Recommendation and safety of vaccinacion in patients with rheumatoid arthritis using immunosuppressive treatment

Authors

DOI:

https://doi.org/10.33448/rsd-v10i7.16440

Keywords:

Rheumatoid Arthritis; Vaccination; Immunosuppression.

Abstract

Introduction: Rheumatoid arthritis (RA) is an inflammatory autoimmune disease often treated using immunosuppressive drugs that are directly related to the occurrence of opportunistic manifestations. Therefore, vaccination can be a means of protection, but its safety and recommendation must be evaluated. Objective: To identify the safety and recommendation of vaccination in patients treating RA. Method: Integrative literature review, developed from 11 articles obtained from the PubMed® database, and 3 articles obtained from the BVS library in which the same descriptors were used in Health Sciences, totaling 14 analyzed works, a time frame was defined, covering articles from the last 5 years. Results: According to the findings, the main recommended and safe vaccines are Pneumococcal, Influenza, Hepatitis B, Human Papilloma Virus (HPV) and Herpes Zoster. However, attention must be paid to the interaction between vaccine-drug, as this relationship can cause damage to the performance of the vaccine or even harm to the patient. Conclusion: Based on the analyzed studies, it is concluded that vaccination is generally recommended and safe for individuals with rheumatoid arthritis undergoing treatment with immunosuppressants.

References

Akikusa, J. D., & Crawford, N. W. (2014). Vaccination in Paediatric Rheumatology. Current Rheumatology Reports, 16(8), 425-432.

Alten, R., et al. (2016). Antibody response to pneumococcal and influenza vaccination in patients with rheumatoid arthritis receiving abatacept. BMC Musculoskeletal Disorders, 17(1), 221-231.

Araujo, J. C. de S., Silva, A. M. B. F. da, Figueiredo, N. M. A. de, & Novaes, C. de O. (2020). Impacto da dor e da fadiga no desempenho ocupacional de clientes com artrite reumatoide na Atenção Básica no Rio de Janeiro. Research, Society and Development, 9(7), e605974243.

Calabrese, L. H., et al. (2020). Live Zoster Vaccine in Patients With Rheumatoid Arthritis Treated With Tofacitinib With or Without Methotrexate, or Adalimumab With Methotrexate: a post hoc analysis of data from a phase iiib/iv randomized study. Arthritis Care & Research, 72(3), 353-359.

Chaudhari, K., Rizvi, S., & Syed, B. A. (2016). Rheumatoid arthritis: current and future trends. Nature(9 Reviews Drug Discovery, 15(5), 305-306.

Fernandez-Martinez, S., Cortes, X., Borrás-Blasco, J., Gracia-Pérez, A., & Casterá, M. E., (2016). Effectiveness of a systematic vaccination program in patients with autoimmune inflammatory disease treated with anti-TNF alpha drugs. Expert Opinion On Biological Therapy, 16(11), 1317-1322.

Hmamouchi, I., Winthrop, K., Launay, O., & Dougados, M. (2015). Low rate of influenza and pneumococcal vaccine coverage in rheumatoid arthritis: data from the international comora cohort. Vaccine, 33(12), 1446-1452.

Izumi, Y., et al. (2017). The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial. Arthritis Research & Therapy, 19(1), 140-149.

Jain, V. K., et al. (2017). Effect of disease-modifying antirheumatic drug therapy on immune response to trivalent influenza vaccine in rheumatoid arthritis. The Indian journal of medical research, 145(4), 464–470.

Kobayashi, I., et al. (2014). Pediatric Rheumatology Association of Japan recommendation for vaccination in pediatric rheumatic diseases. Modern Rheumatology, 25(3), 335-343.

Lampropoulos, C. E., et al. (2015). Adverse events and infections in patients with rheumatoid arthritis treated with conventional drugs or biologic agents: a real world study. Clinical and experimental rheumatology, 33(2), 216–224.

Lee, J., Kim, I. J., Cho, M., & Lee, J. (2017). A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. Journal Of Korean Medical Science, 32(7), 1207-1210.

Mcinnes, I. B., & Schett, G. (2011). The Pathogenesis of Rheumatoid Arthritis. New England Journal Of Medicine, 365(23), 2205-2219.

Meroni, P. L., Zavaglia, D., & Girmenia, C. (2018). Vaccinations in adults with rheumatoid arthritis in an era of new disease-modifying anti-rheumatic drugs. Clinical and experimental rheumatology, 36(2), 317–328.

Migita, K., et al. (2015). Effect of abatacept on the immunogenicity of 23-valent pneumococcal polysaccharide vaccination (PPSV23) in rheumatoid arthritis patients. Arthritis Research & Therapy, 17(1), 1-7.

Park, J. K., et al. (2018). Impact of temporary methotrexate discontinuation for 2 weeks on immunogenicity of seasonal influenza vaccination in patients with rheumatoid arthritis: a randomised clinical trial. Annals Of The Rheumatic Diseases, 77(6), 898-904.

Ramiro S., et al. (2017). Safety of synthetic and biological DMARDs: a systematic literature review informing the 2016 update of the eular recommendations for management of rheumatoid arthritis. Annals Of The Rheumatic Diseases, 76(6), 1101-1136.

Roland, S., Lopes, R. de P. ., Nascimento Júnior, W. do, Nascimento, W. L. do, & Leitão, J. M. S. de R. (2020). Alterações Bioquímicas em Usuários de Metotrexato em Associação ao Leflunomida Para a Artrite Reumatóide. Research, Society and Development, 9(10), e8709109150.

Singh, J. A., et al. (2015). American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis & Rheumatology, 68(1), 1-26.

Smolen J. S., et al. (2016). EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Annals Of The Rheumatic Diseases, 76(6), 960-977.

Solay, A. H., & Eser, F. (2019). High dose hepatitis B vaccine is not effective in patients using immunomodulatory drugs: a pilot study. Human Vaccines & Immunotherapeutics, 15(5), 1177-1182.

Sousa, L. M. M., Marques-Vieira, C. M. A., Severino, S. S. P., & Antunes, A. V. (2017). Metodologia de Revisão Integrativa da Literatura em Enfermagem. Revista Investigação em Enfermagem, 2(21), 17-26.

Winthrop, K. L., et al. (2015) The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis. Annals Of The Rheumatic Diseases, 75(4), 687-695.

Winthrop, K. L., et al (2017). The Safety and Immunogenicity of Live Zoster Vaccination in Patients With Rheumatoid Arthritis Before Starting Tofacitinib: a randomized phase ii trial. Arthritis & Rheumatology, 69(10), 1969-1977.

Winthrop, K. L., et al. (2019). Evaluation of pneumococcal and tetanus vaccine responses in patients with rheumatoid arthritis receiving baricitinib: results from a long-term extension trial substudy. Arthritis Research & Therapy, 21(1), 1-10.

Winthrop, K. L., et al. (2020). Long-term effectiveness of live herpes zoster vaccine in patients with rheumatoid arthritis subsequently treated with tofacitinib. Annals Of The Rheumatic Diseases, 79(5), 669-671.

Published

20/06/2021

How to Cite

SILVA, A. M. M. da .; ARAÚJO, D. K. L. de .; SOUSA, M. N. A. de . Recommendation and safety of vaccinacion in patients with rheumatoid arthritis using immunosuppressive treatment. Research, Society and Development, [S. l.], v. 10, n. 7, p. e23910716440, 2021. DOI: 10.33448/rsd-v10i7.16440. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/16440. Acesso em: 25 apr. 2024.

Issue

Section

Health Sciences