Análise quantitativa temporal sobre os efeitos do uso de agrotóxicos em anfíbios – anuros
DOI:
https://doi.org/10.33448/rsd-v9i8.5682Palavras-chave:
Contaminação ambiental; genotoxicidade; toxicidade; ecotoxicologia; declínio; agricultura.Resumo
A presença de anfíbios em ambientes agrícolas alterados é notável, mas o desaparecimento de algumas espécies traz preocupação com o risco de aplicação de produtos químicos associados à agricultura nas populações de larvas e adultos. A avaliação quantitativa abrangente da sensibilidade comportamental dos anfíbios faz-se imprescindível para entender melhor o impacto populacional e os impactos ecológicos resultantes dos contaminantes. Com isso, o objetivo do estudo foi realizar uma revisão utilizando o método cienciométrico para avaliar os efeitos dos agrotóxicos na população de anuro. Os resultados indicaram que a maioria dos estudos foi realizada na Europa e na Ásia envolvendo estágios larvais e embrionários deste grupo sendo que, 46,33% dos 218 estudos se concentraram nos efeitos dos inseticidas. Em particular, os inseticidas aumentaram as taxas de natação anormal e reduziram as respostas de escape aos ataques de predadores. No entanto nos artigos analisados verificou-se que a falta de testes de campo e a dependência excessiva de testes de toxicidade direta em laboratório podem limitar a capacidade de interpretar os resultados sob condições realistas de campo.
Referências
Albert, L. A. Compuestos orgánicos persistentes En Albert, L. A. (1997). Introducción a la toxicología ambiental. ECO/OPS/OMS. Metepec, México, 334–358.
Almeida, P. R. (2014). Toxicidade aguda (LC50) e efeitos comportamentais e morfológicos do formulado comercial Roundup Original DI em girinos de Physalaemus cuvieri (anura, Leptodactylidae) e Rhinella icterica (anura, Bufonidae). Dissertação (Mestrado em Ciência e Engenharia Ambiental), Universidade Federal de Alfenas – Poços de Calda, MG.
Arcaute, C. R., Pérez-Iglesias, J. M., Nikoloff, N., Natale, G. S., Natale, S., Soloneski, S., Larramendy, M. L. (2014). Genotoxicity evaluation of the insecticide imidacloprid on circulatingblood cells of Montevideo tree frog Hypsiboas pulchellus tadpoles (Anura, Hylidae) by comet and micronucleus bioassays C. Ecological Indicators, 45, 632–639.
Attademo, A. M., Peltzer, P. M., Lajmanovich, R. C., Cabagna, M., Fiorenza, G. (2007). Plasma B-esterase and glutathione S-transferase activity in the toad Chaunus schneideri (Amphibia, Anura) inhabiting rice agroecosystems of Argentina. Ecotoxicology, 16, 533–539.
Bacchetta, R., Mantecca, P., Andrioletti, M., Vismara, C., Vailati, G. (2008). Axial-skeletal defects caused by carbaryl in Xenopus laevis embryos. Science of the Total Environment, 392, 110–118.
Bach, N. C., Marino, D. J. G., Natale, G. S., Somoza, G. M. (2018). Effects of glyphosate and its commercial formulation, Roundup® Ultramax, on liver histology of tadpoles of the neotropical frog, Leptodactylus latrans (Amphibia:Anura). Chemosphere, 202, 289–297.
Beiswenger, R. E. (1988). Lntegrating anuran amphibian species into environmental assessment programs, p.159-165. ln: Szaro, R.C., Severson, K.E. & D.R. Patton (Eds). Management of Amphibians, Reptiles, and Small Mammals in North America: Proceedings of the Symposium. Arizona, USDA Forest Service, General Technical Report RM-166, 458.
Bernabò, I., Bonacci, A., Coscarelli, F., Tripepi, M., Brunelli, E. (2013). Effects of salinity stress on Bufo balearicus and Bufo bufo tadpoles: Tolerance, morphological gill alterations and Na+/K+- ATPase localization. Aquatic Toxicology, 132(133), 119–133.
Berrill, M., Coulson, D., Mcgillivray, L., Pauli, B. (1998). Toxicity of endosulfan to aquatic stages of anuran amphibians. Environmental Toxicology and Chemistry, 17, 1738–1744.
Bevan, C. L., Porter, D. M., Prasad, A., Howard, M. J., Henderson, L. P. (2003). Environmental estrogens alter early development in Xenopus laevis. Environmental Health Perspectives, 111 (4), 488–496.
Bonfanti, P., Colombo, A., Orsi, F.; Nizzetto, I., Andrioletti, M., Bacchetta, R., Mantecca, P., Fascio, U., Vailati, G., Vismara, C. (2004). Comparative teratogenicity of chlorpyrifos and malathion on Xenopus laevis development. Aquatic Toxicology, 70 (3), 189–200.
Boone, M. D. (2008). Examining the single and interactive effects of three insecticides on amphibian metamorphosis. Environmental Toxicology and Chemistry, 27 (7), 1561–1568.
Bridges, C. M. (1999b) Predator–prey interactions between two amphibian species: effects of insecticide exposure. Aquatic Ecology, 33, 205–211.
Bridges, C. M., Semlitsch, R. D. (2000). Variation in pesticide tolerance of tadpoles among and within species of Ranidae and patterns of amphibian decline. Conservation Biology, 14 (5), 1490–1499.
Bridges, C., Little, E., Gardiner, D., Petty, J., Huckins, J. (2004). Assessing the toxicity and teratogenicity of pond water in north-central Minnesota to amphibians. Environmental Science and Pollution Research, 11 (4), 233–239.
Brum, B.R, D’Ávila R.S, Sguarezi, S.B, Santos-Filho, M. & Ignácio, A.R.A. (2020). Temporal analysis of the use of birds, as environmental sentinels in the monitoring of contamination by pesticides. Research, Society and Development, 9(7): 1-26, e752974807.
Carvalho, W. F., De Arcaute, C. R., Pérez-Iglesias, J. M., Laborde, M. R. R.; Soloneski, S., Larramendy, M. L. (2019). DNA damage exerted by mixtures of commercial formulations of glyphosate and imazethapyr herbicides in Rhinella arenarum (Anura, Bufonidae) tadpoles. Ecotoxicology, 28 (3), 367-377.
Cevasco, A., Urbatzka, R., Bottero, S., Massari, A., Pedemonte, F., Kloas, W., Mandich, A. (2008). Endocrine disrupting chemicals (EDC) with (anti)estrogenic and (anti)androgenic modes of action affecting reproductive biology of Xenopus laevis: II. Effects on gonad histomorphology. Comparative Biochemistry and Physiology C Toxicology and Pharmacology, 147 (2), 241–251.
Chiari, Y., Glaberman, S., Serén, N., Carretero, M. A., Capellini, I. (2015). Phylogenetic signal in amphibian sensitivity to copper sulfate relative to experimental temperature. Ecological Applications, 25 (3), 596–602.
Collins, J. P., Storfer, A. (2003). Global amphibian declines: sorting the hypotheses. Diversity and Distributions, 9 (2), 89-98.
Colombo, A., Orsi, F., Bonfanti, P. (2005). Exposure to the organophosphorus pesticide chlorpyrifos inhibits acetylcholinesterase activity and affects muscular integrity in Xenopus laevis larvae. Chemosphere, 61 (11), 1665–1671.
Cooper, C. M. (1993). Biological effects of agriculturally derived surface-water pollutants on aquatic systems: a review. Journal of Environmental Quality, 22 (3), 392–402.
Costa, M. J., Ribeiro, L. R., Salla, R. F., Gamero, F. U., Alves, L. M. L. M., Silva Zacarin, E. C. M. (2015). Effects of the organophosphorus pesticide Folisuper 600 (methyl parathion) on the heart function of bullfrog tadpoles, Lithobates catesbeianus (Shaw, 1802). Brazilian Journal of Biology, 75 (4), 163-168.
Donaldson, D., Kiely, T., Grube, A. (2002). Pesticide industry sales and usage. EPA United States Environmental Protection Agency, Market Estimates, 733.
DuRant, S. E., Hopkins, W. A., Talent, L. G. (2007). Energy acquisition and allocation in an ectothermic predator exposed to a common environmental stressor. Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, 145 (3), 442–448.
Eaton, B. R., Eaves, S., Stevens, C., Puchniak, A., Paszkowski, C.A. (2004). Deformity levels in wild populations of the wood frog (Rana sylvatica) in three ecoregions of western Canada. Journal of Herpetology, 38 (2), 283–287.
El-Merhibi, A., Kumar, A., Smeaton, T. (2004). Role of piperonyl butoxide in the toxicity of chlorpyrifos to Ceriodaphnia dubia and Xenopus laevis. Ecotoxicology and Environmental Safety, 57 (2), 202–212.
Ezemonye L. I. N., Isioma, T. (2010). Acute toxic effects of Endosulfan and Diazinon pesticides on adult amphibians (Bufo regularis). Journal of Environmental Chemistry and Ecotoxicology, 2(5), 73–78.
Ezemonye L. I. N., Tongo, I. (2009). Lethal and Sublethal Effects of Atrazine to Amphibian Larvae. Jordan Journal of Biological Sciences, 2(1), 29–36.
Fellers, G. M., Mcconnell, L. L., Pratt, D., Datta, S. (2004). Pesticides in mountain yellow-legged frogs (Rana muscosa) from the Sierra Nevada mountains of California, USA. Environmental Toxicology and Chemistry, 23(9), 2170–2177.
Fordham, C. L., Tessari, J. D., Ramsdell, H. S., Keefe, T. J. (2001). Effects of malathion on survival, growth, development, and equilibrium posture of bullfrog tadpoles (Rana catesbeiana). Environmental Toxicology and Chemistry, 20(1), 179–184.
Fort, D. J., Guiney, P. D., Weeks, J. A., Thomas, J. H., Rogers, R. L., Noll, A. M., Spaulding, C. D. (2004). Effect of Methoxychlor on Various Life Stages of Xenopus laevis. Toxicological Sciences, 81(2), 454–466.
Fort, D. J., Rogers, R. L., Copley, H. F., Bruning, L. A., Stover, E. L., Helgen, J. C., Burkhart, J. G. (1999b). Progress toward identifying causes of maldevelopment induced in Xenopus by pond water and sediment extracts from Minnesota, USA. Environmental Toxicology and Chemistry, 18(10), 2316–2324.
Furlow, J. D., Neff, E. S. (2006). A developmental switch induced by thyroid hormone: Xenopus laevis metamorphosis. Trends in Endocrinology and Metabolism, 17(2), 40–47.
Gardiner, D. M., Hoppe, D. M. (1999). Environmentally induced limb malformations in mink frogs (Rana septentrionalis). Journal of Experimental Zoology, 284(2), 207–216.
Ghose, S. L., Donell, M. A., Kerby, J., Whitfield, S. M. (2014). Acute toxicity tests and meta-analysis identify gaps in tropical ecotoxicology for amphibians. Environmental Toxicology and Chemistry, 33(9), 2114-2119.
Greulich, K., Pflugmacher, S. (2003). Differences in susceptibility of various life stages of amphibians to pesticide exposure. Aquatic Toxicology, 65(3), 329–336.
Gurushankara, H. P., Krishnamurthy, S. V., Vasudev, V. (2007). Morphological abnormalities in natural populations of common frogs inhabiting agroecosystems of central Western Ghats. Applied Herpetology, 4(1), 39–45.
Gutleb, A. C., Schriks, M., Mossink, L., Van Den Berg, J. H. J., Murk, A. J. (2007). A synchronized amphibian metamorphosis assay as an improved tool to detect thyroid hormone disturbance by endocrine disruptors and apolar sediment extracts. Chemosphere, 70(1), 93–100.
Hammond, J. I., Jones, D. K., Stephens, P. R., Relyea, R. A. (2012). Phylogeny meets ecotoxicology: evolutionary patterns of sensitivity to a common insecticide. Evolutionary Applications, 5(6), 593–606.
Harris, M. L., Chora, L., Bishop, C. A., Bogart, J. P. (2000). Species- and age-related differences in susceptibility to pesticide exposure for two amphibians, Rana pipiens, and Bufo americanus. Bulletin of Environmental Contamination and Toxicology, 64(2), 263–270.
Hayes, T. B., Collins, A., Lee, M., Mendoza, M., Noriega, N., Stuart, A. A., Vonk, A. (20020. Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses. Proceedings of the National Academy of Sciences, 99(8), 5476–5480.
Hayes, T. B., Haston, K., Tsui, M., Hoang, A., Haeffele, C., Vonk, A. (2003). Atrazineinduced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence. Environmental Health Perspectives, 111(4), 568–575.
Hayes, T. B., Khoury, V., Narayan, A., Nazir, M., Park, A., Brown, T., Adame, L., Chan, E., Buchholz, D., Stueve, T., Gallipeau, S. (2010). Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis). Proceedings of the National Academy of Sciences, 107(10), 4612–4617.
Hayes, T. B., Stuart, A. A., Mendoza, M., Collins A., Noriega, N., Vonk, A., Johnston, G., Liu, R., Kpodzo, D. (2006). Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17beta-estradiol): Support for the demasculinization/feminization hypothesis. Environ Health Perspect, 114(1), 134–141.
Helbing, C. C., Gergely, G., Atkinson, B. G. (1992). Sequential up-regulation of thyroid hormone b receptor, ornithine transcarbamylase and carbamyl phosphate synthetase mRNAs in the liver of Rana catesbeiana tadpoles during spontaneous and thyroid hormone-induced metamorphosis. Developmental Genetics, 13(4), 289–301.
Henson-Ramsey, H., Kennedy-Stoskopf, S., Levine, J. F., Taylor, S. K., Shea, D., Stoskopf, M. K. (2008). Acute toxicity and tissue distributions of malathion in Ambystoma tigrinum. Archives of Environmental Contamination and Toxicology, 55(3), 481–487.
Hu, F., Sharma, B., Mukhi, S., Patino, R., Carr, J. A. (2006). The colloidal thyroxine (T4) ring as a novel biomarker of perchlorate exposure in the African clawed frog Xenopus laevis. Toxicological Sciences, n. 93(2), 268–277.
Johnson, P. T. J., Lunde, K. B., Ritchie, E. G., Reaser, J. K., Launer, A. E. (2001b). Morphological abnormality patterns in a California amphibian community. Herpetologica, 57(3), 336–352.
Jones, D. K., Hammond, J. I., Relyea, R. A. (2009). Very highly toxic effects of endosulfan across nine species of tadpoles: lag effects and family-level sensitivity. Environmental Toxicology and Chemistry, 28(9), 1939–1945.
Kang, H. S., Gye, M. C., Kim, M. K. (2008). Effects of endosulfan on survival and development of Bombina orientalis (boulenger) embryos. Bulletin of Environmental Contamination and Toxicology, 81(3), 262–265.
Katagi, T., Ose, K. (2014). Bioconcentration and metabolism of pesticides and industrial chemicals in the frog. Journal of Pesticide Science, 39(2), 55–68.
Kennedy, I. J., Sampath, K. (2001). Short-term and long-term survival studies in Rana tigrina tadpoles with reference to methyl parathion toxicity. Journal of Environmental Biology, 22(4), 267–271.
Lajmanovich, R, C., Sanchez-Hernandez, J. C., Stringhini, G., Peltzer, P. M. (2004). Levels of serum cholinesterase activity in the rococo toad (Bufo paracnemis) in agrosystems of Argentina. Bulletin of Environmental Contamination and Toxicology, 72(3), 586–591
.
Lajmanovich, R. C., Cabagna-Zenklusen, M. C., Attademo, A. M., Junges, C. M., Peltzer, P. M.; Bassó, A., Lorenzatti, E. (2014). Induction of micronuclei and nuclear abnormalities in tadpoles of thecommon toad (Rhinella arenarum) treated with the herbicides Liberty®and glufosinate-ammonium. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 769, 7–12.
Lajmanovich, R. C., Peltzer, P. M., Attademo, A. M., Martinuzzi, C. S., Simoniello, M. F., Colussi, C. L., Boccioni, A. P. C., Sigrist, M. (2019). First evaluation of novel potential synergistic effects of glyphosate and arsenic mixture on Rhinella arenarum (Anura: Bufonidae) tadpoles. Heliyon, 5(10), 02601.
Lavilla, E. O. (2001). Amenazas, declinaciones poblaciones y extinciones en anfíbios Argentinos. Cuaderno de Hepetología, 15(1), 59–82.
Lenkowski, J. R., Reed, J. M., Deininger, L., Mclaughlin, K. A. (2008). Perturbation of organogenesis by the herbicide atrazine in the amphibian Xenopus laevis. Environmental Health Perspectives, 116(2), 223–230.
Linzey, D. W., Burroughs, J., Hudson, L., Marini, M., Robertson, J., Bacon, J. P., Nagarkatti, M., Nagarkatti, P. S. ( 2003). Role of environmental pollutants on immune functions, parasitic infections and limb malformations in marine toads and whistling frogs from Bermuda. International Journal of Environmental Health Research, 13(2), 125–148.
Maharajan, K., Muthulakshmi, S., Nataraj, B., Ramesh, M., Kadirvelu, K. (2018). Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos (Danio rerio): A multi biomarker study. Aquatic Toxicology, 196, 132–145.
Mann, R. M., Hyne, R. V., Choung, C. B., Wilson, S. P. (2009). Amphibians and agricultural chemicals: Review of the risks in a complex environment. Environmental Pollution, 157(11), 2903–2927.
Materna, E. J., Rabeni, C. F., Lapoint, T. W. (1995). Effects of the synthetic pyrethroid insecticide, esfenvalerate, on larval leopard frogs (Rana spp.). Environmental Toxicology and Chemistry, 14(4), 613–622.
McCAIN, K. (1990). Mapping Authors in Intellectual Space: A Technical Overview. Journal of the American Society for Information Science, 41(6), 433–443.
McCallum, M. L., TRAUTH, S. E. (2003). A forty-three year museum study of northern cricket frog (Acris crepitans) abnormalities in Arkansas: upward trends and distributions. Journal of Wildlife Diseases, 39(2), 522–528.
Metts, B. S., Hopkins, W. A., Nestor, J. P. (2005). Interaction of an insecticide with larval density in pond-breeding salamanders (Ambystoma). Freshwater Biology, 50(4), 685–696.
Miyata, K., Ose, K. (2012). Thyroid Hormone-disrupting Effects and the Amphibian Metamorphosis Assay. Journal of Toxicologic Pathology, 25(1), 1–9.
Moreira, J. C., Peres, F., Simões, A. C., Pignati, W. A., Dores, E. De C., Vieira, S. N., Strüssmann, C. Mott, T. (2012). Contaminação de águas superficiais e de chuva por agrotóxicos em uma região do estado do Mato Grosso. Ciência & Saúde Coletiva, 17(6), 1557–1568.
Morgan, M. K., Scheuerman, P. R., Bishop, C. S., Pyles, R. A. (1996). Teratogenic potential of atrazine and 2,4−D using FETAX. Journal of Toxicology and Environmental Health, 48(2), 151–168.
Moron, S. E., Polez, V. L. P., Artoni, R. F., Ribas, J. L. C., Takahashi, H. K. (2006). Estudo de Alterações na Concentração dos Íons Plasmáticos e da Indução de Micronúcleos em Piaractus mesopotamicus Exposto ao Herbicida Atrazina. Journal of the brazilian society of ecotoxicology, 1(1), 27-30.
Mortensen, A. S., Kortner, T. M., Arukwe, A. (2006). Thyroid hormone-dependent gene expression as a biomarker of short-term 1,1-dichloro-2,2- bis(p-chlorophenyl) ethylene (DDE) exposure in European common frog (Rana temporaria) tadpoles. Biomarkers, 11(6), 524–537.
Noriega, N. C., Hayes, T. B. (2000). DDT congener effects on secondary sex coloration in the reed frog Hyperolius argus: a partial evaluation of the Hyperolius argus endocrine screen. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology, 126(2), 231–237.
Ochoa, X., Suthers, D., Verbert, K., Duval, E. (2014). Analysis and Reflections on the Third Learning Analytics and Knowledge Conference (LAK 2013). Journal of Learning Analytics, 1(2), 5–22.
Oka, T., Tooi, O., Mitsui, N., Miyahara, M., Ohnishi, Y., Takase, M., Kashiwagi, A., Santo, N., Iguchi, T. (2008). Effect of atrazine on metamorphosis and sexual differentiation in Xenopus laevis. Aquatic Toxicology, 87(4), 215–226.
Osano, O., Admiraal, W., Otieno, D. (2002a). Developmental disorders in embryos of the frog Xenopus laevis induced by chloroacetanilide herbicides and their degradation products. Environmental Toxicology and Chemistry, 21(2), 375–379.
Osano, O., Oladimeji, A. A., Kraak, M. H. S., Admiraal, W. (2002b). Teratogenic effects of amitraz, 2,4-dimethylaniline, and paraquat on developing frog (Xenopus) embryos. Archives of Environmental Contamination and Toxicology, 43(1), 42–49.
Paganelli, A., Gnazzo, V., Acosta, H., Lopez, S. L., Carrasco, A. E. (2010). Glyphosate based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling. Chemical Research in Toxicology, 23(10), 1586–1595.
Palmer, B. D., Huth, L. K., Pieto, D. L., Selcer, K. W. (1998). Vitellogenin as a biomarker for xenobiotic estrogens in an amphibian model system. Environmental Toxicology and Chemistry, 17(1), 30–36.
Peltzer, M. P., Lajmanovich, R. C., Sanchez, L. C., Attademo, A. M., Junges, C. M., Bionda, C. L., Martino, A. L., Bassó, A. (2001). Morphological abnormalities in amphibian populations from the mid-eastern region of Argentina. Herpetological Conservation and Biology, 6(3), 432–442.
Pérez-Iglesias, J. M., Soloneski, S., Nikoloff, N., Natale, G. S., Larramendy, M. L. (2015). Toxic and genotoxic effects of the imazethapyr-based herbicide formulation Pivot H® on montevideo tree frog Hypsiboas pulchellus tadpoles (Anura, Hylidae). Ecotoxicol and Environ Saf, 119, 15–24.
Perkins, P. J., Boermans, H. J., Stephensen, G. R. (2000). Toxicity of glyphosate and triclopyr using the frog embryo teratogenesis assay-Xenopus. Environmental Toxicology and Chemistry, 19(4), 940-945.
Piha, H., Pekkonen, M., Merila, J. (2006). Morphological abnormalities in amphibians in agricultural habitats: a case study of the common frog Rana temporaria. Copeia, 4, 810–817.
Punzo, F. (2005). Effects of insecticide (carbaryl) exposure on activity and swimming performance of tadpoles of the Rio Grande leopard frog, Rana berlandieri (Anura: Ranidae). Texas Journal of Science, 57(3), 263–272.
Raan, V. A. F. J. (1997). Scientometrics: State-of-the-art. Scientometrics, 38(1), 205–218.
Reeves, R. A. (2014). Amphibian stress, survival, and habitat quality in restored agricultural wetlands in central Iowa. Dissertations, (Ecology and Evolutionary Biology Commons, and the Natural Resources and Conservation Commons) Iowa State University State University Ames – Iowa.
Relyea, R., Hoverman, J. (2006). Assessing the ecology in ecotoxicology: a review and synthesis in freshwater systems. Ecology Letters, n. 9(10), 1157–1171.
Richards, S. M., Kendall, R. J. (2002). Biochemical effects of chlorpyrifos on two developmental stages of Xenopus laevis. Environmental Toxicology and Chemistry, 21(9), 1826–1835.
Sabik, H., Jeanot, R., Roundeau, B. (2000). Multiresidue methods using solid-phase extraction techniques for monitoring priority pesticides, including triazines and degradation products, in ground and surface waters. Journal of Chromatography, 885, 217-236.
Sayim, F. ( 2008). Acute toxic effects of malathion on the 21st stage larvae of the marsh frog. Turkish. Journal of Zoology, 32(1), 99–106.
Schoff, P. K., Johnson, C. M., Schotthoefer, A. M., Murphy, J. E., Lieske, C., Cole, R. A., Johnson, L. B., Beasley, V. R. (2003). Prevalence of skeletal and eye malformations in frogs from north-central United States: estimations based on collections from randomly selected sites. Journal of Wildlife Diseases, 39(3), 510–521.
Sower, S. A., Reed, K. L., Babbitt, K. J. (2000). Limb malformations and abnormal sex hormone concentrations in frogs. Environmental Health Perspectives, 108(11), 1085–1090.
Spadotto, C. A. (2006). Influência das Condições Meteorológicas no Transporte de Agrotóxicos no Ambiente. Embrapa Meio Ambiente.
Sparling, D. W., Fellers, G. M., Mcconnell, L. L. (2001). Pesticides and amphibian population declines in California, USA. Environmental Toxicology and Chemistry, 20(7), 1591–1595.
Stocum, D. L. (2000). Frog limb deformities: an ‘‘eco-devo’’ riddle wrapped in multiple hypotheses surrounded by insufficient data. Teratology, 62(3), 147–150.
Stuart, S. N., Chanson, J. S., Cox, N. A., Young, B. E., Rodrigues, A. S. L., Fischman, D. L., Waller, R. W. (2004). Status and trends of amphibian declines and extinctions worldwide. Science, 306, 1783–1786.
Tavera-Mendoza, L., Ruby, S., Brousseau, P., Fournier, M., Cyr, D., Marcogliese, D. (2002a). Response of the amphibian tadpole (Xenopus laevis) to atrazine during sexual differentiation of the ovary. Environmental Toxicology and Chemistry, 21(6), 1264–1267.
Tavera-Mendoza, L., Ruby, S., Brousseau, P., Fournier, M., Cyr, D., Marcogliese, D.(2002b). Response of the amphibian tadpole (Xenopus laevis) to atrazine during sexual differentiation of the testis. Environmental Toxicology and Chemistry, 21(3), 527–531.
Taylor, B., Skelly, D., Demarchis, L. K., Slade, M. D., Galusha, D., Rabinowitz, P. M. (2005). Proximity to pollution sources and risk of amphibian limb malformation. Environmental Health Perspectives, 113(11), 1497–1501.
Teplitsky, C., Piha, H., Laurila, A., Merila, J. (2005). Common pesticide increases costs of antipredator defenses in Rana temporaria tadpoles. Environmental Science & Technology, 39(16), 6079–6085.
Venturino, A., Pechen De D’angelo, A. M. (2005). Biochemical targets of xenobiotics: biomarkers in amphibian ecotoxicology. Applied Herpetology, 2(3), 335–353.
Vismara, C., Bacchetta, R., Cacciatore, B., Vailati, G., Fascio, U. (2001). Paraquat embryotoxicity in the Xenopus laevis cleavage phase. Aquatic Toxicology, 55(1-2), 85–93.
Vismara, C., Battista, V. V., Vailati, G., Bacchetta, R. (2000). Paraquat induced embryotoxicity on Xenopus laevis development. Aquatic Toxicology, 49(3), 171–179.
Wacksman, M. N., Maul, J. D., Lydy, M. J. (2006). Impact of atrazine on chlorpyrifos toxicity in four aquatic vertebrates. Archives of Environmental Contamination and Toxicology, 51(4), 681–689.
Walker, A., Rodriguez-Cruz, M. S., Mitchell, M. J. (2005). Influence of ageing of residues on the availability of herbicides for leaching. Environmental Pollution, 133(1), 43-51.
White, D. H., Griffith, B. C. (1982). Authors as markers of intellectual space: Co-citation in studies of science, technology and society. Journal of Documentation, 38(4), 255–272.
Widder, P. D., Bidwell, J. (2006). Cholinesterase activity and behavior in chlorpyrifosexposed Rana sphenocephala tadpoles. Environmental Toxicology and Chemistry, 25(9), 2446–2454.
Widder, P. D., Bidwell, J. (2008). Tadpole size, cholinesterase activity, and swim speed in four frog species after exposure to sub-lethal concentrations of chlorpyrifos. Aquatic Toxicology, 88(1), 9–18.
Yang, F.-X., Xu, Y.; Wen, S. (2005). Endocrine-disrupting effects of nonylphenol, bisphenol A, and p, p’-DDE on Rana nigromaculata tadpoles. Bulletin of Environmental Contamination and Toxicology, 75, 1168–1175.
Yoon, C. S., Jin, J. H., Park, J. H., Yeo, C. Y., Kim, S. J., Hwang, Y. G., Hong, S. J., Cheong, S. W. (2008). Toxic effects of carbendazim and n-butyl isocyanate, metabolites of the fungicide benomyl, on early development in the African clawed frog, Xenopus laevis. Environmental Toxicology, 23(1), 131–144.
Zang, W., Jiang, F., Ou, J. (2011). Global pesticide consumption and pollution: with China as a focus. Proceedings of the International Academy of Ecology and Environmental Sciences, 1(2), 125–144.
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