Sleep Quality, Food Cravings and Biochemical Markers of Inflammation in Health Professionals




Inflammation; Sleep Disorders, Circadian Rhythm; Modalities, Alimentary; Electric impedance.


Food craving occurs for those foods that are more palatable, highly processed, with high levels of carbohydrates and refined sugars and/or fat. The direct relationship between changes in the ideal nutritional status (such as obesity) and cardiovascular, neurodegenerative, metabolic and inflammatory diseases and the increase in oxidative stress is already consolidated, however, for the analysis of sleep quality, there is still little evidence. To outline the profile of nutritional status, food craving, biochemical markers of inflammation and sleep quality in health professionals from a university hospital. This pilot study was cross-sectional, quantitative and prospective. The recruited participants were linked to a Brazilian University Hospital. The target population consisted of health professionals from the hospital's clinical staff, who had been admitted for at least six months prior to the beginning of the research. Questionnaires were applied to measure Intense Food Cravings – Trait and State questionnaires; inflammation, recorded together with sociodemographic and body composition data from bioimpedance. For sleep assessment, the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used. Statistically significant correlations were found between inflammation, sleep quality, phase angle and body fat percentage. It is inferred that moderate food cravings influence the quality of poor sleep, biochemical profile of inflammation and body composition of health professionals. We suggest further studies of longitudinal interventions that can assess these long-term relationships.


Acuña, K., & Cruz, T. (2004). Avaliação do estado nutricional de adultos e idosos e situação nutricional da população brasileira. Arquivos Brasileiros de Endocrinologia & Metabologia, 48(3), 345–361.

Cepeda-benito, A., Gleaves, D. H., Williams, T. L., & Erath, S. A. (2000). The Development and Validation of the State and Trait Food-Cravings Questionnaires. Behavior Therapy, a 31, 151–173.

Daiber, A., Steven, S., Weber, A., Shuvaev, V. V, & Vladimir, R. (2017). Review for Themed Issue ‘ Redox biology and oxidative stress in health and disease’ Targeting vascular ( endothelial ) dysfunction. Br J Pharmacol.

Davidson, T. L., Tracy, A. L., Schier, L. A., & Swithers, S. E. (2014). A view of obesity as a learning and memory disorder. Journal of Experimental Psychology: Animal Behavior Processes, 40(3), 261–279.

De Medeiros, Q., Yamamoto, M. E., Cecı, A., Fatima, L., Pedrosa, C., & Simon, C. (2016). The Brazilian version of the three-factor eating questionnaire- R21 : psychometric evaluation and scoring pattern.

de Oliveira, C., de Freitas, J. S., Macedo, I. C., Scarabelot, V. L., Ströher, R., Santos, D. S., Souza, A., Fregni, F., Caumo, W., & Torres, I. L. S. (2019). Transcranial direct current stimulation (tDCS) modulates biometric and inflammatory parameters and anxiety-like behavior in obese rats. Neuropeptides, 73(July 2018), 1–10.

Dziegielewska-Gesiak, S. (2021). Metabolic syndrome in an aging society – role of oxidant-antioxidant imbalance and inflammation markers in disentangling atherosclerosis. Clinical Interventions in Aging, 16(April), 1057–1070.

Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, O. S., Afonso, C. B., Andreadou, I., Antelmann, H., … Daiber, A. (2017). Redox Biology European contribution to the study of ROS : A summary of the fi ndings and prospects for the future from the COST action BM1203 ( EU-ROS ). Redox Biology 13, 13(May), 94–162.

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

García Almeida, J. M., García García, C., Vegas Aguilar, I. M., Bellido Castañeda, V., & Bellido Guerrero, D. (2021). Morphofunctional assessment of patient nutritional status: a global approach. Nutrición Hospitalaria.

Hunt, C. A., Smith, M. T., Mun, C. J., Irwin, M. R., & Finan, P. H. (2021). Trait positive affect buffers the association between experimental sleep disruption and inflammation. Psychoneuroendocrinology, 129(December 2020), 105240.

Ischiropoulos, H., & Beckman, J. S. (2003). Oxidative stress and nitration in neurodegeneration : Cause , effect , or association ? J. Clin. Invest., 111(2), 163–169.

Killgore, W. D. S., Young, A. D., Femia, L. A., Bogorodzki, P., Rogowska, J., & Yurgelun-Todd, D. A. (2003). Cortical and limbic activation during viewing of high- versus low-calorie foods. NeuroImage, 19(4), 1381–1394.

Knauper, B., Pillay, R., Lacaille, J., Mccollam, A., & Kelso, E. (2011). Replacing craving imagery with alternative pleasant imagery reduces craving. Appetite, 57, 173–178.

Lowe, C. J., Staines, W. R., Mannochio, F., & Hall, P. A. (2018). The neurocognitive mechanisms underlying food cravings and snack food consumption. A combined continuous theta burst stimulation (cTBS) and EEG study. NeuroImage, 177, 45–58.

Lv, W., Finlayson, G., & Dando, R. (2018). Sleep, food cravings and taste. Appetite, 125, 210–216.

Modeling, L. M., Measurement, F., Snowrift, O. N., Environmental, A. R., Regional, S., Power, E., Limited, G. C., Influence, T. H. E., Snow, O. F., On, F., Around, S., Embankment, T. H. E., Wind, I. N., Snow, B., Aspect, O. F., On, R. R., Distribution, S., Model, A. A. C., Simulation, N., … Maciejowski, J. M. (2019). No 主観的健康感を中心とした在宅高齢者における 健康関連指標に関する共分散構造分析Title. Journal of Wind Engineering and Industrial Aerodynamics, 26(3), 1–4.

Moreno, S., Fernandez, M. C., & Cepeda-benito, A. (2008). Clinical Validation of the Trait and State Versions of the Food Craving Questionnaire. 15(3), 375–387.

Piber, D. (2021). The role of sleep disturbance and inflammation for spatial memory. Brain, Behavior, & Immunity - Health, 17(March), 100333.

Schumann Kruger, M., Doumid Borges Pretto, A., Bezerra Massaut, K., & Nunes Moreira, Â. (2018). Evaluation of life habits and eating health professionals in a hospital in the city of south of Brazil. Nutricion Clinica y Dietetica Hospitalaria, 38(4), 204–208.

Ulian, M. D., Sato, P. D. M., Benatti, F. B., De Campos-Ferraz, P. L., Roble, O. J., Unsain, R. F., Gualano, B., & Scagliusi, F. B. (2017a). Cross-cultural adaptation of the state and trait food cravings questionnaires (FCQ-S and FCQ-T) into Portuguese. Ciencia e Saude Coletiva, 22(2), 403–416.

Whitelock, V., Nouwen, A., van den Akker, O., & Higgs, S. (2018). The role of working memory sub-components in food choice and dieting success. Appetite, 124, 24–32.

WHO. (2002). The World Health Organization Report 2002: reducing risks, promoting healthy life. WHO Library Cataloguing-in Publication Data, 232.



How to Cite

BATISTA, M. M. da S. L. .; DIAS, R. S. C.; BARROS, G. M. de .; LIMA, G. W. F. .; SILVA, J. K. M. da .; SILVA, M. R. C.; SOUSA, M. A. S.; SANTOS, P. C. dos .; SILVA, R. K. da .; MARTINS, M. do C. de C. e. Sleep Quality, Food Cravings and Biochemical Markers of Inflammation in Health Professionals. Research, Society and Development, [S. l.], v. 10, n. 14, p. e245101422419, 2021. DOI: 10.33448/rsd-v10i14.22419. Disponível em: Acesso em: 17 jun. 2024.



Health Sciences