Physalis peruviana L.: perspectiva de aplicabilidade no tratamento de câncer
DOI:
https://doi.org/10.33448/rsd-v10i10.18700Palavras-chave:
Physalis peruviana; Câncer; Extratos vegetais; Vitanolides.Resumo
A Physalis peruviana L. é uma planta amplamente utilizada na alimentação por proporcionar potenciais benefícios à saúde, associadas a melhorias nos processos fisiológicos, os quais estão relacionados à presença de importantes bioativos, como os fitoesteróis, polifenóis e vitaminas A e C e por ser considerado um alimento funcional natural tem sido alvo de interesse científico e comercial devido a variedade de compostos. O presente estudo buscou realizar de forma sistemática, o levantamento de evidências científicas que possibilitem a utilização desta planta no tratamento do câncer. A revisão foi composta por estudos originais, experimentais, publicados em periódicos nacionais e internacionais, que respondiam à questão norteadora: Quais são as evidências disponíveis na literatura acerca do potencial da espécie Physalis peruviana para o tratamento do câncer? Os resultados da pesquisa demostraram que a Physalis peruviana L. e seus derivados apresentou atividades citotóxicas contra vários tipos de células cancerígenas, por diferentes mecanismos e vias apoptóticas, como ativação de Caspases 9, 8 e 3, liberação de citocromo C, ativação da proteína p53 e ativação de Bax e Bcl-2, importante mecanismo de atividade anticancerígena, além da seletividade demonstrada em alguns dos estudos, possibilitando o desenvolvimento de alternativas terapêuticas mais seguras.
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Copyright (c) 2021 Brenda Nayranne Gomes dos Santos; Leide Maria Soares de Sousa; Nalbert Brendo Gomes dos Santos; Aldenora Maria Ximenes Rodrigues; Antonia Maria das Graças Lopes Citó; Livio Cesar Nunes Cunha; Maria Das Graças Freire de Medeiros
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