The role of antiparasitc drugs and steroids in Covid-19 treatment

Authors

DOI:

https://doi.org/10.33448/rsd-v10i8.17300

Keywords:

Ivermectin; Invertebrates; Chloroquine; Nitazoxanide; Glucocorticoids; COVID-19 vaccine; SARS virus; coronavirus infections.

Abstract

Background: COVID-19 has emerged as a pandemic that spread throughout the world in less than 6 months, leaving hundred thousand deaths behind. Surprisingly, old drug arsenal has now been applied as an option of treatment. Objective: The aim of this article was to accomplish a literature review concerning the antiparasitic chloroquine, ivermectin, nitazoxanide; as well as glucocorticoids as possible therapeutic agents to be applied in patients with COVID-19 in Brazilian hospitals. Methodology: clinical evidence of COVID-infected patients and literature consultation have been used for the construction of this article. On line searches and gray literature have also been consulted, whose database include PUBMED Central, BVS/BIREME, Web of Science, Science Direct, Higher Level Personnel Improvement Coordinator (CAPES), Periodic Door (Portal de Periódicos da CAPES, The Cochrane Library and PROSPERO). Results: chloroquine, ivermectin and nitazoxanide present antiviral characteristics to support their usage in phase 1 of COVID-19 symptoms. Glucocorticoids such as methylprednisolone and dexamethasone seem to be more efficient in patients with pulmonary symptoms such as those in phase 2B and 3. Conclusion: According to the articles raised in this review, antiparasitic agents are promising for patients with COVID-19 in the very beginning of the symptoms. Methylprednisolone and dexamethasone are best indicated for hospitalized patients with pulmonary commitment.

Author Biography

Gabriel Henrique Queiroz Oliveira, Faculdade de Odontologia do Recife

Gabriel Henrique Queiroz, 5th year student from Faculdade de Odontologia do Recife (FOR).He intend to do master degree at Universidade de Pernambuco (UPE) and postgraduation at São Leopoldo Mandic. Participates at Projeto de Extensão at FOR, endodontics teaching assistant at FOR, Joined at Liga Odontológica Professor Lauro Soares Bezerra.Enjoys dentistry surgery.

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14/07/2021

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FILHO, L. B.; MELO JUNIOR, P. R. .; SAMPAIO, G. M. .; OLIVEIRA, G. H. Q. .; SILVA, H. F. da; MAIA, S. S. The role of antiparasitc drugs and steroids in Covid-19 treatment. Research, Society and Development, [S. l.], v. 10, n. 8, p. e39510817300, 2021. DOI: 10.33448/rsd-v10i8.17300. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/17300. Acesso em: 2 aug. 2021.

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