Immunomedied Adverse Reactions in patients treated with Immunological Checkpoints Inhibitors in a filantropic Hospital in Salvador
DOI:
https://doi.org/10.33448/rsd-v10i2.12928Keywords:
Cancer; Immunotherapy; Immunomodulators; Adverse reactions.Abstract
Introduction: Immune Checkpoint Inhibitors (ICI) block the inhibitory effects on receptors such as CTLA-4, PD-1 and PD-L1 and reestablish anti-tumor immunity. Thus, they are associated with gastrointestinal, dermatological, hepatic and endocrine Immune-Mediated Adverse Reactions (RAim). Objective: To analyze the profile of immune-mediated adverse reactions in cancer patients treated with immunological checkpoint inhibitors at a hospital in Salvador / Ba. Method: This is an observational, cross-sectional, retrospective study. All reports of adverse reactions associated with cancer treatment with ICIs, documented between January 2015 and May 2020, were evaluated. The research was approved by the Research Ethics Committee, according to the opinion number 4.074.757 / 2020. Results: During the study period, 27 patients used ICI. As for the RAim, 17 developed RAim. Of the most frequent RAim, 62% involved Nivolumab and 21% Pembrolizumab. 26% of RAim were gastrointestinal reactions, followed by 19% various reactions (such as vaginal bleeding and neuropathy); 53% of RAim were classified as moderate reactions. Among the therapeutic measures adopted to resolve RAIM, 73% of the ICI were discontinued and replaced by other chemotherapeutic agents; 53% of patients used supportive therapies to manage symptoms caused by Raim. As for the clinical outcome, 53% patients recovered from RAim, 24% recovered with sequelae and 23% died. Conclusion: The introduction of targeted therapy, adequate pharmacotherapeutic follow-up and monitoring by pharmacovigilance will favor the identification of immune-mediated adverse reactions, and the safe and appropriate use of ICI.
References
Abdel, R. O. (2019). Toxicity patterns associated with chemotherapy/immune checkpoint inhibitor combinations: a meta-analysis. Immunotherapy, 11(6), 543-554. doi: 10.2217/imt-2018-0186
Barclay, J., Creswell, J., & León, J. (2018). Cancer immunotherapy and the PD-1/PD-L1 checkpoint pathway. Archivos espanoles de urologia, 71(4), 393-399.
Brahmer, J. R., et al. (2018). Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology Clinical Practice Guideline. Journal of clinical oncology: official journal of the American Society of Clinical Oncology, 36(17), 1714. DOI: 10.1200/JCO.2017.77.6385.
Champiat, S. et al. (2016). Management of immune checkpoint blockade dysimmune toxicities: a collaborative position paper. Annals of Oncology, 27(4), 559-574. DOI: 10.1093/annonc/mdv623.
Dine, J., Gordon, R., Shames, Y., Kasler, M. K., & Barton-Burke, M. (2017). Immune checkpoint inhibitors: an innovation in immunotherapy for the treatment and management of patients with cancer. Asia-Pacific journal of oncology nursing, 4(2), 127. DOI: 10.4103/apjon.apjon_4_17.
Eigentler, T. K. et al. (2016). Diagnosis, monitoring and management of immune-related adverse drug reactions of anti-PD-1 antibody therapy. Cancer treatment reviews, 45, 7-18. DOI: 10.1016/j.ctrv.2016.02.003.
Ellithi, M. et al. (2020). Toxicities of Immune Checkpoint Inhibitors: Itis-Ending Adverse Reactions and More. Cureus, 12(2). DOI: 10.7759/cureus.6935.
Hargadon, K. M., Johnson, C. E., & Williams, C. J. (2018). Immune checkpoint blockade therapy for cancer: an overview of FDA-approved immune checkpoint inhibitors. International immunopharmacology, 62, 29-39. DOI: 10.1016/j.intimp.2018.06.001
Lleo, A., Rimassa, L., & Colombo, M. (2019). Hepatotoxicity of immune check point inhibitors: Approach and management. Digestive and Liver Disease, 51(8), 1074-1078. DOI: https://doi.org/10.1016/j.dld.2019.06.017
Pereira A. S.,Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. Santa Maria, RS: UFSM, NTE.
Regalla, D. K. R., Williams, G. R., & kumar P. R. (2018). Immune checkpoint inhibitors in the management of malignancies in transplant recipients. Postgraduate Medical Journal, 94(1118), 704-708. DOI: 10.1136/postgradmedj-2018-136081
Shoushtari, A. N. et al. (2018). Measuring toxic effects and time to treatment failure for nivolumab plus ipilimumab in melanoma. JAMA oncology, 4(1), 98-101. DOI: 10.1001/jamaoncol.2017.2391
Teixeira, H. C., Silva D. L., Menão, T. L., & Oliveira, E. E. (2019). Proteínas de checkpoint imunológico como novo alvo da imunoterapia contra o câncer: revisão da literatura. HU Revista, 45(3), 325-333. DOI: https://doi.org/10.34019/1982-8047.2019.v45.28820.
Wang, D. Y. et al. (2018). Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis. JAMA oncology, 4(12), 1721-1728. DOI: 10.1001/jamaoncol.2018.3923.
Wang, G. et al. (2020). The expression and immunoregulation of immune checkpoint molecule VISTA in autoimmune diseases and cancers. Cytokine & growth factor reviews, 52, 1-14. DOI: 10.1016/j.cytogfr.2020.02.002.
Wainstein, A. J. et al. (2017). Brazilian guidelines for the management of immune-related adverse events associated with checkpoint inhibitors. Brazilian Journal of Oncology, 13(43), 1-15.
Xu, C. et al. (2018). Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis. Bmj, 363. DOI: https://doi.org/10.1136/bmj.k4226.
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Copyright (c) 2021 Juliana Pereira dos Santos; Martamaria de Souza Ferraz Ribeiro; Maria Teresita Bendicho ; Geraldo Bezerra da Silva Júnior ; Rosa Malena Fagundes Xavier
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