Importance of Lectins in Virology - An integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i11.10083

Keywords:

Lectins; Virology; Antiviral.

Abstract

Lectins are a special group of proteins with peculiar characteristics, these bind to carbohydrates of non-immunological origin. Several lectins have already been purified and isolated in nature, including in humans, they play very important roles especially in the process of innate immunity and cell signaling. Based on this information and given the importance of studying this class of proteins, this integrative review proposes to demonstrate the main references in the studies of lectins and their possible activities within the field of virology, being this object of study an important tool in the treatment of viral infections. The data show that in the last 5 years (2015-2020), not only the discovery of new lectins with potential antivirals was made, but studies of structural improvement and modification of the vector / virus link when applicable. It is concluded that the lectins approach a viable alternative of study and knowledge in the treatment of several diseases caused by viruses in different classes and animal species.

References

Adelman, Z. N.; Myles, K. M. The C-type lectin domain gene family in Aedes aegypti and their role in arbovirus infection. Viruses, 10(7).

Ahmed, Z., et al. The role of human dendritic cells in HIV-1 infectionJournal of Investigative DermatologyNature Publishing Group, 5.

Akkouh, O. et al. Lectins with Anti-HIV Activity: A Review. Molecules, 20(1), 648–668.

Ayouba, A. et al. Interactions of plant lectins with the components of the bacterial cell wall peptidoglycan. Biochemical Systematics and Ecology, 22(2), 153–159.

Barroso-Neto, I. L. et al. Structural analysis of a Dioclea sclerocarpa lectin: Study on the vasorelaxant properties of Dioclea lectins. International Journal of Biological Macromolecules, 82, 464–470.

Batool, K. et al. C-type lectin-20 interacts with ALP1 receptor to reduce cry toxicity in aedes aegypti. Toxins, 10(10).

Bermejo-Jambrina, M., et al. C-type lectin receptors in antiviral immunity and viral escapeFrontiers in ImmunologyFrontiers Media S.A.

Chang, Y. S., et al. Cloning and expression of the lectin gene from the mushroom Agrocybe aegerita and the activities of recombinant lectin in the resistance of shrimp white spot syndrome virus infection. Developmental and Comparative Immunology, 90, 1–9.

Charungchitrak, S. et al. Antifungal and antibacterial activities of lectin from the seeds of Archidendron jiringa Nielsen. Food Chemistry, 126(3), 1025–1032.

Favier, A. L., et al. Involvement of surfactant protein D in ebola virus infection enhancement via glycoprotein interaction. Viruses, 11(1).

Fu, L. et al. Plant lectins: Targeting programmed cell death pathways as antitumor agents. The International Journal of Biochemistry & Cell Biology, 43(10), 1442–1449.

Hassan, M. A. A. et al. Mushroom lectins: Specificity, structure and bioactivity relevant to human diseaseInternational Journal of Molecular SciencesMDPI AG.

Hopper, J. T. S. et al. The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans. Structure, 25(5), 773- 782.

Idris, F., Muharram, S. H., DIAH, S. Glycosylation of dengue virus glycoproteins and their interactions with carbohydrate receptors: possible targets for antiviral therapyArchives of VirologySpringer-Verlag Wien.

Lagarda-Diaz, I. et al. Insecticidal Action of PF2 Lectin from Olneya tesota (Palo Fierro) against Zabrotes subfasciatus Larvae and Midgut Glycoconjugate Binding. Journal of Agricultural and Food Chemistry, 57(2), 689–694.

Lagarda-Diaz, I., Guzman-Partida, A., Vazquez-Moreno, L. Legume Lectins: Proteins with Diverse Applications. International Journal of Molecular Sciences, 18(6), 1242.

Li, L. et al. Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro. Archives of Virology, 163(12), 3317–3325.

Liu, Y. et al. The roles of direct recognition by animal lectins in antiviral immunity and viral pathogenesisMoleculesMDPI AG.

Liu, Y. M., et al. A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2. Cell Reports, 32(6), 108016.

Machala, E. A. et al. Restriction of Human Cytomegalovirus Infection by Galectin-9. Journal of Virology, 93(3).

Mason, C. P., Tarr, A. W. Human lectins and their roles in viral infectionsMoleculesMDPI AG.

Mazalovska, M., Kouokam, J. C. Lectins as promising therapeutics for the prevention and treatment of HIV and other potential coinfectionsBioMed Research InternationalHindawi Limited.

Mishra, A., et al. Structure-function and application of plant lectins in disease biology and immunity. Food and Chemical Toxicology, 134, 110827.

Monteiro, J. T. et al. The CARD9-associated C-type lectin, mincle, recognizes la crosse virus (LACV) but plays a limited role in early antiviral responses against LACV. Viruses, 11(3).

Monteiro, J. T., Lepenies, B. Myeloid C-type lectin receptors in viral recognition and antiviral immunityVirusesMDPI AG.

Moreira, R. et al. Plant lectins: Chemical and biological aspects. Memórias do Instituto Oswaldo Cruz, 86(2), 211–218.

Osterne, V. J. S. et al. Structural characterization of a lectin from Canavalia virosa seeds with inflammatory and cytotoxic activities. International Journal of Biological Macromolecules, 94, 271–282.

Pereira, A. S. et al. Método Qualitativo, Quantitativo ou Quali-Quanti. [s.l: s.n.].

Peumans, W. J., Van Damme, E. Lectins as Plant Defense Proteins. Plant Physiology, 109(2), 347–352.

Sharon, N.; LIS, H. History of lectins: From hemagglutinins to biological recognition molecules. Glycobiology, 14(11), 53–62.

Siqueira, A. S. et al. Genomic screening of new putative antiviral lectins from Amazonian cyanobacteria based on a bioinformatics approach. Proteins: Structure, Function and Bioinformatics, 86(10), 1047–1054.

Swanson, M. D. et al. Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity. Cell, 163(3), 746–758.

Tani, H. et al. Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus. Journal of Virology, 90(11), 5292–5301.

White, M. R. et al. Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production. Innate Immunity, 23(1), 77–88.

Woodrum, B. W. et al. A designed “Nested” dimer of cyanovirin-N increases antiviral activity. Viruses, 8(6).

Published

21/11/2020

How to Cite

Moura, R. B. de ., Pereira Júnior, F. N. ., Santos, G. F. A., & Rodrigues, A. R. de S. . (2020). Importance of Lectins in Virology - An integrative review. Research, Society and Development, 9(11), e46491110083. https://doi.org/10.33448/rsd-v9i11.10083

Issue

Section

Agrarian and Biological Sciences