doi.org/10.1590/1807-2577.09116.
Rivera-Yañez, N., Rodriguez-Canales, M., Nieto-Yañez, O., Jimenez-Estrada, M., Ibarra-Barajas, M., Canales-Martinez, M. M., & Rodriguez-Monroy, M. A. (2018). Hypoglycaemic and Antioxidant Effects of Propolis of Chihuahua in a Model of Experimental Diabetes. Evidence-Based Complementary and Alternative Medicine, 2018. https://doi.org/10.1155/2018/4360356.
Rother, E. T. (2007). Revisão sistemática x revisão narrativa. Acta Paul. Enferm. 20(2). https://doi.org/10.1590/S0103-21002007000200001.
Rzepecka-Stojko, A., Kabala-Dzik, A., Mozdzierz, A., Kubina, R., Wojtyczka, R. D., Stojko, R., Dziedzic, A., Jastrzebska-Stojko, Z., Jurzak, M., Buszman, E., & Stojko, J. (2015). Caffeic acid Phenethyl ester and ethanol extract of Propolis induce the complementary Cytotoxic effect on triple-negative breast cancer cell lines. Molecules, 20(5), 9242–9262.
Santos, D. A., Munari, F. M., Frozza, C. O. S., Moura, S., Barcellos, T., Henriques, J. A. P., & Roesch-Ely, M. (2019). Brazilian red propolis extracts: study of chemical composition by ESI-MS/MS (ESI+) and cytotoxic profiles against colon cancer cell lines. Biotechnology Research and Innovation, 3(1), 120–30. https://doi.org/10.1016/j.biori.2019.02.001.
Santos, M. de O., Lima, F. C. da S. de, Martins, L. F. L., Oliveira, J. F. P., Almeida, L. M. de, & Cancela, M. de C. (2023). Estimativa de Incidência de Câncer no Brasil, 2023-2025. Revista Brasileira de Cancerologia, 69(1). https://doi.org/10.32635/2176-9745.rbc.2023v69n1.3700.
Sepúlveda, C., Núñez, O., Torres, A., Guzmán, L., & Wehinger, S. (2020). Antitumor Activity of Propolis: Recent Advances in Cellular Perspectives, Animal Models and Possible Applications. In Food Reviews International. 36(5), 429–55. Taylor and Francis Inc. https://doi.org/10.1080/87559129.2019.1649692.
Seydi, E., Hosseini, S. A., Salimi, A., & Pourahmad, J. (2016). Propolis induce cytotoxicity on cancerous hepatocytes isolated from rat model of hepatocellular carcinoma: Involvement of ROS-mediated mitochondrial targeting. PharmaNutrition, 4(4), 143–150. https://doi.org/10.1016/j.phanu.2016.10.001.
Sforcin, J. M. (2016). Biological Properties and Therapeutic Applications of Propolis. In Phytotherapy Research. 30 (6), 894–905. John Wiley and Sons Ltd. https://doi.org/10.1002/ptr.5605.
Silva-Carvalho, R., Baltazar, F., & Almeida-Aguiar, C. (2015). Propolis: A Complex Natural Product with a Plethora of Biological Activities That Can Be Explored for Drug Development. In Evidence-based Complementary and Alternative Medicine. Hindawi Publishing Corporation. https://doi.org/10.1155/2015/206439.
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660.
Teixeira, A.M., Perez, J. M. P., & Pereira, V. A. S. (2022). Manifestações orais em pacientes submetidos a quimioterapia e radioterapia. Revista Diálogos em Saúde, (4), 2. https://periodicos.iesp.edu.br/dialogosemsaude/article/view/481.
Touzani, S., Imtara, H., Katekhaye, S., Mechchate, H., Ouassou, H., Alqahtani, A. S., Noman, O. M., Nasr, F. A., Fearnley, H., Fearnley, J., Paradkar, A., Elarabi, I., & Lyoussi, B. (2021). Determination of phenolic compounds in various propolis samples collected from an african and an asian region and their impact on antioxidant and antibacterial activities. Molecules, 26(15). https://doi.org/10.3390/molecules26154589.
Wang, J. wen, Chen, S. shan, Zhang, Y. meng, Guan, J., Su, G. Y., Ding, M., Li, W., & Zhao, Y. Q. (2019). Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice. Environmental Toxicology and Pharmacology, 68, 13–18. https://doi.org/10.1016/j.etap.2019.02.005.
Wimardhani, Y. S., & Soegyanto, A. I. (2014). Oral Mucosal Ulceration Caused by the Topical Application of a Concentrated Propolis Extract. Case Reports in Dentistry, 2014, 1–4. https://doi.org/10.1155/2014/307646.
Zabaiou, N., Fouache, A., Trousson, A., Baron, S., Zellagui, A., Lahouel, M., & Lobaccaro, J. M. A. (2017). Biological properties of propolis extracts: Something new from an ancient product. In Chemistry and Physics of Lipid. 207, 214–22. Elsevier Ireland Ltd. https://doi.org/10.1016/j.chemphyslip.2017.04.005.
Zhang, X., Wang, G., Gurley, E. C., & Zhou, H. (2014). Flavonoid apigenin inhibits lipopolysaccharide-induced inflammatory response through multiple mechanisms in Macrophages. PLoS ONE, 9(9). https://doi.org/10.1371/journal.pone.0107072.
Zulhendri, F., Felitti, R., Fearnley, J., & Ravalia, M. (2021). The use of propolis in dentistry, oral health, and medicine: A review. In Journal of Oral Biosciences (Vol. 63, Issue 1, pp. 23–34). Japanese Association for Oral Biology. https://doi.org/10.1016/j.job.2021.01.001.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2024 Mirele Edlânia dos Santos Madeiro; Erika Caroline Steinle ; Sylvia de Araujo Paes-Souza ; Sulamita Karine Medeiros Treuko ; Elaine Judite de Amorim Carvalho
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
