O papel das drogas antiparasitárias e corticóides no tratamento da Covid-19
DOI:
https://doi.org/10.33448/rsd-v10i8.17300Palavras-chave:
Ivermectina; Invertebrados; Cloroquina; Nitazoxanida; Glicocorticóides; COVID-19 vacina; SARS virus; Infecções por Coronavírus.Resumo
Background: COVID-19 emergiu-se como uma pandemia que se espalhou por todo o mundo em menos de 6 meses, causando a morte de milhões. Surpreendentemente, medicamentos antigos estão sendo aplicados para o tratamento. Objetivo: O objetivo desse artigo foi realizar uma revisão de literatura abordando antiparasitários como a Cloroquina, Ivermectina e Nitazoxanida; assim como os glicocorticóides como um possível agente terapêutico para ser aplicado em pacientes com COVID-19 nos hospitais brasileiros. Metodologia: Foi utilizado para a construção desse artigo, evidências clínicas de pacientes infectados e tratados pela COVID-19, além de consulta a literatura. Pesquisas online e literature cinzenta foram também consultadas, database inclui PUBMED Central, BVS/BIREME, Web of Science, Science Direct, Higher Level Personnel Improvement Coordinator (CAPES), Periodic Door (Portal de Periódicos da CAPES, The Cochrane Library and PROSPERO). Resultados: Cloroquina, Ivermectina e Nitazoxanida apresentaram eficiência para ser usado na fase 1 dos sintomas da COVID-19. Glicocorticóides assim como o Metilprednisolona e a dexametasona pareceram ser mais eficientes em pacientes com sintomas pulmonares assim como nas fases 2B e 3. Conclusão: De acordo com os artigos utilizados nessa revisão, agentes antiparasitários são promissores para pacientes com COVID-19 no começo dos sintomas. Metilprednisolona e a Dexametasona são os mais indicados para pacientes hospitalizados com comprometimento pulmonar.
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