Pseudoepitheliomatous hyperplasia: The link between sporotrichosis and squamous cell carcinoma

Authors

DOI:

https://doi.org/10.33448/rsd-v11i4.27390

Keywords:

Carcinoma; Skin; Diagnosis; Biopsy; Epidemiology; Zoonoses.

Abstract

The pseudoepitheliomatous hyperplasia (PEH) is a benign condition. It is a reactive histological pattern characterized by hyperplasia of the epidermis and adnexal epithelium. Therefore, it can be found in several clinically heterogeneous diseases: Infections, neoplasms, dermatoses with inflammation/chronic irritation, and miscellaneous processes. Among the infections group, deep mycoses stand out, and squamous cell carcinoma (SCC) for the neoplasm. As these two lesions can be observed in the same body regions and present visually similar features, it is also natural that they can be mistaken, as seen in previous works. Thus, we propose an individually based, cross-sectional retrospective review of patients with confirmed sporotrichosis (from a total of 86 cutaneous sporotrichosis cases) in which squamous cell carcinoma was also suspected as a clinical hypothesis. Considering the small sample, a qualitative analysis of the results was made. This paper presents an explanation with a microscopic basis for this diagnostic error. We also recommend examining several histological sections, detailed clinical information, and the use of special stains to avoid misdiagnosis.

Author Biography

Miguel Augusto Martins Pereira, Fundação Carlos Chagas de Amparo à Pesquisa do Estado do Rio de Janeiro; Universidade Federal Fluminense

Medical School, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil. Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Rio de Janeiro, Brazil.

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Published

16/03/2022

How to Cite

PEREIRA, M. A. M.; MARTINS, D. L. .; PANTALEÃO, L.; VILAR, E. G. . Pseudoepitheliomatous hyperplasia: The link between sporotrichosis and squamous cell carcinoma. Research, Society and Development, [S. l.], v. 11, n. 4, p. e19211427390, 2022. DOI: 10.33448/rsd-v11i4.27390. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27390. Acesso em: 14 nov. 2024.

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Section

Health Sciences