Use of plasma fibrinogen concentration and erythrocyte sedimentation rate as a prognostic parameter in dogs with leukocytosis
Keywords:ESR; Inflammation; Plasma protein.
The inflammatory process involves several vascular changes controlled by inflammation mediators. Vascular changes are increased vasodilation, increased vascular permeability, decreased local blood flow. The inflammatory process also induces leukocyte mobilization and migration from its storage sites to the site of action. During the process there is an increase in hepatic metabolism that leads to increased levels of acute phase proteins: fibrinogen, C-reactive protein, among others. In this work, parameters in the blood count were measured, such as total plasma protein, fibrinogen and ESR to measure the degree of inflammation, the red series was evaluated taking into account the presence of anemia and its type and the white series classifying leukocytosis and why the appearance of each of them. To obtain these results, a complete blood count, total plasma protein and erythrocyte sedimentation rate were performed using the Westergren method. The main objective of this work is to measure the erythrocyte sedimentation rate, making a comparison between animals with high ESR and animals with ESR within the reference values, observing the recovery time and degree of inflammation of the patient. In the results, we were able to perceive simple changes in the ESR with animals with inflammatory processes, making that, in the near future, this parameter also be used as a complementary exam to assist in the diagnosis of diseases that involve the inflammatory process itself. It is concluded that the ESR is a valid test in inflammatory processes, even with its low specificity.
Abbas, A. K., Lichtman, A, H., & Pillai, S. (2015). Imunologia celular e molecular. Guanabara Koogan.
Cançado, R. D., & Chiattone, C. S. (2002). Anemia de Doença Crônica. Revista brasileira de hematologia hemoterapia, 24, 127-128.
Jannini, P. (1942). As Anemias Hipocromicas e seus tratamentos. 17. <http://www.revistas.usp.br/revistadc/article/viewFile/48458/52320>.
Junior, L. B. (2015). Efeitos da ativação da guanilil ciclase solúvel pelo bay 60-2770 sobre a inflamação alérgica pulmonar murina e atividade quimiotática de eosinófilos humanos isolados . 2015. 111 p. Dissertação (Farmacologia)- UNICAMP.
Junior, V. H., Campos Neto, M. F., & Mendes, A. L. (2013). Mordeduras de animais (selvagens e domésticos) e humanas. Revista de Patologia Tropical, 42, 13-19.
Lee, P. (2017). Regulação da transcrição de hepcidina pela interleucina-1 e interleucina-6. The National Academy of Sciences, 102, 1906.
Monteiro, M. V. B., Santos, M. P., Figueiredo, M. J. F. M., & Monteiro, F. O. B. (2008). Avaliação clínica e hematológica de cães com cinomose em belém, pará. Ciencia animal, 18, 41-44
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003). Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood Journal, 101, 2461-2463.
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004). IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. JCI The jornaul of Clinical Investigation. 113, 1271-1276
Oliveira, T., Ebling, F. R., Lugoch, F. R., Noro, M., & Bicca, F. B. (2008). Associação entre as proteínas plasmáticas em cães revisão bibliográfica, Medicina Veterinária- Unipampa, 8, 2.
Paes, G., Veldeman, J., Paepe, D., Campos, M., & Daminet, S. Immune-mediated hemolytic anemia (IMHA) in cats part 1: A review (2010). Vlaams Diergeneeskundig Tijdschrift. 79, 415-423
Santos, V. M., Cunha, S. F., & Cunha, D. F. (2000). Velocidade de sedimentação das hemácias: utilidade e limitações.Rev. Associação Médica Brasileira 2000, 46, 3, 232-236.
Scott, M. A., & Stockham, S. L. (2011). Fundamentos de Patologia Clínica Veterinária. Guanabara Koogan
Thrall, M. A. et al. (2015). Hematologia e Bioquimica. Clínica Veterinária. Roca.
How to Cite
Copyright (c) 2021 Barbara Portas ; Ana Flávia Alves de Souza ; Barbara Cristina Mazzucatto; Sheila Rezler Wosiacki; Marilda Onghero Taffarel; Michelly Fernandes de Macedo ; Natalie Bertelis Merlini; Paulo Fernandes Marcusso
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.