Physalis peruviana L.: applicability perspective in cancer treatment
DOI:
https://doi.org/10.33448/rsd-v10i10.18700Keywords:
Physalis peruviana; Anticancerígeno; Vegetated extracts; Whitanolides.Abstract
Physalis peruviana L. is a plant widely used in food for providing potential health benefits, associated with melhorias in physiological processes, which are related to the presence of important bioactive, such as phytosteróis, polyphenois and vitamins A and C and to be considered A natural functional food has been alve of scientific and commercial interest due to a variety of compost. Either this study seeks to carry out in a systematic way, or to raise scientific evidence that it is possible to use this plant not for cancer treatment. A review was compiled by original and experimental studies published in national and international journals, responding to the guiding question: What are the evidências available in literature about the potential of the Peruvian Physalis species for the treatment of cancer? The research results will show that Physalis peruviana L. in s-eus derivatives shows cytotoxic activities against various types of cancer cells, by different mechanisms and apoptotic pathways, such as activation of Caspases 9, 8 and 3, release of cytochrome C, activation of p53 protein and activation of Bax and Bcl-2, an important mechanism of anticancer activity, as well as seletivity demonstrated in some two studies, enabling or developing safer therapeutic alternatives.
References
Al-Olayan, E. M. et al (2014). The potential protective effect of Physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression. Oxidative medicine and cellular longevity, 2014.
Arbiastutie, Y. et al. (2017). The potential of understorey plants from Gunung Gede Pangrango National Park (West Java, Indonesia) as cervixs anticancer agents. Biodiversitas Journal of Biological Diversity, 18 (1).
Areiza-Mazo, N. et al. (2018). Extracts of Physalis peruviana protect astrocytic cells under oxidative stress with rotenone. Frontiers in chemistry, 6, 276.
Areiza-Mazo, N.; Maldonado, M. E. & Rojano, B. (2013). Extracto acuoso de uchuva (Physalis peruviana): actividades antiproliferativa, apoptótica y antioxidante. Perspectivas en Nutrición Humana, 15 (1), 41-55.
Augenlicht, L., Heerdt, B. (2001) Mitochondria: integrators in tumorigenesis? Nature Genetics. 28, 104–105.
Ballesteros-Vivas, D. et al. (2019). Anti-proliferative bioactivity against HT-29 colon cancer cells of a withanolides-rich extract from golden berry (Physalis peruviana L.) calyx investigated by Foodomics. Journal of Functional Foods, 63, p. 103567.
Baloyiannis, I. et al (2021). Current evidence regarding the role of adjuvant chemotherapy in rectal cancer patients with pathologic complete response after neoadjuvant chemoradiotherapy: a systematic review and meta-analysis. International Journal of Colorectal Disease, p. 1-12.
Bergers, Gabriele & Fendt, S.M (2021). The metabolism of cancer cells during metastasis. Nature Reviews Cancer, 1-19.
Çakir, Ö. et al. (2014). Evaluation of biological activities of Physalis peruviana ethanol extracts and expression of Bcl-2 genes in HeLa cells. Food Science and Technology, 34 (2), p. 422-430.
Chang, L. C. et al. (2016) Poha berry (Physalis peruviana) with potential anti-inflammatory and cancer prevention activities. Hawai'i Journal of Medicine & Public Health, v. 75, n. 11, p. 353.
Chiu, C. C. et al. (2013). Golden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways. PloS one, 8 (5),64739.
De Almeida, E. M. et al. (2020) Therapeutic potential of medicinal plants indicated by the Brazilian public health system in treating the collateral effects induced by chemotherapy, radiotherapy, and chemoradiotherapy: A systematic review. Complementary therapies in medicine, 49, 102293.
El-Meghawry, El-Kenawy, A.; Elshama, S. S. & Osman, H. E. H. (2015). Effects of Physalis peruviana L on toxicity and lung cancer induction by nicotine derived nitrosamine ketone in rats. Asian Pacific Journal of Cancer Prevention, 16 (4), 5863-5868.
Fouché, G. et al. (2008). In vitro anticancer screening of South African plants. Journal of ethnopharmacology, 119 (3), 455-461.
Galvão, M. C. B. & Ricarte, I. L. M. (2019). Revisão Sistemática Da Literatura: conceituação, produção e publicação. Logeion: Filosofia da Informação, 6(1), 57-73
Hanna, T. P. et al. (2020). Mortality due to cancer treatment delay: systematic review and meta-analysis. BMJ, 371.
Hassan, H. A. et al. (2017). Cape gooseberry (Physalis peruviana) juice as a modulator agent for hepatocellular carcinoma-linked apoptosis and cell cycle arrest. Biomedicine & Pharmacotherapy, 94, 1129-1137.
Henrich, C. J. et al. (2015). Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation. Cell death & disease, 6 (2), e1666-e1666.
Herrera-Calderon, O. et al. (2018). Phytochemical screening, total phenolic content, antioxidant, and cytotoxic activity of five peruvian plants on human tumor cell lines. Pharmacognosy Research, v. 10, n. 2, p. 161.
Hilal-Dandan, R.& Brunton, L. (2015). Quimioterapia das doenças neoplásicas. In: Manual de Farmacologia e Terapêutica de Goodman & Gilman. Ed. 2. Editora: AMGH.
Hsieh, K.Y. et al. (2021). Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells. Scientific reports, 11 (1), 1-12.
Huang, M. et al. (2020). Withanolides from the genus Physalis: A review on their phytochemical and pharmacological aspects. Journal of Pharmacy and Pharmacology, 72 (5), 649-669.
Lan, Y. H. et al. (2009). New cytotoxic withanolides from Physalis peruviana. Food Chemistry, 116 (2), 462-469.
Lee, C.C. et al. (2017). 4β-Hydroxywithanolide E modulates alternative splicing of apoptotic genes in human hepatocellular carcinoma Huh-7 cells. Scientific reports, 7 (1), 1-13.
Martínez-Aledo, N.; Navas-Carrillo, D. & Orenes-Piñero, E. (2020). Medicinal plants: active compounds, properties and antiproliferative effects in colorectal cancer. Phytochemistry Reviews, 19 (1), 123-137.
Mbaveng, Armelle T. et al. (2018). Cytotoxicity of 18 Cameroonian medicinal plants against drug sensitive and multi-factorial drug resistant cancer cells. Journal of ethnopharmacology, 222, 21-33.
Mier-Giraldo, H. et al. (2017) Cytotoxic and immunomodulatory potential activity of Physalis peruviana fruit extracts on cervical cancer (HeLa) and fibroblast (L929) cells. Journal of evidence-based complementary & alternative medicine, 22 (4), 777-787.
Nagata, S., Tanaka, M. (2017). Programmed cell death and the immune system. Nature Reviews Immunology, 7, 333–340.
Ohayon, S.; Refua, M .; Hendler, A .; Aharoni, A .& Brik, A. (2015). Harnessing the oxidation susceptibility of deubiquitinases para a inibição com pequenas moléculas. Angewandte Chemie International Edition, 54, 599–603.
Omara, T. et al. (2020) Medicinal plants used in traditional management of cancer in Uganda: a review of ethnobotanical surveys, phytochemistry, and anticancer studies. Evidence-Based Complementary and Alternative Medicine, 2020, 3529081.
Park, E. J et al. (2016). Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4β‐hydroxywithanolide E isolated from Physalis peruviana. Molecular nutrition & food research, 60 (6), 1482-1500.
Peng, C. Y et al. (2016). The roles of 4β-hydroxywithanolide E from Physalis peruviana on the Nrf2-anti-oxidant system and the cell cycle in breast cancer cells. The American journal of Chinese medicine, 44 (03), 617-636.
Puente, L. et al. (2021). Effects of drying methods on the characterization of fatty acids, bioactive compounds and antioxidant capacity in thin layer of physalis (Physalis peruviana L.) pulp. Journal of Food Science and Technology, 58 (4),1470-1479.
Quispe-Mauricio, A. et al. (2009) Actividad citotóxica de Physalis peruviana (aguaymanto) en cultivos celulares de adenocarcinoma colorectal, próstata y leucemia mieloide crónica. Revista de Gastroenterología del Perú, v. 29 (3), 239-246.
Ramadan, Manal M. et al. (2015) Volatile compounds, antioxidants, and anticancer activities of Cape gooseberry fruit (Physalis peruviana L.): an in-vitro study. Journal of the Arab Society for Medical Research, 10 (2), 56.
Ramadan, M. F. (2020). Bioactive phytochemicals of cape gooseberry (Physalis peruviana L.). Bioactive Compounds in Underutilized Fruits and Nuts, 75-90.
Rao, P.C et al. (2016). Cytotoxicity of withasteroids: Withametelin induces cell cycle arrest at G2/M phase and mitochondria-mediated apoptosis in non-small cell lung cancer A549 cells. Tumor Biology, 37 (9), 12579-12587.
Rodríguez, S. & Rodríguez, E. (2007). Efecto de la ingesta de Physalis peruviana (aguaymanto) sobre la glicemia postprandial en adultos jóvenes. Revista Médica Vallejiana, 4(1), 43−52.
Sedrak, M. S. et al. (2021). Older adult participation in cancer clinical trials: A systematic review of barriers and interventions. CA: A Cancer Journal for Clinicians, 71 (1), 78-92.
Shebbo, S.; El Joumaa, M.; Kawach, R & Borjac, J. (2020) Hepatoprotective effect of Matricaria chamomilla aqueous extract against 1,2-Dimethylhydrazine-induced carcinogenic hepatic damage in mice. Heliyon. 6 (6), e04082.
Shenstone, E; Lippman, Z. & Van Eck, J. (2020). A review of nutritional properties and health benefits of Physalis species. Plant Foods for Human Nutrition, 75, 316-325.
Silveira, E. A. et al. (2021). Visceral obesity and incident cancer and cardiovascular disease: An integrative review of the epidemiological evidence. Obesity Reviews, 22 (1), e13088.
Tang, J.Y. et al. (2018). 4β‐Hydroxywithanolide E selectively induces oxidative DNA damage for selective killing of oral cancer cells. Environmental toxicology, 33 (3), 295-304.
Vega, J.C et al. (2020). Conservation advances on Physalis peruviana L. and Spondia purpurea: a review. Food Science and Technology.
Wu, S.J. et al. (2004a) Antihepatoma activity of Physalis angulata and P. peruviana extracts and their effects on apoptosis in human Hep G2 cells. Life sciences, 74 (16), 2061-2073.
Wu, S.J. et al (2004b). Physalis peruviana extract induces apoptosis in human Hep G2 cells through CD95/CD95L system and the mitochondrial signaling transduction pathway. Cancer Letters. 215, 199–208.
Wu, S. J et al. (2009). Supercritical carbon dioxide extract of Physalis peruviana induced cell cycle arrest and apoptosis in human lung cancer H661 cells. Food and Chemical Toxicology, 47 (6), 1132-1138.
Xu, S.J et al. (2021) The synthesis and cytotoxic activity of derivatives of 4β-hydroxywithanolide E. Steroids, v. 166, 108776.
XU, Y.M. et al. (2017). Withanolides from aeroponically grown Physalis peruviana and their selective cytotoxicity to prostate cancer and renal carcinoma cells. Journal of natural products, 80 (7), 1981-1991.
Ye, Z.N. et al. (2019). Physalis peruviana-Derived 4β-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo. Molecules, 24 (6), 1146.
Yen, C.Y. et al. (2010) 4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G 2/M arrest. BMC cancer, 10 (1),1-8.
You, B.-J. et al. (2014) Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells. Food and chemical toxicology, 65, 205-212.
Yu, T. J et al. (2021). Physalis peruviana-Derived Physapruin A (PHA) Inhibits Breast Cancer Cell Proliferation and Induces Oxidative-Stress-Mediated Apoptosis and DNA Damage. Antioxidants, 10 (3), 393.
Zavala, D et al. (2006) Efecto citotóxico de Physalis peruviana (capulí) en cáncer de colon y leucemia mieloide crónica. In: Anales de la Facultad de Medicina. UNMSM. Facultad de Medicina, 283-289.
Zimmer, T. B, R. et al. (2021) Biological potential of hydroalcoholic extracts of Physalis pubescens L. Biocatalysis and Agricultural Biotechnology, 31, 101895.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Brenda Nayranne Gomes dos Santos; Leide Maria Soares de Sousa; Nalbert Brendo Gomes dos Santos; Aldenora Maria Ximenes Rodrigues; Antonia Maria das Graças Lopes Citó; Livio Cesar Nunes Cunha; Maria Das Graças Freire de Medeiros
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
