Plasma TNF-alfa levels in pregnant women with Zika virus (ZIKV) infection and its relationship to congenital syndrome severity: systematic review and meta-analyses




Zika virus; Congenital syndrome; TNF levels; TNF expression; Pregnancy; Severity.


The pathological process caused by the Zika virus (ZIKV), which is transmitted by mosquitoes of the Aedes genus, presents different signs and symptoms, with some difficulty in finding genetic, biochemical or immunological biomarkers, indicating alterations at the level of target tissues. Thus, the study aims to verify whether the increased expression or plasma levels of TNF-alpha in pregnant women with ZIKV infection are associated with the occurrence/severity of the Congenital Syndrome. As a methodological process, it is a systematic literature review, following the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol for systematic reviews and meta-analysis. The studies were searched in the Scielo, Pubmed, LILACS and Scopus data sources, where all analyzes were performed using the REVMAN 5.4 software (The Cochrane Collaboration, 2020). Due to the heterogeneity of the studies included in the meta-analysis, the random-effects model was selected, and seven studies were used. The results and discussion indicate that the findings in the studies indicated high I2 values ​​(95%; p<0.01) for the outcome, showing considerable heterogeneity, the results demonstrate that there is a considerable elevation of the cytokine TNF- alpha  in SCZ, being that the role of TNF- alpha  both in infectious diseases and in acute and chronic inflammation has been increasingly described, in an attempt to better understand the dynamics of the body's defense response to the invading particles that affect it. When the production of proinflammatory cytokines, the presence of plasma levels of TNF- alpha in pregnant women with ZIKV infection becomes evident as biological markers.


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How to Cite

COSTA, E. I. F. S. .; PORTO, M. de J. .; SOUSA, D. F. de .; FIGUEIREDO, C. A. V. .; CARNEIRO, V. L. Plasma TNF-alfa levels in pregnant women with Zika virus (ZIKV) infection and its relationship to congenital syndrome severity: systematic review and meta-analyses. Research, Society and Development, [S. l.], v. 10, n. 10, p. e428101019080, 2021. DOI: 10.33448/rsd-v10i10.19080. Disponível em: Acesso em: 21 oct. 2021.



Health Sciences