Multivisceral transplantation: a multifactorial approach

Authors

DOI:

https://doi.org/10.33448/rsd-v11i12.26304

Keywords:

Transplant; Intestine; Short Bowel Syndrome.

Abstract

Multivisceral transplantation is the only way to restore nutrition through the digestive tract of patients who suffer from intestinal failure or who have inadequate absorption of macro and micronutrients. Most of these transplants occur in the pediatric population, mainly caused by short bowel syndrome, which disables the child's intestines to secrete fluid and absorb nutrition and energy efficiently. The reality of Brazilian patients who have this injury is very harsh, as the Unified Health System (SUS) and the private network do not offer multivisceral transplantation due to the lack of professionals who master the technique of this procedure. The study made use of scientific publications dated between 2015 and 2021 present in the SciElo, PubMed, Up To Date, Medical News Today, Google Scholar, New England Journal of Medicine and ABTO (Brazilian Association of Organ Transplantation) databases in Portuguese. and English addressing the topic “Multivisceral Transplantation”. Research projects, books, case reports and editorials were excluded from this review. From the analysis of the literature found, it was found that although rejection is still quite frequent, several advances have allowed the clinical application of multivisceral transplantation, such as the emergence of new immunosuppressive drugs, inducers, monoclonal and antilymphocytic antibodies. It is therefore concluded that, initially, this type of transplant did not present satisfactory results, but with the improvement of surgical techniques and infection control, the multivisceral transplant appears to be quite promising.

References

Bhamidimarri, K. R. et al. (2014). Multivisceral Transplantation: Where do we stand?. Clinics In Liver Disease, 18(3), 661-674.

Bodeur, C. et al. (2014). Clinical practice guidelines--Nursing management for pediatric patients with small bowel or multivisceral transplant. Journal for specialists in pediatric nursing : JSPN, 19(1), 90–100.

Caamaño, B. F. et al. (2015) Fracaso intestinal y trasplante en la enfermedad por inclusiones microvellositarias. Anales de Pediatría, 83(3), 160-165.

Celik, N. et al. (2018). Pediatric Intestinal Transplantation. Gastroenterology Clinics Of North America, 47(2), 355-368.

Clift, A. K. et al. (2017). Neoadjuvant peptide receptor radionuclide therapy and modified multivisceral transplantation for an advanced small intestinal neuroendocrine neoplasm: an updated case report. Innovative Surgical Sciences 2(4), 247-253.

Costa, G. et al. (2018). Composite and Multivisceral Transplantation. Gastroenterology Clinics Of North America, 47(2), 393-415.

Faenza, S. et al. (2005). Intensive care complications in liver and multivisceral transplantation. Transplantation proceedings, 37(6), 2618–2621.

Frilling, A. et al. (2015). Modified Liver-free Multivisceral Transplantation for a Metastatic Small Bowel Neuroendocrine Tumor: a case report. Transplantation Proceedings, 47(3), 858-862.

Galvão, F. H. et al. (2008). Experimental multivisceral xenotransplantation. Xenotransplantation, 15(3), 184–190.

Gondolesi, G. E. & Aguirre, N. F. (2017). Techniques for abdominal wall reconstruction in intestinal transplantation. Current Opinion In Organ Transplantation, 22(2), 135-141.

Lee, E. et al. (2017). Multivisceral transplantation for abdominal tumors in children: A single center experience and review of the literature. Pediatric transplantation, 21(5).

Matsumoto, C. S. et al. (2018). Adult Intestinal Transplantation. Gastroenterology Clinics Of North America, 47(2), 341-354.

Meira Filho, S. P. et al. (2015). Intestinal and multivisceral transplantation. Einstein (São Paulo), 13(1), 136-141.

Moulin, L. et al. (2016). Case Report: multivisceral transplantation for an extensive cystic lymphangioma of the mesenteric root. Transplantation Proceedings, 48(2), 543-545.

Nunes, T. C. B. R. (2016). Papel do transplante intestinal na síndrome do intestino curto em pediatria. Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2016.

Palocaren, M. S. (2011). An Overview of Intestine and Multivisceral Transplantation. Critical Care Nursing Clinics Of North America, 23(3), 457-469.

Pascher, A. et al. (2008). Present status and future perspectives of intestinal transplantation. Transplant International, 21(5), 401-414.

Romanielo, A. F. R. et al. (2020). Transplante de intestino delgado: uma realidade ou um desafio?. Brazilian Journal Of Health Review, 3(1), 613-619.

Santos, R. M. (2016). A integralidade do SUS e a Judicialização por transplantes intestinais e multiviscerais. Cadernos Ibero-Americanos de Direito Sanitário 5(2), 130-140.

Selvaggi, G. et al. (2009). Intestinal and multivisceral transplantation at the University of Miami. Clinical transplants, 211–217.

Stringa, P. et al. (2018). Modified Multivisceral Transplantation with Native Spleen Removal in Rats. European Journal Of Pediatric Surgery, 29(03), 253-259.

Trevizol, A. P. et al. (2012). Intestinal and multivisceral transplantation immunosuppression protocols--literature review. Transplantation proceedings, 44(8), 2445–2448.

Tzvetanov, I. G. et al. (2018). Living Donor Intestinal Transplantation. Gastroenterology Clinics Of North America, 47(2), 369-380.

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Published

07/09/2022

How to Cite

ALENCAR, A. C. S. de; FREITAS NETO, V.; LIRA, I. R. A.; MACHADO , L. M.; FERNANDES, I. M. B.; GONÇALVES, S. A.; TARGINO, D. B. D.; OLIVEIRA , B. B. G.; ALMEIDA, B. G. D. de; FONSECA, G. S. G. B. Multivisceral transplantation: a multifactorial approach . Research, Society and Development, [S. l.], v. 11, n. 12, p. e53111226304, 2022. DOI: 10.33448/rsd-v11i12.26304. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/26304. Acesso em: 22 nov. 2024.

Issue

Vol. 11 No. 12

Section

Health Sciences

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Copyright (c) 2022 Ana Clara Silva de Alencar; Valdemiro Freitas Neto; Iago Robinson Alves Lira; Lorena Menegussi Machado ; Isadora Marçal Barbosa Fernandes; Sabrina Albuquerque Gonçalves; Danielle Brena Dantas Targino; Beatriz Barrozo Gonzalez Oliveira ; Bruna Gonçalves Dantas de Almeida; Gustavo Soares Gomes Barros Fonseca

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