Probiotics in the prevention and tratamento of periodontal diseases
DOI:
https://doi.org/10.33448/rsd-v10i2.12365Keywords:
Periodontitis; Gingivitis; Probiotic; Periodontal diseases.Abstract
Literature has shown that probiotics can be a possible ally in the prevention and treatment of periodontal diseases. The present study aims to review the literature regarding the use of probiotics in prevention and treatment of periodontal diseases. In most of the clinical studies included in this literature review, probiotics showed favorable results when used in prevention and as an adjunct to the treatment of gingivitis and periodontitis, bringing an improvement in the plaque index, gingival index and reduction in probing depth, in addition to the reduction of periodontopathogenic microorganisms and alteration of the immune response. Probiotics showed favorable results in most clinical studies included in this literature review, when used in prevention and as an adjunct. Further studies are still needed to establish clearer protocols regarding the most indicated strains, form of administration and time of use.
References
Akram, Z., Vohra, F., & Javed, F (2017). Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a meta-analysis. Journal of Investigative and Clinical Dentistry, 9 (2), 1-12.
Alakomi, H-L., Skytta, E., Saarela, M., Mattila-Sandholm, T., Latva-Kala. K. & Helander I. M (2000). Lactic Acid Permeabilizes Gram-Negative Bacteria by Disrupting the Outer Membrane. Applied and Environmental Microbiology, 66(5), 2001-2005.
Alanzani, A., Honkala, S., Honkala, E., Vargheses, A., Tolvanen, M. & Söderling, E. (2018). Effect Of Lactobacillus Rhamnosus And Bifidobacterium Lactis On Gingival Health, Dental Plaque, And Periodontopathogens In Adolescents: A Randomised Placebo-Controlled Clinical Trial. Beneficial Microbes, 9(4), 593-602.
Carranza, F.A., Takei, H. H., Klokkevold, P. R. & Newman, M. G (2012). Carranza Periodontia Clínica (11a ed.). Elsevier.
Caton, J. G., Armitage, G., Berglundh, T., Chapple, I., Jepsen, S., Kornman, K. S., Mealey, B. L., Papapanou, P. N., Sanz, M. & Tonetti, M. S. (2018). A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. Journal of clinical periodontology, 45 (20), 1–8.
Chapple, I., Mealey, B. L., Van Dyke, T. E, Bartold, P. M., Dommisch, H., Eickholz, P. Geisinger, M. L., Genco, R. J., Glogauer, M., Goldstein, M., Griffin, T. J,. Holmstrup, P., Johnson, G. K., Kapila, Y., Lang, N. P., Meyle, J., Murakami, S., Plemons, J., Romito, G. A., Shapira, L., & Yoshie, H. (2018). Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of clinical periodontology, 45(20), 68–77.
Donos, N., Calciolari, E., Brusselaers, N., Goldoni, M., Bostanci, N., & Belibasakis, G. N. (2020). The adjunctive use of host modulators in non-surgical periodontal therapy. A systematic review of randomized, placebo-controlled clinical studies. Journal of clinical periodontology, 47 (22), 199–238.
Graziani, F., Karapetsa, D., Alonso, B., & Herrera, D. (2017). Nonsurgical and surgical treatment of periodontitis: how many options for one disease?. Periodontology 2000, 75(1), 152-188.
Harini, P. M. & Anegundi, R. T (2010). Efficacy of a probiotic and chlorhexidine mouth rinses: a short-term clinical study. Journal Of Indian Society Of Pedodontics And Preventive Dentistry, 28 (3), 179-182.
Hotel, A. C., & Cordoba, A (2001). Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Prevention, 5 (1), 1-10.
Ikram, S., Hassan, N. Raffat, M. A. Mirza, S. & Akram, Z. (2018). Systematic review and meta‐analysis of double‐blind, placebo‐controlled, randomized clinical trials using probiotics in chronic periodontitis. Journal of investigative and clinical dentistry, 9(3), 1-9.
Ikram, S., Hassan, N., Baig, S. Borges, K. J. J. Raffat, M. A. & Akram, Z. (2018). Effect of local probiotic (Lactobacillus reuteri) vs systemic antibiotic therapy as an adjunct to non‐surgical periodontal treatment in chronic periodontitis. Journal of investigative and clinical dentistry, 10(2), 1-5.
İnce, G., Gürsoy, H., İpçi, Ş. D., Cakar, G., Emekli‐Alturfan, E., & Yılmaz, S. (2015). Clinical and biochemical evaluation of lozenges containing Lactobacillus reuteri as an adjunct to non‐surgical periodontal therapy in chronic periodontitis. Journal of periodontology, 86(6), 746-754.
Invernici, M. M., Salvador, S. L., Silva, P. H., Soares, M. S., Casarin, R., Palioto, D. B., Souza, S. L.S., Junior, M. T., Junior, A. B. N., Furlaneto, F, A, C. & Messora, M. R. (2018). Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trial. Journal of clinical periodontology, 45(10), 1198-1210.
Iwasaki, K., Maeda, K., Hidaka, K., Nemoto, K., Hirose, Y., & Deguchi, S. (2016). Daily intake of heat-killed Lactobacillus plantarum L-137 decreases the probing depth in patients undergoing supportive periodontal therapy. Oral Health Prev Dent, 14(3), 207-14.
Kim, J. W., Jung, B. H., Lee, J. H., Yoo, K. Y., Lee, H., Kang, M. S., & Lee, J. K. (2020). Effect of Weissella cibaria on the reduction of periodontal tissue destruction in mice. Journal of Periodontology.
Kligler, B., & Cohrssen, A. (2008). Probiotics. American family physician, 78(9), 1073-1078.
Kuru, B. E., Laleman, I., Yalnızoğlu, T., Kuru, L., & Teughels, W. (2017). The influence of a Bifidobacterium animalis probiotic on gingival health: a randomized controlled clinical trial. Journal of periodontology, 88(11), 1115-1123.
Laleman, I., Yilmaz, E., Ozcelik, O., Haytac, C., Pauwels, M., Herrero, E. R., Slomka, V., Quirynen, M., Alkaia, B., & Teughels, W. (2015). The effect of a streptococci containing probiotic in periodontal therapy: a randomized controlled trial. Journal of clinical periodontology, 42(11), 1032-1041.
Mahasneh, S. A., & Mahasneh, A. M. (2017). Probiotics: a promising role in dental health. Dentistry journal, 5(4), 26.
Mayanagi, G., Kimura, M., Nakaya, S., Hirata, H., Sakamoto, M., Benno, Y., & Shimauchi, H. (2009). Probiotic effects of orally administered Lactobacillus salivarius WB21‐containing tablets on periodontopathic bacteria: a double‐blinded, placebo‐controlled, randomized clinical trial. Journal of clinical periodontology, 36(6), 506-513.
Metchnikoff, E. (1907). Lactic acid as inhibiting intestinal putrefaction. The prolongation of life: Optimistic studies. W. Heinemann, London, 161-183.
Messora, M. R., Oliveira, L. F., Foureaux, R. C., Taba Jr, M., Zangerônimo, M. G., Furlaneto, F. A., & Pereira, L. J. (2013). Probiotic therapy reduces periodontal tissue destruction and improves the intestinal morphology in rats with ligature‐induced periodontitis. Journal of periodontology, 84(12), 1818-1826.
Meurman, J. H., & Stamatova, I. V. (2018). Probiotics: evidence of oral health implications. Folia medica, 60(1), 21-29.
Morales, A., Carvajal, P., Silva, N., Hernandez, M., Godoy, C., Rodriguez, G., Cabello, R., Garcia-sesnich, J., Hoare, A. & Gamonal, J. (2016). Clinical effects of Lactobacillus rhamnosus in non‐surgical treatment of chronic periodontitis: a randomized placebo‐controlled trial with 1‐year follow‐up. Journal of periodontology, 87(8), 944-952.
Morales, A., Gandolfo, A., Bravo, J., Carvajal, P., Silva, N., Godoy, C., Garcia-sesnich, J. Hoare, A. Diaz, P & Gamonal, J. (2017). Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo-controlled trial with 9-month follow-up. Journal of Applied Oral Science, 26.
Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., Flemmig, T. F.; Garcia, R., Giannobile, W.V.; Graziani, F., Greenwell, H., Herra., D., Kao, R. T., Kebschull, M., Kiane, D. F., Kirkwood, L. K., Kocher, T., Kornman, K. S., Kumar, P. S., Loos, B.G, Machtei, E., Meng, H., Mombelli, A., Needleman, I., Offenbacher, S., Seymour, G. J., Teles, R., & Tonetti, M. S. (2018). Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. Journal of periodontology, 89, 173-182.
Pelekos, G., Ho, S. N., Acharya, A., Leung, W. K., & McGrath, C. (2019). A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care. Journal of Clinical Periodontology, 46(12), 1217-1227.
Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em: 04 jan.
Schlagenhauf, U., Rehder, J., Gelbrich, G., & Jockel‐Schneider, Y. (2020). Consumption of Lactobacillus reuteri‐containing lozenges improves periodontal health in navy sailors at sea: A randomized controlled trial. Journal of Periodontology. 91 (10), 1328-1338.
Shah, M. P., Gujjari, S. K., & Chandrasekhar, V. S. (2013). Evaluation of the effect of probiotic (Inersan®) alone, combination of probiotic with doxycycline and doxycycline alone on aggressive periodontitis–a clinical and microbiological study. Journal of clinical and diagnostic research: JCDR, 7(3), 595.
Shimauchi, H., Mayanagi, G., Nakaya, S., Minamibuchi, M., Ito, Y., Yamaki, K., & Hirata, H. (2008). Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double‐blind, placebo‐controlled study. Journal of clinical periodontology, 35(10), 897-905.
Suzuki, N., Tanabe, K., Takeshita, T., Yoneda, M., Iwamoto, T., Oshiro, S.,Ymashita, Y. & Hirofuji, T. (2012). Effects of oil drops containing Lactobacillus salivarius WB21 on periodontal health and oral microbiota producing volatile sulfur compounds. Journal of breath research, 6(1), 1-8.
Szkaradkiewicz, A. K., Stopa, J., & Karpiński, T. M. (2014). Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis. Archivum immunologiae et therapiae experimentalis, 62(6), 495-500.
Tekce, M., Ince, G., Gursoy, H., Dirikan Ipci, S., Cakar, G., Kadir, T., & Yılmaz, S. (2015). Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1‐year follow‐up study. Journal of Clinical Periodontology, 42(4), 363-372.
Teughels, W., Van Essche, M., Sliepen, I., & Quirynen, M. (2008). Probiotics and oral healthcare. Periodontology 2000, 48(1), 111-147.
Teughels, W., Durukan, A., Ozcelik, O., Pauwels, M., Quirynen, M., & Haytac, M. C. (2013). Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo‐controlled study. Journal of clinical periodontology, 40(11), 1025-1035.
Tissier, H. (1907). Traitement des infections intestinales par la méthode de transformation de la flore bactérienne de l'intestin. 60, 359–361.
Tobita, K., Watanabe, I., Tomokiyo, M., & Saito, M. (2018). Effects of heat-treated Lactobacillus crispatus KT-11 strain consumption on improvement of oral cavity environment: a randomised double-blind clinical trial. Beneficial Microbes, 9(4), 585-592.
Toiviainen, A., Jalasvuori, H., Lahti, E., Gursoy, U., Salminen, S., Fontana, M., Flannagan, S., Eckert, G., Kokaras, A., Paster, B. & Söderling, E. (2015). Impact of orally administered lozenges with Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12 on the number of salivary mutans streptococci, amount of plaque, gingival inflammation and the oral microbiome in healthy adults. Clinical oral investigations, 19(1), 77-83.
Vicario, M., Santos, A., Violant, D., Nart, J., & Giner, L. (2013). Clinical changes in periodontal subjects with the probiotic Lactobacillus reuteri Prodentis: a preliminary randomized clinical trial. Acta Odontologica Scandinavica, 71(3-4), 813-819.
Vivekananda, M. R., Vandana, K. L., & Bhat, K. G. (2010). Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial. Journal of Oral Microbiology, 2(1)
Vohra, F., Bukhari, I. A., Sheikh, S. A., Albaijan, R., Naseem, M., & Hussain, M. (2020). Effectiveness of scaling and root planing with and without adjunct probiotic therapy in the treatment of chronic periodontitis among shamma users and non‐users: A randomized controlled trial. Journal of Periodontology, 91(9), 1177-1185.
Yuki, O. D. A., Furutani, C., Mizota, Y., Wakita, A., Mimura, S., Kihara, T., Ohara, M., Okada, Y., Okada, M & Nikawa, H. (2019). Effect of bovine milk fermented with Lactobacillus rhamnosus L8020 on periodontal disease in individuals with intellectual disability: a randomized clinical trial. Journal of Applied Oral Science, 27, 1-9.
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Copyright (c) 2021 Natan Santos Massambani; Nicolly Cardoso Fernandes; Priscila Paganini Costa ; Maria Beatriz Bergonse Pereira Pedriali; Fernanda Akemi Nakanishi Ito; Luciana Prado Maia
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