Association between inadequate intake of antioxidant micronutrients and lipid concentrations of adolescents in Brazil

Authors

DOI:

https://doi.org/10.33448/rsd-v10i5.15081

Keywords:

Teenagers; Dyslipidemia; Atherosclerosis; Micronutrients; Antioxidants.

Abstract

The association between inadequate intake of antioxidant micronutrients and lipid concentrations of adolescents participating in the Study of Cardiovascular Risks in Adolescents was investigated. Cross-sectional, multicenter, school-based study, carried out in 2013 and 2014, with 36,918 adolescents aged 12 to 17 years, from public and private schools, in Brazilian municipalities with more than 100 thousand in habitants. Participation frequencies (eligible) by macro-regions, sex, age and type of school were calculated. Food consumption data were obtained through a 24-hour Food Recall and the mean intake was analyzed. Biochemical evaluation was performed with CT, HDL-c, TG and LDL-c exams. Data were analyzed using Stata® software, version 15.1 and 95% confidence interval. Pearson's chi-square test and multiple regression were used to estimate the Odds Ratio (OR) and measure the strength of association between the variables, with a significance of 5%. Inadequate vitamin E intake associated with elevated LDL-c in adolescents aged 12 to 14 years and hypertriglyceride average in boys aged 15 to 17 years in public schools. Vitamin B12 was related to low levels of HDL-c and elevated LDL-c in boys aged 12 to 14 years in public schools and with a lower chance of hypertriglyceride average in those aged 15 to 17 years. The inadequacy of manganese associated with low HDL-c and high LDL-c in girls aged 15 to 17. In conclusion, associations were found between inadequate consumption of vitamins E, B12 and Manganese and the lipid profile of the population studied.

References

Adaikalakoteswari, A., Finer, S., Voyias, P. D., McCarthy, C. M., Vatihs, M., Moore, J., Smart-Halajka, M., Bawazeer, N., Ai- Daghri, N., McTernan, P. G., Kumar, S., Hitman, G. A., Saravanan, P. & Tripathi, G (2015). Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes. Clin Epigenetics, 7(1), 14.

Adaikalakoteswari, A., Jayashri., R., Sukumar, N., Venkataraman, H., Pradeepa, R., Gokulakrishnan, K., Anjana, R. M., McTernan, P. G., Trepathi, G., Patel, V., Kumar, S., Mohan, V., Saravanan, P. (2014). Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovasc Diabetol. 13(1), 129.

Albuquerque, M. N. L., Diniz, A. S., Arruda, I. K. G (2016). Elevated serum retinol and low beta-carotene but not alpha-tocopherol concentrations are associated whit dyslipidemia in Brazilian adolescentes. J Nutr Sci Vitaminol, 62, 73-80.

Alves, M. A., Souza, A. M., Barufaldi, L. A., Tavares, B. M., Bloch, K. V., Vasconcellos, F. A. G (2019). Padrões alimentares de adolescentes brasileiros por regiões geográficas: análise do Estudo de Riscos Cardiovasculares em Adolescentes (ERICA). Cad. Saúde Pública, 35(6):e00153818.

Ashor, A. W., Siervo, M., Velde, F. V. D., Willis, N. D., Mather, J. C (2016). Systematic review and meta-analysis of randomised controlled trials testing the effects of vitamin C supplementation on blood lipids. Clinical Nutrition, 35(3), 626-637.

Azevedo, L., Martino, H. S. D., Carvalho, F. G (2010). Estimativa da ingestão de ferro e vitamina C em adolescentes no ciclo menstrual. Ciência & Saúde Coletiva, 15(1), 1359-1367.

Barufaldi, L. A., Abreu, G. Z., Oliveira, J. S., Santos, D. F., Fujimori, E., Vasconcelos, S. M. L., Vasconcelos, F. A. G., Tavares, B. M (2016). ERICA: prevalência de comportamentos alimentares saudáveis em adolescentes brasileiros. Rev Saude Publica. 50 (1):6s.

Barzegar-Amini, M., Hamideh Ghazizadeh, S. M. S (2019). Serum vitamin E as a significan prognostic factor in patients with dyslipidemia disorders. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13, 666e671.

Bauman, C. D., Bauman, J. M., Mourao, D. M., Pinho, L., Brito, M. F. S. F., Carneiro, A. L. G., Silveira, M. F., Oliveira & Silva, C. S (2020). Dyslipidemia prevalence in adolescents in public schools. Rev Bras Enferm. 73(3), e20180523.

Bloch, K. V., Klein, C. H., Kuschnir, M. C., Abreu, G. A., Barufaldi, L. A., Klein, C. H., Vasconcellos, M. T. L (2015). The study of cardiovascular risk in adolescents – ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescentes. BMC Public Health, 94 (15).

Carvalho, L. M. F., Carvalho, L. S. C., Sousa, C. B., Beserra, J. B., Paz, S. M. R. S., Santos, M. S (2020). Study of Cardiovascular Risk Factors in Adolescents: Association between Intake of Vitamins A and E and Lipid Profile. Current Nutrition & Food Science, 16, 1-0.

Conway, J. M., Ingwersen, L. A., Vinyard, B. T., Moshfgh, A. J (2003). Effectiveness of the US Department of Agriculture 5-step multiple-pass method in assessing food intake in obese and nonobese women. Am J Clin Nutr. 77(5), 1171-8.

Cureau, F. V., Bloch, K. V., Henz, A., Shaan, C. W., Klein, C. H., Oliveira, C. L., Giannini, D. T., Leon, E. B., Abreu, G. A., Telo, G. H., Dias, G. M., Carvalho, K. M. B., Barufaldi, L. A., Kuschnir, M. C. C., Szklo, M., Junior, R. M., Silva, T. L. N., Ekelund, V., Schaan, B. D (2017).Challenges for conducting blood collection and biochemical analysis in a large multicenter school-based study with adolescents: lessons from ERICA in Brazil. Cad. Saúde Pública, 33(4).

Faludi, A. A., Izar, M. C. O., Saraiva, J. F. K., Chacra, A. P. M., Bianco, H. T., Afiune Neto, A., Bertolami, A., Pereira, A. C., Lottenberg, A. M., Sposito, A. C., Chagas, A. C. P., Casella-Filho, A., Simão, A. F., Alencar Filho, A. C., Caramelli, B., Magalhães, C. C., Magnoni, D., Negrão, C. E., Ferreira, C. E. S., Scherr, C., Feio, C. M. A., Kovacs, C., Araújo, D. B., Calderar, D., Gualandro, D. M., Mello Junior, E. P., Alexandre, E. R. G., Sato, I. E., Moriguchi, E. H., Rached, F. H., Santos, F. C., Cesena, F. H. Y., Fonseca, F. A. H., Fonseca, H. A. R., Xavier, H. T., Pimentel, I. C., Giuliano, I. C. B., Issa, J. S., Diament, J., Pesquero, J. B., Santos, JE., Faria Neto, J. R., Melo Filho, J. X., Kato, J. T., Torres, K. P., Bertolami, M. C., Assad, M. H. V., Miname, M. H., Scartezini, M., Forti, N. A., Coelho, O. R., Maranhão, R. C., Santos Filho, R. D., Alves, R. J., Cassani, R. L., Betti, R. T. B., Carvalho, T., Martinez, T. L. R., Giraldez, V. Z. R., Salgado Filho, W (2017) Atualização da Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose. Arq Bras Cardiol, 109 (1), 1–76.

Fan, Y., Zhang, C., Bu, J. I. N (2017). Relationship between Selected Serum Metallic Elements and Obesity in Children and Adolescent in the U.S. Nutrients, 9(2), 104.

Faria-neto, J. R., Bento, V. F. R., Baena, C. P., Olandoski, M., Gonçalves, L. G. O., Abreu, G. A., Kuschnir, M. C. C., Bloch, K. V (2016). ERICA: prevalência de dislipidemia em adolescentes brasileiros. Rev Saude Publica. 50(1):10s.

García, O. P., Ronquillo, D., Caamaño, M. C., Martínez, G., Camacho, M., López, V (2013). Zinc, iron and vitamins A, C and E are associated with obesity, inflammation, lipid profile and insulin resistance in Mexican school-aged children. Nutrients, 5(12), 5012-30.

Gil, A.C (2008). Métodos e Técnicas de Pesquisa Social. Atlas.

Guerendiain, M., Mayneris-Perxachs, J., Montes, R., Lopez-Belmonte, G., Martín-Matillas, M., Castellote, A.I., Martín-Bautista, E., Martí, A., Martínez, J.A., Moreno, L., Garagorri, J. M., Wearnberg, J., Caballero, J., Marcos, A., Lopez-Sabater, M. C., Campoy, C (2015). Relation between plasma antioxidant vitamin levels, adiposity and cardio-metabolic profile in adolescents: Effects of a multidisciplinary obesity programme. Clinical Nutrition. 36, 209-21

Iglesia, I., Mouratidou, T., González-Gross, M., Huvbrechts, I., Breidenasse, C., Santabárbara, J., Esperanza Díaz, L., Hallstrõm, L., De Henauw, S., Gottrand, F., Kafatos, A., Whidhalm, K., Manios, Y., Molnar, D., Stehle, P., Moreno, L.A (2016). Foods contributing to vitamin B6, folate, and vitamin B12 intakes and biomarkers status in European adolescents: The HELENA study, Eur J Nutr.

Institute of Medicine (2005) Dietary reference intakes, the essential guide to nutriente requirements. Washington (DC). National Academy Press.

Institute of Medicine, Food and Nutrition Board (2001). Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc: a report of the panel on micronutrients, Subcommittees on Upper Reference Levels of Nutrients and of Interpretation and Uses of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Washington (DC). National Academy Press.

Instituto Brasileiro de Geografia e Estatística (IBGE) (2020). Pesquisa de Orçamentos Familiares 2017-2018: análise do consumo alimentar pessoal no Brasil. IBGE, Rio de Janeiro.

Jordão, K. S. L. U., Assumpção, D., Barros, M. B. A., Filho, A. A. B (2021). Vitamin E intake and food sources in adolescent diet: a cross sectional population-based study. Rev Paul Pediatr, 39:e2019295.

Kim, S. M., Lim, S. M., Yoo, J. A., Woo, M. J., Cho, K. H (2015). Consumption of high-dose vitamin C (1250 mg per day) enhances functional and structural properties of seru lipoprotein to improve antioxidant, anti-atherosclerotic, and anti-aging effects via regulation of anti-inflammatory microRNA. Food & Function, 6(11), 3604-3612.

Li, W. X., Wen-Wen, L. V., Dai, S. X., Pan, M. L., Huang, J. F (2015). Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study. Lipids Health Dis, 14, 101.

Mahalle, N., Kulkarni, M. V., Garg, M. K., Naik, S. S (2013). Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease. J Cardiol, 61 (4), 289-94.

Nascimento, L. M., Gomes, Q. R. O., Mascarenhas, M. D. M., Miranda, C. E. S., Araújo, T. M. E., Frota, K. M. G (2018). Association between the consumption of antioxidant nutrients with lipid alterations and cardiometabolic risk in adolescentes. Rev Nutr, 31(2), 183-197.

Oladipo, O. O., Ayo, J., Ambali, S.F., Mohammed, B., Aluwong, T (2017). Dyslipdemia induced by chronic low dose co-exposure to lead, cadmium and manganese in rats: the role of oxidative stress. Environ Toxicol Pharmacol. 53, 199-205.

Prodanov, C. C., Freitas, E. C (2013). Metodologia do trabalho científico: métodos e técnicas da pesquisa e do trabalho acadêmico. (2ª ed.), Novo Hamburgo. https://docente.ifrn.edu.br/rodrigotertulino/disciplinas/2015.2/seminario-de-iniciacao-cientifica/livro/e-book-metodologia-do-trabalho-cientifico/view

Rodrigues, C. H. G., Fernandes, D. S. P., Souza, E. C. G., Hermsdorff, H. H. M., Duarte, M. S. L (2015). Fatores de risco e consumo de micronutrientes protetores para doença cardiovascular em universitários da área de saúde. Rev. Bras. Nutr.Clin, 30 (2), 146-53.

Saraswhathy, K. N., Joshi, S., Yadav, S., Garg, P. R (2018). Metabolic distress in lipid & one carbono metabolic pathway through low vitamin B-12: a population based study from North India. Lipids in Health and Disease, 17, 96.

Scorsatto, M., Rosa, G., de Oliveira, G. M. M (2016). Antioxidant Vitamin Intake in Dyslipidemic Overweight Individuals. International Journal of Cardiovascular Sciences. 29(3), 210-217.

Shoji, H., Ikeda, N., Kojima, C., Kitamura, T., Suganuma, S., Ueno, T., Miida, T., Shimizu, T (2016). Relationship between copper and lipids and atherogenic indices soon after birth in Japanese preterm infants of 32–35 weeks. Journal of Developmental Origins of Health and Disease. 1-5.

Silva, T. L. N., Klein, C. H., Souza, A. M., Barufaldi, L. A., Abreu, G. A., Kuschnir, M. C. C., Vasconcellos, M. T. L., Bloch, K. V (2016). Participação no Estudo de Riscos Cardiovasculares em Adolescentes- ERICA. Rev Saúde Pública, 50 (1).

Song, X. X., Wang, W., Li, Z., Zhang, D (2018). Association between Serum Copper and Serum Lipids in Adults. Ann Nutr Metab, 73, 282–289

Souza, A. M., Barufaldi, L. A., Abreu, G. A., Gianini, D. T., Oliveira, C. L., Santos, M. M., Leal, V. S., Vasconcelos, F. A. G (2016). ERICA: ingestão de macro e micronutrientes em adolescentes brasileiros. Rev Saúde Pública, 50 (1).

Teixeira, M. G., Mill, J. G., Pereira, A. C., Molina, M. C. B (2016). Consumo de antioxidantes em participantes do ELSA-Brasil: resultados da linha de base. Rev Bras Epidemiol, 19(1), 149-159.

Tureck, C., Locateli, G., Corrêa, V. G., Koehnlein, E. A (2017). Avaliação da ingestão de nutrientes antioxidantes pela população brasileira e sua relação com o estado nutricional. Rev Bras Epidemiol, 20(1), 30-42.

Vasconcellos, M. T. L., Silva, P. L. N., Szklo, M., Kuschnir, M. C. C., Klein, C. H., Abreu, G. A., Barufaldi, L. A., Bloch, K. V (2015). Sampling design for the Study of Cardiovascular Risk in Adolescents (ERICA). Cad. Saúde Pública, 31(5), 1-10.

Veiga, G. V., Costa, R. S., Araújo, M. C., Souza, A. M., Bezerra, L. N., Barbosa, F. S., Sichieri, R., Pereira, R. A (2013). Inadequação do consumo de nutrientes entre adolescentes brasileiros. Rev Saúde Pública, 47(1), 212S-21S.

Vizentin, N. P., Cardoso, P. M. S., Maia, C. A. G., Alves, I. P., Aranha, G. L., Giannini, D. T (2019). Dyslipidemia in Adolescents Seen in a University Hospital in the city of Rio de Janeiro/Brazil: Prevalence and Association. Arq Bras Cardiol, 112(2), 147–151.

WHO. World Health Organization (2005). Multicentre growth reference study group nutrition in adolescence – issues and challenges for the health sector: issues in adolescent health and development. Geneva.

Wolide, A. D., Zawdie, B., Alemayehu, T., Tadesse, S (2017). Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients: a cross sectional study. BMC Endocr Disord, 17(1),64.

Xavier, H. T., Izar, M. C., Faria Neto, J. R., Assad, M. H., Rocha, V. Z., Sposito, A. C., Fonseca, F. A., dos Santos, J. E., Santos, R. D., Bertolami, M. C., Faludi, A. A., Martinez, T. L. R., Diament, J., Guimarães, A., Forti, N. A., Moriguchi, E., Chagas, A. C. P., Coelho, O. R., Ramires, J. A. F (2013). V Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose. Arq Bras Cardiol. 101(1), 1-20.

Zhao, Y., Frank, J., Monahan, B. A., Mcnulty, K. L., Frederick, J. B., Daniel, J. D., Brennan, L., Nugent, A. P., Gibney, E. R (2016). Plasma n‑3 polyunsaturated fatty status and its relationship with vitamin E intake and plasma level. Eur J Nutr.

Published

11/05/2021

How to Cite

SOUSA, C. B. de .; TELES , L. de F. da S. .; BESERRA, J. B. .; CARVALHO, L. de S. .; PAZ , S. M. R. S. da; SANTOS , M. M. dos. Association between inadequate intake of antioxidant micronutrients and lipid concentrations of adolescents in Brazil. Research, Society and Development, [S. l.], v. 10, n. 5, p. e38910515081, 2021. DOI: 10.33448/rsd-v10i5.15081. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/15081. Acesso em: 18 nov. 2024.

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Health Sciences