Primary prevention of delirium in elderly patients under intensive care: an integrative review
DOI:
https://doi.org/10.33448/rsd-v10i12.19917Keywords:
Delirium; Intensive therapy; Seniors.Abstract
Introduction: Delirium is a fluctuating state of cognition and consciousness, which can lead to memory loss, irritability, impaired collaboration and a dysregulated sleep-wake cycle. The prevalence of delirium in Intensive Care Units (ICUs) is related to a long period of time under mechanics, presence of severe pain, hypotension and higher mortality. A hospitalized elderly population is affected in about 15% by this morbidity, ranging to approximately 42%, dependent on associated comorbidities. Therefore, it is essential to gather evidence on the prevention of delirium in elderly patients admitted to the ICU. Methodology: This is an integrative literature review carried out in the SciELO, Medline and LILACS databases, with MESH descriptors and selected from articles published from 2017 to 2021, in any language, that were at the heart of the proposed objective. Exclusion criteria were: being an opinion article, review article, meta-analysis, trial protocol, pre-print or case report. Articles whose abstract, title or methodology did not match what was proposed in this review were also excluded. Results and discussion: Of 71 articles bulletins bulletins, 14 retrieved after applying the exclusion criteria. 7 were randomizations and 7 observational studies. Drugs such as melatonin, simvastatin, xenon, rameltheone, dexmedetomidine and others were added in elderly women in ICU with different comorbidities as potential prophylactic medications for delirium. In addition, non-pharmacological measures, such as night noise reduction, were also eliminated. We highlight the limitations imposed by the integrative review methodology itself, which has its result on the results and research of this study. Conclusion: There are pharmacological and non-pharmacological forms that reduce the impact of delirium in elderly patients admitted to the ICU, and that the heterogeneity of studies that build evidence must be considered, in order to favor the construction of a meta-analysis that statistically assesses them.
References
Balas, M. C., Vasilevskis, E. E., Burke, W. J., Boehm, L., Pun, B. T., Olsen, K. M., Peitz, G. J., & Ely, W. (2012). Critical care nurses’ role in implementing the “ABCDE Bundle” into practice. Critical Care Nurse, 32(2), 35–47. https://doi.org/10.4037/ccn2012229
Baumgartner, L., Lam, K., Lai, J., Barnett, M., Thompson, A., Gross, K., & Morris, A. (2019). Effectiveness of Melatonin for the Prevention of Intensive Care Unit Delirium. Pharmacotherapy, 39(3), 280–287. https://doi.org/10.1002/phar.2222
Coburn, M., Sanders, R. D., Maze, M., Nguyên-Pascal, M. L., Rex, S., Garrigues, B., Carbonell, J. A., Garcia-Perez, M. L., Stevanovic, A., Kienbaum, P., Neukirchen, M., Schaefer, M. S., Borghi, B., van Oven, H., Tognù, A., Al Tmimi, L., Eyrolle, L., Langeron, O., Capdevila, X., ... Kunitz, O. (2018). The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial. British Journal of Anaesthesia, 120(1), 127–137. https://doi.org/10.1016/j.bja.2017.11.015
Cucci, M. D., Cunningham, B. S., Patel, J. S., Shimer, A. T., Mofleh, D. I., & Mullen, C. L. (2021). Impact of Early Reinitiation of Neuropsychiatric Medications on Agitation and Delirium in the Intensive Care Unit: A Retrospective Study. Annals of Pharmacotherapy, 55(1), 15–24. https://doi.org/10.1177/1060028020935589
de la Varga-Martínez, O., Gómez-Pesquera, E., Muñoz-Moreno, M. F., Marcos-Vidal, J. M., López-Gómez, A., Rodenas-Gómez, F., Ramasco, F., Álvarez- Refojo, F., Tamayo, E., & Gómez-Sánchez, E. (2021). Development and validation of a delirium risk prediction preoperative model for cardiac surgery patients (DELIPRECAS): An observational multicentre study. Journal of Clinical Anesthesia, 69(November 2020). https://doi.org/10.1016/j.jclinane.2020.110158
Deiner, S., Luo, X., Lin, H. M., Sessler, D. I., Saager, L., Sieber, F. E., Lee, H. B., & Sano, M. (2017). Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium and cognitive dysfunction in elderly patients undergoing major elective noncardiac surgery : A randomized clinical trial. JAMA Surgery, 152(8), e171505. https://doi.org/10.1001/jamasurg.2017.1505
Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.
Faustino, T. N., Pedreira, L. C., Freitas, Y. S. de, Silva, R. M. de O., & Amaral, J. B. do. (2016). Prevenção e monitorização do delirium no idoso: uma intervenção educativa. Revista Brasileira de Enfermagem, 69(4), 725–732. https://doi.org/10.1590/0034-7167.2016690416i
Ford, A. H., Flicker, L., Kelly, R., Patel, H., Passage, J., Wibrow, B., Anstey, M., Edwards, M., & Almeida, O. P. (2020). The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium. Journal of the American Geriatrics Society, 68(1), 112–119. https://doi.org/10.1111/jgs.16162
Hatta, K., Kishi, Y., Wada, K., Takeuchi, T., Ito, S., Kurata, A., Murakami, K., Sugita, M., Usui, C., & Nakamura, H. (2017). Preventive effects of suvorexant on delirium: A randomized placebo-controlled trial. Journal of Clinical Psychiatry, 78(8), e970–e979. https://doi.org/10.4088/JCP.16m11194
Herling, S., Greve, I., Vasilevskis, E., Egerod, I., Bekker Mortensen, C., Møller, A., Svenningsen, H., & T, T. (2018). Interventions for preventing intensive care unit delirium in adults ( Review ). Cochrane Library [revista en Internet] 2018 [acceso 25 de noviembre de 2019]; 11:1-94. https://doi.org/10.1002/14651858.CD009783.pub2.www.cochranelibrary.com
Koche, J. C. (2011). Fundamentos de metodologia científica. Petrópolis: Vozes. Disponível em: http://www.brunovivas.com/wp- content/uploads/sites/10/2018/07/K%C3%B6che-Jos%C3%A9-Carlos0D0AFundamentos-de-metodologia-cient%C3%ADfica-_-teoria- da0D0Aci%C3%AAncia-e-inicia%C3%A7%C3%A3o-%C3%A0- pesquisa.pdfhttps://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1
Larsen, L. K., Møller, K., Petersen, M., & Egerod, I. (2020). Delirium prevalence and prevention in patients with acute brain injury: A prospective before-and- after intervention study. Intensive and Critical Care Nursing, 59(xxxx), 102816. https://doi.org/10.1016/j.iccn.2020.102816
Ludke, M. & Andre, M. E . D. A. (2013). Pesquisas em educação: uma abordagem qualitativa. São Paulo: E.P.U.
O’Connell, K. M., Quistberg, D. A., Tessler, R., Robinson, B. R. H., Cuschieri, J., Maier, R. V., Rivara, F. P., Vavilala, M. S., Bhalla, P. I., & Arbabi, S. (2018). Decreased risk of delirium with use of regional analgesia in geriatric trauma patients with multiple rib fractures. Annals of Surgery, 268(3), 534–540. https://doi.org/10.1097/SLA.0000000000002929
Page, V. J., Casarin, A., Ely, E. W., Zhao, X. B., McDowell, C., Murphy, L., & McAuley, D. F. (2017). Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS): a randomised, double-blind, placebo-controlled trial. The Lancet Respiratory Medicine, 5(9), 727–737. https://doi.org/10.1016/S2213-2600(17)30234-5
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM.
Rosa, R. G., Tonietto, T. F., Da Silva, D. B., Gutierres, F. A., Ascoli, A. M., Madeira, L. C., Rutzen, W., Falavigna, M., Robinson, C. C., Salluh, J. I., Cavalcanti, A. B., Azevedo, L. C., Cremonese, R. V., Haack, T. R., Eugênio, C. S., Dornelles, A., Bessel, M., Teles, J. M. M., Skrobik, Y., & Teixeira, C. (2017). Effectiveness and safety of an extended icu visitation model for delirium prevention: A before and after study. Critical Care Medicine, 45(10), 1660– 1667. https://doi.org/10.1097/CCM.0000000000002588
Ursi, E. S. (2005). Prevenção de lesões de pele no perioperatório: revisão integrativa da literatura. Revista Latino-Americana de Enfermagem, 14(1), 2–127. van de Pol, I., van Iterson, M., & Maaskant, J. (2017). Effect of nocturnal sound reduction on the incidence of delirium in intensive care unit patients: An interrupted time series analysis. Intensive and Critical Care Nursing, 41, 18–25. https://doi.org/10.1016/j.iccn.2017.01.008
Van Den Boogaard, M., Slooter, A. J. C., Brüggemann, R. J. M., Schoonhoven, L., Beishuizen, A., Vermeijden, J. W., Pretorius, D., De Koning, J., Simons, K. S., Dennesen, P. J. W., Van Der Voort, P. H. J., Houterman, S., Van Der Hoeven, J. G., & Pickkers, P. (2018). Effect of haloperidol on survival among critically ill adults with a high risk of delirium the REDUCE randomized clinical trial. JAMA - Journal of the American Medical Association, 319(7), 680– 690. https://doi.org/10.1001/jama.2018.0160
Yin, R.K. (2015). O estudo de caso. Porto Alegre: Bookman.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Thyago de Oliveira Afonso; Samuel Lopes dos Santos; Gustavo Baroni Araújo; Amanda Costa Maciel; Kellyane Folha Gois Moreira; Andressa Leite Rodrigues Batista; Ricardo Pessoa Rocha Melo; Cedric Adam Spíndola de Araújo Viana; Joelma Maria dos Santos da Silva Apolinário; Lara Maria Teles Guimarães Falcão; Caroliny Ferreira Lira; Layanne Cavalcante de Moura; Filipe Caleb Maia; Adrielle Pieve de Castro; Paulo Henrique Barcelos; Karina Aparecida Resende; Angelo Elias Meri Júnior; Adrila David Meri; Ana Cristina La Guárdia Custódio Pereira
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.